You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
Copy file name to clipboardExpand all lines: README.md
+14-12
Original file line number
Diff line number
Diff line change
@@ -4,7 +4,9 @@ A detailed mathematical modelling of voltage-clamp experiment.
4
4
This repo contains all data and code for reproducing the results in the paper "*Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments*" by Chon Lok Lei, Michael Clerx, Dominic Whittaker, David Gavaghan, Teun de Boer, and Gary Mirams.
5
5
6
6
7
-
### Prerequisite
7
+
### Installing
8
+
9
+
To run the code to generate the data and figures shown in the paper, please follow these steps first:
8
10
9
11
1. Clone [hERGRapidCharacterisation](https://github.com/CardiacModelling/hERGRapidCharacterisation) to the relative path `../hERGRapidCharacterisation`.
10
12
2. To setup, either run (for Linux/macOS users)
@@ -18,29 +20,29 @@ install [PINTS](https://github.com/pints-team/pints) and [Myokit](http://myokit.
18
20
### Results
19
21
20
22
#### Section 3: Validating the mathematical model with electrical model cell experiments
21
-
[model-cell-experiments](./model-cell-experiments): Application of the voltage-clamp experiment model to electrical model cell experiments.
22
23
23
-
It contains results and code to reproduce Figures 4, 5; Table 2; Figures S4, S5; Tables S1, S2.
24
+
-[model-cell-experiments](./model-cell-experiments): Application of the voltage-clamp experiment model to electrical model cell experiments.
25
+
- contains results and code to reproduce Figures 4, 5; Table 2; Figures S4, S5; Tables S1, S2.
24
26
25
27
#### Section 4: Application to variability in CHO-hERG1a patch-clamp data
26
-
[herg-syn-study](./herg-syn-study): Synthetic studies with the voltage-clamp experiment model.
27
28
28
-
It contains results and code to reproduce Figure S6.
29
+
-[herg-syn-study](./herg-syn-study): Synthetic studies with the voltage-clamp experiment model.
30
+
- contains results and code to reproduce Figure S6.
29
31
30
-
[herg-real-data](./herg-real-data): Application of the voltage-clamp experiment model to data in [hERGRapidCharacterisation](https://github.com/CardiacModelling/hERGRapidCharacterisation).
32
+
-[herg-real-data](./herg-real-data): Application of the voltage-clamp experiment model to data in [hERGRapidCharacterisation](https://github.com/CardiacModelling/hERGRapidCharacterisation).
31
33
32
-
It contains results and code to reproduce Hypothesis 2: Figures 7, 8; Figures S7, S8, S9; Tables S3, S4.
33
-
It also contains results and code that are mentioned but not shown in the paper: full voltage-clamp experiment model fitting to hERG data; independent kinetics with independent artefacts 'Hypothesis 3'.
34
+
- Contains results and code to reproduce Hypothesis 2: Figures 7, 8; Figures S7, S8, S9; Tables S3, S4.
35
+
- Also contains results and code that are mentioned but not shown in the paper: full voltage-clamp experiment model fitting to hERG data; independent kinetics with independent artefacts 'Hypothesis 3'.
34
36
35
37
### Supporting files
36
38
37
-
[lib](./lib): Contains all modules/utility functions.
39
+
-[lib](./lib): Contains all modules/utility functions.
38
40
39
-
[mmt-model-files](./mmt-model-files): [Myokit](http://myokit.org/) model files, contains IKr model and voltage clamp experiment model etc.
41
+
-[mmt-model-files](./mmt-model-files): [Myokit](http://myokit.org/) model files, contains IKr model and voltage clamp experiment model etc.
40
42
41
-
[protocol-time-series](./protocol-time-series): Contains protocols as time series, stored as `.csv` files, with time points (in `s`) and voltage (in `mV`)
43
+
-[protocol-time-series](./protocol-time-series): Contains protocols as time series, stored as `.csv` files, with time points (in `s`) and voltage (in `mV`)
42
44
43
-
`data`, `data-autoLC`, `manualselection`, `qc`: symbolic links to [hERGRapidCharacterisation](https://github.com/CardiacModelling/hERGRapidCharacterisation)
45
+
-`data`, `data-autoLC`, `manualselection`, `qc`: symbolic links to [hERGRapidCharacterisation](https://github.com/CardiacModelling/hERGRapidCharacterisation)
0 commit comments