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[USER SUPPORT] Methylation segments data import #11638

@aringeri

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@aringeri

How can we help

  • Guidance and recommendations for methylation data types supported by cbioportal.
  • How to format methylation data for import.

Describe the your question

Hi, I have methylation data I would like to import into a cbioportal instance.
The data I have is the output of the MEDIPS.meth() function. See here for details:
https://bioconductor.org/packages/release/bioc/manuals/MEDIPS/man/MEDIPS.pdf

The data has a row for every 250bp window of the genome, and columns containing: methylation counts, rpkm (Reads Per Kilobase per Million) and rms (root mean square) for each sample. It look something like this:

chr	start	stop	CF	sample1.counts	sample2.counts	sample1.rpkm	sample2.rpkm	sample1.rms	sample2.rms
chr1	1	250	0	0	0	0	0	0	0
chr1	251	500	0	0	0	0	0	0	0
chr1	501	750	0	0	0	0	0	0	0

The existing methylation data format in cbioportal only supports one gene per row: (https://docs.cbioportal.org/file-formats/#methylation-data).
Is there any way to support this segmented methylation data format?
Perhaps using the Segmented Data format with a different 'genetic alteration type'? https://docs.cbioportal.org/file-formats/#segmented-data

I appreciate your help!

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