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# check if the model represented by the design matrix has full rank ie linearly independent columns, which is required to make the model identifiable!
# new: more efficient and computationally stable compared to the svd() function, especially for large matrices, and it does not require rounding the singular values or checking for non-zero values.
if(qr(model_matrix)$rank!= ncol(model_matrix)){
stop("Error: The design matrix representing your model does not have full rank, rendering the model not identifiable.")
}
with limma's function nonEstimable, which shows problematic coloumns and is.fullrank as TRUE/FALSE check.
Consider replacing
dea_limma/workflow/scripts/limma.R
Lines 99 to 103 in 175762a
with limma's function
nonEstimable
, which shows problematic coloumns andis.fullrank
as TRUE/FALSE check.https://www.rdocumentation.org/packages/limma/versions/3.28.14/topics/is.fullrank
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