In recent Debian-based distros (e.g. Debian Trixie, Ubuntu Noble), python3 is linked against lib64/ld-linux-x86-64.so.2. Running an AppImage for such an application packaged with appimage-builder fails, because runtime/compat/lib64 is missing.
Workaround: create a symlink from runtime/compat/usr/lib64 to runtime/compat/lib64 (example).