I have tinkered with my VM setup (Spice -> VGA/VNC display, not sure if related) and after that, ayatana-indicator-a11y crashes on startup with this error message:
(process:<n>): ayatana-indicator-a11y-ERROR **: <time>: Panic: Failed to set CRTC info
The scaling is set to 1.5 (org.ayatana.indicator.a11y scale).