HI-C Classification.ipynb

{
 "cells": [
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Operations on Hi-C Data \n",
    "### Author : Mareedu Mahesh Chandra"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Importing modules"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "import pandas as pd\n",
    "import numpy as np\n",
    "import matplotlib.pyplot as plt"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [],
   "source": [
    "import fanc\n",
    "import fanc.plotting as fancplot"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Loading example image"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [],
   "source": [
    "hic = fanc.load(\"examples/test.hic\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Visualization of Hi-C Data"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.TriangularMatrixPlot(hic, vmax=0.05)\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.SquareMatrixPlot(hic)\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.SquareMatrixPlot(hic, vmax=0.05)\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.SquareMatrixPlot(hic, vmax=0.05, colormap='white_red')\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.SquareMatrixPlot(hic, norm='log')\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.SquareMatrixPlot(hic, vmax=30, matrix_norm=False)\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Expected 100% (634396 of 634396) |#######| Elapsed Time: 0:00:05 Time:  0:00:05\n",
      "/home/mahesh/.local/lib/python3.8/site-packages/fanc/matrix.py:2428: UserWarning: Matrix file opened in read-only mode, cannot save expected values to object. Run 'fanc expected <matrix_file>' on the command line or in Python use mode 'a' to add expected values to an existing object. The results of the current computation are not affected if you don't do this, but it will speed things up in the future.\n",
      "  warnings.warn(\"Matrix file opened in read-only mode, \"\n"
     ]
    },
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "hp = fancplot.SquareMatrixPlot(hic, vmin=-2, vmax=2, oe=True, log=True,\n",
    "                               colormap='RdBu_r')\n",
    "hp.plot('chr18:6mb-10mb')\n",
    "hp.show()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 14,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['.DS_Store',\n",
       " 'architecture',\n",
       " 'bwa-index',\n",
       " 'hg19_chr18_19',\n",
       " 'hg19_chr18_19.fa',\n",
       " 'hg19_chr18_19_re_fragments.bed',\n",
       " 'hicpro',\n",
       " 'SRR4271982_chr18_19_1.fastq.gzip',\n",
       " 'SRR4271982_chr18_19_2.fastq.gzip',\n",
       " 'test.cool',\n",
       " 'test.hic']"
      ]
     },
     "execution_count": 14,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "import os\n",
    "os.listdir(\"examples\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Tasks to-do:\n",
    "        • Run Fan-C to convert raw Hi-C sequences to a Hi-C matrix\n",
    "                • https://github.com/vaquerizaslab/fanc\n",
    "        • Find other tools that will convert raw sequences into a Hi-C matrix\n",
    "        • Read and make a presentation that summarizes this paper\n",
    "                • https://arxiv.org/pdf/2203.12742.pdf"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Run Fan-C to convert raw Hi-C sequences to a Hi-C matrix"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Generating Hi-C matrices with fanc\n",
    "\n",
    "#### Notes\n",
    "1. **fanc auto** command is to  convert any input to binned Hi-C matrices. \n",
    "2. \n",
    "\n",
    "**usage**: \n",
    "\n",
    "fanc auto [-h] [-g GENOME] [-r RESTRICTION_ENZYME] [-i GENOME_INDEX]\\\n",
    "                 [-n BASENAME] [-s STEP_SIZE] [-b BIN_SIZES [BIN_SIZES ...]]\\\n",
    "                 [-t THREADS] [--fanc-parallel] [--split-fastq] [--memory-map]\\\n",
    "                 [--ice] [--norm-method NORM_METHOD] [-q QUALITY_CUTOFF]\\\n",
    "                 [--iterative-quality-cutoff ITERATIVE_QUALITY_CUTOFF]\\\n",
    "                 [--le-inward-cutoff INWARD_CUTOFF]\\\n",
    "                 [--le-outward-cutoff OUTWARD_CUTOFF] [--auto-le-cutoff]\\\n",
    "                 [-tmp] [--iterative] [--no-sam-sort] [--restore-coverage]\\\n",
    "                 [--split-ligation-junction] [--no-filter-pairs] [--no-hic]\\\n",
    "                 [--run-with RUN_WITH] [--job-prefix JOB_PREFIX]\\\n",
    "                 [--grid-startup-commands GRID_STARTUP_COMMANDS]\\\n",
    "                 [--grid-cleanup-commands GRID_CLEANUP_COMMANDS] [-f]\\\n",
    "                 input [input ...] output_folder \\\n",
    "\n",
    "Source : https://vaquerizaslab.github.io/fanc/fanc-executable/fanc-generate-hic/fanc_auto.html#"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Code to Convert single HI-C Sequence to Map"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 27,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n"
     ]
    }
   ],
   "source": [
    "import subprocess\n",
    "\n",
    "command = \"fanc auto examples/test.hic ./example_output/\"\n",
    "\n",
    "ret = subprocess.run(command, capture_output=True, shell=True)\n",
    "\n",
    "print(ret.stdout.decode())"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 29,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "CompletedProcess(args='fanc auto examples/test.hic ./example_output/', returncode=0, stdout=b'', stderr=b'2022-05-28 16:31:39,738 INFO FAN-C version: 0.9.24\\n2022-05-28 16:31:39,752 INFO Output folder: ./example_output/\\n2022-05-28 16:31:39,752 INFO Input files: examples/test.hic\\n2022-05-28 16:31:39,752 INFO Input file types: hic\\n2022-05-28 16:31:39,752 INFO Final basename: test (you can change this with the -n option!)\\n2022-05-28 16:31:39,752 INFO Creating output folders...\\n2022-05-28 16:31:48,339 INFO FAN-C version: 0.9.24\\n2022-05-28 16:31:48,740 INFO Binning Hic file (5000000)\\n2022-05-28 16:31:48,740 INFO Constructing binned genome...\\n2022-05-28 16:31:49,821 INFO Binning edges...\\n2022-05-28 16:31:50,015 INFO Binning Hi-C contacts\\n2022-05-28 16:31:50,857 INFO Launching processes\\n2022-05-28 16:31:59,962 INFO Submitting partitions\\n2022-05-28 16:31:59,971 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 406) |               | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (5 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (9 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (13 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (17 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (21 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (25 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (29 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (33 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (37 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (41 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (45 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (49 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (53 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (57 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (61 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (65 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (70 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (74 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (78 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (82 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (86 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (90 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (94 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (98 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (102 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (106 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (110 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (114 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (118 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (122 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (126 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (130 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (134 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (139 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (143 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (147 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (151 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (155 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (159 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (163 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (167 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (171 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (175 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (179 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (183 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (187 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (191 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (195 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (199 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (204 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (208 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (212 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (216 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (220 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (224 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (228 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (232 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (236 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (240 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (244 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (248 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (252 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (256 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (260 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (264 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (268 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (273 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (277 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (281 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (285 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (289 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (293 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (297 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (301 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (305 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (309 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (313 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (317 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (321 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (325 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (329 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (333 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (337 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (342 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (346 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (350 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (354 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (358 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (362 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (366 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (370 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (374 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (378 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (382 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (386 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (390 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (394 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (398 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (402 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (406 of 406) |#############| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:32:29,112 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:32:29,122 INFO Final absolute cutoff threshold is 3.618e+03\\n2022-05-28 16:32:29,122 INFO Selected a total of 0 (0.0%) regions to be masked\\n2022-05-28 16:32:29,122 INFO Running filters...\\n\\rFilter   0% (0 of 1) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter 100% (1 of 1) |###################| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:32:29,133 INFO Total: 406. Filtered: 0\\n\\rExpected   0% (0 of 406) |               | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (5 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (9 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (13 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (17 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (21 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (25 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (29 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (33 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (37 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (41 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (45 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (49 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (53 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (57 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (61 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (65 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (70 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (74 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (78 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (82 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (86 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (90 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (94 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (98 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (102 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (106 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (110 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (114 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (118 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (122 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (126 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (130 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (134 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (139 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (143 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (147 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (151 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (155 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (159 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (163 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (167 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (171 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (175 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (179 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (183 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (187 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (191 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (195 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (199 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (204 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (208 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (212 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (216 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (220 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (224 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (228 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (232 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (236 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (240 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (244 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (248 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (252 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (256 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (260 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (264 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (268 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (273 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (277 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (281 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (285 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (289 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (293 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (297 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (301 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (305 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (309 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (313 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (317 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (321 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (325 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (329 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (333 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (337 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (342 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (346 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (350 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (354 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (358 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (362 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (366 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (370 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (374 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (378 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (382 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (386 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (390 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (394 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (398 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (402 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (406 of 406) |#############| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:32:29,157 INFO Done.\\n2022-05-28 16:32:29,681 INFO Saving statistics...\\n2022-05-28 16:32:30,061 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 406) |               | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (5 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (9 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (13 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (17 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (21 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (25 of 406) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (29 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (33 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (37 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (41 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (45 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (49 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (53 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (57 of 406) |#             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (61 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (65 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (70 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (74 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (78 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (82 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (86 of 406) |##            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (90 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (94 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (98 of 406) |###           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (102 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (106 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (110 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (114 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (118 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (122 of 406) |###          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (126 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (130 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (134 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (139 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (143 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (147 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (151 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (155 of 406) |####         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (159 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (163 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (167 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (171 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (175 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (179 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (183 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (187 of 406) |#####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (191 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (195 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (199 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (204 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (208 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (212 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (216 of 406) |######       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (220 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (224 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (228 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (232 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (236 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (240 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (244 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (248 of 406) |#######      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (252 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (256 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (260 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (264 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (268 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (273 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (277 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (281 of 406) |########     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (285 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (289 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (293 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (297 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (301 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (305 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (309 of 406) |#########    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (313 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (317 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (321 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (325 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (329 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (333 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (337 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (342 of 406) |##########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (346 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (350 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (354 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (358 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (362 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (366 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (370 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (374 of 406) |###########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (378 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (382 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (386 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (390 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (394 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (398 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (402 of 406) |############ | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (406 of 406) |#############| Elapsed Time: 0:00:00 Time:  0:00:00\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:32:39,975 INFO FAN-C version: 0.9.24\\n2022-05-28 16:32:40,262 INFO Binning Hic file (2000000)\\n2022-05-28 16:32:40,262 INFO Constructing binned genome...\\n2022-05-28 16:32:41,082 INFO Binning edges...\\n2022-05-28 16:32:41,285 INFO Binning Hi-C contacts\\n2022-05-28 16:32:41,836 INFO Launching processes\\n2022-05-28 16:32:51,869 INFO Submitting partitions\\n2022-05-28 16:32:51,880 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 2383) |              | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 2383) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (24 of 2383) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (48 of 2383) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (72 of 2383) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (96 of 2383) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (120 of 2383) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (143 of 2383) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (167 of 2383) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (191 of 2383) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (215 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (239 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (263 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (286 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (310 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (334 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (358 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (382 of 2383) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (406 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (429 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (453 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (477 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (501 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (525 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (549 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (572 of 2383) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (596 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (620 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (644 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (668 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (692 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (715 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (739 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (763 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (787 of 2383) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (811 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (835 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (858 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (882 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (906 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (930 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (954 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (978 of 2383) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (1001 of 2383) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (1025 of 2383) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (1049 of 2383) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (1073 of 2383) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (1097 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (1121 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (1144 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (1168 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (1192 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (1216 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (1240 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (1263 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (1287 of 2383) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (1311 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (1335 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (1359 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (1383 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (1406 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (1430 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (1454 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (1478 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (1502 of 2383) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (1526 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (1549 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (1573 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (1597 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (1621 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (1645 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (1669 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (1692 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (1716 of 2383) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (1740 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (1764 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (1788 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (1812 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (1835 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (1859 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (1883 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (1907 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (1931 of 2383) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (1955 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (1978 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (2002 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (2026 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (2050 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (2074 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (2098 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (2121 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (2145 of 2383) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (2169 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (2193 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (2217 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (2241 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (2264 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (2288 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (2312 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (2336 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (2360 of 2383) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (2383 of 2383) |###########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:32:59,093 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:32:59,158 INFO Final absolute cutoff threshold is 1.669e+03\\n2022-05-28 16:32:59,158 INFO Selected a total of 2 (2.9%) regions to be masked\\n2022-05-28 16:32:59,158 INFO Running filters...\\n\\rFilter   0% (0 of 1) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter 100% (1 of 1) |###################| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:32:59,198 INFO Total: 2383. Filtered: 37\\n\\rExpected   0% (0 of 2346) |              | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 2346) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (24 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (47 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (71 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (94 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (118 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (141 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (165 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (188 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (212 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (235 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (259 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (282 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (305 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (329 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (352 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (376 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (399 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (423 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (446 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (470 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (493 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (517 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (540 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (564 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (587 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (610 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (634 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (657 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (681 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (704 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (728 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (751 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (775 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (798 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (822 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (845 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (869 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (892 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (915 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (939 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (962 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (986 of 2346) |#####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (1009 of 2346) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (1033 of 2346) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (1056 of 2346) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (1080 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (1103 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (1127 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (1150 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (1174 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (1197 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (1220 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (1244 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (1267 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (1291 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (1314 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (1338 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (1361 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (1385 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (1408 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (1432 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (1455 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (1478 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (1502 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (1525 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (1549 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (1572 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (1596 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (1619 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (1643 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (1666 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (1690 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (1713 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (1737 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (1760 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (1783 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (1807 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (1830 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (1854 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (1877 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (1901 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (1924 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (1948 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (1971 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (1995 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (2018 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (2042 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (2065 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (2088 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (2112 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (2135 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (2159 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (2182 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (2206 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (2229 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (2253 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (2276 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (2300 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (2323 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (2346 of 2346) |###########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:32:59,315 INFO Done.\\n2022-05-28 16:33:00,119 INFO Saving statistics...\\n2022-05-28 16:33:00,384 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 2346) |              | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 2346) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (24 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (47 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (71 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (94 of 2346) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (118 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (141 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (165 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (188 of 2346) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (212 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (235 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (259 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (282 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (305 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (329 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (352 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (376 of 2346) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (399 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (423 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (446 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (470 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (493 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (517 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (540 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (564 of 2346) |##          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (587 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (610 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (634 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (657 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (681 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (704 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (728 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (751 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (775 of 2346) |###         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (798 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (822 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (845 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (869 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (892 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (915 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (939 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (962 of 2346) |####        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (986 of 2346) |#####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (1009 of 2346) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (1033 of 2346) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (1056 of 2346) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (1080 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (1103 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (1127 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (1150 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (1174 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (1197 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (1220 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (1244 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (1267 of 2346) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (1291 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (1314 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (1338 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (1361 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (1385 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (1408 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (1432 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (1455 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (1478 of 2346) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (1502 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (1525 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (1549 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (1572 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (1596 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (1619 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (1643 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (1666 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (1690 of 2346) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (1713 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (1737 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (1760 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (1783 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (1807 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (1830 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (1854 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (1877 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (1901 of 2346) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (1924 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (1948 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (1971 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (1995 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (2018 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (2042 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (2065 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (2088 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (2112 of 2346) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (2135 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (2159 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (2182 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (2206 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (2229 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (2253 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (2276 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (2300 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (2323 of 2346) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (2346 of 2346) |###########| Elapsed Time: 0:00:00 Time:  0:00:00\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:33:12,270 INFO FAN-C version: 0.9.24\\n2022-05-28 16:33:12,399 INFO Binning Hic file (1000000)\\n2022-05-28 16:33:12,399 INFO Constructing binned genome...