marble burying

[sbello]

MGI has 119 alleles that have a mention of marble burying in the phenotype annotation notes. Some are annotated to anxiety-like behavior others are annotated to stereotypic behavior.

J:342627 specifically distinguished marble burying as 'compulsive' behavior and states that the mice in this case do NOT display anxiety-like behaviors (other assays) but do display increased compulsive behavior. I've annotated this to 'increased stereotypic behavior'

Should we add a terms for abnormal/increased/decreased compulsive behavior?
Does this belong under stereotypic behavior?
We need to review the existing annotations to see if marble burying has a consistent interpretation.

[anna-anagnostop]

The marble burying assay is able to detect phenotypes related to anxiety and obsessive compulsive disorders. see https://www.taconic.com/products/phenotypic-data-packages/comprehensive/marble-burying-assay

[sbello]

https://vetfolio-vetstreet.s3.amazonaws.com/mmah/33/0e39b1f1c347208f7cf530a38f0df8/filePVE_03_05_248.pdf
"Repetitive behaviors can occur for a variety of reasons other than CD; therefore, a complete medical and behavioral evaluation is essential when CD is suspected. A repetitive behavior that occurs only in the presence of the owner or trainer may be an operantly reinforced behavior problem, which is sometimes called attention- seeking behavior. A repetitive behavior that occurs only in the absence of the owner or another horse or animal to which the horse is socially bonded is likely to be a manifestation of separation anxiety. Repetitive behavior that manifests with an acute onset and is intense in form and high in frequency may be a response to an acute stressor but has not evolved into CD. Psychomotor seizures, dermatologic disorders, vision disorders, and many other illnesses and injuries can manifest symptomatically with some of the behaviors characteristic of common forms of CD

https://app.jove.com/t/50978/marble-burying-nestlet-shredding-as-tests-repetitive-compulsive-like

HPO terms
Compulsive behaviors "Behavior that consists of repetitive acts, characterized by the feeling that one 'has to' perform them, while being aware that these acts are not in line with one's overall goal." HP:0000722

Motor stereotypy "Use of the same abnormal action in response to certain triggers or at random. They may be used as a way to regulate one's internal state but must otherwise have no apparent functional purpose." HP:0000733

Restricted or repetitive behaviors or interests "A broad range of compulsive behaviors are repeated, including simple motor stereotypies and tics, as well as more complex repetitive movements or compulsions." HP:0031432

Compulsive behaviors is a sibling of Restricted or repetitive behaviors or interests

Possibly the most straight forward is add 'compulsive behavior' as a related synonym to 'increased stereotypic behavior'