From 88889151b73f75aa0c1e9941b8434b78d983dda6 Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Fri, 7 Jun 2024 15:20:26 -0700 Subject: [PATCH 1/8] [nextclade]: Add outgroup to DENVx trees Adds the reconstructed root of the All serotype tree as an outgroup for the DENVx trees. --- nextclade/config/config_dengue.yaml | 2 ++ nextclade/config/outgroup.fasta | 2 ++ nextclade/rules/prepare_sequences.smk | 16 +++++++++++++++- 3 files changed, 19 insertions(+), 1 deletion(-) create mode 100644 nextclade/config/outgroup.fasta diff --git a/nextclade/config/config_dengue.yaml b/nextclade/config/config_dengue.yaml index ed088a2e..90888136 100644 --- a/nextclade/config/config_dengue.yaml +++ b/nextclade/config/config_dengue.yaml @@ -21,6 +21,8 @@ filter: denv3: '36' denv4: '36' +outgroup: "config/outgroup.fasta" + refine: root_id: all: "Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome" diff --git a/nextclade/config/outgroup.fasta b/nextclade/config/outgroup.fasta new file mode 100644 index 00000000..08495c13 --- /dev/null +++ b/nextclade/config/outgroup.fasta @@ -0,0 +1,2 @@ +>Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome +AGTTGTTAGTCTACGTGGACCGACAAGGACAGTTTCGAATCGGAAGCTTGCTTAACGTAGTTCTAACAGTTTTTTTAATTAGAGAGCAGATCTCTGAGATGAACAACCAACGGAAAAAGGCGGGAAAACCGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTGTCAACTGTACAACAGTTGGCGAAGAGATTCTCAATAGGATTGCTGTAAGGGCAAGGACCATTAAAATTGGTTATGGCTTTCATAGCATTCCTACGATTCCTAGCCATCCCACCAACAGCAGGGATTTTGAAAAGATGGGGAACATTCAAGAAGTCTAAGGCTATCAAGGTACTGAGAGGATTCAGGAAGGAGATCGGAAGCATGCTGAACATTTTGAACAGGAGAAAAAGAACAGCAATCATTCTCATGATGCTGATTCCAACAGTAATGGCGTTCCATTTGACCACACGAGATGGAGAGCCGCACATGATTGTGAGCAAGCATGAAAGAGGAAAATCCCTTCTGTTTAAGACAGCGGATGGAATCAACATGTGCACCCTCATTGCCATGGATCTGGGTGAGTTGTGTGAGGACACAATCACGTACAAATGCCCCCTTCTCACCGAAACCGAACCAGAAGACATTGACTGCTGGTGCAATCCCACGTCCACATGGGTGACCTATGGGACGTGTACCCAAACTGGAGAACACAGACGAGAGAAAAGATCAGTGGCACTAGCCCCACATGTGGGAATGGGACTGGAAACAAGAACTGAAACATGGATGTCATCAGAAGGAGCTTGGAAACAAGCCCAGAGAGTAGAGACTTGGATTCTGAGACACCCAGGATTCACGATAATGGCAGTATTTCTGGCATACACCATAGGAACAACATATATCCAGAGAGTCGTTATTTTTATCCTACTGATGCTGGTCGCCCCATCCATGACAATGCGATGCGTGGGAGTAGGAAACAGAGACTTTGTGGAAGGAGTTTCAGGAGGAACGTGGGTTGACGTGGTGCTAGAACATGGAAGTTGTGTCACAACCATGGCAAAGAACAAACCAACACTGGACTTTGAACTGATGAAGACAGAAGCCAAACAACCGGCCACACTAAGGAAATTCTGCATTGAAGCTAAAATAACCAACACAACAACAGAATCAAGATGTCCAACACAAGGGGAACCCAATCTAGTAGAGGAGCAGGACCAGAAGTTCGTCTGCAAACAAACGATGGTGGACAGAGGATGGGGCAATGGCTGTGGTTTGTTTGGAAAAGGAGGCATTGTGACATGTGCGAAGTTTACATGCTTGAAGAAAATAGAAGGAAAAGTGGTGCAACCTGAAAACTTAGAATACACCGTGGTCATAACAGTCCACACAGGAGACGAACACGCAGTGGGAAATGACACAACAAAACATGGAATGACGGCCAAGATAACACCCCAGGCTTCCACCGCAGAAGCTAAACTGACAGACTATGGAACTCTCACGCTGGATTGCTCACCAAGAACAGGTCTCGACTTTAATGAGATGGTCTTGTTGAAAATGAAAAACAAAGCATGGCTTGTACACAGACAATGGTTCCTAGACCTACCTCTACCATGGACATCAGGAGCTGACACATAAGAAGCAAATTGGAACCAGAAAGAGATGCTGGTGACATTCAAAAATCCTCATGCAAAGAAACAGGATGTAGTCGTCCTAGGATCCCAAGAAGGAGCCATGCACACAGCACTCACAGGAGCTACAGAAATCCAAACGTCAGGAGGAAACTTAATGTTTGCAGGACACCTGAAGTGCAGACTGAGAATGGACAAACTGAAACTCAAAGGGATGTCATACGCGATGTGCACAGGAAAGTTCAAAATTGAGAAAGAAATGGCAGAAACACAGCATGGAACAATAGTCATTAAGGTTAAGTATGAAGGAGATGGTGCACCATGCAAGATCCCTTTTGAGATAAAGGATGTGAAAAAGAAAAATGTCATTGGGCGACTGATCACAGCCAACCCAATAGTCACAGAGAAAGACAGTCCAGTCAACATTGAAGCAGAACCTCCTTTTGGGGACAGCTACATCGTGATAGGAGTAGGAGAAAGAGCATTGAAACTCAACTGGTTCAAGAAAGGAAGCTCCATTGGGAAAATGTTTGAGGCAACTGCCAGAGGAGCAAAAAGAATGGCCATCTTGGGAGACACAGCCTGGGATTTTGGATCTGTAGGAGGAGTGTTCACATCAGTAGGAAAGGCGGTGCACCAGGTTTTTGGAACTGTCTATGGGGCTATGTTTAGCGGAGTCTCATGGACCATGAAAATCCTAATAGGGGTTCTCATAACATGGATAGGAATGAATTCAAGAAGCACTTCCCTGTCAATGACATGCATAGCAGTAGGAATCGTCACACTGTACCTGGGAGTCATGGTGCAGGCGGACATGGGTTGTGTTGTGAACTGGAAAGGCAAAGAACTGAAATGTGGAAGTGGAATTTTTGTCACTGACAACGTGCACACTTGGACAGAACAATACAAATTCCAACCAGACTCCCCAACAAGACTGGCGTCAGCCATTCCGAAAGCTCATGAGGAGGGAGTCTGTGGAATCCGATCAGCAACAAGACTGGAGAATCTCATGTGGAAGCAAATAACAAATGAATTGAACCACATCCTATGGGAAAATGAAATCAAACTAACTGTAGTGGCAGGAGACATTAAAGGAATCTTGGAGAAAGGGAAAAGAACACTTACACCTCAACCCATTGAGCTGAAATATTCATGGAAAACATGGGGAAAAGCAAAAATACTCACAGCAGAAGTACAAAATAACACCTTCCTCATAGACGGTCCAGACACACCAGAATGCCCTAATGACCAAAGAGCATGGAATTTTCTGGAAGTTGAGGACTATGGATTTGGAATCTTCACGACCAACATATGGCTGAAATTGCGAGAAGAGTACACCGAAGTGTGTGACCACAGGCTAATGTCAGCAGCCATCAAGGACAACAGGGCCGTCCATGCTGACATGGGCTATTGGATAGAAAGCGCAAAGAATGAGACCTGGAAGATAGAGAAAGCATCCTTCATTGAAGTTAAAACCTGCCTCTGGCCAAAATCACACACTCTTTGGAGCAATGGAGTGCTAGAAAGTGAAATGATAATTCCAAAGATTTTTGCTGGACCAATTTCACAGCACAACTACAGACCAGGCTATTACACACAAACAGCAGGACCATGGCACTTAGGCAAATTGGAGATGGACTTTGATTTTTGTGAAGGAACCACAGTTGTAGTGACTGAGGACTGTGGAAATAGAGGCCCATCTTTGAGAACAACCACAGCCTCAGGAAAACTGATAACTGAATGGTGCTGCCGATCTTGCACATTACCTCCCCTAAGATACATAGGAGAGGATGGATGCTGGTATGGGATGGAAATCAGACCCTTGAATGAGAAAGAAGAGAACCTGGTCAAGTCATTGGTCACAGCCGGGCATGGAAAGGTGGACAATTTTTCAATAGGACTCTTGTGCATGGCATTGTTCATGGAAGAGGTGCTGAGAACCAGAGTTGGCAGAAAACACATGATATTAGTAGTAGTGGTTACCTTCGTGACCCTCATCACAGGGAATATGACATGGAGAGACCTGGTAAGAGTACTTATCATGGTGGGAGCCACTATGTCTGATAGAATGGGGGGCGTGACTTACCTAGCTTTAATGGCAGCTTTCAAAATGAGACCAATCTTCGCAGTGGGATTGTTCTTGAGGAAACTGACTTCAAGAGAAATAATACTGATGACAATAGGAATGGCCCTGGTAACATCGTTCCAAATACCAGATGCCATTGTGGAACTGACTGATGGAATAGCATTGGGGATAATGGTGCTTAAAATGGTGACACATTTTGAAAAATACCAGTTGGGAGCGACCATCCTGTCCTTGACGTGCATCAAAACAACTATGACATTGCATAATGCATGGAAAACAATCACCATTATATTGGCAGTAGTTTCTCTTTTCCCATTGTGCCTGACTTCCTCCCTTCAAAAACAGACAGATTGGATACCAATAACATTGACAATCATAGGAGTCAAACCACTACCCATGTTTCTAATAACTTTAACAAAAACCAGCAAAAAAAGAAGTTGGCCTCTCAATGAGGGCATTATGGCTGTTGGAATGGTGAGCATTCTAGCAAGTTCTCTCCTAAAGAATGATGTTCCCATGGCTGGACCATTAGTGGCTGGAGGCTTGCTCATAGCGTGCTACGTGATAACTGGCAGCTCAGCAGACTTGTCACTGGAGAAAGCCGCCGATGTGAAATGGGAAGAAGAGGCAGAGATATCAGGAGCCAGCCCAATCATATTAGTCACAGTAGAAGAAGATGGTACCATGTCAATAAAGGATGAAGAGGAAGAGAACACACTAACCATACTCATAAAAACAGCACTGCTAGTAGTGTCAGGCCTCTTCCCATTGTCAATACCAGTCACAATGGCGGTATGGTACATGTGGCAAATGAAAAAACAAAGATCCGGAGTGCTGTGGGACGTCCCCTCACCCCCAGCAGTGGAAAAAGCTGAACTGGAAGATGGAGTCTATAGAATCAAGCAAAGAGGGATTTTTGGGAAATCCCAAGTTGGAGTTGGAGTATACAAAGAAGGAGTATTCCACACAATGTGGCACGTCACAAGAGGAGCTGTCCTCATGCATAAAGGGAAGAGACTGGAACCATCTTGGGCTGACGTCAAGAAAGACTTGATATCATATGGAGGAGGTTGGAGGCTTGAAGGAAAATGGAAAAAAGGAGAAGAAGTGCAGGTCTTGGCCGTAGAACCTGGGAAAAATCCAAAAAACGTCCAAACAAAACCTGGCCTTTTCAAGACCACTACAGGAGAAATAGGAGCCGTAGCCCTGGACTTCAAACCTGGAACATCAGGATCTCCCATCATTAACAAAAAAGGAAAAGTTGTGGGTCTCTATGGAAATGGAGTGGTTACAAAAAGTGGAGCCTATGTCAGTGCCATAGCGCAAACTGAAAAAATTGAAGAGCCGAATCCAGAGATTGAAGATGACATCTTTAGAAAGAAAAGATTAACCATAATGGACCTACATCCAGGAGCGGGAAAGACAAAAAGATATCTCCCAGCCATAGTCAGAGAGGCCATAAAAAGAAGCCTGAGAACTCTAATCTTGGCTCCCACAAGAGTGGTGGCAGCTGAAATGGAAGAAGCCCTAAGAGGACTCCCAATAAGTTATCAGACCCCAGCCATGAAGGCTGAACACACAGGAAGGGAGATTGTAGACCTAATGTGCCATGCCACTTTCACCATGAGACTGCTGTCACCAATCAGGGTTCCAAATTACAACCTGATAATAATGGATGAAGCACATTTCACAGACCCAGCCAGCATAGCGGCTAGAGGATACATCTCAACCCGAGTGGAAATGGGAGAGGCAGCTGCAATTTTTATGACAGCCACTCCCCCAGGAACGACAGATCCCTTTCCTCAGAGCAACGCCCCAATCAAAGATGAAGAAAGAGAAATTCCTGAACGCTCATGGAATTCAGGATATGAATGGATCACAGATTTTCAAGGGAAGACAGTGTGGTTTGTTCCAAGCATAAAAGCCGGAAATGACATAGCAAACTGCTTGAGAAAAAATGGAAAAAGGGTGATTCAACTGAGTAGGAAAACCTTTGACACAGAATATCCAAAAACAAAAATCAATGACTGGGACTTTGTGGTCACAACAGACATTTCCGAAATGGGAGCCAATTTCAAAGCTGAGAGAGTGATAGACCCAAGGAGATGCCTGAAGCCAGTTATACTGACAGATGGTCCAGAGCGGGTGATTCTGGCAGGACCCATGCCAGTGACCCTAGCAAGTGCTGCCCAAAGAAGAGGGAGAATAGGAAGGAACCCAAAAAAAGAAAATGACCAGTACATTTACATGGGAGAGCCTCTAAAAAATGATGAAGACCATGCTCACTGGACAGAAGCAAAGATGCTCCTTGACAACATCAACACACCAGAAGGGATCATCCCAACCCTGTTTGAACCAGAAAGGGAAAAGACTGAAGCCATAGACGGTGAATACCGCCTGAGAGGGGAAGCAAGGAAAACCTTTGTGGAACTAATGAGAAGAGGAGACCTACCAGTTTGGCTGGCCTACAAAGTAGCTTCAGAAGGCATCAAATACACAGACAGAAGGTGGTGCTTTGATGGAGAAAGGAACAATCAAATTTTGGAGGAGAACATGGAAGTGGAAATCTGGACAAAAGAAGGAGAAAGGAAGAAATTAAGACCTAGATGGTTGGATGCTAGAACTTATTCTGACCCACTGGCACTAAAGGAATTCAAGGAGTTTGCAGCTGGAAGAAAGTCCATAACCCTTGACCTAATAACAGAAATAGGTAGACTGCCAACTTACTTGACCCACAGGGCCAGAAATGCCCTGGACAACTTGGTCATGCTGCACACGACAGAAAAAGGAGGAAGGGCCTACAAACATGCTCTGAATGAACTACCAGAAACCCTGGAAACATTCATGCTCCTAGCTCTGTTGGCTGCGATGACAGGAGGAATCTTTCTGTTCTTGATGTAAGGAAGAGGTATAGGGAAAATGTCCATGGGACTGATCTGCATAATGGCAGCCAGCGGCCTGCTATGGATGGCAGAAATCCAGCCCCATTGGATAGCGGCCTCAATAATACTGGAGTTTTTTCTCATGGTACTGCTTATTCCAGAACCAGAAAAGCAGAGAACTCCCCAGGACAACCAATTGACCTATGTCGTGATAGCCATCCTCACAATGGTTGCAACAATAGCAGCCAATGAAATGGGATTGTTGGAAAAAACAAAGAAAGATCTTGGGTTTGGCCATGTAGCAACTGAAAATACAATTCTGGACGTAGATCTACGTCCAGCATCAGCATGGACACTCTATGCAGTGGCCACAACAATTATCACACCAATGTTGAGACACACCATAGAAAACTCCTCAGCAAATGTGTCCCTGACAGCCATTGCCAACCAGGCAGCGGTCTTGATGGGTCTTGGAAAAGGATGGCCATTATCGAAAATGGACATAGGAGTTCCACTTCTCGCCTTGGGATGCTATTCACAAGTGAACCCAATAACTCTCACAGCAGCACTACTTTTGCTAGTGGCACATTATGCCATAATAGGTCCAGGACTGCAAGCAAAAGCCACTAGAGAAGCTCAGAAAAGGACAGCAGCTGGAATCATGAAGAATCCAACGGTGGATGGGATAACAGTAATAGACCTAGATCCAATACCCTATGATCCAAAATTTGAAAAGCAGTTAGGACAAGTAATGCTCCTGGTCCTTTGTGCAGCACAGCTACTGTTGATGAGAACTACATGGGCTTTGTGTGAAGCCTTAACCCTAGCCACAGGACCAATATCAACACTGTGGGAAGGAAATCCAGGGAAATTCTGGAACACAACGATAGCTGTGTCCATGGCTAACATTTTCAGAGGGAGTTATTTGGCCGGAGCTGGACTTGCTTTTTCTATCATGAAGAATGCAGGAAGCGCAAGGAGAGGAACTGGGACCATAGGAGAAACACTGGGAGAAAAATGGAAAAGACAACTAAACCCATTGGGCAGGAAAGAATTCGAAATATACAAGAAAAGTGGAATTCTAGAAGTGGACAGAACCGAAGCCAAAGAAGGCTTGAAAAGAGGAGAAACAACCCACCATGCCGTGTCGAGAGGCTCCGCAAAACTGAGATGGTTCGTTGAGAGAAACATGGTCAAACCAGAAGGGAAAGTCGTAGACCTTGGTTGTGGAAGAGGAGGCTGGTCATATTACTGTGCGGGACTGAAGAATGTGACAGAAGTGAAAGGATACACAAAAGGAGGACCAGGACATGAAGAACCAATCCCTATGTCTACATATGGATGGAACCTAGTCAAGCTTCAGAGTGGAGTGGATGTGTTCTTCACTCCACCTGAGAAATGTGACACCCTGTTGTGTGACATTGGGGAATCATCACCAAATCCAACAGTAGAAGAAGGAAGAACATTAAGAGTTCTGAAGATGGTGGAACCATGGCTCAACAACAACACTCAATTTTGCATAAAAGTTCTCAACCCCTACATGCCAACAGTCATAGAAAAACTGGAAAAACTACAAAGGAAACATGGAGGAATCCTTGTGAGAAATCCACTCTCACGAAATTCCACCCATGAGATGTACTGGGTGTCCAATGCTTCAGGAAACATTGTGTCTTCAGTGAACATGATATCAAGAATGTTGCTGAACAGATTCACAATGAGACACAGGAAACCCACTTATGAGAAAGACGTGGACCTTGGAGCTGGAACACGAAATGTCGCAATTGAAACAGAAACACCAAACATGGATATCATTGGGAAAAGGATAGAGAAAATAAAAGAAGAGCATAAAACAACATGGCACTATGATCAGGACAATCCATACAAAACATGGGCTTACCATGGAAGCTATGAAGCCAAACCGACAGGATCAGCATCATCCATGGTGAATGGAGTGGTGAGACTGCTGACAAAACCCTGGGACGTGATTCCCATGGTGACACAGATGGCAATGACAGACACAACTCCCTTTGGACAACAGAGAGTTTTTAAAGAGAAAGTGGACACGAGAACACCAAAACCAAAACCAGGCACAAGAAAAGTTATGAAGATCACAGCCGAGTGGCTTTGGAGATTCCTTGGAAGGAAAAAAAAACCCAGAATGTGCACAAGAGAAGAGTTCACAAAAAAAGTTAGAACCAACGCAGCTATGGGCGCCGTGTTCACTGATGAGAACAAATGGAACTCAGCAAGTGAAGCTGTTGAAGACGAACGGTTTTGGGAACTGGTGGACAAAGAAAGGGATCTTCACCAAGAAGGAAAGTGTGAAACGTGTGTCTACAACATGATGGGAAAAAGAGAGAAGAAACTAGGAGAGTTTGGCAAAGCAAAAGGCAGCAGAGCAATATGGTACATGTGGCTGGGAGCACGCTTCCTAGAGTTTGAAGCCCTAGGTTTCTTGAATGAAGACCACTGGTTCTCCAGAGAAAATTCACTGAGTGGAGTGGAAGGAGAAGGACTGCACAAGCTGGGATACATCCTAAGAGACATAAACAAGAAAGAAGGAGGAGCAATGTATGCTGATGACACAGCTGGTTGGGACACAAGAATCACAGAAGATGACCTGCAGAATGAAGAAATGATCACAGACCAAATGGACCCTGAACATAAGAAATTGGCCAAGGCCATTTTCAAACTAACATACCAAAACAAGGTGGTGAGAGTCCAAAGACCAACACCAAAAGGCACGGTGATGGATATCATATCCAGGAGAGACCAAAGAGGCAGTGGACAGGTTGGAACTTATGGTCTGAACACTTTCACCAACATGGAAGCACAACTAATCAGACAAATGGAAGGTGAAGGAGTCTTTACACCAAAAGAATTCTAGACCCCACATCTGCTAGAAAAAAGAGTTCAAGAATGGTTGGAAAAACATGGAGTCGAAAGGTTAAAAAGAATGGCAATCAGTGGAGATGATTGTGTGGTGAAACCACTAGATGACAGGTTCGCCACAGCCCTAACAGCTTTGAATGACATGGGAAAGGTTAGGAAAGACATACCGCAATGGGAACCTTCAAAAGGATGGAATGATTGGCAACAAGTGCCTTTCTGCTCCCACCACTTTCATGAGCTGATCATGAAAGATGGTCGCACGCTAGTAGTTCCATGCAGAAACCAAGATGAACTGATAGGTAGAGCCAGAATCTCTCAGGGAGCTGGATGGAGCTTGAGAGAAACAGCCTGTCTGGGGAAGTCTTACGCCCAAATGTGGAGGCTGATGTACTTCCACAGAAGAGATCTGAGGCTGGCGGCCAATGCCATATGTTCAGCAGTTCCAGTACATTGGGTTCCAACAAGCAGAACAACCTGGTCGATCCATGCCCACCATCAATGGATGACAACAGAAGACATGTTTACAGTCTGGAACAGGGTGTGGATAGAGGACAACCCATGGATGGAAGACAAAACTCCAGTCTAATCTTGGGAAGACATACCATACCTAGGGAAAAGAGAAGACCAGTGGTGTGGATCCCTGATTGGCCTAACATCCAGGGCCACCTGGGCAAAGAACATTCAAACAGCCATAAACCAAGTCAGAAGCCTCATTGGGAATGAGGAGTATATAGATTACATGCCATCAATGAAAAGATTCAGGAATGAGGAGGAGAACGAAGGAGTTCTGTGGTAAACAGCAAAAGAAGTCAGGCATAAAAGAAGTCAGGCCACTAATGCCACGGCTTGAGCAAACCGTGCTGCCTGTAGCTCCACCAAAAAGGGGAGGTGTAAAAAAACCCCGGGAGGCCACAAACCATGGAAGCTGTACGCATGGTGTAGTGGACTAGCGGTTAGAGGAGACCCCTCCCATGACAGACAAAACGCAGCACAAGGGGGCCCAAAGCCAGGAGGAAGCTGTACTCTCGTTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAAAACAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT diff --git a/nextclade/rules/prepare_sequences.smk b/nextclade/rules/prepare_sequences.smk index 4a00795a..1ec4e385 100644 --- a/nextclade/rules/prepare_sequences.smk +++ b/nextclade/rules/prepare_sequences.smk @@ -78,13 +78,27 @@ rule filter: --exclude-where country=? region=? date=? \ """ +rule add_outgorup: + """ + Adding outgroup to the filtered sequences + """ + input: + sequences = "results/{gene}/filtered_{serotype}.fasta", + outgroup = config["outgroup"], + output: + sequences = "results/{gene}/filtered_{serotype}_with_outgroup.fasta" + shell: + """ + cat {input.sequences} {input.outgroup} > {output.sequences} + """ + rule align: """ Aligning sequences to {input.reference} - filling gaps with N """ input: - sequences = "results/{gene}/filtered_{serotype}.fasta", + sequences = lambda wildcard: "results/{gene}/filtered_{serotype}.fasta" if wildcard.serotype in ['all'] else "results/{gene}/filtered_{serotype}_with_outgroup.fasta", reference = "resources/{serotype}/reference.fasta", output: alignment = "results/{gene}/aligned_{serotype}.fasta" From 918452ac279b302edc98d67ec687acfdeac34c82 Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Fri, 7 Jun 2024 15:27:01 -0700 Subject: [PATCH 2/8] [nextclade]: Split clade file by serotype --- nextclade/config/clades_genotypes_denv1.tsv | 15 ++++++++++++++ nextclade/config/clades_genotypes_denv2.tsv | 23 +++++++++++++++++++++ nextclade/config/clades_genotypes_denv3.tsv | 9 ++++++++ nextclade/config/clades_genotypes_denv4.tsv | 9 ++++++++ nextclade/config/config_dengue.yaml | 8 +++---- 5 files changed, 60 insertions(+), 4 deletions(-) create mode 100644 nextclade/config/clades_genotypes_denv1.tsv create mode 100644 nextclade/config/clades_genotypes_denv2.tsv create mode 100644 nextclade/config/clades_genotypes_denv3.tsv create mode 100644 nextclade/config/clades_genotypes_denv4.tsv diff --git a/nextclade/config/clades_genotypes_denv1.tsv b/nextclade/config/clades_genotypes_denv1.tsv new file mode 100644 index 00000000..58707591 --- /dev/null +++ b/nextclade/config/clades_genotypes_denv1.tsv @@ -0,0 +1,15 @@ +clade gene site alt +DENV1/I E 461 V +DENV1/I E 484 L +DENV1/I M 122 R +DENV1/II E 345 A +DENV1/II E 432 M +DENV1/III E 297 V +DENV1/III M 118 R +DENV1/IV E 339 S +DENV1/IV M 72 E +DENV1/IV E 88 T +DENV1/V NS1 324 R +DENV1/V NS2A 142 P +DENV1/V NS3 185 K +DENV1/V NS5 834 E diff --git a/nextclade/config/clades_genotypes_denv2.tsv b/nextclade/config/clades_genotypes_denv2.tsv new file mode 100644 index 00000000..f1e4f9a9 --- /dev/null +++ b/nextclade/config/clades_genotypes_denv2.tsv @@ -0,0 +1,23 @@ +clade gene site alt +DENV2/AM E 71 D +DENV2/AM E 81 T +DENV2/AM E 129 I +DENV2/AM NS1 21 V +DENV2/AM NS1 73 S +DENV2/AM NS1 99 V +DENV2/AM NS1 170 R +DENV2/AA E 491 A +DENV2/AA M 15 G +DENV2/AA M 39 I +DENV2/AI E 484 I +DENV2/AI NS1 222 N +DENV2/AI NS5 687 I +DENV2/AII NS1 51 Q +DENV2/AII NS2A 142 R +DENV2/AII NS3 160 S +DENV2/C E 71 A +DENV2/C E 149 N +DENV2/C E 462 V +DENV2/S E 59 F +DENV2/S E 236 M +DENV2/S E 432 V diff --git a/nextclade/config/clades_genotypes_denv3.tsv b/nextclade/config/clades_genotypes_denv3.tsv new file mode 100644 index 00000000..a139618d --- /dev/null +++ b/nextclade/config/clades_genotypes_denv3.tsv @@ -0,0 +1,9 @@ +clade gene site alt +DENV3/I M 128 F +DENV3/I E 68 V +DENV3/II M 57 A +DENV3/II NS5 749 K +DENV3/III E 132 Y +DENV3/III E 301 T +DENV3/IV NS1 139 S +DENV3/IV NS5 638 P diff --git a/nextclade/config/clades_genotypes_denv4.tsv b/nextclade/config/clades_genotypes_denv4.tsv new file mode 100644 index 00000000..729b5f95 --- /dev/null +++ b/nextclade/config/clades_genotypes_denv4.tsv @@ -0,0 +1,9 @@ +clade gene site alt +DENV4/I E 429 L +DENV4/I NS1 98 S +DENV4/II E 265 A +DENV4/II E 46 T +DENV4/II NS1 246 S +DENV4/S E 132 V +DENV4/S E 154 S +DENV4/S E 162 T diff --git a/nextclade/config/config_dengue.yaml b/nextclade/config/config_dengue.yaml index 90888136..4a15e364 100644 --- a/nextclade/config/config_dengue.yaml +++ b/nextclade/config/config_dengue.yaml @@ -43,7 +43,7 @@ traits: clades: clade_definitions: all: '../phylogenetic/config/clades_serotypes.tsv' - denv1: '../phylogenetic/config/clades_genotypes.tsv' - denv2: '../phylogenetic/config/clades_genotypes.tsv' - denv3: '../phylogenetic/config/clades_genotypes.tsv' - denv4: '../phylogenetic/config/clades_genotypes.tsv' + denv1: 'config/clades_genotypes_denv1.tsv' + denv2: 'config/clades_genotypes_denv2.tsv' + denv3: 'config/clades_genotypes_denv3.tsv' + denv4: 'config/clades_genotypes_denv4.tsv' From cf178a192c515a62e1718f40ee560bbc88ffd733 Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Fri, 7 Jun 2024 15:33:20 -0700 Subject: [PATCH 3/8] [nextclade]: Attempt to get a reasonable root --- nextclade/rules/construct_phylogeny.smk | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/nextclade/rules/construct_phylogeny.smk b/nextclade/rules/construct_phylogeny.smk index 8cd3f138..be657f6e 100644 --- a/nextclade/rules/construct_phylogeny.smk +++ b/nextclade/rules/construct_phylogeny.smk @@ -49,7 +49,7 @@ rule refine: root_flag = lambda wildcard: ( f"--root '{config['refine']['root_id'][wildcard.serotype]}'" if wildcard.serotype in config["refine"]['root_id'] - else "" + else "--root min_dev" ) shell: """ From 92d60a8db4fcee2cdb4a3dcd940f832a210da83b Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Mon, 10 Jun 2024 14:19:06 -0700 Subject: [PATCH 4/8] Exclude gappy denv2 --- phylogenetic/config/exclude.txt | 7 +++++++ 1 file changed, 7 insertions(+) diff --git a/phylogenetic/config/exclude.txt b/phylogenetic/config/exclude.txt index bffbfab6..354abeed 100644 --- a/phylogenetic/config/exclude.txt +++ b/phylogenetic/config/exclude.txt @@ -890,3 +890,10 @@ HQ332171 # duplicate of HQ332170 HQ332178 # duplicate of HQ332177 MS631898 # PAT MB466022 # PAT +OR393991 # denv2 too divergent +OR389022 # denv2 many Ns +OR389024 # denv2 many Ns +OR389026 # denv2 many Ns +OR389325 # denv2 many Ns +OR389023 # denv2 many Ns +OR389307 # denv2 many Ns From f6dd413a7d564c1a11683f301f3930fafc612fbd Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Mon, 10 Jun 2024 14:20:52 -0700 Subject: [PATCH 5/8] [nextclade]: Try rooting by two nodes --- nextclade/config/config_dengue.yaml | 10 +++++----- nextclade/rules/construct_phylogeny.smk | 8 ++++---- 2 files changed, 9 insertions(+), 9 deletions(-) diff --git a/nextclade/config/config_dengue.yaml b/nextclade/config/config_dengue.yaml index 4a15e364..ca529d54 100644 --- a/nextclade/config/config_dengue.yaml +++ b/nextclade/config/config_dengue.yaml @@ -25,11 +25,11 @@ outgroup: "config/outgroup.fasta" refine: root_id: - all: "Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome" - denv1: "Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv1/genome" - denv2: "Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv2/genome" - denv3: "Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv3/genome" - denv4: "Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv4/genome" + all: ["Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome"] + denv1: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv1/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] + denv2: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv2/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] + denv3: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv3/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] + denv4: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv4/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] traits: sampling_bias_correction: '3' diff --git a/nextclade/rules/construct_phylogeny.smk b/nextclade/rules/construct_phylogeny.smk index be657f6e..132c6174 100644 --- a/nextclade/rules/construct_phylogeny.smk +++ b/nextclade/rules/construct_phylogeny.smk @@ -46,10 +46,10 @@ rule refine: date_inference = "marginal", clock_filter_iqd = 4, strain_id = config.get("strain_id_field", "strain"), - root_flag = lambda wildcard: ( - f"--root '{config['refine']['root_id'][wildcard.serotype]}'" + root_args = lambda wildcard: ( + " ".join(f"'{id}'" for id in config['refine']['root_id'][wildcard.serotype]) if wildcard.serotype in config["refine"]['root_id'] - else "--root min_dev" + else "min_dev" ) shell: """ @@ -63,5 +63,5 @@ rule refine: --divergence-unit mutations \ --keep-polytomies \ --use-fft \ - {params.root_flag} + --root {params.root_args} """ \ No newline at end of file From f851077b459a1b5343c2c39bff1dd408ebc03acd Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Mon, 10 Jun 2024 14:48:46 -0700 Subject: [PATCH 6/8] [nextclade]: Use reconstructed root of denv4 as outgroup for denv2 --- nextclade/config/config_dengue.yaml | 8 ++++++-- nextclade/config/outgroup_denv2.fasta | 2 ++ nextclade/rules/prepare_sequences.smk | 2 +- 3 files changed, 9 insertions(+), 3 deletions(-) create mode 100644 nextclade/config/outgroup_denv2.fasta diff --git a/nextclade/config/config_dengue.yaml b/nextclade/config/config_dengue.yaml index ca529d54..00e15564 100644 --- a/nextclade/config/config_dengue.yaml +++ b/nextclade/config/config_dengue.yaml @@ -21,13 +21,17 @@ filter: denv3: '36' denv4: '36' -outgroup: "config/outgroup.fasta" +outgroup: + denv1: "config/outgroup.fasta" + denv2: "config/outgroup_denv2.fasta" + denv3: "config/outgroup.fasta" + denv4: "config/outgroup.fasta" refine: root_id: all: ["Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome"] denv1: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv1/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] - denv2: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv2/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] + denv2: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv2/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv4/genome'] denv3: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv3/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] denv4: ['Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv4/genome', 'Reconstructed_root_sequence_of_https_nextstrain_org_dengue/all/genome'] diff --git a/nextclade/config/outgroup_denv2.fasta b/nextclade/config/outgroup_denv2.fasta new file mode 100644 index 00000000..a6b134fc --- /dev/null +++ b/nextclade/config/outgroup_denv2.fasta @@ -0,0 +1,2 @@ +>Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv4/genome +AGTTGTTAGTCTGTGTGGACCGACAAGGACAGTTCCAAATCGGAAGCTTGCTTAACACAGTTCTAACAGTTTGTTTAAATAGAGAGCAGATCTCTGGAAAAATGAACCAACGAAAAAAGGTGGTTAGACCGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTATCAACCCCTCAAGGGTTGGTGAAGAGATTCTCAACCGGACTGTTTTCCGGGAAAGGACCCTTACGGATGGTGCTAGCATTCATCACGTTTTTGCGAGTCCTTTCCATCCCACCAACAGCAGGGATTCTGAAAAGATGGGGACAGTTGAAGAAAAACAAGGCCATCAAGATACTGACTGGATTCAGGAAGGAGATAGGCCGCATGCTGAACATCTTGAACGGGAGAAAGAGGTCAACAATAACATTGCTATGCTTGATTCCCACCGTAATGGCATTCCACTTGTCAACAAGAGATGGCGAACCCCTTATGATAGTAGCAAAACACGAAAGGGGGAGACCTCTCTTGTTTAAGACAACAGAAGGAATCAACAAATGCACTCTTATTGCCATGGACTTGGGTGAAATGTGTGAGGACACCGTCACGTATAAATGCCCTCTACTGGTCAACACCGAACCTGAAGACATTGATTGCTGGTGCAATCTCACGTCTACCTGGGTCATGTATGGGACATGTACCCAGAGCGGAGAACGGAGACGAGAGAAGCGCTCAGTAGCTTTAACACCACATTCAGGAATGGGATTGGAAACAAGGGCTGAGACATGGATGTCATCGGAAGGGGCTTGGAAACATGCCCAGAGAGTGGAGAGCTGGATACTCAGAAACCCAGGATTCGCGCTCTTGGCAGGATTTATGGCTTATATGATTGGGCAAACAGGAATCCAGCGAACTGTCTTCTTTGTTCTAATGATGCTGGTCGCTCCATCCTACGGAATGCGATGCGTAGGAGTGGGGAACAGAGATTTTGTGGAAGGAGTCTCAGGTGGAGCATGGGTCGATCTGGTGCTAGAACACGGAGGATGTGTCACAACCATGGCCCAGGGAAAACCAACCTTGGATTTTGAATTGATCAAGACAACAGCCAAGGAAGTGGCTCTGTTAAGAACTTATTGCATTGAAGCCTCGATATCAAACATAACCACGGCAACAAGATGTCCAACGCAAGGAGAACCTTATCTCAAAGAGGAACAAGACCAACAGTACATTTGCCGGAGAGATGTGGTAGACAGAGGGTGGGGCAATGGCTGTGGCCTGTTTGGAAAAGGAGGAGTTGTGACATGTGCAAAGTTTTCATGCTCGGGGAAGATAACAGGCAACTTGGTCCAAATTGAAAACCTTGAATACACAGTGGTTGTGACAGTCCACAATGGAGACACCCACGCAGTAGGAAATGACACATCCAACCATGGAGTGACAGCCACGATAACTCCCAGGTCACCATCGGTAGAAGTTAAATTACCGGACTATGGAGAACTAACACTCGATTGTGAACCCAGGTCCGGAATTGACTTTAATGAGATGATTCTGATGAAAATGAAAAAGAAAACGTGGCTTGTGCACAAGCAATGGTTTTTGGATCTACCTCTGCCATGGACAGCAGGAGCAGACACATCAGAAGTCCATTGGAATTATAAAGAGAGAATGGTGACATTCAAGGTTCCTCATGCCAAGAGACAGGATGTGACAGTGCTAGGATCTCAGGAAGGAGCCATGCATTCTGCCCTCACCGGAGCCACAGAAGTGGATTCCGGTGATGGAAACCACATGTTTGCAGGACATCTAAAGTGCAAAGTACGCATGGAGAAATTGAGAATCAAGGGAATGTCATACACGATGTGCTCAGGAAAGTTCTCAATTGACAAGGAGATGGCAGAAACACAGCATGGGACAACAGTGGTGAAAGTCAAGTATGAAGGTACTGGAGCTCCATGCAAAGTCCCCATAGAGATAAGAGATGTGAACAAGGAAAAAGTGGTTGGGCGCATCATTTCATCTACTCCTTTTGCTGAGAATACCAACAGTGTAACCAATATTGAATTAGAACCCCCCTTTGGGGACAGCTACATAGTGATAGGTGTTGGAGACAGTGCATTAACACTCCATTGGTTTAGGAAAGGGAGTTCCATTGGCAAGATGTTTGAGTCCACATACAGAGGTGCAAAGCGAATGGCCATTCTAGGTGAAACAGCTTGGGATTTTGGTTCTGTTGGTGGACTGTTCACATCATTGGGAAAAGCTGTGCACCAGGTTTTTGGTAGTGTCTACACAACTATGTTTGGAGGAGTCTCATGGATGGTTAGAATCCTAATTGGGTTCTTAGTGTTGTGGATCGGCACGAACTCAAGAAACACTTCAATGGCAATGACGTGCATAGCTGTTGGAGGAATCACTCTGTTTCTGGGTTTCACGGTTCAAGCAGACATGGGTTGTGTGGTGTCATGGAGTGGGAAAGAATTGAAATGTGGAAGTGGAATTTTTGTGATTGACAACGTGCACACTTGGACAGAACAGTACAAATTTCAACCAGAGTCCCCAGCGAGACTAGCGTCCGCAATATTGAATGCCCACAAAGATGGGGTCTGTGGAATTAGATCAACCACGAGGCTGGAAAATGTCATGTGGAAACAAATAACCAACGAGCTAAACTATGTTCTCTGGGAAGGAGGACATGACCTCACTGTGGTGGCCGGGGATGTGAAAGGGGTGTTGACCAAAGGCAAGAGAGCACTCACACCTCCAGTGAATGATTTGAAATATTCATGGAAGACATGGGGGAAAGCAAAAATCTTTACTCCAGAAGCAAGAAATAGCACATTCTTGATAGACGGACCAGACACCTCCGAATGCCCCAATGAACGAAGAGCATGGAACTTTCTTGAGGTAGAAGACTATGGATTTGGCATGTTCACGACCAACATATGGATGAAATTTCGAGAAGGAAGTTCAGAAGTGTGTGACCACAGGTTAATGTCAGCGGCAATCAAAGATCAGAAAGCCGTGCATGCTGACATGGGCTATTGGATAGAGAGCTCAAAAAACCAGACCTGGCAGATAGAGAAAGCATCCCTTATTGAAGTGAAAACATGTCTGTGGCCCAAGACTCACACATTGTGGAGCAATGGAGTGCTGGAAAGCCAGATGCTCATTCCAAAAGCATATGCAGGCCCCTTTTCACAGCACAATTACCGCCAGGGCTATGCCACGCAGACCATGGGCCCATGGCACTTGGGCAAATTGGAAATAGACTTTGGAGAATGCCCCGGAACAACAGTCACAATTCAGGAGGATTGTGACCACAGAGGCCCATCTTTGAGGACCACCACTGCATCTGGAAAATTGGTCACACAGTGGTGCTGCCGCTCCTGCACGATGCCTCCCTTAAGGTTTTTGGGAGAGGATGGGTGTTGGTATGGGATGGAAATTAGGCCCTTAAGTGAAAAAGAAGAGAACATGGTCAAATCACAGGTGTCGGCCGGACAGGGTTCATCAGAAACTTTTTCTATGGGGCTGTTATGTCTGACCCTGTTCATGGAAGAATGCTTGAGGAGAAGAGTCACTAGGAAACACATGATATTGGTTGTGGTGACCACCCTTTGTGCCATCATCCTAGGAGGTCTCACGTGGATGGACTTACTACGAGCCATTATCATGTTAGGGGACACCATGTTTGGTAGAATGGGAGGACAGATTCACCTAGCCATCATGGCAGTGTTCAAGATGTCACCAGGATACGTGCTGGGTGTGTTTTTAAGGAAACTCACTTCAAGAGAGACAGCACTAATGGTGATAGGAATGGCCATGACAACGGTGTTTTCAATTCCACATGACCTTATGGAATTCATTGATGGAATATCATTGGGGCTAATCTTGCTGAAAATGGTAACACATTTTGACAACACCCAAGTGGGAACTTTAGCCCTTTCCTTAACTTTCATAAGATCAACAATGCCATTGATCATGGCTTGGAGGACCATCATGGCTGTGTTGTTTGTGGTCACACTCATTCCTTTATGTAGGACAAGCTGTCTTCAAAAGCAGTCCCACTGGGTAGAAATAACAGCAATCATCTTAGGAGCCCAGGCTCTGCCAGTGTACTTAATGACTCTCATGAAAGGAGCCTCAAAAAGATCTTGGCCTCTTAACGAGGGCATAATGGCTGTGGGCTTGGTCAGTCTCTTGGGAAGCGCCCTTCTAAAGAATGATGTCCCTTTGGCTGGTCCAATGGTGGCAGGAGGTTTACTTCTGGCAGCCTACGTGATGAGTGGTAGCTCAGCAGACCTGTCACTAGAGAAGGCCGCCAATGTGCAGTGGGATGAGATGGCAGACATAACAGGCTCAAGCCCAATCATAGAAGTGAAGCAGGATGAAGATGGCTCTTTCTCCATACGGGACGTCGAGGAAACCAACATGATAACCCTTTTGGTGAAACTGGCACTGATAACTGTGTCAGGTCTCTACCCCTTGGCAATTCCAGTCACAATGACTTTATGGTACATGTGGCAAGTGAAAACACAAAGATCAGGAGCCCTGTGGGACGTTCCCTCACCCGCTACCGCTCAGAAAGCCACACTGACTGAAGGAGTGTACAGGATCATGCAAAGAGGGTTGTTTGGGAAAACTCAGGTTGGAGTAGGGATACACATGGAAGGTGTATTTCACACAATGTGGCATGTAACAAGAGGATCAGTGATCTGCCATGAGACTGGGAGATTGGAGCCATCTTGGGCTGACGTCAGGAACGACATGATATCATACGGTGGGGGATGGAGGCTCGGAGACAAATGGGACAAAGAAGAAGATGTTCAGGTCCTAGCCATAGAACCAGGAAAAAATCCGAAACATGTCCAAACGAAACCCGGCCTTTTCAAGACCCTAACTGGAGAAATTGGAGCAGTAACATTGGATTTCAAACCCGGAACATCTGGTTCTCCCATCATTAACAAGAAAGGAAAAGTTATCGGACTCTATGGAAATGGAGTAGTTACCAAATCAGGTGATTACGTCAGTGCCATAACGCAAGCCGAAAGAATTGGTGAGCCAGATTATGAAGTGGATGAGGACATCTTTCGAAAGAAAAGATTAACCATAATGGACTTACACCCCGGAGCTGGCAAGACAAAAAGAATTCTCCCATCAATAGTCAGAGAAGCTCTAAAAAGGAGGCTGCGAACCCTGATTTTGGCTCCCACGAGAGTGGTGGCAGCCGAGATGGAAGAGGCCCTTCGCGGACTACCAATCCGTTATCAGACCCCAGCTGTGAAATCAGAACACACAGGAAGAGAGATTGTAGACCTCATGTGTCATGCAACCTTCACAACAAGACTCTTGTCATCAACCAGAGTTCCAAATTACAACCTCATAGTAATGGATGAAGCGCATTTCACAGACCCTTCTAGTGTCGCAGCTAGAGGATACATCTCAACCAGGGTGGAAATGGGAGAGGCAGCAGCCATCTTCATGACTGCAACCCCTCCCGGAGCAACAGATCCCTTCCCCCAGAGCAACAGCCCAATAGAAGACATCGAGAGAGAAATTCCAGAAAGGTCATGGAATACAGGATTCGACTGGATAACAGACTACCAAGGGAAGACTGTGTGGTTTGTTCCCAGCATAAAAGCTGGAAATGACATTGCAAATTGCTTGAGAAAGTCGGGAAAGAAGGTGATCCAGTTGAGTAGGAAAACCTTTGACACAGAGTATCCAAAAACGAAACTCACAGACTGGGATTTTGTGGTCACCACAGACATATCTGAAATGGGGGCCAATTTTAGAGCTGGGAGAGTGATAGACCCCAGGAGATGCCTCAAGCCAGTCATCCTAACAGATGGGCCAGAGAGAGTCATTTTGGCAGGTCCCATTCCAGTGACTCCAGCAAGCGCTGCTCAGAGAAGAGGGCGAATAGGTAGAAACCCAGCACAAGAAGACGACCAGTATGTCTTCTCTGGAGACCCATTGAAAAATGATGAAGATCATGCCCACTGGACAGAAGCAAAGATGCTGCTTGACAATATCTACACCCCGGAAGGGATCATTCCAACATTGTTTGGTCCGGAAAGGGAAAAAACCCAAGCCATTGATGGAGAGTTTCGCCTCAGAGGGGAACAAAGGAAGACTTTTGTGGAATTAATGAGGAGAGGAGACCTTCCGGTGTGGCTGAGCTATAAGGTAGCTTCAGCTGGTATTTCTTACAAAGACCGGGAATGGTGCTTCACAGGGGAAAGGAATAACCAAATTTTAGAAGAAAACATGGAGGTTGAAATTTGGACTAGAGAGGGAGAAAAGAAAAAACTAAGACCAAAATGGTTAGATGCACGTGTCTATGCTGACCCCATGGCTTTGAAGGATTTCAAGGAGTTTGCTAGTGGAAGAAAGAGCATAACCCTTGACATCCTGACAGAGATTGCCAGCTTGCCAACTTACCTTTCCTCTAGGGCCAAGCTCGCCCTTGACAACATAGTCATGCTCCACACAACAGAAAGGGGAGGGAGGGCCTACCAACACGCCCTGAACGAACTCCCGGAGTCATTGGAAACACTCATGCTTGTAGCTTTATTAGGTGCTATGACAGCAGGCATCTTCCTGTTTTTTATGCAAGGAAAAGGGATAGGGAAACTGTCAATGGGTTTGATAGCTATTGCGGTAGCTAGTGGCTTACTCTGGGTAGCAGAAATTCAGCCCCAGTGGATAGCGGCCTCAATCATACTGGAGTTTTTTCTCATGGTGCTGTTGATACCAGAACCAGAAAAACAAAGGACCCCACAAGACAACCAGTTGATCTATGTCATACTGGCCATTCTCACCATTATTGGTCTCATAGCAGCCAACGAGATGGGGCTGATTGAAAAAACAAAAACGGATTTTGGGTTTTACCAGGTAAAAACAGAAACCACCATCCTCGATGTGGATTTGAGACCAGCTTCAGCATGGACGCTCTATGCAGTAGCCACCACTATTCTGACTCCCATGCTGAGACACACCATAGAAAACACATCTGCCAACCTATCTCTGGCGGCCATTGCCAATCAAGCAGCTGTCCTAATGGGGCTTGGAAAAGGATGGCCGCTCCACAGAATGGACCTTGGTGTGCCGCTGTTAGCAATGGGATGTTATTCTCAAGTGAACCCAACAACTTTGACAGCATCCTTAGTCATGCTTTTAGTCCATTATGCAATAATAGGTCCAGGATTGCAGGCAAAAGCCACAAGAGAGGCTCAGAAAAGGACAGCTGCTGGGATCATGAAGAACCCCACGGTGGATGGAATAACAGTAATAGATCTAGAACCAATATCTTATGACCCAAAGTTTGAAAAGCAATTAGGGCAGGTCATGCTACTAGTCTTGTGTGCTGGACAACTACTCTTGATGAGAACAACATGGGCTTTCTGTGAAGTCTTGACTTTGGCCACAGGACCAGTCTTAACTTTGTGGGAGGGCAACCCGGGAAGATTTTGGAACACGACTATAGCCGTATCCACTGCCAACATTTTCAGGGGAAGCTACTTGGCGGGAGCTGGACTGGCTTTCTCACTCATAAAGAATGCACAAACCCCCAGGAGGGGAACTGGGACCACAGGAGAGACACTGGGAGAGAAGTGGAAGAGACAGCTAAACTCATTAGATAGGAAGGAGTTTGAAGAGTACAAGAGAAGTGGAATACTAGAAGTGGACAGGACTGAAGCCAAGTCTGCCCTGAAAGATGGGTCTAAAATCAAGCATGCAGTGTCCAGAGGGTCCAGCAAGATCAGATGGATTGTTGAAAGAGGGATGGTAAAGCCAAAAGGGAAAGTTGTGGATCTTGGTTGCGGGAGAGGAGGATGGTCGTATTACATGGCGACACTCAAGAACGTGACTGAGGTGAAAGGGTACACGAAAGGAGGTCCAGGACATGAAGAACCGATTCCCATGGCTACCTATGGCTGGAATTTGGTCAAGCTCCATTCAGGGGTTGACGTGTTCTACAAACCCACTGAGCAAGTGGACACCCTGCTCTGTGATATTGGAGAGTCATCTTCTAATCCGACAATAGAGGAAGGAAGAACATTAAGAGTTCTGAAGATGGTGGAGCCATGGCTCTCTTCAAAACCTGAATTCTGCATCAAAGTCCTTAACCCCTACATGCCAACAGTCATAGAAGAACTGGAGAAACTGCAGAGAAAGCATGGTGGAAGTCTTATCAGATGCCCGCTATCCAGGAATTCCACTCATGAGATGTATTGGGTGTCAGGTGCGTCGGGAAACATCGTGAGCTCTGTGAACACAACATCAAAGATGCTGTTGAACAGGTTTACCACGAGGCATAGGAAACCCACCTATGAGAAGGACGTAGACCTTGGAGCAGGAACAAGAAGTGTCTCCACTGAAACAGAAAAACCAGACATGACAATCATTGGGAGAAGGCTTCAGCGATTGCAAGAAGAGCACAAAGAAACTTGGCACTATGATCAGGAAAATCCATACAGAACCTGGGCGTATCATGGAAGCTATGAAGCTCCTTCGACAGGCTCAGCATCCTCCATGGTAAACGGGGTAGTAAAACTGCTGACAAAACCTTGGGACGTGATTCCAATGGTGACCCAGTTAGCCATGACAGACACAACCCCCTTTGGGCAACAAAGAGTGTTTAAAGAGAAGGTGGACACCAGAACACCACAACCAAAACCAGGCACACGAGTGGTTATGACCACAACAGCCAATTGGCTGTGGGCCCTCCTTGGGAGGAAGAAAAATCCCAGACTGTGCACGAGGGAAGAGTTCATCTCAAAAGTTAGGTCAAACGCAGCCATAGGTGCAGTCTTTCAGGAAGAACAGGGATGGACATCAGCCAGTGAAGCTGTGAATGACAGCCGGTTTTGGGAACTGGTTGACAAAGAAAGGGCTCTGCACCAGGAAGGGAAATGTGAATCGTGTGTCTACAACATGATGGGAAAACGTGAGAAAAAACTAGGAGAGTTTGGTAGAGCCAAAGGAAGCCGAGCAATCTGGTACATGTGGCTGGGAGCGCGGTTTCTGGAATTTGAAGCCCTGGGTTTCTTAAATGAAGATCACTGGTTTGGCAGAGAAAATTCATGGAGTGGAGTGGAAGGAGAAGGTCTGCATAGATTGGGATACATCCTAGAGGACATAGACAAGAAGGATGGAGACCTGATGTATGCTGATGACACAGCAGGTTGGGACACAAGAATCACTGAAGATGACCTTCTAAATGAAGAACTGATCACGGAACAGATGGCCCCTCATCATAAGATCTTAGCCAAAGCCATTTTCAAACTAACTTATCAAAACAAAGTGGTAAAAGTCCTCAGACCCACACCGAAAGGAGCGGTGATGGACATCATATCCAGGAAAGACCAAAGAGGTAGTGGACAGGTTGGAACATATGGTTTGAACACATTCACCAACATGGAAGTACAACTCATCCGCCAAATGGAAGCTGAAGGAGTCATCACACAAGATGACATGCAGAACCCAAAAGGGCTGAAAGAAAGAGTTGAGAAATGGCTGAAAGAGTGTGGTGTCGACAGGTTGAAGAGGATGGCAATCAGTGGAGATGATTGTGTGGTGAAGCCCCTGGATGAGAGGTTCAGCACTTCCCTCCTCTTCTTGAACGACATGGGAAAGGTGAGGAAAGACATTCCGCAGTGGGAACCATCCAAGGGATGGAAAAATTGGCAAGAGGTTCCTTTTTGCTCCCACCACTTTCACAAGATCTTCATGAAGGATGGCCGCTCACTAGTTGTTCCATGTAGAAACCAGGATGAACTGATAGGGAGAGCCAGAATCTCGCAGGGGGCTGGATGGAGCTTAAAAGAAACAGCCTGTCTGGGCAAAGCTTACGCCCAGATGTGGTCGCTCATGTATTTTCACAGAAGGGACCTGCGTTTAGCCTCCATGGCCATATGCTCAGCAGTTCCAACGGAATGGTTTCCAACAAGCAGAACAACATGGTCAATCCACGCCCACCATCAGTGGATGACCACTGAAGACATGCTCAAAGTGTGGAACAGAGTGTGGATAGAAGACAACCCTAACATGACTGACAAAACTCCAGTCCATTCGTGGGAAGACATACCTTACCTAGGGAAAAGAGAGGATTTGTGGTGTGGATCCTTGATTGGACTTTCTTCCAGAGCCACCTGGGCGAAAAACATTCACACAGCCATAACCCAAGTCAGGAACCTGATCGGGAAAGAGGAGTATGTGGATTACATGCCAGTCATGAAAAGATACAGCGCTCCTTTCGAGAGTGAAGGAGTTCTGTAATTACCAACAACAAACACCAAAGCCTATTGAAGTCAGGCCACTTGTGCCACGGCTTGAGCAAACCGTGCTGCCTGTAGCTCCGCCAATAACGGGAGGCGTAAAAATTCCCAGGGAGGCCATGCGCCACGGAAGCTGTACGCGTGGCATATTGGACTAGCGGTTAGAGGAGACCCCTCCCATCACTGACAAAACGCAGCAAAAGGGGGCCCGAAGCCAGGAGGAAGCTGTACTCCTGGTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAACACAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCTGCAACATCAATCCAGGCACAGAGCGCCGCAAGATGGATTGGTGTTGTTGATCCAACAGGTTCT diff --git a/nextclade/rules/prepare_sequences.smk b/nextclade/rules/prepare_sequences.smk index 1ec4e385..63b76561 100644 --- a/nextclade/rules/prepare_sequences.smk +++ b/nextclade/rules/prepare_sequences.smk @@ -84,7 +84,7 @@ rule add_outgorup: """ input: sequences = "results/{gene}/filtered_{serotype}.fasta", - outgroup = config["outgroup"], + outgroup = lambda wildcard: config["outgroup"][wildcard.serotype], output: sequences = "results/{gene}/filtered_{serotype}_with_outgroup.fasta" shell: From 33de742fb8a7f433373abd5a4ad7f43c8df52644 Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Mon, 10 Jun 2024 15:20:28 -0700 Subject: [PATCH 7/8] [nextclade]: Update genotype trees with outgroups --- nextclade/datasets/denv1/tree.json | 2 +- nextclade/datasets/denv2/tree.json | 2 +- nextclade/datasets/denv3/tree.json | 2 +- nextclade/datasets/denv4/tree.json | 2 +- 4 files changed, 4 insertions(+), 4 deletions(-) diff --git a/nextclade/datasets/denv1/tree.json b/nextclade/datasets/denv1/tree.json index 86fd9c53..0f6251cd 100644 --- a/nextclade/datasets/denv1/tree.json +++ b/nextclade/datasets/denv1/tree.json @@ -1 +1 @@ -{"version": "v2", "meta": {"title": "Real-time tracking of dengue virus evolution", "updated": "2024-06-04", "build_url": "https://github.com/nextstrain/dengue", "maintainers": [{"name": "the Nextstrain team", "url": "https://nextstrain.org/team"}], "display_defaults": {"map_triplicate": true, "color_by": "clade_membership"}, "genome_annotations": {"nuc": {"end": 10735, "start": 1, "strand": "+", "type": "##sequence-region pragma", "seqid": "resources/denv1/genome_annotation.gff3"}, "2K": {"end": 6826, "seqid": "resources/denv1/genome_annotation.gff3", "start": 6758, "strand": "+", "type": "gene"}, "C": {"end": 436, "seqid": "resources/denv1/genome_annotation.gff3", "start": 95, "strand": "+", "type": "gene"}, "E": {"end": 2419, "seqid": "resources/denv1/genome_annotation.gff3", "start": 935, "strand": "+", "type": "gene"}, "M": {"end": 934, "seqid": "resources/denv1/genome_annotation.gff3", "start": 437, "strand": "+", "type": "gene"}, "NS1": {"end": 3475, "seqid": "resources/denv1/genome_annotation.gff3", "start": 2420, "strand": "+", "type": "gene"}, "NS2A": {"end": 4129, "seqid": "resources/denv1/genome_annotation.gff3", "start": 3476, "strand": "+", "type": "gene"}, "NS2B": {"end": 4519, "seqid": "resources/denv1/genome_annotation.gff3", "start": 4130, "strand": "+", "type": "gene"}, "NS3": {"end": 6376, "seqid": "resources/denv1/genome_annotation.gff3", "start": 4520, "strand": "+", "type": "gene"}, "NS4A": {"end": 6757, "seqid": "resources/denv1/genome_annotation.gff3", "start": 6377, "strand": "+", "type": "gene"}, "NS4B": {"end": 7573, "seqid": "resources/denv1/genome_annotation.gff3", "start": 6827, "strand": "+", "type": "gene"}, "NS5": {"end": 10270, "seqid": "resources/denv1/genome_annotation.gff3", "start": 7574, "strand": "+", "type": "gene"}, "pr": {"end": 709, "seqid": 