\\n2022-05-28 16:33:13,089 INFO Binning edges...\\n2022-05-28 16:33:13,262 INFO Binning Hi-C contacts\\n2022-05-28 16:33:13,665 INFO Launching processes\\n2022-05-28 16:33:23,199 INFO Submitting partitions\\n2022-05-28 16:33:23,210 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 8858) |              | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 8858) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (89 of 8858) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (178 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (266 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (355 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (443 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (532 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (621 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (709 of 8858) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (798 of 8858) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (886 of 8858) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (975 of 8858) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (1063 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (1152 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (1241 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (1329 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (1418 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (1506 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (1595 of 8858) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (1684 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (1772 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (1861 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (1949 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (2038 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (2126 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (2215 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (2304 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (2392 of 8858) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (2481 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (2569 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (2658 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (2746 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (2835 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (2924 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (3012 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (3101 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (3189 of 8858) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (3278 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (3367 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (3455 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (3544 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (3632 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (3721 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (3809 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (3898 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (3987 of 8858) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (4075 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (4164 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (4252 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (4341 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (4429 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (4518 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (4607 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (4695 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (4784 of 8858) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (4872 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (4961 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (5050 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (5138 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (5227 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (5315 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (5404 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (5492 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (5581 of 8858) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (5670 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (5758 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (5847 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (5935 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (6024 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (6113 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (6201 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (6290 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (6378 of 8858) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (6467 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (6555 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (6644 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (6733 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (6821 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (6910 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (6998 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (7087 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (7175 of 8858) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (7264 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (7353 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (7441 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (7530 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (7618 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (7707 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (7796 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (7884 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (7973 of 8858) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (8061 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (8150 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (8238 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (8327 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (8416 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (8504 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (8593 of 8858) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (8681 of 8858) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (8770 of 8858) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (8858 of 8858) |###########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:33:31,300 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:33:31,429 INFO Final absolute cutoff threshold is 968.9\\n2022-05-28 16:33:31,430 INFO Selected a total of 6 (4.3%) regions to be masked\\n2022-05-28 16:33:31,430 INFO Running filters...\\n\\rFilter   0% (0 of 1) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter 100% (1 of 1) |###################| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:33:31,489 INFO Total: 8858. Filtered: 151\\n\\rExpected   0% (0 of 8707) |              | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 8707) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (88 of 8707) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (175 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (262 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (349 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (436 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (523 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (610 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (697 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (784 of 8707) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (871 of 8707) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (958 of 8707) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (1045 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (1132 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (1219 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (1307 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (1394 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (1481 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (1568 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (1655 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (1742 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (1829 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (1916 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (2003 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (2090 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (2177 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (2264 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (2351 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (2438 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (2526 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (2613 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (2700 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (2787 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (2874 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (2961 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (3048 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (3135 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (3222 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (3309 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (3396 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (3483 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (3570 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (3657 of 8707) |####       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (3745 of 8707) |####       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (3832 of 8707) |####       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (3919 of 8707) |####       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (4006 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (4093 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (4180 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (4267 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (4354 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (4441 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (4528 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (4615 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (4702 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (4789 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (4876 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (4963 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (5051 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (5138 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (5225 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (5312 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (5399 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (5486 of 8707) |######     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (5573 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (5660 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (5747 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (5834 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (5921 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (6008 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (6095 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (6182 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (6270 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (6357 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (6444 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (6531 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (6618 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (6705 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (6792 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (6879 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (6966 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (7053 of 8707) |########   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (7140 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (7227 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (7314 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (7401 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (7489 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (7576 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (7663 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (7750 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (7837 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (7924 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (8011 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (8098 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (8185 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (8272 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (8359 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (8446 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (8533 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (8620 of 8707) |########## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (8707 of 8707) |###########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:33:31,725 INFO Done.\\n2022-05-28 16:33:32,373 INFO Saving statistics...\\n2022-05-28 16:33:32,695 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 8707) |              | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 8707) |              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (88 of 8707) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (175 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (262 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (349 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (436 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (523 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (610 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (697 of 8707) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (784 of 8707) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (871 of 8707) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (958 of 8707) |#           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (1045 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (1132 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (1219 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (1307 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (1394 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (1481 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (1568 of 8707) |#          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (1655 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (1742 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (1829 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (1916 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (2003 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (2090 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (2177 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (2264 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (2351 of 8707) |##         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (2438 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (2526 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (2613 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (2700 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (2787 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (2874 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (2961 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (3048 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (3135 of 8707) |###        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (3222 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (3309 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (3396 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (3483 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (3570 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  42% (3657 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  43% (3745 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  44% (3832 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  45% (3919 of 8707) |####       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  46% (4006 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  47% (4093 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  48% (4180 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  49% (4267 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  50% (4354 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  51% (4441 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  52% (4528 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  53% (4615 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  54% (4702 of 8707) |#####      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  55% (4789 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  56% (4876 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  57% (4963 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  58% (5051 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  59% (5138 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  60% (5225 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  61% (5312 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  62% (5399 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  63% (5486 of 8707) |######     | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  64% (5573 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  65% (5660 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  66% (5747 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  67% (5834 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  68% (5921 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  69% (6008 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  70% (6095 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  71% (6182 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  72% (6270 of 8707) |#######    | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  73% (6357 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  74% (6444 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  75% (6531 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  76% (6618 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  77% (6705 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  78% (6792 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  79% (6879 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  80% (6966 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  81% (7053 of 8707) |########   | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  82% (7140 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  83% (7227 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  84% (7314 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  85% (7401 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  86% (7489 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  87% (7576 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  88% (7663 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  89% (7750 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  90% (7837 of 8707) |#########  | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  91% (7924 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  92% (8011 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  93% (8098 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  94% (8185 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  95% (8272 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  96% (8359 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  97% (8446 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  98% (8533 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  99% (8620 of 8707) |########## | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected 100% (8707 of 8707) |###########| Elapsed Time: 0:00:00 Time:  0:00:00\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:33:44,105 INFO FAN-C version: 0.9.24\\n2022-05-28 16:33:44,605 INFO Binning Hic file (500000)\\n2022-05-28 16:33:44,606 INFO Constructing binned genome...\\n2022-05-28 16:33:45,738 INFO Binning edges...\\n2022-05-28 16:33:46,030 INFO Binning Hi-C contacts\\n2022-05-28 16:33:46,620 INFO Launching processes\\n2022-05-28 16:33:59,252 INFO Submitting partitions\\n2022-05-28 16:33:59,263 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 28049) |             | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 28049) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (281 of 28049) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (561 of 28049) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (842 of 28049) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (1122 of 28049) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (1403 of 28049) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (1683 of 28049) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (1964 of 28049) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (2244 of 28049) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (2525 of 28049) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (2805 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (3086 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (3366 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (3647 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (3927 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (4208 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (4488 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (4769 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (5049 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (5330 of 28049) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (5610 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (5891 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (6171 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (6452 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (6732 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (7013 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (7293 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (7574 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (7854 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (8135 of 28049) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (8415 of 28049) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (8696 of 28049) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (8976 of 28049) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (9257 of 28049) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (9537 of 28049) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (9818 of 28049) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (10098 of 28049) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (10379 of 28049) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (10659 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  39% (10940 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  40% (11220 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  41% (11501 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (11781 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (12062 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (12342 of 28049) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (12623 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (12903 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (13184 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (13464 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (13745 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (14025 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (14305 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (14586 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (14866 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (15147 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (15427 of 28049) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (15708 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (15988 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (16269 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (16549 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (16830 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (17110 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (17391 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (17671 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (17952 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (18232 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (18513 of 28049) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (18793 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (19074 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (19354 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (19635 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (19915 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (20196 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (20476 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (20757 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (21037 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (21318 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (21598 of 28049) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (21879 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (22159 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (22440 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (22720 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (23001 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (23281 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (23562 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (23842 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (24123 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (24403 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (24684 of 28049) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (24964 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (25245 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (25525 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (25806 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (26086 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (26367 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (26647 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (26928 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (27208 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (27489 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (27769 of 28049) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (28049 of 28049) |#########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:34:05,684 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:34:06,079 INFO Final absolute cutoff threshold is 497.7\\n2022-05-28 16:34:06,080 INFO Selected a total of 13 (4.7%) regions to be masked\\n2022-05-28 16:34:06,080 INFO Running filters...\\n\\rFilter   0% (0 of 1) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter 100% (1 of 1) |###################| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:34:06,159 INFO Total: 28049. Filtered: 212\\n\\rExpected   0% (0 of 27837) |             | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 27837) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (279 of 27837) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (557 of 27837) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (836 of 27837) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (1114 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (1392 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (1671 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (1949 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (2227 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (2506 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (2784 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (3063 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (3341 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (3619 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (3898 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (4176 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (4454 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (4733 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (5011 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (5290 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (5568 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (5846 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (6125 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (6403 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (6681 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (6960 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  26% (7238 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  27% (7516 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  28% (7795 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  29% (8073 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  30% (8352 of 27837) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  31% (8630 of 27837) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  32% (8908 of 27837) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  33% (9187 of 27837) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  34% (9465 of 27837) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  35% (9743 of 27837) |###       | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  36% (10022 of 27837) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  37% (10300 of 27837) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  38% (10579 of 27837) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  39% (10857 of 27837) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  40% (11135 of 27837) |###      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  41% (11414 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (11692 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (11970 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (12249 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (12527 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (12806 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (13084 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (13362 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (13641 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (13919 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (14197 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (14476 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (14754 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (15032 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (15311 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (15589 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (15868 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (16146 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (16424 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (16703 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (16981 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (17259 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (17538 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (17816 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (18095 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (18373 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (18651 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (18930 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (19208 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (19486 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (19765 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (20043 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (20322 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (20600 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (20878 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (21157 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (21435 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (21713 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (21992 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (22270 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (22548 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (22827 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (23105 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (23384 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (23662 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (23940 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (24219 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (24497 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (24775 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (25054 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (25332 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (25611 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (25889 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (26167 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (26446 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (26724 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (27002 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (27281 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (27559 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (27837 of 27837) |#########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:34:06,450 INFO Done.\\n2022-05-28 16:34:07,194 INFO Saving statistics...\\n2022-05-28 16:34:07,592 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 27837) |             | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 27837) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (279 of 27837) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (557 of 27837) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (836 of 27837) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (1114 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (1392 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (1671 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (1949 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (2227 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (2506 of 27837) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (2784 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (3063 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (3341 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (3619 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (3898 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (4176 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (4454 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (4733 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (5011 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (5290 of 27837) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (5568 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (5846 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  22% (6125 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  23% (6403 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  24% (6681 of 27837) |##        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  25% (6960 of 27837) |##        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  26% (7238 of 27837) |##        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  27% (7516 of 27837) |##        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  28% (7795 of 27837) |##        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  29% (8073 of 27837) |##        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  30% (8352 of 27837) |###       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  31% (8630 of 27837) |###       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  32% (8908 of 27837) |###       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  33% (9187 of 27837) |###       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  34% (9465 of 27837) |###       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  35% (9743 of 27837) |###       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  36% (10022 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  37% (10300 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  38% (10579 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  39% (10857 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  40% (11135 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  41% (11414 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (11692 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (11970 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (12249 of 27837) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (12527 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (12806 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (13084 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (13362 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (13641 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (13919 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (14197 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (14476 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (14754 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (15032 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (15311 of 27837) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (15589 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (15868 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (16146 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (16424 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (16703 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (16981 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (17259 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (17538 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (17816 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (18095 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (18373 of 27837) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (18651 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (18930 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (19208 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (19486 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (19765 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (20043 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (20322 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (20600 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (20878 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (21157 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (21435 of 27837) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (21713 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (21992 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (22270 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (22548 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (22827 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (23105 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (23384 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (23662 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (23940 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (24219 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (24497 of 27837) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (24775 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (25054 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (25332 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (25611 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (25889 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (26167 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (26446 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (26724 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (27002 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (27281 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (27559 of 27837) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (27837 of 27837) |#########| Elapsed Time: 0:00:00 Time:  0:00:00\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:34:15,997 INFO FAN-C version: 0.9.24\\n2022-05-28 16:34:16,327 INFO Binning Hic file (250000)\\n2022-05-28 16:34:16,327 INFO Constructing binned genome...\\n2022-05-28 16:34:17,335 INFO Binning edges...