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Hi all, over in the NIPY world, we've just decided to deprecate (u)int64 support in NIfTI: nipy/nibabel#1089
Basically nobody else (AFNI, FSL, SPM) supports them, and there's no compelling use case for them, but they're easy to make in Python if you aren't paying careful attention to types, so we're going to be making it hard to do unintentionally. Not sure if your technical situation is similar, but in case it is, I wanted to bring this to your attention before it becomes a painful decision.