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The construction of the PintRun quickly becomes very expensive, for example with N=10 and K=10. It seems that the calls to simplify() and subs() from sympy are quite expensive. The functions are called for every n,k combination in the PinTRun, resulting in very expensive generations. Even for N=10 and K=10, this can easily lead to 4-5 seconds to create the PintRun.
I don't have a good idea at the moment how to fix this, but with these long runtimes for simulating relatively small block iterations, it is not really reasonable.
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