\\n2022-05-28 16:34:17,531 INFO Binning Hi-C contacts\\n2022-05-28 16:34:18,231 INFO Launching processes\\n2022-05-28 16:34:30,086 INFO Submitting partitions\\n2022-05-28 16:34:30,105 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 79611) |             | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 79611) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (797 of 79611) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (1593 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (2389 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (3185 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (3981 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (4777 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (5573 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (6369 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (7165 of 79611) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (7962 of 79611) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (8758 of 79611) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (9554 of 79611) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (10350 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (11146 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (11942 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  16% (12738 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  17% (13534 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  18% (14330 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  19% (15127 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  20% (15923 of 79611) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  21% (16719 of 79611) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  22% (17515 of 79611) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  23% (18311 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  24% (19107 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  25% (19903 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  26% (20699 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  27% (21495 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  28% (22292 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  29% (23088 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  30% (23884 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  31% (24680 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  32% (25476 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  33% (26272 of 79611) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  34% (27068 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  35% (27864 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  36% (28660 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  37% (29457 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  38% (30253 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  39% (31049 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  40% (31845 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  41% (32641 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (33437 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (34233 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (35029 of 79611) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (35825 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (36622 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (37418 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (38214 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (39010 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (39806 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (40602 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (41398 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (42194 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (42990 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (43787 of 79611) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (44583 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (45379 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (46175 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (46971 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (47767 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (48563 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (49359 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (50155 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (50952 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (51748 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (52544 of 79611) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (53340 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (54136 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (54932 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (55728 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (56524 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (57320 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (58117 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (58913 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (59709 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (60505 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (61301 of 79611) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (62097 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (62893 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (63689 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (64485 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (65282 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (66078 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (66874 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (67670 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (68466 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (69262 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (70058 of 79611) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (70854 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (71650 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (72447 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (73243 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (74039 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (74835 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (75631 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (76427 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (77223 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (78019 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (78815 of 79611) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (79611 of 79611) |#########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:34:37,848 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:34:38,359 INFO Final absolute cutoff threshold is 253.1\\n2022-05-28 16:34:38,359 INFO Selected a total of 26 (4.7%) regions to be masked\\n2022-05-28 16:34:38,360 INFO Running filters...\\n\\rFilter   0% (0 of 1) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter 100% (1 of 1) |###################| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:34:38,627 INFO Total: 79611. Filtered: 304\\n\\rExpected   0% (0 of 79307) |             | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 79307) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (794 of 79307) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (1587 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (2380 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (3173 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (3966 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (4759 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (5552 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (6345 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (7138 of 79307) |          | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  10% (7931 of 79307) |#         | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  11% (8724 of 79307) |#         | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  12% (9517 of 79307) |#         | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  13% (10310 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  14% (11103 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  15% (11897 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  16% (12690 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  17% (13483 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  18% (14276 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  19% (15069 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  20% (15862 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  21% (16655 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  22% (17448 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  23% (18241 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  24% (19034 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  25% (19827 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  26% (20620 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  27% (21413 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  28% (22206 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  29% (23000 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  30% (23793 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  31% (24586 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  32% (25379 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  33% (26172 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  34% (26965 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  35% (27758 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  36% (28551 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  37% (29344 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  38% (30137 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  39% (30930 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  40% (31723 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  41% (32516 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (33309 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (34103 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (34896 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (35689 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (36482 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (37275 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (38068 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (38861 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (39654 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (40447 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (41240 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (42033 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (42826 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (43619 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (44412 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (45205 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (45999 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (46792 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (47585 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (48378 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (49171 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (49964 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (50757 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (51550 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (52343 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (53136 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (53929 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (54722 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (55515 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (56308 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (57102 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (57895 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (58688 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (59481 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (60274 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (61067 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (61860 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (62653 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (63446 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (64239 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (65032 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (65825 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (66618 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (67411 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (68205 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (68998 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (69791 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (70584 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (71377 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (72170 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (72963 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (73756 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (74549 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (75342 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (76135 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (76928 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (77721 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (78514 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (79307 of 79307) |#########| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:34:39,387 INFO Done.\\n2022-05-28 16:34:40,140 INFO Saving statistics...\\n2022-05-28 16:34:40,539 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 79307) |             | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 79307) |             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (794 of 79307) |           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (1587 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (2380 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (3173 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (3966 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (4759 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (5552 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (6345 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   9% (7138 of 79307) |          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  10% (7931 of 79307) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  11% (8724 of 79307) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  12% (9517 of 79307) |#         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  13% (10310 of 79307) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  14% (11103 of 79307) |#        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected  15% (11897 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  16% (12690 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  17% (13483 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  18% (14276 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  19% (15069 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  20% (15862 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  21% (16655 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  22% (17448 of 79307) |#        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  23% (18241 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  24% (19034 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  25% (19827 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  26% (20620 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  27% (21413 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  28% (22206 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  29% (23000 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  30% (23793 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  31% (24586 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  32% (25379 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  33% (26172 of 79307) |##       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  34% (26965 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  35% (27758 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  36% (28551 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  37% (29344 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  38% (30137 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  39% (30930 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  40% (31723 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  41% (32516 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (33309 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (34103 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (34896 of 79307) |###      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (35689 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (36482 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (37275 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (38068 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (38861 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (39654 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (40447 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (41240 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (42033 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (42826 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (43619 of 79307) |####     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (44412 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (45205 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (45999 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (46792 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (47585 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (48378 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  62% (49171 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  63% (49964 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  64% (50757 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  65% (51550 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  66% (52343 of 79307) |#####    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  67% (53136 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  68% (53929 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  69% (54722 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  70% (55515 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  71% (56308 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  72% (57102 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  73% (57895 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  74% (58688 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  75% (59481 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  76% (60274 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  77% (61067 of 79307) |######   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  78% (61860 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  79% (62653 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  80% (63446 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  81% (64239 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  82% (65032 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  83% (65825 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  84% (66618 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  85% (67411 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  86% (68205 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  87% (68998 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  88% (69791 of 79307) |#######  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  89% (70584 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  90% (71377 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  91% (72170 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  92% (72963 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  93% (73756 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  94% (74549 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  95% (75342 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  96% (76135 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  97% (76928 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  98% (77721 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  99% (78514 of 79307) |######## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected 100% (79307 of 79307) |#########| Elapsed Time: 0:00:00 Time:  0:00:00\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:34:50,858 INFO FAN-C version: 0.9.24\\n2022-05-28 16:34:51,364 INFO Binning Hic file (100000)\\n2022-05-28 16:34:51,364 INFO Constructing binned genome...\\n2022-05-28 16:34:52,163 INFO Binning edges...\\n2022-05-28 16:34:52,433 INFO Binning Hi-C contacts\\n2022-05-28 16:34:53,020 INFO Launching processes\\n2022-05-28 16:35:04,751 INFO Submitting partitions\\n2022-05-28 16:35:04,763 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 3) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers  33% (1 of 3) |######            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  66% (2 of 3) |############      | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers 100% (3 of 3) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 239665) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 239665) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (2397 of 239665) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (4794 of 239665) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (7190 of 239665) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (9587 of 239665) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (11984 of 239665) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (14380 of 239665) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (16777 of 239665) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   8% (19174 of 239665) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected   9% (21570 of 239665) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  10% (23967 of 239665) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  11% (26364 of 239665) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  12% (28760 of 239665) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  13% (31157 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  14% (33554 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  15% (35950 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  16% (38347 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  17% (40744 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  18% (43140 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  19% (45537 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  20% (47934 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  21% (50330 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  22% (52727 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  23% (55123 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  24% (57520 of 239665) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  25% (59917 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  26% (62313 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  27% (64710 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  28% (67107 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  29% (69503 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  30% (71900 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  31% (74297 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  32% (76693 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  33% (79090 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  34% (81487 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  35% (83883 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  36% (86280 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  37% (88677 of 239665) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  38% (91073 of 239665) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  39% (93470 of 239665) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  40% (95866 of 239665) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  41% (98263 of 239665) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  42% (100660 of 239665) |##     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  43% (103056 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  44% (105453 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (107850 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (110246 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (112643 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (115040 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (117436 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (119833 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (122230 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (124626 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (127023 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (129420 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (131816 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (134213 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (136610 of 239665) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (139006 of 239665) |####   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (141403 of 239665) |####   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (143799 of 239665) |####   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (146196 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  62% (148593 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  63% (150989 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  64% (153386 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  65% (155783 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  66% (158179 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  67% (160576 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  68% (162973 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  69% (165369 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  70% (167766 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  71% (170163 of 239665) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  72% (172559 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  73% (174956 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  74% (177353 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  75% (179749 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  76% (182146 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  77% (184543 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  78% (186939 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  79% (189336 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  80% (191732 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  81% (194129 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  82% (196526 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  83% (198922 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  84% (201319 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  85% (203716 of 239665) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  86% (206112 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  87% (208509 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  88% (210906 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  89% (213302 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  90% (215699 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  91% (218096 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  92% (220492 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  93% (222889 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  94% (225286 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  95% (227682 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  96% (230079 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  97% (232476 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  98% (234872 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  99% (237269 of 239665) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected 100% (239665 of 239665) |#######| Elapsed Time: 0:00:02 Time:  0:00:02\\n2022-05-28 16:35:15,240 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:35:17,213 INFO Final absolute cutoff threshold is 102.4\\n2022-05-28 16:35:17,213 INFO Selected a total of 68 (5.0%) regions to be masked\\n2022-05-28 16:35:17,213 INFO Running filters...\\n\\rFilter   0% (0 of 3) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter  33% (1 of 3) |######             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rFilter  66% (2 of 3) |############       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rFilter 100% (3 of 3) |###################| Elapsed Time: 0:00:00 Time:  0:00:00\\n2022-05-28 16:35:18,785 INFO Total: 239665. Filtered: 376\\n\\rExpected   0% (0 of 239289) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 239289) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (2393 of 239289) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (4786 of 239289) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (7179 of 239289) |         | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   4% (9572 of 239289) |         | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   5% (11965 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   6% (14358 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   7% (16751 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   8% (19144 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   9% (21537 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  10% (23929 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  11% (26322 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  12% (28715 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  13% (31108 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  14% (33501 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  15% (35894 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  16% (38287 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  17% (40680 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  18% (43073 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  19% (45465 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  20% (47858 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  21% (50251 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  22% (52644 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  23% (55037 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  24% (57430 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  25% (59823 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  26% (62216 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  27% (64609 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  28% (67001 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  29% (69394 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  30% (71787 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  31% (74180 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  32% (76573 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  33% (78966 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  34% (81359 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  35% (83752 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  36% (86145 of 239289) |##      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  37% (88537 of 239289) |##      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  38% (90930 of 239289) |###     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  39% (93323 of 239289) |###     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  40% (95716 of 239289) |###     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  41% (98109 of 239289) |###     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  42% (100502 of 239289) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  43% (102895 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  44% (105288 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  45% (107681 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  46% (110073 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  47% (112466 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  48% (114859 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  49% (117252 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  50% (119645 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  51% (122038 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  52% (124431 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  53% (126824 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  54% (129217 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  55% (131609 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  56% (134002 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  57% (136395 of 239289) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  58% (138788 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  59% (141181 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  60% (143574 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  61% (145967 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  62% (148360 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  63% (150753 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  64% (153145 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  65% (155538 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  66% (157931 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  67% (160324 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  68% (162717 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  69% (165110 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  70% (167503 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  71% (169896 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  72% (172289 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  73% (174681 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  74% (177074 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  75% (179467 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  76% (181860 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  77% (184253 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  78% (186646 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  79% (189039 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  80% (191432 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  81% (193825 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  82% (196217 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  83% (198610 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  84% (201003 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  85% (203396 of 239289) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  86% (205789 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  87% (208182 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  88% (210575 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  89% (212968 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  90% (215361 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  91% (217753 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  92% (220146 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  93% (222539 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  94% (224932 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  95% (227325 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  96% (229718 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  97% (232111 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  98% (234504 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  99% (236897 of 239289) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected 100% (239289 of 239289) |#######| Elapsed Time: 0:00:02 Time:  0:00:02\\n2022-05-28 16:35:21,559 INFO Done.\\n2022-05-28 16:35:22,355 INFO Saving statistics...\\n2022-05-28 16:35:22,701 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 239289) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 239289) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (2393 of 239289) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (4786 of 239289) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (7179 of 239289) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (9572 of 239289) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (11965 of 239289) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   6% (14358 of 239289) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   7% (16751 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected   8% (19144 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected   9% (21537 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  10% (23929 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  11% (26322 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  12% (28715 of 239289) |        | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  13% (31108 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  14% (33501 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  15% (35894 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  16% (38287 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  17% (40680 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  18% (43073 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  19% (45465 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  20% (47858 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  21% (50251 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  22% (52644 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  23% (55037 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  24% (57430 of 239289) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  25% (59823 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  26% (62216 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  27% (64609 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  28% (67001 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  29% (69394 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  30% (71787 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  31% (74180 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  32% (76573 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  33% (78966 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  34% (81359 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  35% (83752 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  36% (86145 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  37% (88537 of 239289) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  38% (90930 of 239289) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  39% (93323 of 239289) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  40% (95716 of 239289) |###     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  41% (98109 of 239289) |###     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  42% (100502 of 239289) |##     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  43% (102895 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  44% (105288 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  45% (107681 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  46% (110073 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  47% (112466 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  48% (114859 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  49% (117252 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  50% (119645 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  51% (122038 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  52% (124431 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  53% (126824 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  54% (129217 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  55% (131609 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  56% (134002 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  57% (136395 of 239289) |###    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  58% (138788 of 239289) |####   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  59% (141181 of 239289) |####   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  60% (143574 of 239289) |####   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rExpected  61% (145967 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  62% (148360 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  63% (150753 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  64% (153145 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  65% (155538 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  66% (157931 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  67% (160324 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  68% (162717 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  69% (165110 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  70% (167503 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  71% (169896 of 239289) |####   | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  72% (172289 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  73% (174681 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  74% (177074 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  75% (179467 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  76% (181860 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  77% (184253 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  78% (186646 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  79% (189039 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  80% (191432 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  81% (193825 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  82% (196217 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  83% (198610 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  84% (201003 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  85% (203396 of 239289) |#####  | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  86% (205789 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  87% (208182 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  88% (210575 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  89% (212968 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  90% (215361 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  91% (217753 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  92% (220146 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  93% (222539 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  94% (224932 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  95% (227325 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  96% (229718 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  97% (232111 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  98% (234504 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected  99% (236897 of 239289) |###### | Elapsed Time: 0:00:01 ETA:   0:00:00\\rExpected 100% (239289 of 239289) |#######| Elapsed Time: 0:00:01 Time:  0:00:01\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:35:38,883 INFO FAN-C version: 0.9.24\\n2022-05-28 16:35:39,380 INFO Binning Hic file (50000)\\n2022-05-28 16:35:39,381 INFO Constructing binned genome...\\n2022-05-28 16:35:40,215 INFO Binning edges...