The documentation on passed values (https://flask-smorest.readthedocs.io/en/latest/arguments.html) for form values, json, headers, query, etc. do not have case sensitivity documented. I would expect locations like json would be case sensitive, but locations like headers to be case insensitive. Looking at https://github.com/marshmallow-code/flask-smorest/blob/e06325d7a201af6d07caa2e8e103fba15eb4b9b7/flask_smorest/arguments.py#L105 I'd guess everything is case sensitive.