make_peptide.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "id": "metric-discovery",
   "metadata": {},
   "outputs": [],
   "source": [
    "import copy\n",
    "\n",
    "import chembl_downloader\n",
    "from lxml import etree\n",
    "from rdkit import Chem\n",
    "from rdkit.Chem import Draw, molzip, rdChemReactions\n",
    "from rdkit.Chem.Draw import IPythonConsole\n",
    "\n",
    "Draw.SetComicMode = True\n",
    "Draw.rdDepictor.SetPreferCoordGen(True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "id": "f42606d7",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "'31'"
      ]
     },
     "execution_count": 2,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "version = chembl_downloader.latest()\n",
    "version"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "id": "caced6ac",
   "metadata": {},
   "outputs": [],
   "source": [
    "root = chembl_downloader.get_monomer_library_root(version=version)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "id": "accepted-purse",
   "metadata": {},
   "outputs": [],
   "source": [
    "monomer_list = root[0][0][:]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 5,
   "id": "therapeutic-visiting",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "[<Element '{lmr}MonomerID' at 0x10a5eafc0>,\n",
       " <Element '{lmr}MonomerSmiles' at 0x10a5eb010>,\n",
       " <Element '{lmr}MonomerMolFile' at 0x10a5eac00>,\n",
       " <Element '{lmr}MonomerType' at 0x10a5ebbf0>,\n",
       " <Element '{lmr}PolymerType' at 0x10a5ebd30>,\n",
       " <Element '{lmr}NaturalAnalog' at 0x10a5ebc90>,\n",
       " <Element '{lmr}MonomerName' at 0x1242d7c90>,\n",
       " <Element '{lmr}Attachments' at 0x1242d7ce0>]"
      ]
     },
     "execution_count": 5,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "list(monomer_list[0])"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 6,
   "id": "multiple-possibility",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[12:59:58] atom 35 is not associated with bond 39 in w block\n",
      "[12:59:58] atom 16 is not associated with bond 17 in w block\n"
     ]
    }
   ],
   "source": [
    "mols = []\n",
    "for m in monomer_list:\n",
    "    mol = Chem.MolFromSmiles(m[1].text)\n",
    "    if mol is None:\n",
    "        continue\n",
    "    mol.SetProp(\"Type\", m[3].text)\n",
    "    mols.append(mol)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 7,
   "id": "painted-niger",
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "2849"
      ]
     },
     "execution_count": 7,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "len(mols)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 8,
   "id": "sharp-filing",
   "metadata": {},
   "outputs": [],
   "source": [
    "def combine_fragments(m1, m2):\n",
    "    m1 = Chem.Mol(m1)\n",
    "    m2 = Chem.Mol(m2)\n",
    "    for atm in m1.GetAtoms():\n",
    "        if atm.HasProp(\"atomLabel\") and atm.GetProp(\"atomLabel\") == \"_R2\":\n",
    "            atm.SetAtomMapNum(1)\n",
    "    for atm in m2.GetAtoms():\n",
    "        if atm.HasProp(\"atomLabel\") and atm.GetProp(\"atomLabel\") == \"_R1\":\n",
    "            atm.SetAtomMapNum(1)\n",
    "    return molzip(m1, m2)\n",
    "\n",
    "\n",
    "def make_peptide(monomerlist):\n",
    "    monomerlist = copy.deepcopy(monomerlist)\n",
    "    for idx, monomer in enumerate(monomerlist):\n",
    "        if Chem.MolToSmiles(monomer).count(\"*\") == 1:\n",
    "            continue\n",
    "        if idx == 0:\n",
    "            res = monomer\n",
    "        else:\n",
    "            res = combine_fragments(res, monomer)\n",
    "    return res\n",
    "\n",
    "\n",
    "def cap_terminal(m):\n",
    "    m = Chem.Mol(m)\n",
    "    n_term = Chem.MolFromSmiles(\"CC(=O)[*:1]\")\n",