\\n2022-05-28 16:35:40,515 INFO Binning Hi-C contacts\\n2022-05-28 16:35:40,924 INFO Launching processes\\n2022-05-28 16:35:50,823 INFO Submitting partitions\\n2022-05-28 16:35:50,834 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 6) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers  16% (1 of 6) |###               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  33% (2 of 6) |######            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  50% (3 of 6) |#########         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  66% (4 of 6) |############      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  83% (5 of 6) |###############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers 100% (6 of 6) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 376220) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 376220) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (3763 of 376220) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (7525 of 376220) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (11287 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   4% (15049 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   5% (18812 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   6% (22574 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   7% (26336 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   8% (30098 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   9% (33860 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  10% (37623 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  11% (41385 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  12% (45147 of 376220) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  13% (48909 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  14% (52671 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  15% (56433 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  16% (60196 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  17% (63958 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  18% (67720 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  19% (71482 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  20% (75244 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  21% (79007 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  22% (82769 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  23% (86531 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  24% (90293 of 376220) |#       | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  25% (94055 of 376220) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  26% (97818 of 376220) |##      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  27% (101580 of 376220) |#      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  28% (105342 of 376220) |#      | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  29% (109104 of 376220) |##     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  30% (112866 of 376220) |##     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  31% (116629 of 376220) |##     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  32% (120391 of 376220) |##     | Elapsed Time: 0:00:00 ETA:   0:00:01\\rExpected  33% (124153 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  34% (127915 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  35% (131677 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  36% (135440 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  37% (139202 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  38% (142964 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  39% (146726 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  40% (150489 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  41% (154251 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  42% (158013 of 376220) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  43% (161775 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  44% (165537 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  45% (169300 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  46% (173062 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  47% (176824 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  48% (180586 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  49% (184348 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  50% (188111 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  51% (191873 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  52% (195635 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  53% (199397 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  54% (203159 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  55% (206922 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  56% (210684 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  57% (214446 of 376220) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  58% (218208 of 376220) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  59% (221970 of 376220) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  60% (225733 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  61% (229495 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  62% (233257 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  63% (237019 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  64% (240781 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  65% (244544 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  66% (248306 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  67% (252068 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  68% (255830 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  69% (259592 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  70% (263355 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  71% (267117 of 376220) |####   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  72% (270879 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  73% (274641 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  74% (278403 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  75% (282166 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  76% (285928 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  77% (289690 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  78% (293452 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  79% (297214 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  80% (300977 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  81% (304739 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  82% (308501 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  83% (312263 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  84% (316025 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  85% (319788 of 376220) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  86% (323550 of 376220) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  87% (327312 of 376220) |###### | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  88% (331074 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  89% (334836 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  90% (338599 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  91% (342361 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  92% (346123 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  93% (349885 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  94% (353647 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  95% (357410 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  96% (361172 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  97% (364934 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  98% (368696 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  99% (372458 of 376220) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected 100% (376220 of 376220) |#######| Elapsed Time: 0:00:03 Time:  0:00:03\\n2022-05-28 16:36:04,101 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:36:07,105 INFO Final absolute cutoff threshold is 50.1\\n2022-05-28 16:36:07,106 INFO Selected a total of 157 (5.7%) regions to be masked\\n2022-05-28 16:36:07,106 INFO Running filters...\\n\\rFilter   0% (0 of 6) |                   | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter  16% (1 of 6) |###                | Elapsed Time: 0:00:00 ETA:   0:00:01\\rFilter  33% (2 of 6) |######             | Elapsed Time: 0:00:00 ETA:   0:00:01\\rFilter  50% (3 of 6) |#########          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rFilter  66% (4 of 6) |############       | Elapsed Time: 0:00:01 ETA:   0:00:00\\rFilter  83% (5 of 6) |###############    | Elapsed Time: 0:00:01 ETA:   0:00:00\\rFilter 100% (6 of 6) |###################| Elapsed Time: 0:00:01 Time:  0:00:01\\n2022-05-28 16:36:09,123 INFO Total: 376220. Filtered: 761\\n\\rExpected   0% (0 of 375459) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 375459) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (3755 of 375459) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (7510 of 375459) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (11264 of 375459) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (15019 of 375459) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   5% (18773 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   6% (22528 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   7% (26283 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   8% (30037 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   9% (33792 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  10% (37546 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  11% (41301 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  12% (45056 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  13% (48810 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  14% (52565 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  15% (56319 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  16% (60074 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  17% (63829 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  18% (67583 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  19% (71338 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  20% (75092 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  21% (78847 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  22% (82601 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  23% (86356 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  24% (90111 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  25% (93865 of 375459) |##      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  26% (97620 of 375459) |##      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  27% (101374 of 375459) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  28% (105129 of 375459) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  29% (108884 of 375459) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  30% (112638 of 375459) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  31% (116393 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  32% (120147 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  33% (123902 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  34% (127657 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  35% (131411 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  36% (135166 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  37% (138920 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  38% (142675 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  39% (146430 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  40% (150184 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  41% (153939 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  42% (157693 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  43% (161448 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  44% (165202 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  45% (168957 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  46% (172712 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  47% (176466 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  48% (180221 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  49% (183975 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  50% (187730 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  51% (191485 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  52% (195239 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  53% (198994 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  54% (202748 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  55% (206503 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  56% (210258 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  57% (214012 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  58% (217767 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  59% (221521 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  60% (225276 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  61% (229030 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  62% (232785 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  63% (236540 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  64% (240294 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  65% (244049 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  66% (247803 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  67% (251558 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  68% (255313 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  69% (259067 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  70% (262822 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  71% (266576 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  72% (270331 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  73% (274086 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  74% (277840 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  75% (281595 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  76% (285349 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  77% (289104 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  78% (292859 of 375459) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  79% (296613 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  80% (300368 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  81% (304122 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  82% (307877 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  83% (311631 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  84% (315386 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  85% (319141 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  86% (322895 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  87% (326650 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  88% (330404 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  89% (334159 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  90% (337914 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  91% (341668 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  92% (345423 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  93% (349177 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  94% (352932 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  95% (356687 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  96% (360441 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  97% (364196 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  98% (367950 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  99% (371705 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected 100% (375459 of 375459) |#######| Elapsed Time: 0:00:03 Time:  0:00:03\\n2022-05-28 16:36:13,370 INFO Done.\\n2022-05-28 16:36:14,378 INFO Saving statistics...\\n2022-05-28 16:36:14,734 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 375459) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 375459) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (3755 of 375459) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (7510 of 375459) |         | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   3% (11264 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   4% (15019 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   5% (18773 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   6% (22528 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   7% (26283 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   8% (30037 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected   9% (33792 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  10% (37546 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  11% (41301 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  12% (45056 of 375459) |        | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  13% (48810 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  14% (52565 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  15% (56319 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:03\\rExpected  16% (60074 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  17% (63829 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  18% (67583 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  19% (71338 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  20% (75092 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  21% (78847 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  22% (82601 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  23% (86356 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  24% (90111 of 375459) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  25% (93865 of 375459) |##      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  26% (97620 of 375459) |##      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  27% (101374 of 375459) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  28% (105129 of 375459) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  29% (108884 of 375459) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  30% (112638 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  31% (116393 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  32% (120147 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  33% (123902 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  34% (127657 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  35% (131411 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  36% (135166 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  37% (138920 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  38% (142675 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  39% (146430 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  40% (150184 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  41% (153939 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  42% (157693 of 375459) |##     | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  43% (161448 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  44% (165202 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  45% (168957 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  46% (172712 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  47% (176466 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  48% (180221 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  49% (183975 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  50% (187730 of 375459) |###    | Elapsed Time: 0:00:01 ETA:   0:00:02\\rExpected  51% (191485 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  52% (195239 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  53% (198994 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  54% (202748 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  55% (206503 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  56% (210258 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  57% (214012 of 375459) |###    | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  58% (217767 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  59% (221521 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  60% (225276 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  61% (229030 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  62% (232785 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  63% (236540 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  64% (240294 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  65% (244049 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  66% (247803 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  67% (251558 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  68% (255313 of 375459) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  69% (259067 of 375459) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  70% (262822 of 375459) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  71% (266576 of 375459) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  72% (270331 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  73% (274086 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  74% (277840 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  75% (281595 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  76% (285349 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  77% (289104 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  78% (292859 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  79% (296613 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  80% (300368 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  81% (304122 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  82% (307877 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  83% (311631 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  84% (315386 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  85% (319141 of 375459) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  86% (322895 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  87% (326650 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  88% (330404 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  89% (334159 of 375459) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  90% (337914 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  91% (341668 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  92% (345423 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  93% (349177 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  94% (352932 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  95% (356687 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  96% (360441 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  97% (364196 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  98% (367950 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  99% (371705 of 375459) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected 100% (375459 of 375459) |#######| Elapsed Time: 0:00:04 Time:  0:00:04\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:36:35,575 INFO FAN-C version: 0.9.24\\n2022-05-28 16:36:36,000 INFO Binning Hic file (25000)\\n2022-05-28 16:36:36,000 INFO Constructing binned genome...\\n2022-05-28 16:36:37,091 INFO Binning edges...\\n2022-05-28 16:36:37,468 INFO Binning Hi-C contacts\\n2022-05-28 16:36:38,066 INFO Launching processes\\n2022-05-28 16:36:49,416 INFO Submitting partitions\\n2022-05-28 16:36:49,424 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 21) |                 | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers   4% (1 of 21) |                 | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   9% (2 of 21) |#                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  14% (3 of 21) |##               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  19% (4 of 21) |###              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  23% (5 of 21) |####             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  28% (6 of 21) |####             | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  33% (7 of 21) |#####            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  38% (8 of 21) |######           | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  42% (9 of 21) |#######          | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  47% (10 of 21) |#######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  52% (11 of 21) |########        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  57% (12 of 21) |#########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  61% (13 of 21) |#########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  66% (14 of 21) |##########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  71% (15 of 21) |###########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  76% (16 of 21) |############    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  80% (17 of 21) |############    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  85% (18 of 21) |#############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  90% (19 of 21) |##############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  95% (20 of 21) |############### | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers 100% (21 of 21) |################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 486132) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 486132) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (4862 of 486132) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (9723 of 486132) |         | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   3% (14584 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   4% (19446 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   5% (24307 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   6% (29168 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   7% (34030 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   8% (38891 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   9% (43752 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  10% (48614 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  11% (53475 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  12% (58336 of 486132) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  13% (63198 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  14% (68059 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  15% (72920 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  16% (77782 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  17% (82643 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  18% (87504 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  19% (92366 of 486132) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  20% (97227 of 486132) |#       | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  21% (102088 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  22% (106950 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  23% (111811 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  24% (116672 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  25% (121534 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  26% (126395 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  27% (131256 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  28% (136117 of 486132) |#      | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  29% (140979 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  30% (145840 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  31% (150701 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  32% (155563 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  33% (160424 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  34% (165285 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  35% (170147 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  36% (175008 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  37% (179869 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  38% (184731 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  39% (189592 of 486132) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  40% (194453 of 486132) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  41% (199315 of 486132) |##     | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  42% (204176 of 486132) |##     | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  43% (209037 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  44% (213899 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  45% (218760 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  46% (223621 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  47% (228483 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  48% (233344 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  49% (238205 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  50% (243067 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  51% (247928 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  52% (252789 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  53% (257650 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  54% (262512 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  55% (267373 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  56% (272234 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  57% (277096 of 486132) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  58% (281957 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  59% (286818 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  60% (291680 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  61% (296541 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  62% (301402 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  63% (306264 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  64% (311125 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  65% (315986 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  66% (320848 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  67% (325709 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  68% (330570 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  69% (335432 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  70% (340293 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  71% (345154 of 486132) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  72% (350016 of 486132) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  73% (354877 of 486132) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  74% (359738 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  75% (364600 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  76% (369461 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  77% (374322 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  78% (379183 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  79% (384045 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  80% (388906 of 486132) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  81% (393767 of 486132) |#####  | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  82% (398629 of 486132) |#####  | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  83% (403490 of 486132) |#####  | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  84% (408351 of 486132) |#####  | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  85% (413213 of 486132) |#####  | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  86% (418074 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  87% (422935 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:01\\rExpected  88% (427797 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  89% (432658 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  90% (437519 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  91% (442381 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  92% (447242 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  93% (452103 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  94% (456965 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  95% (461826 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  96% (466687 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  97% (471549 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  98% (476410 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  99% (481271 of 486132) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected 100% (486132 of 486132) |#######| Elapsed Time: 0:00:05 Time:  0:00:05\\n2022-05-28 16:43:14,999 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:43:19,891 INFO Final absolute cutoff threshold is 24.7\\n2022-05-28 16:43:19,892 INFO Selected a total of 393 (7.2%) regions to be masked\\n2022-05-28 16:43:19,892 INFO Running filters...\\n\\rFilter   0% (0 of 21) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter   4% (1 of 21) |                  | Elapsed Time: 0:00:00 ETA:   0:00:04\\rFilter   9% (2 of 21) |#                 | Elapsed Time: 0:00:00 ETA:   0:00:03\\rFilter  14% (3 of 21) |##                | Elapsed Time: 0:00:00 ETA:   0:00:03\\rFilter  19% (4 of 21) |###               | Elapsed Time: 0:00:00 ETA:   0:00:02\\rFilter  23% (5 of 21) |####              | Elapsed Time: 0:00:00 ETA:   0:00:02\\rFilter  28% (6 of 21) |#####             | Elapsed Time: 0:00:00 ETA:   0:00:02\\rFilter  33% (7 of 21) |######            | Elapsed Time: 0:00:01 ETA:   0:00:02\\rFilter  38% (8 of 21) |######            | Elapsed Time: 0:00:01 ETA:   0:00:02\\rFilter  42% (9 of 21) |#######           | Elapsed Time: 0:00:01 ETA:   0:00:01\\rFilter  47% (10 of 21) |########         | Elapsed Time: 0:00:01 ETA:   0:00:01\\rFilter  52% (11 of 21) |########         | Elapsed Time: 0:00:01 ETA:   0:00:01\\rFilter  57% (12 of 21) |#########        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rFilter  61% (13 of 21) |##########       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rFilter  66% (14 of 21) |###########      | Elapsed Time: 0:00:01 ETA:   0:00:00\\rFilter  71% (15 of 21) |############     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rFilter  76% (16 of 21) |############     | Elapsed Time: 0:00:02 ETA:   0:00:00\\rFilter  80% (17 of 21) |#############    | Elapsed Time: 0:00:02 ETA:   0:00:00\\rFilter  85% (18 of 21) |##############   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rFilter  90% (19 of 21) |###############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rFilter  95% (20 of 21) |################ | Elapsed Time: 0:00:02 ETA:   0:00:00\\rFilter 100% (21 of 21) |#################| Elapsed Time: 0:00:02 Time:  0:00:02\\n2022-05-28 16:43:22,880 INFO Total: 486132. Filtered: 1027\\n\\rExpected   0% (0 of 485105) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 485105) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (4852 of 485105) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (9703 of 485105) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (14554 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   4% (19405 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   5% (24256 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   6% (29107 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected   7% (33958 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   8% (38809 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   9% (43660 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected  10% (48511 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected  11% (53362 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected  12% (58213 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  13% (63064 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  14% (67915 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  15% (72766 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  16% (77617 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  17% (82468 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  18% (87319 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:04\\rExpected  19% (92170 of 485105) |#       | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  20% (97022 of 485105) |#       | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  21% (101873 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  22% (106724 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  23% (111575 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  24% (116426 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  25% (121277 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  26% (126128 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  27% (130979 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  28% (135830 of 485105) |#      | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  29% (140681 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  30% (145532 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  31% (150383 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  32% (155234 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  33% (160085 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:04\\rExpected  34% (164936 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:03\\rExpected  35% (169787 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  36% (174638 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  37% (179489 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  38% (184340 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  39% (189191 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  40% (194042 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  41% (198894 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  42% (203745 of 485105) |##     | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  43% (208596 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  44% (213447 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  45% (218298 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  46% (223149 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  47% (228000 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  48% (232851 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:03\\rExpected  49% (237702 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  50% (242553 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  51% (247404 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  52% (252255 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  53% (257106 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  54% (261957 of 485105) |###    | Elapsed Time: 0:00:02 ETA:   0:00:02\\rExpected  55% (266808 of 485105) |###    | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  56% (271659 of 485105) |###    | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  57% (276510 of 485105) |###    | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  58% (281361 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  59% (286212 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  60% (291063 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  61% (295915 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  62% (300766 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:02\\rExpected  63% (305617 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  64% (310468 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  65% (315319 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  66% (320170 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  67% (325021 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  68% (329872 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  69% (334723 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  70% (339574 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  71% (344425 of 485105) |####   | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  72% (349276 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  73% (354127 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  74% (358978 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  75% (363829 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  76% (368680 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:01\\rExpected  77% (373531 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  78% (378382 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  79% (383233 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:01\\rExpected  80% (388084 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  81% (392936 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  82% (397787 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  83% (402638 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  84% (407489 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  85% (412340 of 485105) |#####  | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  86% (417191 of 485105) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  87% (422042 of 485105) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  88% (426893 of 485105) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  89% (431744 of 485105) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  90% (436595 of 485105) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  91% (441446 of 485105) |###### | Elapsed Time: 0:00:04 ETA:   0:00:00\\rExpected  92% (446297 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  93% (451148 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  94% (455999 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  95% (460850 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  96% (465701 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  97% (470552 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  98% (475403 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected  99% (480254 of 485105) |###### | Elapsed Time: 0:00:05 ETA:   0:00:00\\rExpected 100% (485105 of 485105) |#######| Elapsed Time: 0:00:05 Time:  0:00:05\\n2022-05-28 16:43:28,912 INFO Done.\\n2022-05-28 16:43:29,922 INFO Saving statistics...