diff --git a/CMake/FindNumPy.cmake b/CMake/FindNumPy.cmake
index 31b0d052..b5ba8aef 100644
--- a/CMake/FindNumPy.cmake
+++ b/CMake/FindNumPy.cmake
@@ -16,7 +16,7 @@ FIND_PACKAGE(PythonInterp REQUIRED)
 
 # Look for the include path
 # WARNING: The variable PYTHON_EXECUTABLE is defined by the script FindPythonInterp.cmake
-EXECUTE_PROCESS(COMMAND "${PYTHON_EXECUTABLE}" -c "import numpy; print numpy.get_include(); print numpy.version.version"
+EXECUTE_PROCESS(COMMAND "${PYTHON_EXECUTABLE}" -c "from __future__ import print_function; import numpy; print(numpy.get_include()); print(numpy.version.version)"
                  OUTPUT_VARIABLE NUMPY_OUTPUT
                  ERROR_VARIABLE NUMPY_ERROR)
                  
@@ -30,4 +30,4 @@ INCLUDE(FindPackageHandleStandardArgs)
 
 FIND_PACKAGE_HANDLE_STANDARD_ARGS(NumPy DEFAULT_MSG NUMPY_VERSION NUMPY_INCLUDE_DIR)
 
-MARK_AS_ADVANCED(NUMPY_INCLUDE_DIR)
\ No newline at end of file
+MARK_AS_ADVANCED(NUMPY_INCLUDE_DIR)
diff --git a/Packaging/CMakeLists.txt b/Packaging/CMakeLists.txt
index 4ba0be8b..07371400 100644
--- a/Packaging/CMakeLists.txt
+++ b/Packaging/CMakeLists.txt
@@ -24,5 +24,8 @@ IF(BTK_WRAP_PYTHON)
   GET_TARGET_PROPERTY(BTK_SWIG_PYTHON_MODULE_LOCATION "_btk" LOCATION)
   ADD_CUSTOM_TARGET(Package_Python
                     COMMAND ${CMAKE_COMMAND} -D BTK_SWIG_PYTHON_MODULE_LOCATION:STRING=${BTK_SWIG_PYTHON_MODULE_LOCATION} -D ARCH_64_BIT:BOOL=${HAVE_64_BIT} -D BTK_VERSION_STRING:STRING=${BTK_VERSION_STRING} -D BTK_BINARY_DIR:STRING=${BTK_BINARY_DIR} -D BTK_SOURCE_DIR:STRING=${BTK_SOURCE_DIR} -P "${BTK_SOURCE_DIR}/Packaging/Python/btkPackagePythonBinding.cmake")
-  ADD_DEPENDENCIES(package Package_Python)
+                ADD_DEPENDENCIES(package Package_Python)
+  ADD_CUSTOM_TARGET(python-wheel
+                    COMMAND ${CMAKE_COMMAND} -D BTK_VERSION_STRING=${BTK_VERSION_STRING} -D BTK_SOURCE_DIR:STRING=${BTK_SOURCE_DIR} -D BTK_BINARY_DIR:STRING=${BTK_BINARY_DIR} -P "${BTK_SOURCE_DIR}/Packaging/Python/btkPackagePythonWheel.cmake")
+  ADD_DEPENDENCIES(package python-wheel)
 ENDIF(BTK_WRAP_PYTHON)
diff --git a/Packaging/Python/btkPackagePythonWheel.cmake b/Packaging/Python/btkPackagePythonWheel.cmake
new file mode 100644
index 00000000..dc498d80
--- /dev/null
+++ b/Packaging/Python/btkPackagePythonWheel.cmake
@@ -0,0 +1,44 @@
+SET(CMAKE_MODULE_PATH "${BTK_SOURCE_DIR}/CMake")
+FIND_PACKAGE(PythonInterp REQUIRED QUIET)
+FIND_PACKAGE(SWIG 2.0 REQUIRED)
+FIND_PACKAGE(PythonLibs REQUIRED)
+FIND_PACKAGE(NumPy REQUIRED)
+
+SET(BTK_PYTHON_WRAPPING_SOURCE_DIR "${BTK_SOURCE_DIR}/Wrapping/Python")
+SET(BTK_PYTHON_WHEEL_SOURCE_DIR "${BTK_SOURCE_DIR}/Packaging/Python/wheel")
+SET(BTK_PYTHON_WHEEL_BINARY_DIR "${BTK_BINARY_DIR}/Packaging/Python/wheel")
+
+MESSAGE(STATUS "---------------------------")
+MESSAGE(STATUS "Packaging Python Wheel ...")
+MESSAGE(STATUS "---------------------------")
+
+FILE(MAKE_DIRECTORY "${BTK_PYTHON_WHEEL_BINARY_DIR}")
+
