@@ -52,7 +52,7 @@ recommended prior to executing an analysis on SomaScan data, along with
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## Filtering Features
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The goal of this pre-processing step is to remove features (SeqIds) typically
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- not useful for analalysis from a SomaScan dataset, while also retaining
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+ not useful for analysis from a SomaScan dataset, while also retaining
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* relevant* features that will enable broad discovery during downstream analysis.
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The filtering logic typically used for protein features (i.e. SOMAmer
@@ -532,8 +532,8 @@ assessment and further evaluation.
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While centering and scaling standardizes the RFU distributions across all
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SeqIds for multivariate analysis, it is important to understand that this does
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* not* enable meaningful comparison of expression values between different
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- SeqIds. Take, for instance, hypothetical SeqId A with a z-socre of 2 and
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- hypothetical SeqId B with a z-socre of -1. One cannot infer that the protein
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+ SeqIds. Take, for instance, hypothetical SeqId A with a z-score of 2 and
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+ hypothetical SeqId B with a z-score of -1. One cannot infer that the protein
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target of SeqId A was present at a higher concentration than the target of
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SeqId B in the original sample prep. All comparisons should be made between
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sample groups * within* a given SeqId. The RFU value, as well as log10 RFU and
@@ -550,11 +550,11 @@ factors intrinsic to the SOMAmer Reagent within the SomaScan assay.
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The ` preProcessAdat() ` function is available to perform the steps
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outlined in this vignette. By default, it will filter features and
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samples using the standard QC and normalization acceptance criteria
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- described earlier, and drop sample-level RFU outliers. It also has option to
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- perform log-10 and center & scale transformations to the untransformed RFU
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- values. If data QC plots by endpoints or clinical variables are desired,
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- the names of the variables should be explicitly passed to the ` data.qc `
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- argument. Please see the ` preProcessAdat() ` function documentation for
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+ described earlier, but _ will not _ drop sample-level RFU outliers. It also has
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+ the option to perform log-10 and center & scale transformations to the
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+ untransformed RFU values. If data QC plots by endpoints or clinical variables
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+ are desired, the names of the variables should be explicitly passed to the
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+ ` data.qc ` argument. Please see the ` preProcessAdat() ` function documentation for
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more details.
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``` {r recreate-vignette-data}
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