\\n2022-05-28 16:43:30,316 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 485105) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 485105) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (4852 of 485105) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (9703 of 485105) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (14554 of 485105) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   4% (19405 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   5% (24256 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   6% (29107 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   7% (33958 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   8% (38809 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected   9% (43660 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  10% (48511 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  11% (53362 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  12% (58213 of 485105) |        | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  13% (63064 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  14% (67915 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  15% (72766 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  16% (77617 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  17% (82468 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  18% (87319 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  19% (92170 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  20% (97022 of 485105) |#       | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  21% (101873 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  22% (106724 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  23% (111575 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  24% (116426 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  25% (121277 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  26% (126128 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  27% (130979 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  28% (135830 of 485105) |#      | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  29% (140681 of 485105) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  30% (145532 of 485105) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  31% (150383 of 485105) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  32% (155234 of 485105) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  33% (160085 of 485105) |##     | Elapsed Time: 0:00:00 ETA:   0:00:02\\rExpected  34% (164936 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  35% (169787 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  36% (174638 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  37% (179489 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  38% (184340 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  39% (189191 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  40% (194042 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  41% (198894 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  42% (203745 of 485105) |##     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  43% (208596 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  44% (213447 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  45% (218298 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  46% (223149 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  47% (228000 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  48% (232851 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  49% (237702 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  50% (242553 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  51% (247404 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  52% (252255 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  53% (257106 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  54% (261957 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  55% (266808 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  56% (271659 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  57% (276510 of 485105) |###    | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  58% (281361 of 485105) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  59% (286212 of 485105) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  60% (291063 of 485105) |####   | Elapsed Time: 0:00:01 ETA:   0:00:01\\rExpected  61% (295915 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  62% (300766 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  63% (305617 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  64% (310468 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  65% (315319 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  66% (320170 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  67% (325021 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  68% (329872 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  69% (334723 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  70% (339574 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:01\\rExpected  71% (344425 of 485105) |####   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  72% (349276 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  73% (354127 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  74% (358978 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  75% (363829 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  76% (368680 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  77% (373531 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  78% (378382 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  79% (383233 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  80% (388084 of 485105) |#####  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rExpected  81% (392936 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  82% (397787 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  83% (402638 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  84% (407489 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  85% (412340 of 485105) |#####  | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  86% (417191 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  87% (422042 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  88% (426893 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  89% (431744 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  90% (436595 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  91% (441446 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  92% (446297 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  93% (451148 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  94% (455999 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  95% (460850 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  96% (465701 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  97% (470552 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  98% (475403 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected  99% (480254 of 485105) |###### | Elapsed Time: 0:00:03 ETA:   0:00:00\\rExpected 100% (485105 of 485105) |#######| Elapsed Time: 0:00:03 Time:  0:00:03\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:43:48,139 INFO FAN-C version: 0.9.24\\n2022-05-28 16:43:48,326 INFO Binning Hic file (10000)\\n2022-05-28 16:43:48,326 INFO Constructing binned genome...\\n2022-05-28 16:43:49,270 INFO Binning edges...\\n2022-05-28 16:43:49,588 INFO Binning Hi-C contacts\\n2022-05-28 16:43:50,365 INFO Launching processes\\n2022-05-28 16:43:56,246 INFO Submitting partitions\\n2022-05-28 16:43:56,259 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 105) |                | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers   0% (1 of 105) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   1% (2 of 105) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   2% (3 of 105) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   3% (4 of 105) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   4% (5 of 105) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   5% (6 of 105) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   6% (7 of 105) |#               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   7% (8 of 105) |#               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   8% (9 of 105) |#               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   9% (10 of 105) |#              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  10% (11 of 105) |#              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  11% (12 of 105) |#              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  12% (13 of 105) |#              | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers  13% (14 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  14% (15 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  15% (16 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  16% (17 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  17% (18 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  18% (19 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  19% (20 of 105) |##             | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  20% (22 of 105) |###            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  21% (23 of 105) |###            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  22% (24 of 105) |###            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  23% (25 of 105) |###            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  24% (26 of 105) |###            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  25% (27 of 105) |###            | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  26% (28 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  27% (29 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  28% (30 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  29% (31 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  30% (32 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  31% (33 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  32% (34 of 105) |####           | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  33% (35 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  34% (36 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  35% (37 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  36% (38 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  37% (39 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  38% (40 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  39% (41 of 105) |#####          | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  40% (42 of 105) |######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  41% (44 of 105) |######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  42% (45 of 105) |######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  43% (46 of 105) |######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  44% (47 of 105) |######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  45% (48 of 105) |######         | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  46% (49 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  47% (50 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  48% (51 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  49% (52 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  50% (53 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  51% (54 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  52% (55 of 105) |#######        | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  53% (56 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  54% (57 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  55% (58 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  56% (59 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  57% (60 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  58% (61 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  59% (62 of 105) |########       | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  60% (63 of 105) |#########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  61% (65 of 105) |#########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  62% (66 of 105) |#########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  63% (67 of 105) |#########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  64% (68 of 105) |#########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  65% (69 of 105) |#########      | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  66% (70 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  67% (71 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  68% (72 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  69% (73 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  70% (74 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  71% (75 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  72% (76 of 105) |##########     | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  73% (77 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  74% (78 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  75% (79 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  76% (80 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  77% (81 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  78% (82 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  79% (83 of 105) |###########    | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  80% (84 of 105) |############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  81% (86 of 105) |############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  82% (87 of 105) |############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  83% (88 of 105) |############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  84% (89 of 105) |############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  85% (90 of 105) |############   | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  86% (91 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  87% (92 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  88% (93 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  89% (94 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  90% (95 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  91% (96 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  92% (97 of 105) |#############  | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  93% (98 of 105) |############## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  94% (99 of 105) |############## | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  95% (100 of 105) |############# | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  96% (101 of 105) |############# | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  97% (102 of 105) |############# | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  98% (103 of 105) |############# | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers  99% (104 of 105) |############# | Elapsed Time: 0:00:00 ETA:   0:00:00\\rBuffers 100% (105 of 105) |##############| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rExpected   0% (0 of 579697) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 579697) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (5797 of 579697) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (11594 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   3% (17391 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   4% (23188 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   5% (28985 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   6% (34782 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   7% (40579 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:07\\rExpected   8% (46376 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:09\\rExpected   9% (52173 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:08\\rExpected  10% (57970 of 579697) |        | Elapsed Time: 0:00:00 ETA:   0:00:08\\rExpected  11% (63767 of 579697) |        | Elapsed Time: 0:00:01 ETA:   0:00:08\\rExpected  12% (69564 of 579697) |        | Elapsed Time: 0:00:01 ETA:   0:00:08\\rExpected  13% (75361 of 579697) |#       | Elapsed Time: 0:00:01 ETA:   0:00:08\\rExpected  14% (81158 of 579697) |#       | Elapsed Time: 0:00:01 ETA:   0:00:08\\rExpected  15% (86955 of 579697) |#       | Elapsed Time: 0:00:01 ETA:   0:00:08\\rExpected  16% (92752 of 579697) |#       | Elapsed Time: 0:00:01 ETA:   0:00:08\\rExpected  17% (98549 of 579697) |#       | Elapsed Time: 0:00:01 ETA:   0:00:07\\rExpected  18% (104346 of 579697) |#      | Elapsed Time: 0:00:01 ETA:   0:00:07\\rExpected  19% (110143 of 579697) |#      | Elapsed Time: 0:00:01 ETA:   0:00:07\\rExpected  20% (115940 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  21% (121737 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  22% (127534 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  23% (133331 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  24% (139128 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  25% (144925 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  26% (150722 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  27% (156519 of 579697) |#      | Elapsed Time: 0:00:02 ETA:   0:00:08\\rExpected  28% (162316 of 579697) |#      | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  29% (168113 of 579697) |##     | Elapsed Time: 0:00:03 ETA:   0:00:09\\rExpected  30% (173910 of 579697) |##     | Elapsed Time: 0:00:03 ETA:   0:00:09\\rExpected  31% (179707 of 579697) |##     | Elapsed Time: 0:00:03 ETA:   0:00:09\\rExpected  32% (185504 of 579697) |##     | Elapsed Time: 0:00:03 ETA:   0:00:10\\rExpected  33% (191301 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:10\\rExpected  34% (197097 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:09\\rExpected  35% (202894 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:09\\rExpected  36% (208691 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:08\\rExpected  37% (214488 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:08\\rExpected  38% (220285 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:08\\rExpected  39% (226082 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:08\\rExpected  40% (231879 of 579697) |##     | Elapsed Time: 0:00:04 ETA:   0:00:09\\rExpected  41% (237676 of 579697) |##     | Elapsed Time: 0:00:05 ETA:   0:00:09\\rExpected  42% (243473 of 579697) |##     | Elapsed Time: 0:00:05 ETA:   0:00:09\\rExpected  43% (249270 of 579697) |###    | Elapsed Time: 0:00:05 ETA:   0:00:09\\rExpected  44% (255067 of 579697) |###    | Elapsed Time: 0:00:05 ETA:   0:00:08\\rExpected  45% (260864 of 579697) |###    | Elapsed Time: 0:00:05 ETA:   0:00:07\\rExpected  46% (266661 of 579697) |###    | Elapsed Time: 0:00:05 ETA:   0:00:07\\rExpected  47% (272458 of 579697) |###    | Elapsed Time: 0:00:05 ETA:   0:00:07\\rExpected  48% (278255 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:07\\rExpected  49% (284052 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:07\\rExpected  50% (289849 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:06\\rExpected  51% (295646 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:06\\rExpected  52% (301443 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:06\\rExpected  53% (307240 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:06\\rExpected  54% (313037 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:06\\rExpected  55% (318834 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:06\\rExpected  56% (324631 of 579697) |###    | Elapsed Time: 0:00:06 ETA:   0:00:05\\rExpected  57% (330428 of 579697) |###    | Elapsed Time: 0:00:07 ETA:   0:00:05\\rExpected  58% (336225 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:05\\rExpected  59% (342022 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:05\\rExpected  60% (347819 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:05\\rExpected  61% (353616 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:05\\rExpected  62% (359413 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:04\\rExpected  63% (365210 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:04\\rExpected  64% (371007 of 579697) |####   | Elapsed Time: 0:00:07 ETA:   0:00:04\\rExpected  65% (376804 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:04\\rExpected  66% (382601 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:04\\rExpected  67% (388397 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:04\\rExpected  68% (394194 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  69% (399991 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  70% (405788 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  71% (411585 of 579697) |####   | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  72% (417382 of 579697) |#####  | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  73% (423179 of 579697) |#####  | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  74% (428976 of 579697) |#####  | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  75% (434773 of 579697) |#####  | Elapsed Time: 0:00:09 ETA:   0:00:03\\rExpected  76% (440570 of 579697) |#####  | Elapsed Time: 0:00:09 ETA:   0:00:02\\rExpected  77% (446367 of 579697) |#####  | Elapsed Time: 0:00:09 ETA:   0:00:02\\rExpected  78% (452164 of 579697) |#####  | Elapsed Time: 0:00:10 ETA:   0:00:07\\rExpected  79% (457961 of 579697) |#####  | Elapsed Time: 0:00:12 ETA:   0:00:31\\rExpected  80% (463758 of 579697) |#####  | Elapsed Time: 0:00:13 ETA:   0:00:27\\rExpected  81% (469555 of 579697) |#####  | Elapsed Time: 0:00:14 ETA:   0:00:21\\rExpected  82% (475352 of 579697) |#####  | Elapsed Time: 0:00:14 ETA:   0:00:16\\rExpected  83% (481149 of 579697) |#####  | Elapsed Time: 0:00:14 ETA:   0:00:15\\rExpected  84% (486946 of 579697) |#####  | Elapsed Time: 0:00:14 ETA:   0:00:06\\rExpected  85% (492743 of 579697) |#####  | Elapsed Time: 0:00:14 ETA:   0:00:05\\rExpected  86% (498540 of 579697) |###### | Elapsed Time: 0:00:14 ETA:   0:00:05\\rExpected  87% (504337 of 579697) |###### | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  88% (510134 of 579697) |###### | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  89% (515931 of 579697) |###### | Elapsed Time: 0:00:15 ETA:   0:00:02\\rExpected  90% (521728 of 579697) |###### | Elapsed Time: 0:00:15 ETA:   0:00:02\\rExpected  91% (527525 of 579697) |###### | Elapsed Time: 0:00:15 ETA:   0:00:01\\rExpected  92% (533322 of 579697) |###### | Elapsed Time: 0:00:15 ETA:   0:00:01\\rExpected  93% (539119 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:01\\rExpected  94% (544916 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:00\\rExpected  95% (550713 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:00\\rExpected  96% (556510 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:00\\rExpected  97% (562307 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:00\\rExpected  98% (568104 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:00\\rExpected  99% (573901 of 579697) |###### | Elapsed Time: 0:00:16 ETA:   0:00:00\\rExpected 100% (579697 of 579697) |#######| Elapsed Time: 0:00:16 Time:  0:00:16\\n2022-05-28 16:44:46,767 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:45:01,214 INFO Final absolute cutoff threshold is 10.6\\n2022-05-28 16:45:01,216 INFO Selected a total of 2205 (16.1%) regions to be masked\\n2022-05-28 16:45:01,216 INFO Running filters...\\n\\rFilter   0% (0 of 105) |                 | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter   0% (1 of 105) |                 | Elapsed Time: 0:00:00 ETA:   0:00:23\\rFilter   1% (2 of 105) |                 | Elapsed Time: 0:00:00 ETA:   0:00:18\\rFilter   2% (3 of 105) |                 | Elapsed Time: 0:00:00 ETA:   0:00:18\\rFilter   3% (4 of 105) |                 | Elapsed Time: 0:00:00 ETA:   0:00:13\\rFilter   4% (5 of 105) |                 | Elapsed Time: 0:00:00 ETA:   0:00:13\\rFilter   5% (6 of 105) |                 | Elapsed Time: 0:00:00 ETA:   0:00:13\\rFilter   6% (7 of 105) |#                | Elapsed Time: 0:00:01 ETA:   0:00:14\\rFilter   7% (8 of 105) |#                | Elapsed Time: 0:00:01 ETA:   0:00:14\\rFilter   8% (9 of 105) |#                | Elapsed Time: 0:00:01 ETA:   0:00:14\\rFilter   9% (10 of 105) |#               | Elapsed Time: 0:00:01 ETA:   0:00:14\\rFilter  10% (11 of 105) |#               | Elapsed Time: 0:00:01 ETA:   0:00:13\\rFilter  11% (12 of 105) |#               | Elapsed Time: 0:00:01 ETA:   0:00:13\\rFilter  12% (13 of 105) |#               | Elapsed Time: 0:00:01 ETA:   0:00:12\\rFilter  13% (14 of 105) |##              | Elapsed Time: 0:00:02 ETA:   0:00:13\\rFilter  14% (15 of 105) |##              | Elapsed Time: 0:00:02 ETA:   0:00:13\\rFilter  15% (16 of 105) |##              | Elapsed Time: 0:00:02 ETA:   0:00:13\\rFilter  16% (17 of 105) |##              | Elapsed Time: 0:00:02 ETA:   0:00:14\\rFilter  17% (18 of 105) |##              | Elapsed Time: 0:00:02 ETA:   0:00:14\\rFilter  18% (19 of 105) |##              | Elapsed Time: 0:00:02 ETA:   0:00:13\\rFilter  19% (20 of 105) |###             | Elapsed Time: 0:00:02 ETA:   0:00:13\\rFilter  20% (22 of 105) |###             | Elapsed Time: 0:00:03 ETA:   0:00:11\\rFilter  21% (23 of 105) |###             | Elapsed Time: 0:00:03 ETA:   0:00:11\\rFilter  22% (24 of 105) |###             | Elapsed Time: 0:00:03 ETA:   0:00:10\\rFilter  23% (25 of 105) |###             | Elapsed Time: 0:00:03 ETA:   0:00:10\\rFilter  24% (26 of 105) |###             | Elapsed Time: 0:00:03 ETA:   0:00:10\\rFilter  25% (27 of 105) |####            | Elapsed Time: 0:00:03 ETA:   0:00:09\\rFilter  26% (28 of 105) |####            | Elapsed Time: 0:00:03 ETA:   0:00:10\\rFilter  27% (29 of 105) |####            | Elapsed Time: 0:00:04 ETA:   0:00:10\\rFilter  28% (30 of 105) |####            | Elapsed Time: 0:00:04 ETA:   0:00:10\\rFilter  29% (31 of 105) |####            | Elapsed Time: 0:00:04 ETA:   0:00:09\\rFilter  30% (32 of 105) |####            | Elapsed Time: 0:00:04 ETA:   0:00:09\\rFilter  31% (33 of 105) |#####           | Elapsed Time: 0:00:04 ETA:   0:00:09\\rFilter  32% (34 of 105) |#####           | Elapsed Time: 0:00:04 ETA:   0:00:09\\rFilter  33% (35 of 105) |#####           | Elapsed Time: 0:00:04 ETA:   0:00:09\\rFilter  34% (36 of 105) |#####           | Elapsed Time: 0:00:05 ETA:   0:00:09\\rFilter  35% (37 of 105) |#####           | Elapsed Time: 0:00:05 ETA:   0:00:10\\rFilter  36% (38 of 105) |#####           | Elapsed Time: 0:00:05 ETA:   0:00:10\\rFilter  37% (39 of 105) |#####           | Elapsed Time: 0:00:05 ETA:   0:00:11\\rFilter  38% (40 of 105) |######          | Elapsed Time: 0:00:05 ETA:   0:00:11\\rFilter  39% (41 of 105) |######          | Elapsed Time: 0:00:06 ETA:   0:00:10\\rFilter  40% (42 of 105) |######          | Elapsed Time: 0:00:06 ETA:   0:00:10\\rFilter  41% (44 of 105) |######          | Elapsed Time: 0:00:06 ETA:   0:00:09\\rFilter  42% (45 of 105) |######          | Elapsed Time: 0:00:06 ETA:   0:00:08\\rFilter  43% (46 of 105) |#######         | Elapsed Time: 0:00:06 ETA:   0:00:08\\rFilter  44% (47 of 105) |#######         | Elapsed Time: 0:00:06 ETA:   0:00:07\\rFilter  45% (48 of 105) |#######         | Elapsed Time: 0:00:06 ETA:   0:00:07\\rFilter  46% (49 of 105) |#######         | Elapsed Time: 0:00:06 ETA:   0:00:06\\rFilter  47% (50 of 105) |#######         | Elapsed Time: 0:00:06 ETA:   0:00:06\\rFilter  48% (51 of 105) |#######         | Elapsed Time: 0:00:06 ETA:   0:00:06\\rFilter  49% (52 of 105) |#######         | Elapsed Time: 0:00:07 ETA:   0:00:06\\rFilter  50% (53 of 105) |########        | Elapsed Time: 0:00:07 ETA:   0:00:06\\rFilter  51% (54 of 105) |########        | Elapsed Time: 0:00:07 ETA:   0:00:06\\rFilter  52% (55 of 105) |########        | Elapsed Time: 0:00:07 ETA:   0:00:06\\rFilter  53% (56 of 105) |########        | Elapsed Time: 0:00:07 ETA:   0:00:06\\rFilter  54% (57 of 105) |########        | Elapsed Time: 0:00:07 ETA:   0:00:05\\rFilter  55% (58 of 105) |########        | Elapsed Time: 0:00:07 ETA:   0:00:05\\rFilter  56% (59 of 105) |########        | Elapsed Time: 0:00:08 ETA:   0:00:05\\rFilter  57% (60 of 105) |#########       | Elapsed Time: 0:00:08 ETA:   0:00:05\\rFilter  58% (61 of 105) |#########       | Elapsed Time: 0:00:08 ETA:   0:00:07\\rFilter  59% (62 of 105) |#########       | Elapsed Time: 0:00:08 ETA:   0:00:07\\rFilter  60% (63 of 105) |#########       | Elapsed Time: 0:00:08 ETA:   0:00:07\\rFilter  61% (65 of 105) |#########       | Elapsed Time: 0:00:09 ETA:   0:00:06\\rFilter  62% (66 of 105) |##########      | Elapsed Time: 0:00:09 ETA:   0:00:06\\rFilter  63% (67 of 105) |##########      | Elapsed Time: 0:00:09 ETA:   0:00:05\\rFilter  64% (68 of 105) |##########      | Elapsed Time: 0:00:09 ETA:   0:00:05\\rFilter  65% (69 of 105) |##########      | Elapsed Time: 0:00:09 ETA:   0:00:06\\rFilter  66% (70 of 105) |##########      | Elapsed Time: 0:00:10 ETA:   0:00:06\\rFilter  67% (71 of 105) |##########      | Elapsed Time: 0:00:10 ETA:   0:00:06\\rFilter  68% (72 of 105) |##########      | Elapsed Time: 0:00:10 ETA:   0:00:05\\rFilter  69% (73 of 105) |###########     | Elapsed Time: 0:00:10 ETA:   0:00:05\\rFilter  70% (74 of 105) |###########     | Elapsed Time: 0:00:10 ETA:   0:00:05\\rFilter  71% (75 of 105) |###########     | Elapsed Time: 0:00:10 ETA:   0:00:04\\rFilter  72% (76 of 105) |###########     | Elapsed Time: 0:00:10 ETA:   0:00:03\\rFilter  73% (77 of 105) |###########     | Elapsed Time: 0:00:10 ETA:   0:00:03\\rFilter  74% (78 of 105) |###########     | Elapsed Time: 0:00:10 ETA:   0:00:03\\rFilter  75% (79 of 105) |############    | Elapsed Time: 0:00:10 ETA:   0:00:03\\rFilter  76% (80 of 105) |############    | Elapsed Time: 0:00:10 ETA:   0:00:02\\rFilter  77% (81 of 105) |############    | Elapsed Time: 0:00:11 ETA:   0:00:02\\rFilter  78% (82 of 105) |############    | Elapsed Time: 0:00:11 ETA:   0:00:02\\rFilter  79% (83 of 105) |############    | Elapsed Time: 0:00:11 ETA:   0:00:02\\rFilter  80% (84 of 105) |############    | Elapsed Time: 0:00:11 ETA:   0:00:02\\rFilter  81% (86 of 105) |#############   | Elapsed Time: 0:00:11 ETA:   0:00:02\\rFilter  82% (87 of 105) |#############   | Elapsed Time: 0:00:11 ETA:   0:00:02\\rFilter  83% (88 of 105) |#############   | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  84% (89 of 105) |#############   | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  85% (90 of 105) |#############   | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  86% (91 of 105) |#############   | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  87% (92 of 105) |##############  | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  88% (93 of 105) |##############  | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  89% (94 of 105) |##############  | Elapsed Time: 0:00:12 ETA:   0:00:01\\rFilter  90% (95 of 105) |##############  | Elapsed Time: 0:00:13 ETA:   0:00:01\\rFilter  91% (96 of 105) |##############  | Elapsed Time: 0:00:13 ETA:   0:00:01\\rFilter  92% (97 of 105) |##############  | Elapsed Time: 0:00:13 ETA:   0:00:01\\rFilter  93% (98 of 105) |##############  | Elapsed Time: 0:00:13 ETA:   0:00:01\\rFilter  94% (99 of 105) |############### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rFilter  95% (100 of 105) |############## | Elapsed Time: 0:00:13 ETA:   0:00:00\\rFilter  96% (101 of 105) |############## | Elapsed Time: 0:00:13 ETA:   0:00:00\\rFilter  97% (102 of 105) |############## | Elapsed Time: 0:00:13 ETA:   0:00:00\\rFilter  98% (103 of 105) |############## | Elapsed Time: 0:00:14 ETA:   0:00:00\\rFilter  99% (104 of 105) |############## | Elapsed Time: 0:00:14 ETA:   0:00:00\\rFilter 100% (105 of 105) |###############| Elapsed Time: 0:00:14 Time:  0:00:14\\n2022-05-28 16:45:23,913 INFO Total: 579697. Filtered: 297\\n\\rExpected   0% (0 of 579400) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 579400) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (5795 of 579400) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (11589 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   3% (17383 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   4% (23177 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   5% (28971 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   6% (34765 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:05\\rExpected   7% (40559 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:07\\rExpected   8% (46353 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:08\\rExpected   9% (52147 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:08\\rExpected  10% (57941 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  11% (63735 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  12% (69529 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  13% (75323 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  14% (81117 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:10\\rExpected  15% (86911 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  16% (92705 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  17% (98499 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:09\\rExpected  18% (104293 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:09\\rExpected  19% (110087 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:09\\rExpected  20% (115881 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  21% (121675 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  22% (127469 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  23% (133263 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  24% (139057 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  25% (144851 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:09\\rExpected  26% (150645 of 579400) |#      | Elapsed Time: 0:00:03 ETA:   0:00:09\\rExpected  27% (156439 of 579400) |#      | Elapsed Time: 0:00:03 ETA:   0:00:09\\rExpected  28% (162233 of 579400) |#      | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  29% (168027 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  30% (173821 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  31% (179615 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  32% (185409 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  33% (191203 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  34% (196997 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  35% (202791 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  36% (208585 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:07\\rExpected  37% (214379 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:07\\rExpected  38% (220173 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  39% (225967 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  40% (231761 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  41% (237555 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  42% (243349 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:05\\rExpected  43% (249143 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:05\\rExpected  44% (254937 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:04\\rExpected  45% (260731 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:04\\rExpected  46% (266525 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:04\\rExpected  47% (272319 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:04\\rExpected  48% (278113 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:05\\rExpected  49% (283907 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  50% (289701 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  51% (295495 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  52% (301289 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  53% (307083 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  54% (312877 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  55% (318671 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  56% (324465 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  57% (330259 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  58% (336053 of 579400) |####   | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  59% (341847 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  60% (347641 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  61% (353435 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  62% (359229 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  63% (365023 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  64% (370817 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  65% (376611 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:03\\rExpected  66% (382405 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  67% (388199 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  68% (393993 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  69% (399787 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  70% (405581 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  71% (411375 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  72% (417169 of 579400) |#####  | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  73% (422963 of 579400) |#####  | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  74% (428757 of 579400) |#####  | Elapsed Time: 0:00:07 ETA:   0:00:02\\rExpected  75% (434551 of 579400) |#####  | Elapsed Time: 0:00:07 ETA:   0:00:01\\rExpected  76% (440345 of 579400) |#####  | Elapsed Time: 0:00:07 ETA:   0:00:01\\rExpected  77% (446139 of 579400) |#####  | Elapsed Time: 0:00:07 ETA:   0:00:01\\rExpected  78% (451933 of 579400) |#####  | Elapsed Time: 0:00:08 ETA:   0:00:02\\rExpected  79% (457727 of 579400) |#####  | Elapsed Time: 0:00:09 ETA:   0:00:07\\rExpected  80% (463521 of 579400) |#####  | Elapsed Time: 0:00:10 ETA:   0:00:20\\rExpected  81% (469315 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:23\\rExpected  82% (475109 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:15\\rExpected  83% (480903 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:11\\rExpected  84% (486697 of 579400) |#####  | Elapsed Time: 0:00:12 ETA:   0:00:09\\rExpected  85% (492491 of 579400) |#####  | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  86% (498285 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:04\\rExpected  87% (504079 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:03\\rExpected  88% (509873 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:03\\rExpected  89% (515667 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:03\\rExpected  90% (521461 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:02\\rExpected  91% (527255 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:02\\rExpected  92% (533049 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  93% (538843 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  94% (544637 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  95% (550431 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected  96% (556225 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected  97% (562019 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected  98% (567813 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected  99% (573607 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected 100% (579400 of 579400) |#######| Elapsed Time: 0:00:13 Time:  0:00:13\\n2022-05-28 16:45:45,263 INFO Done.\\n2022-05-28 16:45:51,447 INFO Saving statistics...\\n2022-05-28 16:45:51,723 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 579400) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 579400) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (5795 of 579400) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (11589 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   3% (17383 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   4% (23177 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   5% (28971 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:09\\rExpected   6% (34765 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:09\\rExpected   7% (40559 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:09\\rExpected   8% (46353 of 579400) |        | Elapsed Time: 0:00:00 ETA:   0:00:10\\rExpected   9% (52147 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:10\\rExpected  10% (57941 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:10\\rExpected  11% (63735 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:10\\rExpected  12% (69529 of 579400) |        | Elapsed Time: 0:00:01 ETA:   0:00:10\\rExpected  13% (75323 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:11\\rExpected  14% (81117 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:11\\rExpected  15% (86911 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:11\\rExpected  16% (92705 of 579400) |#       | Elapsed Time: 0:00:01 ETA:   0:00:10\\rExpected  17% (98499 of 579400) |#       | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  18% (104293 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  19% (110087 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  20% (115881 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  21% (121675 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:11\\rExpected  22% (127469 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  23% (133263 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  24% (139057 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  25% (144851 of 579400) |#      | Elapsed Time: 0:00:02 ETA:   0:00:10\\rExpected  26% (150645 of 579400) |#      | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  27% (156439 of 579400) |#      | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  28% (162233 of 579400) |#      | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  29% (168027 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:08\\rExpected  30% (173821 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  31% (179615 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  32% (185409 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  33% (191203 of 579400) |##     | Elapsed Time: 0:00:03 ETA:   0:00:07\\rExpected  34% (196997 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:07\\rExpected  35% (202791 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:07\\rExpected  36% (208585 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:07\\rExpected  37% (214379 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:07\\rExpected  38% (220173 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  39% (225967 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  40% (231761 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  41% (237555 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:06\\rExpected  42% (243349 of 579400) |##     | Elapsed Time: 0:00:04 ETA:   0:00:05\\rExpected  43% (249143 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:05\\rExpected  44% (254937 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:05\\rExpected  45% (260731 of 579400) |###    | Elapsed Time: 0:00:04 ETA:   0:00:04\\rExpected  46% (266525 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  47% (272319 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  48% (278113 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  49% (283907 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  50% (289701 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  51% (295495 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  52% (301289 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  53% (307083 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:04\\rExpected  54% (312877 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  55% (318671 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  56% (324465 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  57% (330259 of 579400) |###    | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  58% (336053 of 579400) |####   | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  59% (341847 of 579400) |####   | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  60% (347641 of 579400) |####   | Elapsed Time: 0:00:05 ETA:   0:00:03\\rExpected  61% (353435 of 579400) |####   | Elapsed Time: 0:00:05 ETA:   0:00:02\\rExpected  62% (359229 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  63% (365023 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  64% (370817 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  65% (376611 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  66% (382405 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  67% (388199 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  68% (393993 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  69% (399787 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  70% (405581 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:02\\rExpected  71% (411375 of 579400) |####   | Elapsed Time: 0:00:06 ETA:   0:00:01\\rExpected  72% (417169 of 579400) |#####  | Elapsed Time: 0:00:06 ETA:   0:00:01\\rExpected  73% (422963 of 579400) |#####  | Elapsed Time: 0:00:06 ETA:   0:00:01\\rExpected  74% (428757 of 579400) |#####  | Elapsed Time: 0:00:06 ETA:   0:00:01\\rExpected  75% (434551 of 579400) |#####  | Elapsed Time: 0:00:06 ETA:   0:00:01\\rExpected  76% (440345 of 579400) |#####  | Elapsed Time: 0:00:07 ETA:   0:00:01\\rExpected  77% (446139 of 579400) |#####  | Elapsed Time: 0:00:07 ETA:   0:00:01\\rExpected  78% (451933 of 579400) |#####  | Elapsed Time: 0:00:08 ETA:   0:00:03\\rExpected  79% (457727 of 579400) |#####  | Elapsed Time: 0:00:08 ETA:   0:00:06\\rExpected  80% (463521 of 579400) |#####  | Elapsed Time: 0:00:10 ETA:   0:00:15\\rExpected  81% (469315 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:20\\rExpected  82% (475109 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:14\\rExpected  83% (480903 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:10\\rExpected  84% (486697 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:08\\rExpected  85% (492491 of 579400) |#####  | Elapsed Time: 0:00:11 ETA:   0:00:07\\rExpected  86% (498285 of 579400) |###### | Elapsed Time: 0:00:11 ETA:   0:00:06\\rExpected  87% (504079 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:03\\rExpected  88% (509873 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:03\\rExpected  89% (515667 of 579400) |###### | Elapsed Time: 0:00:12 ETA:   0:00:03\\rExpected  90% (521461 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:02\\rExpected  91% (527255 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  92% (533049 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  93% (538843 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  94% (544637 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  95% (550431 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:01\\rExpected  96% (556225 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected  97% (562019 of 579400) |###### | Elapsed Time: 0:00:13 ETA:   0:00:00\\rExpected  98% (567813 of 579400) |###### | Elapsed Time: 0:00:14 ETA:   0:00:00\\rExpected  99% (573607 of 579400) |###### | Elapsed Time: 0:00:14 ETA:   0:00:00\\rExpected 100% (579400 of 579400) |#######| Elapsed Time: 0:00:14 Time:  0:00:14\\nClosing remaining open files:examples/test.hic...done\\n2022-05-28 16:46:50,119 INFO FAN-C version: 0.9.24\\n2022-05-28 16:46:50,456 INFO Binning Hic file (5000)\\n2022-05-28 16:46:50,456 INFO Constructing binned genome...