    "    c_term = Chem.MolFromSmiles(\"CO[*:2]\")\n",
    "    for atm in m.GetAtoms():\n",
    "        if atm.HasProp(\"atomLabel\") and atm.GetProp(\"atomLabel\") == \"_R1\":\n",
    "            atm.SetAtomMapNum(1)\n",
    "        if atm.HasProp(\"atomLabel\") and atm.GetProp(\"atomLabel\") == \"_R2\":\n",
    "            atm.SetAtomMapNum(2)\n",
    "    res = molzip(m, n_term)\n",
    "    res = molzip(res, c_term)\n",
    "    return res"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 9,
   "id": "successful-woman",
   "metadata": {},
   "outputs": [
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       "<path class=\"atom-14\" d=\"M 761.2 174.1 Q 761.5 173.2, 762.4 172.7 Q 763.2 172.2, 764.4 172.2 Q 765.8 172.2, 766.7 173.0 Q 767.5 173.8, 767.5 175.2 Q 767.5 176.6, 766.4 177.9 Q 765.4 179.3, 763.2 180.9 L 767.6 180.9 L 767.6 181.9 L 761.1 181.9 L 761.1 181.0 Q 762.9 179.8, 764.0 178.8 Q 765.1 177.8, 765.6 177.0 Q 766.1 176.1, 766.1 175.2 Q 766.1 174.3, 765.6 173.8 Q 765.2 173.3, 764.4 173.3 Q 763.6 173.3, 763.1 173.6 Q 762.6 173.9, 762.2 174.6 L 761.2 174.1 \" fill=\"#191919\"/>\n",
       "<path class=\"atom-15\" d=\"M 705.5 177.2 Q 705.5 174.9, 706.6 173.6 Q 707.8 172.3, 709.9 172.3 Q 712.1 172.3, 713.2 173.6 Q 714.3 174.9, 714.3 177.2 Q 714.3 179.6, 713.2 180.9 Q 712.0 182.2, 709.9 182.2 Q 707.8 182.2, 706.6 180.9 Q 705.5 179.6, 705.5 177.2 M 709.9 181.1 Q 711.4 181.1, 712.2 180.2 Q 713.0 179.2, 713.0 177.2 Q 713.0 175.3, 712.2 174.4 Q 711.4 173.4, 709.9 173.4 Q 708.4 173.4, 707.6 174.4 Q 706.8 175.3, 706.8 177.2 Q 706.8 179.2, 707.6 180.2 Q 708.4 181.1, 709.9 181.1 \" fill=\"#FF0000\"/>\n",
       "</svg>"
      ],
      "text/plain": [
       "<IPython.core.display.SVG object>"
      ]
     },
     "execution_count": 9,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "m1 = combine_fragments(mols[1], mols[2])\n",
    "m2 = combine_fragments(mols[2], mols[1])\n",
    "Draw.MolsToGridImage([mols[1], mols[2], m1, m2], molsPerRow=4, useSVG=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 10,
   "id": "single-enhancement",
   "metadata": {},
   "outputs": [
    {
     "data": {
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       "</svg>"
      ],
      "text/plain": [
       "<IPython.core.display.SVG object>"
      ]
     },
     "execution_count": 10,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "m3 = make_peptide(mols[:10])\n",
    "Draw.MolsToGridImage(mols[:10] + [m3], molsPerRow=4, subImgSize=(150, 150), useSVG=True)"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 11,
   "id": "impossible-arthritis",
   "metadata": {},
   "outputs": [
    {
     "name": "stderr",
     "output_type": "stream",
     "text": [
      "[12:59:58] Incomplete atom labelling, cannot make bond\n"
     ]
    },
    {
     "data": {
      "image/png": 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       "<table><tr><td colspan=\"2\" style=\"text-align: center;\"><image 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\"></td></tr>\n",
       "<tr><th style=\"text-align: right\">Type</th><td style=\"text-align: left\">Backbone</td></tr></table>"
      ],
      "text/plain": [
       "<rdkit.Chem.rdchem.Mol at 0x1256925c0>"
      ]
     },
     "execution_count": 11,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "cap_terminal(m3)"
   ]
  }
 ],
 "metadata": {
  "kernelspec": {
   "display_name": "Python 3 (ipykernel)",
   "language": "python",
   "name": "python3"
  },
  "language_info": {
   "codemirror_mode": {
    "name": "ipython",
    "version": 3
   },
   "file_extension": ".py",
   "mimetype": "text/x-python",
   "name": "python",
   "nbconvert_exporter": "python",
   "pygments_lexer": "ipython3",
   "version": "3.10.8"
  }
 },
 "nbformat": 4,
 "nbformat_minor": 5
}