thymus lobes versus lobules

[obophenotype-user]

It appears that, in the mouse, the lobes of the thymus are not subdivided into lobules but only in the central medulla and a peripheral cortex (i.e. there is no distinct sublobulation). In humans, the two thymus lobes are composed of many lobules of various sizes which contain follicles, each comprising a medulla and a cortex. in the rat, the thymus is partially subdivided into lobules separated by thin bands of connective tissue which are continuous with the thin connective tissue capsule.

I am wondering whether we should relabel "abnormal thymus lobule morphology [MP:0002367]" to "abnormal thymus lobe morphology" to reflect the bi-lobar structure in mouse.

SOURCES:

https://books.google.com/books?id=8-99vCN_riAC&pg=PA521&lpg=PA521&dq=mouse+thymus+lobulation&source=bl&ots=h7TFr4pJV5&sig=-xGWK11uOMYrSw1Sjq-GetD5kVk&hl=en&sa=X&ei=R2wAVf3OPMSlyASckoH4BQ&ved=0CC8Q6AEwAzgK#v=onepage&q=mouse%20thymus%20lobulation&f=false

http://tpx.sagepub.com/content/34/5/504.full

https://books.google.com/books?id=Wh4tBAAAQBAJ&pg=PA232&lpg=PA232&dq=mice+and++thymus+lobe+and+lobule&source=bl&ots=w6fOIrKlRf&sig=M3LPBLgw4f4VcsKaxbFYTOOPzoY&hl=en&sa=X&ei=K3MAVa_UNsKOyATXooKoAQ&ved=0CEMQ6AEwBjgK#v=onepage&q=mice%20and%20%20thymus%20lobe%20and%20lobule&f=false

Thanks

Anna

Reported by: anna_anagnos

Original Ticket: obo/mammalian-phenotype-requests/2052