\\n2022-05-28 16:46:51,743 INFO Binning edges...\\n2022-05-28 16:46:52,604 INFO Binning Hi-C contacts\\n2022-05-28 16:46:53,382 INFO Launching processes\\n2022-05-28 16:47:02,012 INFO Submitting partitions\\n2022-05-28 16:47:02,026 INFO Collecting results\\n\\rBinning   0% (0 of 1) |                  | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBinning 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\\n\\rBuffers   0% (0 of 406) |                | Elapsed Time: 0:00:00 ETA:  --:--:--\\rBuffers   0% (1 of 406) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   1% (5 of 406) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   2% (9 of 406) |                | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   3% (13 of 406) |               | Elapsed Time: 0:00:00 ETA:  00:00:00\\rBuffers   4% (17 of 406) |               | Elapsed Time: 0:00:00 ETA:   0:00:02\\rBuffers   5% (21 of 406) |               | Elapsed Time: 0:00:00 ETA:   0:00:02\\rBuffers   6% (25 of 406) |               | Elapsed Time: 0:00:00 ETA:   0:00:02\\rBuffers   7% (29 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers   8% (33 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers   9% (37 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  10% (41 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  11% (45 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:04\\rBuffers  12% (49 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  13% (53 of 406) |#              | Elapsed Time: 0:00:00 ETA:   0:00:04\\rBuffers  14% (57 of 406) |##             | Elapsed Time: 0:00:00 ETA:   0:00:04\\rBuffers  15% (61 of 406) |##             | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  16% (65 of 406) |##             | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  17% (70 of 406) |##             | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  18% (74 of 406) |##             | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  19% (78 of 406) |##             | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  20% (82 of 406) |###            | Elapsed Time: 0:00:00 ETA:   0:00:03\\rBuffers  21% (86 of 406) |###            | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  22% (90 of 406) |###            | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  23% (94 of 406) |###            | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  24% (98 of 406) |###            | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  25% (102 of 406) |###           | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  26% (106 of 406) |###           | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  27% (110 of 406) |###           | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  28% (114 of 406) |###           | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  29% (118 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:03\\rBuffers  30% (122 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  31% (126 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  32% (130 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  33% (134 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  34% (139 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  35% (143 of 406) |####          | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  36% (147 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  37% (151 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  38% (155 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  39% (159 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  40% (163 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  41% (167 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:02\\rBuffers  42% (171 of 406) |#####         | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  43% (175 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  44% (179 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  45% (183 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  46% (187 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  47% (191 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  48% (195 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  49% (199 of 406) |######        | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  50% (204 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  51% (208 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  52% (212 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  53% (216 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  54% (220 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  55% (224 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  56% (228 of 406) |#######       | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  57% (232 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  58% (236 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  59% (240 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  60% (244 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  61% (248 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  62% (252 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  63% (256 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  64% (260 of 406) |########      | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  65% (264 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:01\\rBuffers  66% (268 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  67% (273 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  68% (277 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  69% (281 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  70% (285 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  71% (289 of 406) |#########     | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  72% (293 of 406) |##########    | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  73% (297 of 406) |##########    | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  74% (301 of 406) |##########    | Elapsed Time: 0:00:01 ETA:   0:00:00\\rBuffers  75% (305 of 406) |##########    | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  76% (309 of 406) |##########    | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  77% (313 of 406) |##########    | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  78% (317 of 406) |##########    | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  79% (321 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  80% (325 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  81% (329 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  82% (333 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  83% (337 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  84% (342 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  85% (346 of 406) |###########   | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  86% (350 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  87% (354 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  88% (358 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  89% (362 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  90% (366 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  91% (370 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  92% (374 of 406) |############  | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  93% (378 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  94% (382 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  95% (386 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  96% (390 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  97% (394 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  98% (398 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers  99% (402 of 406) |############# | Elapsed Time: 0:00:02 ETA:   0:00:00\\rBuffers 100% (406 of 406) |##############| Elapsed Time: 0:00:02 Time:  0:00:02\\n\\rExpected   0% (0 of 620545) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 620545) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (6206 of 620545) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (12411 of 620545) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (18617 of 620545) |        | Elapsed Time: 0:00:00 ETA:   0:00:10\\rExpected   4% (24822 of 620545) |        | Elapsed Time: 0:00:00 ETA:   0:00:15\\rExpected   5% (31028 of 620545) |        | Elapsed Time: 0:00:00 ETA:   0:00:15\\rExpected   6% (37233 of 620545) |        | Elapsed Time: 0:00:00 ETA:   0:00:15\\rExpected   7% (43439 of 620545) |        | Elapsed Time: 0:00:01 ETA:   0:00:15\\rExpected   8% (49644 of 620545) |        | Elapsed Time: 0:00:01 ETA:   0:00:16\\rExpected   9% (55850 of 620545) |        | Elapsed Time: 0:00:01 ETA:   0:00:16\\rExpected  10% (62055 of 620545) |        | Elapsed Time: 0:00:01 ETA:   0:00:14\\rExpected  11% (68260 of 620545) |        | Elapsed Time: 0:00:01 ETA:   0:00:15\\rExpected  12% (74466 of 620545) |        | Elapsed Time: 0:00:02 ETA:   0:00:15\\rExpected  13% (80671 of 620545) |#       | Elapsed Time: 0:00:02 ETA:   0:00:18\\rExpected  14% (86877 of 620545) |#       | Elapsed Time: 0:00:02 ETA:   0:00:18\\rExpected  15% (93082 of 620545) |#       | Elapsed Time: 0:00:02 ETA:   0:00:18\\rExpected  16% (99288 of 620545) |#       | Elapsed Time: 0:00:03 ETA:   0:00:17\\rExpected  17% (105493 of 620545) |#      | Elapsed Time: 0:00:03 ETA:   0:00:19\\rExpected  18% (111699 of 620545) |#      | Elapsed Time: 0:00:03 ETA:   0:00:24\\rExpected  19% (117904 of 620545) |#      | Elapsed Time: 0:00:04 ETA:   0:00:27\\rExpected  20% (124109 of 620545) |#      | Elapsed Time: 0:00:05 ETA:   0:00:41\\rExpected  21% (130315 of 620545) |#      | Elapsed Time: 0:00:05 ETA:   0:00:37\\rExpected  22% (136520 of 620545) |#      | Elapsed Time: 0:00:05 ETA:   0:00:36\\rExpected  23% (142726 of 620545) |#      | Elapsed Time: 0:00:05 ETA:   0:00:27\\rExpected  24% (148931 of 620545) |#      | Elapsed Time: 0:00:05 ETA:   0:00:25\\rExpected  25% (155137 of 620545) |#      | Elapsed Time: 0:00:06 ETA:   0:00:24\\rExpected  26% (161342 of 620545) |#      | Elapsed Time: 0:00:06 ETA:   0:00:24\\rExpected  27% (167548 of 620545) |#      | Elapsed Time: 0:00:06 ETA:   0:00:24\\rExpected  28% (173753 of 620545) |#      | Elapsed Time: 0:00:06 ETA:   0:00:19\\rExpected  29% (179959 of 620545) |##     | Elapsed Time: 0:00:07 ETA:   0:00:18\\rExpected  30% (186164 of 620545) |##     | Elapsed Time: 0:00:07 ETA:   0:00:14\\rExpected  31% (192369 of 620545) |##     | Elapsed Time: 0:00:07 ETA:   0:00:17\\rExpected  32% (198575 of 620545) |##     | Elapsed Time: 0:00:07 ETA:   0:00:17\\rExpected  33% (204780 of 620545) |##     | Elapsed Time: 0:00:08 ETA:   0:00:17\\rExpected  34% (210986 of 620545) |##     | Elapsed Time: 0:00:08 ETA:   0:00:16\\rExpected  35% (217191 of 620545) |##     | Elapsed Time: 0:00:08 ETA:   0:00:16\\rExpected  36% (223397 of 620545) |##     | Elapsed Time: 0:00:08 ETA:   0:00:14\\rExpected  37% (229602 of 620545) |##     | Elapsed Time: 0:00:08 ETA:   0:00:14\\rExpected  38% (235808 of 620545) |##     | Elapsed Time: 0:00:09 ETA:   0:00:14\\rExpected  39% (242013 of 620545) |##     | Elapsed Time: 0:00:09 ETA:   0:00:15\\rExpected  40% (248219 of 620545) |##     | Elapsed Time: 0:00:09 ETA:   0:00:14\\rExpected  41% (254424 of 620545) |##     | Elapsed Time: 0:00:09 ETA:   0:00:14\\rExpected  42% (260629 of 620545) |##     | Elapsed Time: 0:00:09 ETA:   0:00:13\\rExpected  43% (266835 of 620545) |###    | Elapsed Time: 0:00:10 ETA:   0:00:11\\rExpected  44% (273040 of 620545) |###    | Elapsed Time: 0:00:10 ETA:   0:00:10\\rExpected  45% (279246 of 620545) |###    | Elapsed Time: 0:00:10 ETA:   0:00:10\\rExpected  46% (285451 of 620545) |###    | Elapsed Time: 0:00:10 ETA:   0:00:11\\rExpected  47% (291657 of 620545) |###    | Elapsed Time: 0:00:11 ETA:   0:00:11\\rExpected  48% (297862 of 620545) |###    | Elapsed Time: 0:00:11 ETA:   0:00:11\\rExpected  49% (304068 of 620545) |###    | Elapsed Time: 0:00:11 ETA:   0:00:09\\rExpected  50% (310273 of 620545) |###    | Elapsed Time: 0:00:11 ETA:   0:00:09\\rExpected  51% (316478 of 620545) |###    | Elapsed Time: 0:00:11 ETA:   0:00:08\\rExpected  52% (322684 of 620545) |###    | Elapsed Time: 0:00:11 ETA:   0:00:08\\rExpected  53% (328889 of 620545) |###    | Elapsed Time: 0:00:12 ETA:   0:00:09\\rExpected  54% (335095 of 620545) |###    | Elapsed Time: 0:00:12 ETA:   0:00:09\\rExpected  55% (341300 of 620545) |###    | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  56% (347506 of 620545) |###    | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  57% (353711 of 620545) |###    | Elapsed Time: 0:00:12 ETA:   0:00:07\\rExpected  58% (359917 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  59% (366122 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  60% (372328 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:06\\rExpected  61% (378533 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:06\\rExpected  62% (384738 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:06\\rExpected  63% (390944 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:06\\rExpected  64% (397149 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:06\\rExpected  65% (403355 of 620545) |####   | Elapsed Time: 0:00:13 ETA:   0:00:05\\rExpected  66% (409560 of 620545) |####   | Elapsed Time: 0:00:14 ETA:   0:00:05\\rExpected  67% (415766 of 620545) |####   | Elapsed Time: 0:00:14 ETA:   0:00:05\\rExpected  68% (421971 of 620545) |####   | Elapsed Time: 0:00:14 ETA:   0:00:05\\rExpected  69% (428177 of 620545) |####   | Elapsed Time: 0:00:14 ETA:   0:00:04\\rExpected  70% (434382 of 620545) |####   | Elapsed Time: 0:00:14 ETA:   0:00:04\\rExpected  71% (440587 of 620545) |####   | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  72% (446793 of 620545) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  73% (452998 of 620545) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  74% (459204 of 620545) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  75% (465409 of 620545) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  76% (471615 of 620545) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  77% (477820 of 620545) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  78% (484026 of 620545) |#####  | Elapsed Time: 0:00:20 ETA:   0:01:38\\rExpected  79% (490231 of 620545) |#####  | Elapsed Time: 0:00:25 ETA:   0:01:54\\rExpected  80% (496437 of 620545) |#####  | Elapsed Time: 0:00:30 ETA:   0:01:30\\rExpected  81% (502642 of 620545) |#####  | Elapsed Time: 0:00:34 ETA:   0:01:09\\rExpected  82% (508847 of 620545) |#####  | Elapsed Time: 0:00:34 ETA:   0:00:38\\rExpected  83% (515053 of 620545) |#####  | Elapsed Time: 0:00:35 ETA:   0:00:27\\rExpected  84% (521258 of 620545) |#####  | Elapsed Time: 0:00:35 ETA:   0:00:22\\rExpected  85% (527464 of 620545) |#####  | Elapsed Time: 0:00:36 ETA:   0:00:07\\rExpected  86% (533669 of 620545) |###### | Elapsed Time: 0:00:36 ETA:   0:00:07\\rExpected  87% (539875 of 620545) |###### | Elapsed Time: 0:00:37 ETA:   0:00:06\\rExpected  88% (546080 of 620545) |###### | Elapsed Time: 0:00:37 ETA:   0:00:06\\rExpected  89% (552286 of 620545) |###### | Elapsed Time: 0:00:38 ETA:   0:00:06\\rExpected  90% (558491 of 620545) |###### | Elapsed Time: 0:00:38 ETA:   0:00:05\\rExpected  91% (564696 of 620545) |###### | Elapsed Time: 0:00:38 ETA:   0:00:04\\rExpected  92% (570902 of 620545) |###### | Elapsed Time: 0:00:39 ETA:   0:00:03\\rExpected  93% (577107 of 620545) |###### | Elapsed Time: 0:00:39 ETA:   0:00:02\\rExpected  94% (583313 of 620545) |###### | Elapsed Time: 0:00:39 ETA:   0:00:02\\rExpected  95% (589518 of 620545) |###### | Elapsed Time: 0:00:40 ETA:   0:00:01\\rExpected  96% (595724 of 620545) |###### | Elapsed Time: 0:00:40 ETA:   0:00:01\\rExpected  97% (601929 of 620545) |###### | Elapsed Time: 0:00:40 ETA:   0:00:00\\rExpected  98% (608135 of 620545) |###### | Elapsed Time: 0:00:41 ETA:   0:00:00\\rExpected  99% (614340 of 620545) |###### | Elapsed Time: 0:00:41 ETA:   0:00:00\\rExpected 100% (620545 of 620545) |#######| Elapsed Time: 0:00:41 Time:  0:00:41\\n2022-05-28 16:50:58,149 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\\n2022-05-28 16:51:38,198 INFO Final absolute cutoff threshold is 6.7\\n2022-05-28 16:51:38,207 INFO Selected a total of 9453 (34.4%) regions to be masked\\n2022-05-28 16:51:38,207 INFO Running filters...\\n\\rFilter   0% (0 of 406) |                 | Elapsed Time: 0:00:00 ETA:  --:--:--\\rFilter   0% (1 of 406) |                 | Elapsed Time: 0:00:00 ETA:   0:00:42\\rFilter   1% (5 of 406) |                 | Elapsed Time: 0:00:00 ETA:   0:01:02\\rFilter   2% (9 of 406) |                 | Elapsed Time: 0:00:01 ETA:   0:00:49\\rFilter   3% (13 of 406) |                | Elapsed Time: 0:00:01 ETA:   0:00:51\\rFilter   4% (17 of 406) |                | Elapsed Time: 0:00:02 ETA:   0:00:49\\rFilter   5% (21 of 406) |                | Elapsed Time: 0:00:02 ETA:   0:00:45\\rFilter   6% (25 of 406) |                | Elapsed Time: 0:00:02 ETA:   0:00:41\\rFilter   7% (29 of 406) |#               | Elapsed Time: 0:00:03 ETA:   0:00:43\\rFilter   8% (33 of 406) |#               | Elapsed Time: 0:00:03 ETA:   0:00:41\\rFilter   9% (37 of 406) |#               | Elapsed Time: 0:00:04 ETA:   0:00:42\\rFilter  10% (41 of 406) |#               | Elapsed Time: 0:00:04 ETA:   0:00:42\\rFilter  11% (45 of 406) |#               | Elapsed Time: 0:00:05 ETA:   0:00:39\\rFilter  12% (49 of 406) |#               | Elapsed Time: 0:00:05 ETA:   0:00:40\\rFilter  13% (53 of 406) |##              | Elapsed Time: 0:00:06 ETA:   0:00:38\\rFilter  14% (57 of 406) |##              | Elapsed Time: 0:00:06 ETA:   0:00:38\\rFilter  15% (61 of 406) |##              | Elapsed Time: 0:00:07 ETA:   0:00:39\\rFilter  16% (65 of 406) |##              | Elapsed Time: 0:00:07 ETA:   0:00:44\\rFilter  17% (70 of 406) |##              | Elapsed Time: 0:00:08 ETA:   0:00:39\\rFilter  18% (74 of 406) |##              | Elapsed Time: 0:00:08 ETA:   0:00:39\\rFilter  19% (78 of 406) |###             | Elapsed Time: 0:00:09 ETA:   0:00:39\\rFilter  20% (82 of 406) |###             | Elapsed Time: 0:00:09 ETA:   0:00:38\\rFilter  21% (86 of 406) |###             | Elapsed Time: 0:00:10 ETA:   0:00:40\\rFilter  22% (90 of 406) |###             | Elapsed Time: 0:00:10 ETA:   0:00:40\\rFilter  23% (94 of 406) |###             | Elapsed Time: 0:00:11 ETA:   0:00:40\\rFilter  24% (98 of 406) |###             | Elapsed Time: 0:00:11 ETA:   0:00:41\\rFilter  25% (102 of 406) |###            | Elapsed Time: 0:00:12 ETA:   0:00:44\\rFilter  26% (106 of 406) |###            | Elapsed Time: 0:00:12 ETA:   0:00:42\\rFilter  27% (110 of 406) |####           | Elapsed Time: 0:00:13 ETA:   0:00:45\\rFilter  28% (114 of 406) |####           | Elapsed Time: 0:00:14 ETA:   0:00:46\\rFilter  29% (118 of 406) |####           | Elapsed Time: 0:00:14 ETA:   0:00:48\\rFilter  30% (122 of 406) |####           | Elapsed Time: 0:00:15 ETA:   0:00:46\\rFilter  31% (126 of 406) |####           | Elapsed Time: 0:00:16 ETA:   0:00:42\\rFilter  32% (130 of 406) |####           | Elapsed Time: 0:00:16 ETA:   0:00:42\\rFilter  33% (134 of 406) |####           | Elapsed Time: 0:00:17 ETA:   0:00:45\\rFilter  34% (139 of 406) |#####          | Elapsed Time: 0:00:18 ETA:   0:00:45\\rFilter  35% (143 of 406) |#####          | Elapsed Time: 0:00:18 ETA:   0:00:43\\rFilter  36% (147 of 406) |#####          | Elapsed Time: 0:00:19 ETA:   0:00:40\\rFilter  37% (151 of 406) |#####          | Elapsed Time: 0:00:20 ETA:   0:00:39\\rFilter  38% (155 of 406) |#####          | Elapsed Time: 0:00:20 ETA:   0:00:37\\rFilter  39% (159 of 406) |#####          | Elapsed Time: 0:00:21 ETA:   0:00:36\\rFilter  40% (163 of 406) |######         | Elapsed Time: 0:00:22 ETA:   0:00:36\\rFilter  41% (167 of 406) |######         | Elapsed Time: 0:00:22 ETA:   0:00:33\\rFilter  42% (171 of 406) |######         | Elapsed Time: 0:00:22 ETA:   0:00:32\\rFilter  43% (175 of 406) |######         | Elapsed Time: 0:00:23 ETA:   0:00:33\\rFilter  44% (179 of 406) |######         | Elapsed Time: 0:00:24 ETA:   0:00:33\\rFilter  45% (183 of 406) |######         | Elapsed Time: 0:00:25 ETA:   0:00:40\\rFilter  46% (187 of 406) |######         | Elapsed Time: 0:00:25 ETA:   0:00:35\\rFilter  47% (191 of 406) |#######        | Elapsed Time: 0:00:25 ETA:   0:00:30\\rFilter  48% (195 of 406) |#######        | Elapsed Time: 0:00:26 ETA:   0:00:30\\rFilter  49% (199 of 406) |#######        | Elapsed Time: 0:00:27 ETA:   0:00:29\\rFilter  50% (204 of 406) |#######        | Elapsed Time: 0:00:28 ETA:   0:00:32\\rFilter  51% (208 of 406) |#######        | Elapsed Time: 0:00:28 ETA:   0:00:27\\rFilter  52% (212 of 406) |#######        | Elapsed Time: 0:00:28 ETA:   0:00:23\\rFilter  53% (216 of 406) |#######        | Elapsed Time: 0:00:28 ETA:   0:00:19\\rFilter  54% (220 of 406) |########       | Elapsed Time: 0:00:29 ETA:   0:00:20\\rFilter  55% (224 of 406) |########       | Elapsed Time: 0:00:29 ETA:   0:00:18\\rFilter  56% (228 of 406) |########       | Elapsed Time: 0:00:30 ETA:   0:00:17\\rFilter  57% (232 of 406) |########       | Elapsed Time: 0:00:30 ETA:   0:00:19\\rFilter  58% (236 of 406) |########       | Elapsed Time: 0:00:31 ETA:   0:00:22\\rFilter  59% (240 of 406) |########       | Elapsed Time: 0:00:32 ETA:   0:00:22\\rFilter  60% (244 of 406) |#########      | Elapsed Time: 0:00:32 ETA:   0:00:23\\rFilter  61% (248 of 406) |#########      | Elapsed Time: 0:00:33 ETA:   0:00:23\\rFilter  62% (252 of 406) |#########      | Elapsed Time: 0:00:33 ETA:   0:00:22\\rFilter  63% (256 of 406) |#########      | Elapsed Time: 0:00:34 ETA:   0:00:20\\rFilter  64% (260 of 406) |#########      | Elapsed Time: 0:00:34 ETA:   0:00:18\\rFilter  65% (264 of 406) |#########      | Elapsed Time: 0:00:35 ETA:   0:00:16\\rFilter  66% (268 of 406) |#########      | Elapsed Time: 0:00:35 ETA:   0:00:14\\rFilter  67% (273 of 406) |##########     | Elapsed Time: 0:00:36 ETA:   0:00:13\\rFilter  68% (277 of 406) |##########     | Elapsed Time: 0:00:36 ETA:   0:00:12\\rFilter  69% (281 of 406) |##########     | Elapsed Time: 0:00:36 ETA:   0:00:13\\rFilter  70% (285 of 406) |##########     | Elapsed Time: 0:00:37 ETA:   0:00:13\\rFilter  71% (289 of 406) |##########     | Elapsed Time: 0:00:37 ETA:   0:00:13\\rFilter  72% (293 of 406) |##########     | Elapsed Time: 0:00:38 ETA:   0:00:12\\rFilter  73% (297 of 406) |##########     | Elapsed Time: 0:00:38 ETA:   0:00:12\\rFilter  74% (301 of 406) |###########    | Elapsed Time: 0:00:39 ETA:   0:00:12\\rFilter  75% (305 of 406) |###########    | Elapsed Time: 0:00:39 ETA:   0:00:12\\rFilter  76% (309 of 406) |###########    | Elapsed Time: 0:00:40 ETA:   0:00:11\\rFilter  77% (313 of 406) |###########    | Elapsed Time: 0:00:40 ETA:   0:00:11\\rFilter  78% (317 of 406) |###########    | Elapsed Time: 0:00:41 ETA:   0:00:11\\rFilter  79% (321 of 406) |###########    | Elapsed Time: 0:00:41 ETA:   0:00:10\\rFilter  80% (325 of 406) |############   | Elapsed Time: 0:00:42 ETA:   0:00:10\\rFilter  81% (329 of 406) |############   | Elapsed Time: 0:00:42 ETA:   0:00:10\\rFilter  82% (333 of 406) |############   | Elapsed Time: 0:00:43 ETA:   0:00:09\\rFilter  83% (337 of 406) |############   | Elapsed Time: 0:00:43 ETA:   0:00:08\\rFilter  84% (342 of 406) |############   | Elapsed Time: 0:00:44 ETA:   0:00:07\\rFilter  85% (346 of 406) |############   | Elapsed Time: 0:00:44 ETA:   0:00:06\\rFilter  86% (350 of 406) |############   | Elapsed Time: 0:00:44 ETA:   0:00:05\\rFilter  87% (354 of 406) |#############  | Elapsed Time: 0:00:45 ETA:   0:00:05\\rFilter  88% (358 of 406) |#############  | Elapsed Time: 0:00:45 ETA:   0:00:05\\rFilter  89% (362 of 406) |#############  | Elapsed Time: 0:00:46 ETA:   0:00:05\\rFilter  90% (366 of 406) |#############  | Elapsed Time: 0:00:46 ETA:   0:00:04\\rFilter  91% (370 of 406) |#############  | Elapsed Time: 0:00:47 ETA:   0:00:04\\rFilter  92% (374 of 406) |#############  | Elapsed Time: 0:00:47 ETA:   0:00:03\\rFilter  93% (378 of 406) |#############  | Elapsed Time: 0:00:48 ETA:   0:00:03\\rFilter  94% (382 of 406) |############## | Elapsed Time: 0:00:48 ETA:   0:00:03\\rFilter  95% (386 of 406) |############## | Elapsed Time: 0:00:49 ETA:   0:00:02\\rFilter  96% (390 of 406) |############## | Elapsed Time: 0:00:49 ETA:   0:00:02\\rFilter  97% (394 of 406) |############## | Elapsed Time: 0:00:50 ETA:   0:00:01\\rFilter  98% (398 of 406) |############## | Elapsed Time: 0:00:51 ETA:   0:00:01\\rFilter  99% (402 of 406) |############## | Elapsed Time: 0:00:51 ETA:   0:00:00\\rFilter 100% (406 of 406) |###############| Elapsed Time: 0:00:51 Time:  0:00:51\\n2022-05-28 16:52:57,774 INFO Total: 620545. Filtered: 207\\n\\rExpected   0% (0 of 620338) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 620338) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (6204 of 620338) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (12407 of 620338) |        | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   3% (18611 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:06\\rExpected   4% (24814 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:11\\rExpected   5% (31017 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:15\\rExpected   6% (37221 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:17\\rExpected   7% (43424 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:19\\rExpected   8% (49628 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:20\\rExpected   9% (55831 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:20\\rExpected  10% (62034 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:17\\rExpected  11% (68238 of 620338) |        | Elapsed Time: 0:00:02 ETA:   0:00:17\\rExpected  12% (74441 of 620338) |        | Elapsed Time: 0:00:02 ETA:   0:00:22\\rExpected  13% (80644 of 620338) |#       | Elapsed Time: 0:00:03 ETA:   0:00:23\\rExpected  14% (86848 of 620338) |#       | Elapsed Time: 0:00:03 ETA:   0:00:24\\rExpected  15% (93051 of 620338) |#       | Elapsed Time: 0:00:03 ETA:   0:00:24\\rExpected  16% (99255 of 620338) |#       | Elapsed Time: 0:00:03 ETA:   0:00:28\\rExpected  17% (105458 of 620338) |#      | Elapsed Time: 0:00:04 ETA:   0:00:29\\rExpected  18% (111661 of 620338) |#      | Elapsed Time: 0:00:04 ETA:   0:00:28\\rExpected  19% (117865 of 620338) |#      | Elapsed Time: 0:00:04 ETA:   0:00:27\\rExpected  20% (124068 of 620338) |#      | Elapsed Time: 0:00:05 ETA:   0:00:30\\rExpected  21% (130271 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:33\\rExpected  22% (136475 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:33\\rExpected  23% (142678 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:25\\rExpected  24% (148882 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:24\\rExpected  25% (155085 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:23\\rExpected  26% (161288 of 620338) |#      | Elapsed Time: 0:00:07 ETA:   0:00:25\\rExpected  27% (167492 of 620338) |#      | Elapsed Time: 0:00:07 ETA:   0:00:22\\rExpected  28% (173695 of 620338) |#      | Elapsed Time: 0:00:07 ETA:   0:00:22\\rExpected  29% (179899 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:19\\rExpected  30% (186102 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:17\\rExpected  31% (192305 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:14\\rExpected  32% (198509 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:13\\rExpected  33% (204712 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:15\\rExpected  34% (210915 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:14\\rExpected  35% (217119 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:12\\rExpected  36% (223322 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:12\\rExpected  37% (229526 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:11\\rExpected  38% (235729 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:10\\rExpected  39% (241932 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:10\\rExpected  40% (248136 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:13\\rExpected  41% (254339 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:12\\rExpected  42% (260542 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:11\\rExpected  43% (266746 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:10\\rExpected  44% (272949 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:09\\rExpected  45% (279153 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:09\\rExpected  46% (285356 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:08\\rExpected  47% (291559 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:10\\rExpected  48% (297763 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:10\\rExpected  49% (303966 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:10\\rExpected  50% (310170 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:08\\rExpected  51% (316373 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:07\\rExpected  52% (322576 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:07\\rExpected  53% (328780 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:07\\rExpected  54% (334983 of 620338) |###    | Elapsed Time: 0:00:12 ETA:   0:00:07\\rExpected  55% (341186 of 620338) |###    | Elapsed Time: 0:00:12 ETA:   0:00:07\\rExpected  56% (347390 of 620338) |###    | Elapsed Time: 0:00:12 ETA:   0:00:07\\rExpected  57% (353593 of 620338) |###    | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  58% (359797 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:08\\rExpected  59% (366000 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  60% (372203 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:08\\rExpected  61% (378407 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:08\\rExpected  62% (384610 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:08\\rExpected  63% (390813 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  64% (397017 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:07\\rExpected  65% (403220 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:07\\rExpected  66% (409424 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:07\\rExpected  67% (415627 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:07\\rExpected  68% (421830 of 620338) |####   | Elapsed Time: 0:00:15 ETA:   0:00:06\\rExpected  69% (428034 of 620338) |####   | Elapsed Time: 0:00:15 ETA:   0:00:05\\rExpected  70% (434237 of 620338) |####   | Elapsed Time: 0:00:15 ETA:   0:00:05\\rExpected  71% (440440 of 620338) |####   | Elapsed Time: 0:00:15 ETA:   0:00:06\\rExpected  72% (446644 of 620338) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:05\\rExpected  73% (452847 of 620338) |#####  | Elapsed Time: 0:00:16 ETA:   0:00:05\\rExpected  74% (459051 of 620338) |#####  | Elapsed Time: 0:00:16 ETA:   0:00:06\\rExpected  75% (465254 of 620338) |#####  | Elapsed Time: 0:00:16 ETA:   0:00:05\\rExpected  76% (471457 of 620338) |#####  | Elapsed Time: 0:00:16 ETA:   0:00:05\\rExpected  77% (477661 of 620338) |#####  | Elapsed Time: 0:00:16 ETA:   0:00:04\\rExpected  78% (483864 of 620338) |#####  | Elapsed Time: 0:00:20 ETA:   0:01:14\\rExpected  79% (490068 of 620338) |#####  | Elapsed Time: 0:00:23 ETA:   0:01:13\\rExpected  80% (496271 of 620338) |#####  | Elapsed Time: 0:00:29 ETA:   0:01:58\\rExpected  81% (502474 of 620338) |#####  | Elapsed Time: 0:00:32 ETA:   0:00:45\\rExpected  82% (508678 of 620338) |#####  | Elapsed Time: 0:00:32 ETA:   0:00:26\\rExpected  83% (514881 of 620338) |#####  | Elapsed Time: 0:00:33 ETA:   0:00:20\\rExpected  84% (521084 of 620338) |#####  | Elapsed Time: 0:00:33 ETA:   0:00:16\\rExpected  85% (527288 of 620338) |#####  | Elapsed Time: 0:00:34 ETA:   0:00:08\\rExpected  86% (533491 of 620338) |###### | Elapsed Time: 0:00:34 ETA:   0:00:08\\rExpected  87% (539695 of 620338) |###### | Elapsed Time: 0:00:35 ETA:   0:00:06\\rExpected  88% (545898 of 620338) |###### | Elapsed Time: 0:00:35 ETA:   0:00:06\\rExpected  89% (552101 of 620338) |###### | Elapsed Time: 0:00:36 ETA:   0:00:06\\rExpected  90% (558305 of 620338) |###### | Elapsed Time: 0:00:36 ETA:   0:00:05\\rExpected  91% (564508 of 620338) |###### | Elapsed Time: 0:00:37 ETA:   0:00:04\\rExpected  92% (570711 of 620338) |###### | Elapsed Time: 0:00:37 ETA:   0:00:03\\rExpected  93% (576915 of 620338) |###### | Elapsed Time: 0:00:37 ETA:   0:00:02\\rExpected  94% (583118 of 620338) |###### | Elapsed Time: 0:00:38 ETA:   0:00:02\\rExpected  95% (589322 of 620338) |###### | Elapsed Time: 0:00:38 ETA:   0:00:01\\rExpected  96% (595525 of 620338) |###### | Elapsed Time: 0:00:38 ETA:   0:00:01\\rExpected  97% (601728 of 620338) |###### | Elapsed Time: 0:00:39 ETA:   0:00:01\\rExpected  98% (607932 of 620338) |###### | Elapsed Time: 0:00:39 ETA:   0:00:00\\rExpected  99% (614135 of 620338) |###### | Elapsed Time: 0:00:39 ETA:   0:00:00\\rExpected 100% (620338 of 620338) |#######| Elapsed Time: 0:00:39 Time:  0:00:39\\n2022-05-28 16:54:02,816 INFO Done.\\n2022-05-28 16:54:26,399 INFO Saving statistics...\\n2022-05-28 16:54:26,758 INFO Normalising binned Hic file\\n\\rExpected   0% (0 of 620338) |            | Elapsed Time: 0:00:00 ETA:  --:--:--\\rExpected   0% (1 of 620338) |            | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   1% (6204 of 620338) |         | Elapsed Time: 0:00:00 ETA:  00:00:00\\rExpected   2% (12407 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:14\\rExpected   3% (18611 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:14\\rExpected   4% (24814 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:14\\rExpected   5% (31017 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:13\\rExpected   6% (37221 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:13\\rExpected   7% (43424 of 620338) |        | Elapsed Time: 0:00:00 ETA:   0:00:13\\rExpected   8% (49628 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:12\\rExpected   9% (55831 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:12\\rExpected  10% (62034 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:11\\rExpected  11% (68238 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:13\\rExpected  12% (74441 of 620338) |        | Elapsed Time: 0:00:01 ETA:   0:00:13\\rExpected  13% (80644 of 620338) |#       | Elapsed Time: 0:00:02 ETA:   0:00:15\\rExpected  14% (86848 of 620338) |#       | Elapsed Time: 0:00:02 ETA:   0:00:20\\rExpected  15% (93051 of 620338) |#       | Elapsed Time: 0:00:02 ETA:   0:00:20\\rExpected  16% (99255 of 620338) |#       | Elapsed Time: 0:00:03 ETA:   0:00:29\\rExpected  17% (105458 of 620338) |#      | Elapsed Time: 0:00:03 ETA:   0:00:29\\rExpected  18% (111661 of 620338) |#      | Elapsed Time: 0:00:03 ETA:   0:00:28\\rExpected  19% (117865 of 620338) |#      | Elapsed Time: 0:00:04 ETA:   0:00:29\\rExpected  20% (124068 of 620338) |#      | Elapsed Time: 0:00:04 ETA:   0:00:28\\rExpected  21% (130271 of 620338) |#      | Elapsed Time: 0:00:05 ETA:   0:00:25\\rExpected  22% (136475 of 620338) |#      | Elapsed Time: 0:00:05 ETA:   0:00:23\\rExpected  23% (142678 of 620338) |#      | Elapsed Time: 0:00:05 ETA:   0:00:23\\rExpected  24% (148882 of 620338) |#      | Elapsed Time: 0:00:05 ETA:   0:00:22\\rExpected  25% (155085 of 620338) |#      | Elapsed Time: 0:00:05 ETA:   0:00:21\\rExpected  26% (161288 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:20\\rExpected  27% (167492 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:20\\rExpected  28% (173695 of 620338) |#      | Elapsed Time: 0:00:06 ETA:   0:00:20\\rExpected  29% (179899 of 620338) |##     | Elapsed Time: 0:00:06 ETA:   0:00:14\\rExpected  30% (186102 of 620338) |##     | Elapsed Time: 0:00:06 ETA:   0:00:13\\rExpected  31% (192305 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:12\\rExpected  32% (198509 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:13\\rExpected  33% (204712 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:15\\rExpected  34% (210915 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:13\\rExpected  35% (217119 of 620338) |##     | Elapsed Time: 0:00:07 ETA:   0:00:13\\rExpected  36% (223322 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:12\\rExpected  37% (229526 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:12\\rExpected  38% (235729 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:15\\rExpected  39% (241932 of 620338) |##     | Elapsed Time: 0:00:08 ETA:   0:00:15\\rExpected  40% (248136 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:15\\rExpected  41% (254339 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:15\\rExpected  42% (260542 of 620338) |##     | Elapsed Time: 0:00:09 ETA:   0:00:12\\rExpected  43% (266746 of 620338) |###    | Elapsed Time: 0:00:09 ETA:   0:00:11\\rExpected  44% (272949 of 620338) |###    | Elapsed Time: 0:00:09 ETA:   0:00:10\\rExpected  45% (279153 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:10\\rExpected  46% (285356 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:12\\rExpected  47% (291559 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:12\\rExpected  48% (297763 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:12\\rExpected  49% (303966 of 620338) |###    | Elapsed Time: 0:00:10 ETA:   0:00:10\\rExpected  50% (310170 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:09\\rExpected  51% (316373 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:09\\rExpected  52% (322576 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:08\\rExpected  53% (328780 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:10\\rExpected  54% (334983 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:09\\rExpected  55% (341186 of 620338) |###    | Elapsed Time: 0:00:11 ETA:   0:00:09\\rExpected  56% (347390 of 620338) |###    | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  57% (353593 of 620338) |###    | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  58% (359797 of 620338) |####   | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  59% (366000 of 620338) |####   | Elapsed Time: 0:00:12 ETA:   0:00:08\\rExpected  60% (372203 of 620338) |####   | Elapsed Time: 0:00:12 ETA:   0:00:07\\rExpected  61% (378407 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  62% (384610 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  63% (390813 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  64% (397017 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:07\\rExpected  65% (403220 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:05\\rExpected  66% (409424 of 620338) |####   | Elapsed Time: 0:00:13 ETA:   0:00:05\\rExpected  67% (415627 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:06\\rExpected  68% (421830 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:06\\rExpected  69% (428034 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:05\\rExpected  70% (434237 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:04\\rExpected  71% (440440 of 620338) |####   | Elapsed Time: 0:00:14 ETA:   0:00:04\\rExpected  72% (446644 of 620338) |#####  | Elapsed Time: 0:00:14 ETA:   0:00:04\\rExpected  73% (452847 of 620338) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  74% (459051 of 620338) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  75% (465254 of 620338) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:04\\rExpected  76% (471457 of 620338) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  77% (477661 of 620338) |#####  | Elapsed Time: 0:00:15 ETA:   0:00:03\\rExpected  78% (483864 of 620338) |#####  | Elapsed Time: 0:00:19 ETA:   0:01:28\\rExpected  79% (490068 of 620338) |#####  | Elapsed Time: 0:00:24 ETA:   0:01:46\\rExpected  80% (496271 of 620338) |#####  | Elapsed Time: 0:00:28 ETA:   0:01:13\\rExpected  81% (502474 of 620338) |#####  | Elapsed Time: 0:00:31 ETA:   0:00:58\\rExpected  82% (508678 of 620338) |#####  | Elapsed Time: 0:00:31 ETA:   0:00:30\\rExpected  83% (514881 of 620338) |#####  | Elapsed Time: 0:00:32 ETA:   0:00:21\\rExpected  84% (521084 of 620338) |#####  | Elapsed Time: 0:00:32 ETA:   0:00:16\\rExpected  85% (527288 of 620338) |#####  | Elapsed Time: 0:00:32 ETA:   0:00:12\\rExpected  86% (533491 of 620338) |###### | Elapsed Time: 0:00:33 ETA:   0:00:11\\rExpected  87% (539695 of 620338) |###### | Elapsed Time: 0:00:33 ETA:   0:00:04\\rExpected  88% (545898 of 620338) |###### | Elapsed Time: 0:00:34 ETA:   0:00:05\\rExpected  89% (552101 of 620338) |###### | Elapsed Time: 0:00:34 ETA:   0:00:04\\rExpected  90% (558305 of 620338) |###### | Elapsed Time: 0:00:34 ETA:   0:00:04\\rExpected  91% (564508 of 620338) |###### | Elapsed Time: 0:00:35 ETA:   0:00:03\\rExpected  92% (570711 of 620338) |###### | Elapsed Time: 0:00:35 ETA:   0:00:02\\rExpected  93% (576915 of 620338) |###### | Elapsed Time: 0:00:35 ETA:   0:00:02\\rExpected  94% (583118 of 620338) |###### | Elapsed Time: 0:00:35 ETA:   0:00:01\\rExpected  95% (589322 of 620338) |###### | Elapsed Time: 0:00:36 ETA:   0:00:01\\rExpected  96% (595525 of 620338) |###### | Elapsed Time: 0:00:36 ETA:   0:00:01\\rExpected  97% (601728 of 620338) |###### | Elapsed Time: 0:00:36 ETA:   0:00:00\\rExpected  98% (607932 of 620338) |###### | Elapsed Time: 0:00:36 ETA:   0:00:00\\rExpected  99% (614135 of 620338) |###### | Elapsed Time: 0:00:37 ETA:   0:00:00\\rExpected 100% (620338 of 620338) |#######| Elapsed Time: 0:00:37 Time:  0:00:37\\nClosing remaining open files:examples/test.hic...done\\n')\n"
     ]
    }
   ],
   "source": [
    "print(ret)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Ouput\n",
    "- Hi-C Maps at various resolutions"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 43,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "['test_100kb.hic',\n",
       " 'test_10kb.hic',\n",
       " 'test_1mb.hic',\n",
       " 'test_250kb.hic',\n",
       " 'test_25kb.hic',\n",
       " 'test_2mb.hic',\n",
       " 'test_500kb.hic',\n",
       " 'test_50kb.hic',\n",
       " 'test_5kb.hic',\n",
       " 'test_5mb.hic']"
      ]
     },
     "execution_count": 43,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "import os\n",
    "os.listdir(\"example_output/hic/binned\")"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Code to Convert  HI-C fastq Sequences to Map\n",
    "\n",
    "Note : As the process was taking more time and notebook was turning slow,ran it in shell,saved the log in a file. Below is the same."
