diff --git a/changelogs/fragments/2262-ec2_vpc_route_table-fix-changing-existing-route.yml b/changelogs/fragments/2262-ec2_vpc_route_table-fix-changing-existing-route.yml
new file mode 100644
index 00000000000..e579e9613c5
--- /dev/null
+++ b/changelogs/fragments/2262-ec2_vpc_route_table-fix-changing-existing-route.yml
@@ -0,0 +1,2 @@
+bugfixes:
+  - ec2_vpc_route_table - Fix changing an existing route tied to a IPv6 CIDR blocks (https://github.com/ansible-collections/amazon.aws/pull/2662).
diff --git a/plugins/modules/ec2_vpc_route_table.py b/plugins/modules/ec2_vpc_route_table.py
index 1fc1066eeb6..cd0092573dc 100644
--- a/plugins/modules/ec2_vpc_route_table.py
+++ b/plugins/modules/ec2_vpc_route_table.py
@@ -486,7 +486,7 @@ def ensure_routes(
                 )
         else:
             if match[0] == "replace":
-                if route_spec.get("DestinationCidrBlock"):
+                if route_spec.get("DestinationCidrBlock") or route_spec.get("DestinationIpv6CidrBlock"):
                     route_specs_to_recreate.append(route_spec)
                 else:
                     module.warn(f"Skipping recreating route {route_spec} because it has no destination cidr block.")