Dependoparvovirus Extension Data

Background

Dependoparvoviruses are a genus within the subfamily Parvovirinae. They possess a remarkably broad host range encompassing all major amniote vertebrate lineages from squamate reptiles to primates.

Most members of this genus cannot replicate autonomously. They require co-infection with a helper virus, such as adenoviruses or herpesviruses, which provide essential replication factors.

These helper-dependent adeno-associated viruses (AAVs) do not seem to cause disease under normal circumstances. However, the genus also includes other, autonomously replicating virus species that can cause severe disease (e.g. the autonomous waterfowl viruses).

Multiple Sequence Alignments

Multiple sequence alignments (MSAs) spanning complete dependoparvovirus genomes can be found here.

Phylogenies

• Rep 78 tree

• VP1 tree