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 19,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "\n"
     ]
    }
   ],
   "source": [
    "import subprocess\n",
    "\n",
    "# !fanc auto SRR4271982_chr18_19_1.fastq.gzip SRR4271982_chr18_19_2.fastq.gzip \\\n",
    "#           ./example_output/ -i bwa-index/hg19_chr18_19.fa \\\n",
    "#           -g hg19_chr18_19_re_fragments.bed\n",
    "\n",
    "### Equivalent Python code\n",
    "\n",
    "command = \"cd examples; fanc auto SRR4271982_chr18_19_1.fastq.gzip SRR4271982_chr18_19_2.fastq.gzip \\\n",
    "          ./example_output/ -i bwa-index/hg19_chr18_19.fa \\\n",
    "          -g hg19_chr18_19_re_fragments.bed\"\n",
    "\n",
    "ret = subprocess.run(command, capture_output=True, shell=True)\n",
    "\n",
    "\n",
    "\n",
    "print(ret.stdout.decode())"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 61,
   "metadata": {
    "scrolled": true
   },
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "mahesh@WINDOWS-KMOT8DP:/mnt/c/Users/user1/Documents/Hi-C Classification/examples$ fanc auto SRR4271982_chr18_19_1.fastq.gzip SRR4271982_chr18_19_2.fastq.gzip           ./example_output/ -i bwa-index/hg19_chr18_19.fa           -g hg19_chr18_19_re_fragments.bed\n",
      "2022-05-28 14:46:18,582 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:46:18,618 INFO Getting regions\n",
      "2022-05-28 14:46:18,633 INFO Output folder: ./example_output/\n",
      "2022-05-28 14:46:18,633 INFO Input files: SRR4271982_chr18_19_1.fastq.gzip, SRR4271982_chr18_19_2.fastq.gzip\n",
      "2022-05-28 14:46:18,634 INFO Input file types: fastq, fastq\n",
      "2022-05-28 14:46:18,634 INFO Final basename: SRR4271982_chr18_19 (you can change this with the -n option!)\n",
      "2022-05-28 14:46:18,634 INFO Creating output folders...\n",
      "2022-05-28 14:46:22,079 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:46:22,094 INFO Starting mapping for SRR4271982_chr18_19_1.fastq.gzip\n",
      "2022-05-28 14:46:22,153 INFO Starting to output alignments to intermediate SAM file /tmp/tmpm_j03tem/intermediate.sam\n",
      "2022-05-28 14:51:27,631 INFO Converting intermediate SAM file to BAM (./example_output/sam/SRR4271982_chr18_19_1.bam)\n",
      "2022-05-28 14:51:55,018 INFO Success, removing intermediate.\n",
      "2022-05-28 14:51:58,334 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:51:58,343 INFO Starting mapping for SRR4271982_chr18_19_2.fastq.gzip\n",
      "2022-05-28 14:51:58,406 INFO Starting to output alignments to intermediate SAM file /tmp/tmp5qbv_s68/intermediate.sam\n",
      "2022-05-28 14:57:07,109 INFO Converting intermediate SAM file to BAM (./example_output/sam/SRR4271982_chr18_19_2.bam)\n",
      "2022-05-28 14:57:50,736 INFO Success, removing intermediate.\n",
      "2022-05-28 14:57:56,304 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:57:56,360 INFO Cannot find sambamba on this machine, falling back to samtools sort. This is not a problem, but if you want to speed up your SAM/BAM file sorting, install sambamba and ensure it is in your PATH!\n",
      "2022-05-28 14:59:06,282 INFO Replacing input SAM/BAM file ./example_output/sam/SRR4271982_chr18_19_1.bam with sorted version...\n",
      "2022-05-28 14:59:11,902 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:59:11,956 INFO Cannot find sambamba on this machine, falling back to samtools sort. This is not a problem, but if you want to speed up your SAM/BAM file sorting, install sambamba and ensure it is in your PATH!\n",
      "2022-05-28 15:00:08,180 INFO Replacing input SAM/BAM file ./example_output/sam/SRR4271982_chr18_19_2.bam with sorted version...\n",
      "2022-05-28 15:00:14,472 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:00:14,474 INFO Getting genome regions (fragments or bins)\n",
      "2022-05-28 15:00:14,474 INFO Getting regions\n",
      "2022-05-28 15:00:14,491 INFO Three arguments detected, assuming SAM/BAM input.\n",
      "[E::idx_find_and_load] Could not retrieve index file for './example_output/sam/SRR4271982_chr18_19_1.bam'\n",
      "2022-05-28 15:00:14,496 INFO Using filters appropriate for BWA.\n",
      "[E::idx_find_and_load] Could not retrieve index file for './example_output/sam/SRR4271982_chr18_19_1.bam'\n",
      "[E::idx_find_and_load] Could not retrieve index file for './example_output/sam/SRR4271982_chr18_19_2.bam'\n",
      "Buffers 100% (630 of 630) |#####################################################################################################################################| Elapsed Time: 0:00:06 Time:  0:00:06\n",
      "2022-05-28 15:06:17,524 INFO Updating region mappability\n",
      "Mappability 100% (2046456 of 2046456) |#########################################################################################################################| Elapsed Time: 0:00:28 Time:  0:00:28\n",
      "2022-05-28 15:07:08,950 INFO All done.\n",
      "2022-05-28 15:07:14,285 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:07:14,287 INFO One argument received, assuming existing Pairs object.\n",
      "2022-05-28 15:07:14,463 INFO Filtering reads with RE distance > 10000bp\n",
      "2022-05-28 15:07:14,466 INFO Filtering self-ligated read pairs\n",
      "2022-05-28 15:07:14,468 INFO Filtering PCR duplicates, threshold <= 2bp\n",
      "2022-05-28 15:07:47,350 INFO PCR duplicate stats: 210927 (10.3%) of pairs marked as duplicate.  (multiplicity:occurances) 3:17111 2:170119 4:1696 5:216 10:5 12:2 6:49 8:11 7:18 9:4 11:1 15:1\n",
      "2022-05-28 15:07:47,350 INFO Running filters...\n",
      "Filter 100% (630 of 630) |######################################################################################################################################| Elapsed Time: 0:01:21 Time:  0:01:21\n",
      "2022-05-28 15:09:30,730 INFO Total: 2046456. Valid: 981229\n",
      "2022-05-28 15:09:30,730 INFO Updating region mappability\n",
      "Mappability 100% (981229 of 981229) |###########################################################################################################################| Elapsed Time: 0:00:20 Time:  0:00:20\n",
      "2022-05-28 15:10:10,257 INFO Done.\n",
      "2022-05-28 15:10:50,730 INFO Saving statistics...\n",
      "2022-05-28 15:10:51,252 INFO All done.\n",
      "2022-05-28 15:10:54,773 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:10:54,774 INFO One argument received, assuming existing Pairs object.\n",
      "Ligation error 100% (2046456 of 2046456) |######################################################################################################################| Elapsed Time: 0:00:46 Time:  0:00:46\n",
      "2022-05-28 15:12:19,539 INFO Pairs: 981229\n",
      "2022-05-28 15:12:19,539 INFO Inter-chromosomal: 139186\n",
      "2022-05-28 15:12:19,539 INFO Same fragment: 925594\n",
      "2022-05-28 15:12:19,539 INFO Same: 417664\n",
      "2022-05-28 15:12:19,540 INFO Inward: 217804\n",
      "2022-05-28 15:12:19,540 INFO Outward: 208669\n",
      "2022-05-28 15:12:22,099 INFO All done.\n",
      "2022-05-28 15:12:25,537 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:12:25,539 INFO One argument received, assuming existing Pairs object.\n",
      "/home/mahesh/.local/lib/python3.8/site-packages/seaborn/distributions.py:2619: FutureWarning: `distplot` is a deprecated function and will be removed in a future version. Please adapt your code to use either `displot` (a figure-level function with similar flexibility) or `histplot` (an axes-level function for histograms).\n",
      "  warnings.warn(msg, FutureWarning)\n",
      "2022-05-28 15:12:30,062 INFO All done.\n",
      "2022-05-28 15:12:33,556 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:12:33,675 INFO Converting Pairs files\n",
      "2022-05-28 15:12:33,771 INFO Converting ./example_output/pairs/SRR4271982_chr18_19.pairs to Hic\n",
      "Hi-C convert 100% (981229 of 981229) |##########################################################################################################################| Elapsed Time: 0:00:35 Time:  0:00:35\n",
      "2022-05-28 15:13:40,317 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:13:40,471 INFO Binning Hic file (5000000)\n",
      "2022-05-28 15:13:40,471 INFO Constructing binned genome...\n",
      "2022-05-28 15:13:40,705 INFO Binning edges...\n",
      "2022-05-28 15:13:40,787 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:13:41,144 INFO Launching processes\n",
      "2022-05-28 15:13:44,562 INFO Submitting partitions\n",
      "2022-05-28 15:13:44,570 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (406 of 406) |####################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:11,659 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:14:11,670 INFO Final absolute cutoff threshold is 5.225e+03\n",
      "2022-05-28 15:14:11,671 INFO Selected a total of 0 (0.0%) regions to be masked\n",
      "2022-05-28 15:14:11,671 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:11,683 INFO Total: 406. Filtered: 0\n",
      "Expected 100% (406 of 406) |####################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:11,710 INFO Done.\n",
      "2022-05-28 15:14:12,169 INFO Saving statistics...\n",
      "2022-05-28 15:14:12,433 INFO Normalising binned Hic file\n",
      "Expected 100% (406 of 406) |####################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:14:16,073 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:14:16,247 INFO Binning Hic file (2000000)\n",
      "2022-05-28 15:14:16,248 INFO Constructing binned genome...\n",
      "2022-05-28 15:14:16,472 INFO Binning edges...\n",
      "2022-05-28 15:14:16,544 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:14:16,870 INFO Launching processes\n",
      "2022-05-28 15:14:20,956 INFO Submitting partitions\n",
      "2022-05-28 15:14:20,967 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (2396 of 2396) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:41,557 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:14:41,581 INFO Final absolute cutoff threshold is 2.464e+03\n",
      "2022-05-28 15:14:41,581 INFO Selected a total of 2 (2.9%) regions to be masked\n",
      "2022-05-28 15:14:41,581 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:41,597 INFO Total: 2396. Filtered: 50\n",
      "Expected 100% (2346 of 2346) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:41,646 INFO Done.\n",
      "2022-05-28 15:14:42,183 INFO Saving statistics...\n",
      "2022-05-28 15:14:42,461 INFO Normalising binned Hic file\n",
      "Expected 100% (2346 of 2346) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:14:46,072 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:14:46,261 INFO Binning Hic file (1000000)\n",
      "2022-05-28 15:14:46,261 INFO Constructing binned genome...\n",
      "2022-05-28 15:14:46,504 INFO Binning edges...\n",
      "2022-05-28 15:14:46,578 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:14:46,867 INFO Launching processes\n",
      "2022-05-28 15:14:49,949 INFO Submitting partitions\n",
      "2022-05-28 15:14:49,962 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (9113 of 9113) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:12,183 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:15:12,247 INFO Final absolute cutoff threshold is 1.307e+03\n",
      "2022-05-28 15:15:12,247 INFO Selected a total of 6 (4.3%) regions to be masked\n",
      "2022-05-28 15:15:12,247 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:12,281 INFO Total: 9113. Filtered: 202\n",
      "Expected 100% (8911 of 8911) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:12,390 INFO Done.\n",
      "2022-05-28 15:15:12,874 INFO Saving statistics...\n",
      "2022-05-28 15:15:13,136 INFO Normalising binned Hic file\n",
      "Expected 100% (8911 of 8911) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:15:17,063 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:15:17,255 INFO Binning Hic file (500000)\n",
      "2022-05-28 15:15:17,255 INFO Constructing binned genome...\n",
      "2022-05-28 15:15:17,484 INFO Binning edges...\n",
      "2022-05-28 15:15:17,563 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:15:17,880 INFO Launching processes\n",
      "2022-05-28 15:15:21,061 INFO Submitting partitions\n",
      "2022-05-28 15:15:21,076 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (34953 of 34953) |################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:45,834 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:15:46,066 INFO Final absolute cutoff threshold is 682.8\n",
      "2022-05-28 15:15:46,066 INFO Selected a total of 12 (4.3%) regions to be masked\n",
      "2022-05-28 15:15:46,067 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:46,181 INFO Total: 34953. Filtered: 87\n",
      "Expected 100% (34866 of 34866) |################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:46,571 INFO Done.\n",
      "2022-05-28 15:15:47,201 INFO Saving statistics...\n",
      "2022-05-28 15:15:47,551 INFO Normalising binned Hic file\n",
      "Expected 100% (34866 of 34866) |################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:15:51,989 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:15:52,234 INFO Binning Hic file (250000)\n",
      "2022-05-28 15:15:52,234 INFO Constructing binned genome...\n",
      "2022-05-28 15:15:52,488 INFO Binning edges...\n",
      "2022-05-28 15:15:52,582 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:15:52,912 INFO Launching processes\n",
      "2022-05-28 15:15:57,590 INFO Submitting partitions\n",
      "2022-05-28 15:15:57,605 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (123156 of 123156) |##############################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:16:25,893 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:16:26,891 INFO Final absolute cutoff threshold is 352.1\n",
      "2022-05-28 15:16:26,892 INFO Selected a total of 24 (4.4%) regions to be masked\n",
      "2022-05-28 15:16:26,892 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:16:27,170 INFO Total: 123156. Filtered: 101\n",
      "Expected 100% (123055 of 123055) |##############################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "2022-05-28 15:16:28,298 INFO Done.\n",
      "2022-05-28 15:16:29,051 INFO Saving statistics...\n",
      "2022-05-28 15:16:29,505 INFO Normalising binned Hic file\n",
      "Expected 100% (123055 of 123055) |##############################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:16:35,978 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:16:36,184 INFO Binning Hic file (100000)\n",
      "2022-05-28 15:16:36,184 INFO Constructing binned genome...\n",
      "2022-05-28 15:16:36,455 INFO Binning edges...\n",
      "2022-05-28 15:16:36,543 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:16:36,947 INFO Launching processes\n",
      "2022-05-28 15:16:40,491 INFO Submitting partitions\n",
      "2022-05-28 15:16:40,505 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (3 of 3) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (376465 of 376465) |##############################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "2022-05-28 15:17:27,528 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:17:29,699 INFO Final absolute cutoff threshold is 138.8\n",
      "2022-05-28 15:17:29,699 INFO Selected a total of 63 (4.6%) regions to be masked\n",
      "2022-05-28 15:17:29,699 INFO Running filters...\n",
      "Filter 100% (3 of 3) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:17:30,878 INFO Total: 376465. Filtered: 223\n",
      "Expected 100% (376242 of 376242) |##############################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "2022-05-28 15:17:33,115 INFO Done.\n",
      "2022-05-28 15:17:33,701 INFO Saving statistics...\n",
      "2022-05-28 15:17:33,984 INFO Normalising binned Hic file\n",
      "Expected 100% (376242 of 376242) |##############################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:17:44,379 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:17:44,663 INFO Binning Hic file (50000)\n",
      "2022-05-28 15:17:44,663 INFO Constructing binned genome...\n",
      "2022-05-28 15:17:44,988 INFO Binning edges...\n",
      "2022-05-28 15:17:45,116 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:17:45,484 INFO Launching processes\n",
      "2022-05-28 15:17:49,180 INFO Submitting partitions\n",
      "2022-05-28 15:17:49,193 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (6 of 6) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (570991 of 570991) |##############################################################################################################################| Elapsed Time: 0:00:04 Time:  0:00:04\n",
      "2022-05-28 15:18:24,673 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:18:27,951 INFO Final absolute cutoff threshold is 68.4\n",
      "2022-05-28 15:18:27,952 INFO Selected a total of 139 (5.1%) regions to be masked\n",
      "2022-05-28 15:18:27,952 INFO Running filters...\n",
      "Filter 100% (6 of 6) |##########################################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "2022-05-28 15:18:29,837 INFO Total: 570991. Filtered: 463\n",
      "Expected 100% (570528 of 570528) |##############################################################################################################################| Elapsed Time: 0:00:03 Time:  0:00:03\n",
      "2022-05-28 15:18:33,613 INFO Done.\n",
      "2022-05-28 15:18:34,340 INFO Saving statistics...\n",
      "2022-05-28 15:18:34,713 INFO Normalising binned Hic file\n",
      "Expected 100% (570528 of 570528) |##############################################################################################################################| Elapsed Time: 0:00:03 Time:  0:00:03\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:18:49,304 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:18:49,618 INFO Binning Hic file (25000)\n",
      "2022-05-28 15:18:49,618 INFO Constructing binned genome...\n",
      "2022-05-28 15:18:49,928 INFO Binning edges...\n",
      "2022-05-28 15:18:50,102 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:18:50,580 INFO Launching processes\n",
      "2022-05-28 15:18:55,147 INFO Submitting partitions\n",
      "2022-05-28 15:18:55,162 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (21 of 21) |#######################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (709432 of 709432) |##############################################################################################################################| Elapsed Time: 0:00:05 Time:  0:00:05\n",
      "2022-05-28 15:32:05,461 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:32:10,129 INFO Final absolute cutoff threshold is 34.1\n",
      "2022-05-28 15:32:10,130 INFO Selected a total of 339 (6.2%) regions to be masked\n",
      "2022-05-28 15:32:10,131 INFO Running filters...\n",
      "Filter 100% (21 of 21) |########################################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "2022-05-28 15:32:12,653 INFO Total: 709432. Filtered: 208\n",
      "Expected 100% (709224 of 709224) |##############################################################################################################################| Elapsed Time: 0:00:05 Time:  0:00:05\n",
      "2022-05-28 15:32:18,537 INFO Done.\n",
      "2022-05-28 15:32:19,386 INFO Saving statistics...\n",
      "2022-05-28 15:32:19,720 INFO Normalising binned Hic file\n",
      "Expected 100% (709224 of 709224) |##############################################################################################################################| Elapsed Time: 0:00:04 Time:  0:00:04\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:32:36,850 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:32:37,130 INFO Binning Hic file (10000)\n",
      "2022-05-28 15:32:37,130 INFO Constructing binned genome...\n",
      "2022-05-28 15:32:37,687 INFO Binning edges...\n",
      "2022-05-28 15:32:38,000 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:32:38,525 INFO Launching processes\n",
      "2022-05-28 15:32:42,183 INFO Submitting partitions\n",
      "2022-05-28 15:32:42,196 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (105 of 105) |#####################################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "Expected 100% (815960 of 815960) |##############################################################################################################################| Elapsed Time: 0:00:09 Time:  0:00:09\n",
      "2022-05-28 15:33:40,888 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:33:50,891 INFO Final absolute cutoff threshold is 14.8\n",
      "2022-05-28 15:33:50,892 INFO Selected a total of 2170 (15.8%) regions to be masked\n",
      "2022-05-28 15:33:50,892 INFO Running filters...\n",
      "Filter 100% (105 of 105) |######################################################################################################################################| Elapsed Time: 0:00:06 Time:  0:00:06\n",
      "2022-05-28 15:34:01,352 INFO Total: 815960. Filtered: 95\n",
      "Expected 100% (815865 of 815865) |##############################################################################################################################| Elapsed Time: 0:00:08 Time:  0:00:08\n",
      "2022-05-28 15:34:12,468 INFO Done.\n",
      "2022-05-28 15:34:16,201 INFO Saving statistics...\n",
      "2022-05-28 15:34:16,445 INFO Normalising binned Hic file\n",
      "Expected 100% (815865 of 815865) |##############################################################################################################################| Elapsed Time: 0:00:08 Time:  0:00:08\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:34:57,207 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:34:57,470 INFO Binning Hic file (5000)\n",
      "2022-05-28 15:34:57,470 INFO Constructing binned genome...\n",
      "2022-05-28 15:34:58,130 INFO Binning edges...\n",
      "2022-05-28 15:34:58,725 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:34:59,249 INFO Launching processes\n",
      "2022-05-28 15:35:03,914 INFO Submitting partitions\n",
      "2022-05-28 15:35:03,929 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (406 of 406) |#####################################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "Expected 100% (859683 of 859683) |##############################################################################################################################| Elapsed Time: 0:00:15 Time:  0:00:15\n",
      "2022-05-28 15:37:47,081 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:38:06,167 INFO Final absolute cutoff threshold is 9.2\n",
      "2022-05-28 15:38:06,172 INFO Selected a total of 9410 (34.3%) regions to be masked\n",
      "2022-05-28 15:38:06,172 INFO Running filters...\n",
      "Filter 100% (406 of 406) |######################################################################################################################################| Elapsed Time: 0:00:15 Time:  0:00:15\n",
      "2022-05-28 15:38:36,916 INFO Total: 859683. Filtered: 96\n",
      "Expected 100% (859587 of 859587) |##############################################################################################################################| Elapsed Time: 0:00:18 Time:  0:00:18\n",
      "2022-05-28 15:39:04,884 INFO Done.\n",
      "2022-05-28 15:39:21,163 INFO Saving statistics...\n",
      "2022-05-28 15:39:21,475 INFO Normalising binned Hic file\n",
      "Expected 100% (859587 of 859587) |##############################################################################################################################| Elapsed Time: 0:00:37 Time:  0:00:37\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done$ fanc auto SRR4271982_chr18_19_1.fastq.gzip SRR4271982_chr18_19_2.fastq.gzip           ./example_output/ -i bwa-index/hg19_chr18_19.fa           -g hg19_chr18_19_re_fragments.bed\n",
      "2022-05-28 14:46:18,582 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:46:18,618 INFO Getting regions\n",
      "2022-05-28 14:46:18,633 INFO Output folder: ./example_output/\n",
      "2022-05-28 14:46:18,633 INFO Input files: SRR4271982_chr18_19_1.fastq.gzip, SRR4271982_chr18_19_2.fastq.gzip\n",
      "2022-05-28 14:46:18,634 INFO Input file types: fastq, fastq\n",
      "2022-05-28 14:46:18,634 INFO Final basename: SRR4271982_chr18_19 (you can change this with the -n option!)\n",
      "2022-05-28 14:46:18,634 INFO Creating output folders...\n",
      "2022-05-28 14:46:22,079 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:46:22,094 INFO Starting mapping for SRR4271982_chr18_19_1.fastq.gzip\n",
      "2022-05-28 14:46:22,153 INFO Starting to output alignments to intermediate SAM file /tmp/tmpm_j03tem/intermediate.sam\n",
      "2022-05-28 14:51:27,631 INFO Converting intermediate SAM file to BAM (./example_output/sam/SRR4271982_chr18_19_1.bam)\n",
      "2022-05-28 14:51:55,018 INFO Success, removing intermediate.\n",
      "2022-05-28 14:51:58,334 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:51:58,343 INFO Starting mapping for SRR4271982_chr18_19_2.fastq.gzip\n",
      "2022-05-28 14:51:58,406 INFO Starting to output alignments to intermediate SAM file /tmp/tmp5qbv_s68/intermediate.sam\n",
      "2022-05-28 14:57:07,109 INFO Converting intermediate SAM file to BAM (./example_output/sam/SRR4271982_chr18_19_2.bam)\n",
      "2022-05-28 14:57:50,736 INFO Success, removing intermediate.\n",
      "2022-05-28 14:57:56,304 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:57:56,360 INFO Cannot find sambamba on this machine, falling back to samtools sort. This is not a problem, but if you want to speed up your SAM/BAM file sorting, install sambamba and ensure it is in your PATH!\n",
      "2022-05-28 14:59:06,282 INFO Replacing input SAM/BAM file ./example_output/sam/SRR4271982_chr18_19_1.bam with sorted version...\n",
      "2022-05-28 14:59:11,902 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 14:59:11,956 INFO Cannot find sambamba on this machine, falling back to samtools sort. This is not a problem, but if you want to speed up your SAM/BAM file sorting, install sambamba and ensure it is in your PATH!\n",
      "2022-05-28 15:00:08,180 INFO Replacing input SAM/BAM file ./example_output/sam/SRR4271982_chr18_19_2.bam with sorted version...\n",
      "2022-05-28 15:00:14,472 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:00:14,474 INFO Getting genome regions (fragments or bins)\n",
      "2022-05-28 15:00:14,474 INFO Getting regions\n",
      "2022-05-28 15:00:14,491 INFO Three arguments detected, assuming SAM/BAM input.\n",
      "[E::idx_find_and_load] Could not retrieve index file for './example_output/sam/SRR4271982_chr18_19_1.bam'\n",