+MESSAGE(STATUS "Preparing sources in ${BTK_PYTHON_WHEEL_BINARY_DIR}")
+
+# btk.py file
+FILE(MAKE_DIRECTORY "${BTK_PYTHON_WHEEL_BINARY_DIR}/btk")
+FILE(COPY "${BTK_BINARY_DIR}/bin/btk.py" DESTINATION "${BTK_PYTHON_WHEEL_BINARY_DIR}/btk")
+FILE(RENAME "${BTK_PYTHON_WHEEL_BINARY_DIR}/btk/btk.py" "${BTK_PYTHON_WHEEL_BINARY_DIR}/btk/__init__.py")
+
+SET(BTKSWIG_SOURCES
+    libBTKBasicFilters.a
+    libBTKCommon.a
+    libBTKIO.a
+    btkSwigPYTHON_wrap.cxx)
+
+# .a files and cxx file
+FOREACH(dep IN LISTS BTKSWIG_SOURCES)
+  MESSAGE(STATUS " - ${dep}")
+  FILE(COPY "${BTK_BINARY_DIR}/bin/${dep}" DESTINATION "${BTK_PYTHON_WHEEL_BINARY_DIR}")
+ENDFOREACH(dep)
+
+
+MESSAGE(STATUS "Creating setup.py for build")
+CONFIGURE_FILE(${BTK_PYTHON_WHEEL_SOURCE_DIR}/setup.py.in
+               ${BTK_PYTHON_WHEEL_BINARY_DIR}/setup.py @ONLY IMMEDIATE)
+
+# Package files
+MESSAGE(STATUS "Creating Python wheel using setup.py bdist_wheel in ${BTK_PYTHON_WHEEL_BINARY_DIR}")
+EXECUTE_PROCESS(COMMAND ${PYTHON_EXECUTABLE} setup.py bdist_wheel
+                WORKING_DIRECTORY "${BTK_PYTHON_WHEEL_BINARY_DIR}/")
diff --git a/Packaging/Python/wheel/setup.py.in b/Packaging/Python/wheel/setup.py.in
new file mode 100644
index 00000000..72cdc12e
--- /dev/null
+++ b/Packaging/Python/wheel/setup.py.in
@@ -0,0 +1,50 @@
+# coding=utf-8
+from setuptools import setup, Extension
+import glob
+import os.path
+
+version = '@BTK_VERSION_STRING@'
+
+WRAPPER_SOURCES = '@BTK_PYTHON_WRAPPING_SOURCE_DIR@'
+WRAPPER_OBJECTS = '@BTK_PYTHON_WHEEL_BINARY_DIR@'
+
+
+def get_wrapper_sources():
+    sources = [
+       'btkBasicFiltersSwig.cpp',
+       'btkCommonSwig.cpp',
+       'btkIOSwig.cpp'
+    ]
+    return [os.path.join(WRAPPER_SOURCES, s) for s in sources]
+
+
+_btk = Extension('_btk',
+                include_dirs=[
+                    '.',
+                    '..',
+                    '@CMAKE_CURRENT_SOURCE_DIR@',
+                    '@BTK_BINARY_DIR@',
+                    '@BTK_SOURCE_DIR@/Wrapping/Python/',
+                    '@BTK_SOURCE_DIR@/Code/BasicFilters',
+                    '@BTK_SOURCE_DIR@/Code/Common',
+                    '@BTK_SOURCE_DIR@/Code/IO',
+                    '@BTK_SOURCE_DIR@/Utilities/boost',
+                    '@BTK_SOURCE_DIR@/Utilities/eigen3',
+                    '@BTK_SOURCE_DIR@/Utilities/SWIG',
+                    '@NUMPY_INCLUDE_DIR@'
+                ],
+                sources=get_wrapper_sources() + ['btkSwigPYTHON_wrap.cxx'],
+                extra_objects=['libBTKBasicFilters.a', 'libBTKCommon.a', 'libBTKIO.a'])
+
+
+setup(name='btk',
+      version=version,
+      description='BTK Python bindings',
+      long_description='''@BTK_PYTHON_PACKAGE_LONG_DESCRIPTION@''',
+      author='Arnaud Barré',
+      author_email='arnaud.barre@gmail.com',
+      url='https://code.google.com/p/b-tk/',
+      license='New BSD License',
+      packages=['btk'],
+      setup_requires=['wheel'],
+      ext_modules=[_btk])