diff --git a/.github/scripts/ci-test-large-heap.sh b/.github/scripts/ci-test-large-heap.sh
new file mode 100755
index 00000000..8502aba3
--- /dev/null
+++ b/.github/scripts/ci-test-large-heap.sh
@@ -0,0 +1,13 @@
+set -xe
+
+. $(dirname "$0")/common.sh
+
+# With a heap size larger than 4G, OpenJDK encodes compressed pointers differently.
+# Run a few plans with heap size larger than 4G.
+
+MMTK_PLAN=Immix runbms_dacapo2006_with_heap_size fop 20 8000
+MMTK_PLAN=GenImmix runbms_dacapo2006_with_heap_size fop 20 8000
+MMTK_PLAN=StickyImmix runbms_dacapo2006_with_heap_size fop 20 8000
+MMTK_PLAN=GenCopy runbms_dacapo2006_with_heap_size fop 20 8000
+MMTK_PLAN=MarkCompact runbms_dacapo2006_with_heap_size fop 20 8000
+MMTK_PLAN=MarkSweep runbms_dacapo2006_with_heap_size fop 20 8000
diff --git a/.github/workflows/run-dacapo-2006.yml b/.github/workflows/run-dacapo-2006.yml
index c353bf44..6decf961 100644
--- a/.github/workflows/run-dacapo-2006.yml
+++ b/.github/workflows/run-dacapo-2006.yml
@@ -45,7 +45,11 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        test-script: ["ci-test-only-normal", "ci-test-only-normal-no-compressed-oops", "ci-test-only-weak-ref"]
+        test-script:
+            - ci-test-only-normal
+            - ci-test-only-normal-no-compressed-oops
+            - ci-test-only-weak-ref
+            - ci-test-large-heap
     steps:
       # We need to check out the binding repo to get the running configs and test scripts
       - name: Checkout MMTk OpenJDK binding