      "2022-05-28 15:00:14,496 INFO Using filters appropriate for BWA.\n",
      "[E::idx_find_and_load] Could not retrieve index file for './example_output/sam/SRR4271982_chr18_19_1.bam'\n",
      "[E::idx_find_and_load] Could not retrieve index file for './example_output/sam/SRR4271982_chr18_19_2.bam'\n",
      "Buffers 100% (630 of 630) |#####################################################################################################################################| Elapsed Time: 0:00:06 Time:  0:00:06\n",
      "2022-05-28 15:06:17,524 INFO Updating region mappability\n",
      "Mappability 100% (2046456 of 2046456) |#########################################################################################################################| Elapsed Time: 0:00:28 Time:  0:00:28\n",
      "2022-05-28 15:07:08,950 INFO All done.\n",
      "2022-05-28 15:07:14,285 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:07:14,287 INFO One argument received, assuming existing Pairs object.\n",
      "2022-05-28 15:07:14,463 INFO Filtering reads with RE distance > 10000bp\n",
      "2022-05-28 15:07:14,466 INFO Filtering self-ligated read pairs\n",
      "2022-05-28 15:07:14,468 INFO Filtering PCR duplicates, threshold <= 2bp\n",
      "2022-05-28 15:07:47,350 INFO PCR duplicate stats: 210927 (10.3%) of pairs marked as duplicate.  (multiplicity:occurances) 3:17111 2:170119 4:1696 5:216 10:5 12:2 6:49 8:11 7:18 9:4 11:1 15:1\n",
      "2022-05-28 15:07:47,350 INFO Running filters...\n",
      "Filter 100% (630 of 630) |######################################################################################################################################| Elapsed Time: 0:01:21 Time:  0:01:21\n",
      "2022-05-28 15:09:30,730 INFO Total: 2046456. Valid: 981229\n",
      "2022-05-28 15:09:30,730 INFO Updating region mappability\n",
      "Mappability 100% (981229 of 981229) |###########################################################################################################################| Elapsed Time: 0:00:20 Time:  0:00:20\n",
      "2022-05-28 15:10:10,257 INFO Done.\n",
      "2022-05-28 15:10:50,730 INFO Saving statistics...\n",
      "2022-05-28 15:10:51,252 INFO All done.\n",
      "2022-05-28 15:10:54,773 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:10:54,774 INFO One argument received, assuming existing Pairs object.\n",
      "Ligation error 100% (2046456 of 2046456) |######################################################################################################################| Elapsed Time: 0:00:46 Time:  0:00:46\n",
      "2022-05-28 15:12:19,539 INFO Pairs: 981229\n",
      "2022-05-28 15:12:19,539 INFO Inter-chromosomal: 139186\n",
      "2022-05-28 15:12:19,539 INFO Same fragment: 925594\n",
      "2022-05-28 15:12:19,539 INFO Same: 417664\n",
      "2022-05-28 15:12:19,540 INFO Inward: 217804\n",
      "2022-05-28 15:12:19,540 INFO Outward: 208669\n",
      "2022-05-28 15:12:22,099 INFO All done.\n",
      "2022-05-28 15:12:25,537 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:12:25,539 INFO One argument received, assuming existing Pairs object.\n",
      "/home/mahesh/.local/lib/python3.8/site-packages/seaborn/distributions.py:2619: FutureWarning: `distplot` is a deprecated function and will be removed in a future version. Please adapt your code to use either `displot` (a figure-level function with similar flexibility) or `histplot` (an axes-level function for histograms).\n",
      "  warnings.warn(msg, FutureWarning)\n",
      "2022-05-28 15:12:30,062 INFO All done.\n",
      "2022-05-28 15:12:33,556 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:12:33,675 INFO Converting Pairs files\n",
      "2022-05-28 15:12:33,771 INFO Converting ./example_output/pairs/SRR4271982_chr18_19.pairs to Hic\n",
      "Hi-C convert 100% (981229 of 981229) |##########################################################################################################################| Elapsed Time: 0:00:35 Time:  0:00:35\n",
      "2022-05-28 15:13:40,317 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:13:40,471 INFO Binning Hic file (5000000)\n",
      "2022-05-28 15:13:40,471 INFO Constructing binned genome...\n",
      "2022-05-28 15:13:40,705 INFO Binning edges...\n",
      "2022-05-28 15:13:40,787 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:13:41,144 INFO Launching processes\n",
      "2022-05-28 15:13:44,562 INFO Submitting partitions\n",
      "2022-05-28 15:13:44,570 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (406 of 406) |####################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:11,659 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:14:11,670 INFO Final absolute cutoff threshold is 5.225e+03\n",
      "2022-05-28 15:14:11,671 INFO Selected a total of 0 (0.0%) regions to be masked\n",
      "2022-05-28 15:14:11,671 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:11,683 INFO Total: 406. Filtered: 0\n",
      "Expected 100% (406 of 406) |####################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:11,710 INFO Done.\n",
      "2022-05-28 15:14:12,169 INFO Saving statistics...\n",
      "2022-05-28 15:14:12,433 INFO Normalising binned Hic file\n",
      "Expected 100% (406 of 406) |####################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:14:16,073 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:14:16,247 INFO Binning Hic file (2000000)\n",
      "2022-05-28 15:14:16,248 INFO Constructing binned genome...\n",
      "2022-05-28 15:14:16,472 INFO Binning edges...\n",
      "2022-05-28 15:14:16,544 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:14:16,870 INFO Launching processes\n",
      "2022-05-28 15:14:20,956 INFO Submitting partitions\n",
      "2022-05-28 15:14:20,967 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (2396 of 2396) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:41,557 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:14:41,581 INFO Final absolute cutoff threshold is 2.464e+03\n",
      "2022-05-28 15:14:41,581 INFO Selected a total of 2 (2.9%) regions to be masked\n",
      "2022-05-28 15:14:41,581 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:41,597 INFO Total: 2396. Filtered: 50\n",
      "Expected 100% (2346 of 2346) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:14:41,646 INFO Done.\n",
      "2022-05-28 15:14:42,183 INFO Saving statistics...\n",
      "2022-05-28 15:14:42,461 INFO Normalising binned Hic file\n",
      "Expected 100% (2346 of 2346) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:14:46,072 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:14:46,261 INFO Binning Hic file (1000000)\n",
      "2022-05-28 15:14:46,261 INFO Constructing binned genome...\n",
      "2022-05-28 15:14:46,504 INFO Binning edges...\n",
      "2022-05-28 15:14:46,578 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:14:46,867 INFO Launching processes\n",
      "2022-05-28 15:14:49,949 INFO Submitting partitions\n",
      "2022-05-28 15:14:49,962 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (9113 of 9113) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:12,183 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:15:12,247 INFO Final absolute cutoff threshold is 1.307e+03\n",
      "2022-05-28 15:15:12,247 INFO Selected a total of 6 (4.3%) regions to be masked\n",
      "2022-05-28 15:15:12,247 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:12,281 INFO Total: 9113. Filtered: 202\n",
      "Expected 100% (8911 of 8911) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:12,390 INFO Done.\n",
      "2022-05-28 15:15:12,874 INFO Saving statistics...\n",
      "2022-05-28 15:15:13,136 INFO Normalising binned Hic file\n",
      "Expected 100% (8911 of 8911) |##################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:15:17,063 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:15:17,255 INFO Binning Hic file (500000)\n",
      "2022-05-28 15:15:17,255 INFO Constructing binned genome...\n",
      "2022-05-28 15:15:17,484 INFO Binning edges...\n",
      "2022-05-28 15:15:17,563 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:15:17,880 INFO Launching processes\n",
      "2022-05-28 15:15:21,061 INFO Submitting partitions\n",
      "2022-05-28 15:15:21,076 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (34953 of 34953) |################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:45,834 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:15:46,066 INFO Final absolute cutoff threshold is 682.8\n",
      "2022-05-28 15:15:46,066 INFO Selected a total of 12 (4.3%) regions to be masked\n",
      "2022-05-28 15:15:46,067 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:46,181 INFO Total: 34953. Filtered: 87\n",
      "Expected 100% (34866 of 34866) |################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:15:46,571 INFO Done.\n",
      "2022-05-28 15:15:47,201 INFO Saving statistics...\n",
      "2022-05-28 15:15:47,551 INFO Normalising binned Hic file\n",
      "Expected 100% (34866 of 34866) |################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:15:51,989 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:15:52,234 INFO Binning Hic file (250000)\n",
      "2022-05-28 15:15:52,234 INFO Constructing binned genome...\n",
      "2022-05-28 15:15:52,488 INFO Binning edges...\n",
      "2022-05-28 15:15:52,582 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:15:52,912 INFO Launching processes\n",
      "2022-05-28 15:15:57,590 INFO Submitting partitions\n",
      "2022-05-28 15:15:57,605 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (123156 of 123156) |##############################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:16:25,893 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:16:26,891 INFO Final absolute cutoff threshold is 352.1\n",
      "2022-05-28 15:16:26,892 INFO Selected a total of 24 (4.4%) regions to be masked\n",
      "2022-05-28 15:16:26,892 INFO Running filters...\n",
      "Filter 100% (1 of 1) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:16:27,170 INFO Total: 123156. Filtered: 101\n",
      "Expected 100% (123055 of 123055) |##############################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "2022-05-28 15:16:28,298 INFO Done.\n",
      "2022-05-28 15:16:29,051 INFO Saving statistics...\n",
      "2022-05-28 15:16:29,505 INFO Normalising binned Hic file\n",
      "Expected 100% (123055 of 123055) |##############################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:16:35,978 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:16:36,184 INFO Binning Hic file (100000)\n",
      "2022-05-28 15:16:36,184 INFO Constructing binned genome...\n",
      "2022-05-28 15:16:36,455 INFO Binning edges...\n",
      "2022-05-28 15:16:36,543 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:16:36,947 INFO Launching processes\n",
      "2022-05-28 15:16:40,491 INFO Submitting partitions\n",
      "2022-05-28 15:16:40,505 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (3 of 3) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (376465 of 376465) |##############################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "2022-05-28 15:17:27,528 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:17:29,699 INFO Final absolute cutoff threshold is 138.8\n",
      "2022-05-28 15:17:29,699 INFO Selected a total of 63 (4.6%) regions to be masked\n",
      "2022-05-28 15:17:29,699 INFO Running filters...\n",
      "Filter 100% (3 of 3) |##########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 15:17:30,878 INFO Total: 376465. Filtered: 223\n",
      "Expected 100% (376242 of 376242) |##############################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "2022-05-28 15:17:33,115 INFO Done.\n",
      "2022-05-28 15:17:33,701 INFO Saving statistics...\n",
      "2022-05-28 15:17:33,984 INFO Normalising binned Hic file\n",
      "Expected 100% (376242 of 376242) |##############################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:17:44,379 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:17:44,663 INFO Binning Hic file (50000)\n",
      "2022-05-28 15:17:44,663 INFO Constructing binned genome...\n",
      "2022-05-28 15:17:44,988 INFO Binning edges...\n",
      "2022-05-28 15:17:45,116 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:17:45,484 INFO Launching processes\n",
      "2022-05-28 15:17:49,180 INFO Submitting partitions\n",
      "2022-05-28 15:17:49,193 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (6 of 6) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (570991 of 570991) |##############################################################################################################################| Elapsed Time: 0:00:04 Time:  0:00:04\n",
      "2022-05-28 15:18:24,673 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:18:27,951 INFO Final absolute cutoff threshold is 68.4\n",
      "2022-05-28 15:18:27,952 INFO Selected a total of 139 (5.1%) regions to be masked\n",
      "2022-05-28 15:18:27,952 INFO Running filters...\n",
      "Filter 100% (6 of 6) |##########################################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "2022-05-28 15:18:29,837 INFO Total: 570991. Filtered: 463\n",
      "Expected 100% (570528 of 570528) |##############################################################################################################################| Elapsed Time: 0:00:03 Time:  0:00:03\n",
      "2022-05-28 15:18:33,613 INFO Done.\n",
      "2022-05-28 15:18:34,340 INFO Saving statistics...\n",
      "2022-05-28 15:18:34,713 INFO Normalising binned Hic file\n",
      "Expected 100% (570528 of 570528) |##############################################################################################################################| Elapsed Time: 0:00:03 Time:  0:00:03\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:18:49,304 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:18:49,618 INFO Binning Hic file (25000)\n",
      "2022-05-28 15:18:49,618 INFO Constructing binned genome...\n",
      "2022-05-28 15:18:49,928 INFO Binning edges...\n",
      "2022-05-28 15:18:50,102 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:18:50,580 INFO Launching processes\n",
      "2022-05-28 15:18:55,147 INFO Submitting partitions\n",
      "2022-05-28 15:18:55,162 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (21 of 21) |#######################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (709432 of 709432) |##############################################################################################################################| Elapsed Time: 0:00:05 Time:  0:00:05\n",
      "2022-05-28 15:32:05,461 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:32:10,129 INFO Final absolute cutoff threshold is 34.1\n",
      "2022-05-28 15:32:10,130 INFO Selected a total of 339 (6.2%) regions to be masked\n",
      "2022-05-28 15:32:10,131 INFO Running filters...\n",
      "Filter 100% (21 of 21) |########################################################################################################################################| Elapsed Time: 0:00:02 Time:  0:00:02\n",
      "2022-05-28 15:32:12,653 INFO Total: 709432. Filtered: 208\n",
      "Expected 100% (709224 of 709224) |##############################################################################################################################| Elapsed Time: 0:00:05 Time:  0:00:05\n",
      "2022-05-28 15:32:18,537 INFO Done.\n",
      "2022-05-28 15:32:19,386 INFO Saving statistics...\n",
      "2022-05-28 15:32:19,720 INFO Normalising binned Hic file\n",
      "Expected 100% (709224 of 709224) |##############################################################################################################################| Elapsed Time: 0:00:04 Time:  0:00:04\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:32:36,850 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:32:37,130 INFO Binning Hic file (10000)\n",
      "2022-05-28 15:32:37,130 INFO Constructing binned genome...\n",
      "2022-05-28 15:32:37,687 INFO Binning edges...\n",
      "2022-05-28 15:32:38,000 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:32:38,525 INFO Launching processes\n",
      "2022-05-28 15:32:42,183 INFO Submitting partitions\n",
      "2022-05-28 15:32:42,196 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (105 of 105) |#####################################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "Expected 100% (815960 of 815960) |##############################################################################################################################| Elapsed Time: 0:00:09 Time:  0:00:09\n",
      "2022-05-28 15:33:40,888 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:33:50,891 INFO Final absolute cutoff threshold is 14.8\n",
      "2022-05-28 15:33:50,892 INFO Selected a total of 2170 (15.8%) regions to be masked\n",
      "2022-05-28 15:33:50,892 INFO Running filters...\n",
      "Filter 100% (105 of 105) |######################################################################################################################################| Elapsed Time: 0:00:06 Time:  0:00:06\n",
      "2022-05-28 15:34:01,352 INFO Total: 815960. Filtered: 95\n",
      "Expected 100% (815865 of 815865) |##############################################################################################################################| Elapsed Time: 0:00:08 Time:  0:00:08\n",
      "2022-05-28 15:34:12,468 INFO Done.\n",
      "2022-05-28 15:34:16,201 INFO Saving statistics...\n",
      "2022-05-28 15:34:16,445 INFO Normalising binned Hic file\n",
      "Expected 100% (815865 of 815865) |##############################################################################################################################| Elapsed Time: 0:00:08 Time:  0:00:08\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n",
      "2022-05-28 15:34:57,207 INFO FAN-C version: 0.9.24\n",
      "2022-05-28 15:34:57,470 INFO Binning Hic file (5000)\n",
      "2022-05-28 15:34:57,470 INFO Constructing binned genome...\n",
      "2022-05-28 15:34:58,130 INFO Binning edges...\n",
      "2022-05-28 15:34:58,725 INFO Binning Hi-C contacts\n",
      "2022-05-28 15:34:59,249 INFO Launching processes\n",
      "2022-05-28 15:35:03,914 INFO Submitting partitions\n",
      "2022-05-28 15:35:03,929 INFO Collecting results\n",
      "Binning 100% (1 of 1) |#########################################################################################################################################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (406 of 406) |#####################################################################################################################################| Elapsed Time: 0:00:01 Time:  0:00:01\n",
      "Expected 100% (859683 of 859683) |##############################################################################################################################| Elapsed Time: 0:00:15 Time:  0:00:15\n",
      "2022-05-28 15:37:47,081 INFO Filtering low-coverage bins using absolute cutoff 0.0, relative cutoff 10.0%\n",
      "2022-05-28 15:38:06,167 INFO Final absolute cutoff threshold is 9.2\n",
      "2022-05-28 15:38:06,172 INFO Selected a total of 9410 (34.3%) regions to be masked\n",
      "2022-05-28 15:38:06,172 INFO Running filters...\n",
      "Filter 100% (406 of 406) |######################################################################################################################################| Elapsed Time: 0:00:15 Time:  0:00:15\n",
      "2022-05-28 15:38:36,916 INFO Total: 859683. Filtered: 96\n",
      "Expected 100% (859587 of 859587) |##############################################################################################################################| Elapsed Time: 0:00:18 Time:  0:00:18\n",
      "2022-05-28 15:39:04,884 INFO Done.\n",
      "2022-05-28 15:39:21,163 INFO Saving statistics...\n",
      "2022-05-28 15:39:21,475 INFO Normalising binned Hic file\n",
      "Expected 100% (859587 of 859587) |##############################################################################################################################| Elapsed Time: 0:00:37 Time:  0:00:37\n",
      "Closing remaining open files:./example_output/hic/SRR4271982_chr18_19.hic...done\n"
     ]
    }
   ],
   "source": [
    "with open(\"log.log\") as f:\n",
    "    print(f.read())\n",
    "    "
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Analysis"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 62,
   "metadata": {},
   "outputs": [],
   "source": [
    "import fanc\n",
    "import fanc.plotting as fancplot\n",
    "import matplotlib.pyplot as plt\n",
    "\n",
    "hic_5mb = fanc.load(\"examples/example_output/hic/binned/SRR4271982_chr18_19_5mb.hic\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 63,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "AB 100% (2 of 2) |#######################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Buffers 100% (1 of 1) |##################| Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "Expected 100% (214 of 214) |#############| Elapsed Time: 0:00:00 Time:  0:00:00\n"
     ]
    }
   ],
   "source": [
    "ab = fanc.ABCompartmentMatrix.from_hic(hic_5mb)\n",
    "ab_chr18 = ab.matrix(('chr18', 'chr18'))"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 64,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 2 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, ax = plt.subplots()\n",
    "mp = fancplot.SquareMatrixPlot(ab, ax=ax,\n",
    "                           norm='lin', colormap='RdBu_r',\n",
    "                           vmin=-1, vmax=1,\n",
    "                           draw_minor_ticks=False)\n",
    "mp.plot('chr18')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Eigen vectors"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 65,
   "metadata": {},
   "outputs": [],
   "source": [
    "ev = ab.eigenvector()"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 66,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": "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\n",
      "text/plain": [
       "<Figure size 360x144 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, ax = plt.subplots(figsize=(5, 2))\n",
    "lp = fancplot.LinePlot(ab, colors=['darkturquoise'])\n",
    "lp.plot('chr18')\n",
    "plt.show()"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Enrichment profiles (Saddle plot)\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 67,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "2022-05-28 19:06:26,869 INFO Generating profile...\n",
      "2022-05-28 19:06:26,888 INFO Using GC content to orient eigenvector...\n"
     ]
    },
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 1500x1500 with 3 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "profile, cutoffs = ab.enrichment_profile(hic_1mb, genome='hg19_chr18_19.fa')\n",
    "fig, axes = fancplot.saddle_plot(profile, cutoffs)"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### PCA"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 69,
   "metadata": {},
   "outputs": [],
   "source": [
    "import fanc\n",
    "import fanc.plotting as fancplot\n",
    "from fanc.architecture.comparisons import hic_pca\n",
    "\n",
    "lowc_hindiii_100k = fanc.load(\"examples/architecture/other-hic/lowc_hindiii_100k_1mb.hic\")\n",
    "lowc_hindiii_5M = fanc.load(\"examples/architecture/other-hic/lowc_hindiii_5M_1mb.hic\")\n",
    "lowc_mboi_1M = fanc.load(\"examples/architecture/other-hic/lowc_mboi_1M_1mb.hic\")\n",
    "lowc_mboi_100k = fanc.load(\"examples/architecture/other-hic/lowc_mboi_100k_1mb.hic\")\n",
    "lowc_mboi_50k = fanc.load(\"examples/architecture/other-hic/lowc_mboi_50k_1mb.hic\")"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 70,
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "Edge collection 100% (13964612 of 13964612) || Elapsed Time: 0:00:00 Time:  0:00:00\n",
      "2022-05-28 19:08:01,163 INFO Valid edges: 1770/1770\n",
      "2022-05-28 19:08:01,343 INFO Variance explained: [8.69079856e-01 1.12265450e-01 1.67886424e-02 1.86605135e-03\n",
      " 7.93826954e-32]\n"
     ]
    }
   ],
   "source": [
    "pca_info, pca_result = hic_pca(lowc_hindiii_5M, lowc_hindiii_100k,\n",
    "                               lowc_mboi_1M, lowc_mboi_50k,\n",
    "                               lowc_mboi_100k, ignore_zeros=True,\n",
    "                               scale=False, region='chr19', sample_size=100000,\n",
    "                               strategy='variance')"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 71,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, ax = fancplot.pca_plot(pca_result, variance=pca_info,\n",
    "                            names=[\"HindIII 5M\", \"HindIII 100k\",\n",
    "                                   \"MboI 1M\", \"MboI 50k\", \"MboI 100k\"])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 72,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, ax = fancplot.pca_plot(pca_result, variance=pca_info,\n",
    "                            names=[\"HindIII 5M\", \"HindIII 100k\",\n",
    "                                   \"MboI 1M\", \"MboI 50k\", \"MboI 100k\"],\n",
    "                            colors=[\"orange\", \"orange\", \"cyan\", \"cyan\", \"cyan\"],\n",
    "                            markers=[\"*\", \"o\", \"*\", \"o\", \"o\"])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 73,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "image/png": 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\n",
      "text/plain": [
       "<Figure size 432x288 with 1 Axes>"
      ]
     },
     "metadata": {
      "needs_background": "light"
     },
     "output_type": "display_data"
    }
   ],
   "source": [
    "fig, ax = fancplot.pca_plot(pca_result, variance=pca_info,\n",
    "                            eigenvectors=(1, 2),\n",
    "                            names=[\"HindIII 5M\", \"HindIII 100k\",\n",
    "                                   \"MboI 1M\", \"MboI 50k\", \"MboI 100k\"],\n",
    "                            colors=[\"orange\", \"orange\", \"cyan\", \"cyan\", \"cyan\"],\n",
    "                            markers=[\"*\", \"o\", \"*\", \"o\", \"o\"])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### References\n",
    "\n",
    "[1] https://vaquerizaslab.github.io/fanc/index.html\n",
    "\n",
    "[2] https://github.com/XiaoTaoWang"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "### Other tools \n",
    "\n",
    "1. runHiC - https://pypi.org/project/runHiC/"
   ]
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3 (ipykernel)",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.8.10"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 2
}