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"AGTTGTTAGTCTACGTGGACCGACAAGAACAGTTTCGAATCGGAAGCTTGCTTAACGTAGTTCTAACAGTTTTTTATTAGAGAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGTCGACCGTCTTTCAATATGCTGAAACGCGCGAGAAACCGCGTGTCAACTGTTTCACAGTTGGCGAAGAGATTCTCAAAAGGATTGCTCTCAGGCCAAGGACCCATGAAATTGGTGATGGCTTTCATAGCATTCCTAAGATTTCTAGCCATACCCCCAACAGCAGGAATTTTGGCTAGATGGGGCTCATTCAAGAAGAATGGAGCGATTAAAGTGTTACGGGGTTTCAAGAAAGAAATCTCAAACATGTTGAACATAATGAACAGGAGGAAAAGATCCGTGACCATGCTCCTTATGCTGCTGCCCACAGCCCTGGCGTTCCATCTGACCACACGAGGGGGAGAGCCGCACATGATAGTTAGCAAGCAGGAAAGAGGAAAGTCACTTTTGTTTAAGACCTCTGCAGGTGTCAACATGTGCACCCTTATTGCGATGGATTTGGGAGAGTTATGTGAGGACACAATGACCTACAAATGCCCCCGGATCACTGAGGCGGAACCAGATGACGTTGACTGTTGGTGCAATGCCACGGACACATGGGTGACCTATGGAACGTGTTCTCAAACTGGCGAACACCGACGAGACAAACGTTCCGTCGCACTGGCCCCACACGTGGGGCTTGGTCTAGAAACAAGAACCGAAACGTGGATGTCCTCTGAAGGCGCTTGGAAACAAATACAAAAAGTGGAGACTTGGGCTCTGAGACACCCAGGATTCACGGTGATAGCCCTTTTTCTAGCACATGCCATAGGAACATCCATCACCCAGAAAGGGATTATTTTCATTTTGCTGATGCTGGTAACACCATCCATGGCCATGCGATGCGTGGGAATAGGCAACAGAGACTTCGTGGAAGGACTGTCAGGAGCAACGTGGGTGGATGTGGTACTGGAGCATGGAAGTTGCGTCACCACCATGGCAAAAAATAAACCAACATTGGACATTGAACTCTTGAAGACGGAGGTCACAAACCCTGCCGTCCTGCGCAAACTGTGCATTGAAGCTAAAATATCAAACACCACCACCGATTCAAGATGTCCAACACAAGGAGAAGCCACACTGGTGGAAGAACAAGACGCGAACTTTGTGTGTCGACGAACGTTCGTGGACAGAGGCTGGGGCAATGGCTGTGGGCTATTCGGAAAAGGTAGCCTAATAACGTGTGCTAAGTTCAAGTGTGTGACAAAACTAGAAGGAAAGATAGTTCAATATGAAAACTTAAAATATTCAGTGATAGTCACCGTCCACACTGGAGACCAGCACCAGGTGGGAAATGAGACCACAGAACATGGAACAACTGCAACCATAACACCTCAAGCTCCTACGTCGGAAATACAGCTGACCGACTACGGAGCCCTTACATTGGATTGCTCACCTAGAACAGGGCTAGACTTTAATGAGATGGTGTTGTTGACAATGAAAGAAAAATCATGGCTTGTCCACAAACAATGGTTTCTAGACTTACCACTGCCTTGGACCTCGGGGGCTTCAACATCCCAAGAGACTTGGAACAGACAAGATTTGCTGGTCACATTTAAGACAGCTCATGCAAAGAAGCAGGAAGTAGTCGTACTAGGATCACAAGAAGGAGCAATGCACACTGCGTTGACTGGAGCGACAGAAATCCAAACGTCAGGAACGACAACAATTTTTGCAGGACACCTGAAATGCAGACTAAAAATGGACAAACTGACTTTAAAAGGGATGTCATATGTGATGTGCACAGGCTCATTCAAGTTAGAGAAAGAAGTGGCTGAGACCCAGCATGGAACTGTTCTAGTGCAGGTTAAATACGAAGGAACAGATGCACCATGCAAGATCCCCTTTTCGACCCAAGATGAGAAAGGAGTAACCCAGAATGGGAGATTGATAACAGCCAACCCCATAGTCACTGACAAAGAAAAACCAGTCAACATTGAGGCAGAACCACCTTTTGGTGAGAGCTACATCGTGGTAGGAGCAGGTGAAAAAGCTTTGAAACTAAGCTGGTTCAAGAAAGGAAGCAGCATAGGGAAAATGTTTGAAGCAACTGCCCGAGGAGCACGAAGGATGGCCATCCTGGGAGACACCGCATGGGACTTCGGTTCTATAGGAGGAGTGTTCACGTCTGTGGGAAAACTGGTACACCAGGTTTTTGGAACTGCATATGGAGTTTTGTTCAGCGGTGTTTCTTGGACCATGAAAATAGGAATAGGGATTCTGCTGACATGGCTAGGATTAAATTCAAGGAGCACGTCCCTTTCGATGACGTGCATTGCAGTTGGCATGGTCACACTGTACCTAGGAGTCATGGTTCAGGCGGACTCGGGATGTGTAATCAACTGGAAAGGCAGAGAACTCAAATGTGGAAGTGGCATTTTTGTCACTAATGAAGTTCACACTTGGACAGAGCAATACAAATTCCAGGCTGACTCCCCAAAGAGACTATCAGCAGCCATTGGGAAGGCATGGGAGGAGGGTGTGTGTGGAATTCGATCAGCCACTCGTCTCGAGAACATCATGTGGAAGCAAATATCAAATGAATTGAACCACATCCTACTTGAAAATGACATGAAATTCACAGTGGTCGTAGGAGATGTTAGTGGAATCTTGGCCCAAGGAAAAAAAATGATTAGGCCACAACCCATGGAACACAAATACTCGTGGAAAAGCTGGGGAAAAGCCAAAATCATAGGAGCAGATGTACAGAACACCACCTTCATCATCGACGGCCCAAACACCCCAGAATGCCCTGATGACCAAAGAGCATGGAACATTTGGGAAGTTGAGGACTATGGATTTGGAATTTTCACGACAAACATATGGTTGAAATTGCGTGACTCCTACACCCAAGTGTGTGACCACCGGCTAATGTCAGCTGCCATCAAGGACAGCAAGGCAGTCCATGCTGACATGGGGTACTGGATAGAAAGTGAAAAGAACGAGACCTGGAAGCTGGCGAGAGCCTCCTTCATAGAAGTTAAGACATGCATCTGGCCAAAATCCCACACTCTATGGAGCAATGGAGTTCTGGAAAGTGAAATGATAATCCCAAAGATATATGGAGGACCAATATCTCAGCACAACTACAGACCAGGATATTTCACACAAACAGCAGGGCCGTGGCACCTAGGCAAGTTGGAACTAGATTTTGATTTGTGTGAAGGTACCACAGTTGTTGTGGATGAACATTGTGGAAATCGAGGACCATCTCTTAGAACCACAACAGTCACAGGAAAGATAATCCATGAATGGTGCTGCAGATCTTGTACGCTACCCCCCTTACGTTTCAAAGGAGAAGACGGGTGTTGGTACGGCATGGAAATCAGACCAGTCAAGGAGAAGGAAGAGAACCTAGTCAAGTCAATGGTCTCTGCAGGGTCAGGAGAAGTGGACAGCTTTTCACTAGGACTGCTATGCATATCAATAATGATTGAAGAGGTGATGAGATCCAGATGGAGTAGAAAAATGCTGATGACTGGAACACTGGCTGTGTTCCTCCTTCTTATAATGGGACAATTGACATGGAATGATCTGATCAGGTTATGCATCATGGTTGGAGCCAATGCTTCAGACAGGATGGGGATGGGAACAACGTACCTAGCTTTGATGGCCACTTTCAAAATGAGACCAATGTTCGCTGTCGGGCTATTATTTCGCAGACTAACATCTAGAGAAGTTCTTCTTCTTACAATTGGATTGAGCCTGGTGGCATCCGTGGAGCTACCAAATTCCTTAGAGGAGCTGGGGGATGGACTTGCAATGGGCATCATGATGTTAAAATTACTGACTGATTTTCAGTCACACCAGCTATGGGCTACCTTGCTGTCCTTGACATTTATCAAAACAACTTTTTCATTGCACTATGCATGGAAGACAATGGCTATGGTACTGTCAATTGTATCTCTCTTCCCTTTATGCCTGTCCACGACCTCTCAAAAAACAACATGGCTTCCGGTGCTGTTGGGATCTCTTGGATGCAAACCACTAACCATGTTTCTTATAACAGAAAACAAAATCTGGGGAAGGAAAAGTTGGCCCCTCAATGAAGGAATTATGGCTGTTGGAATAGTTAGCATTCTACTAAGTTCACTCCTCAAAAATGATGTGCCGCTAGCCGGCCCACTAATAGCTGGAGGCATGCTAATAGCATGTTATGTCATATCCGGAAGCTCAGCCGATTTATCACTGGAGAAAGCGGCTGAGGTCTCCTGGGAAGAAGAAGCAGAACACTCTGGTGCCTCACACAACATACTAGTGGAGGTCCAAGATGATGGAACCATGAAGATAAAAGATGAAGAGAGAGATGACACACTCACCATTCTCCTTAAAGCAACTCTGCTGGCAGTCTCAGGGGTGTACCCAATGTCAATACCAGCGACCCTTTTTGTGTGGTATTTTTGGCAGAAAAAGAAACAGAGATCAGGAGTGCTATGGGACACACCCAGCCCTCCAGAAGTGGAAAGAGCAGTTCTTGATGATGGTATCTATAGAATTTTGCAAAGAGGACTGTTGGGCAGGTCCCAAGTAGGAGTAGGAGTTTTCCAAGAAGGCGTGTTCCACACAATGTGGCACGTCACCAGGGGAGCTGTCCTCATGTATCAAGGGAAGAGGCTGGAACCAAGCTGGGCCAGTGTCAAAAAAGACTTGATCTCATATGGAGGAGGTTGGAGGTTTCAAGGATCCTGGAACACGGGAGAAGAAGTGCAGGTGATTGCTGTTGAACCGGGAAAAAACCCCAAAAATGTACAGACAGCGCCGGGCACCTTCAAGACCCCTGAAGGCGAAGTTGGAGCCATAGCCCTAGATTTTAAACCCGGCACATCTGGATCTCCCATCGTGAACAGAGAGGGAAAAATAGTAGGTCTTTATGGAAATGGAGTGGTGACAACAAGTGGAACCTACGTCAGTGCCATAGCTCAAGCTAAAGCATCACAAGAAGGGCCTCTACCAGAGATTGAGGACGAGGTGTTTAGGAAAAGAAACTTAACAATAATGGACCTACATCCAGGATCGGGAAAAACAAGAAGATATCTTCCAGCCATAGTCCGTGAGGCCATAAAAAGGAAGCTGCGCACGCTAATCTTGGCTCCCACAAGAGTTGTCGCTTCTGAAATGGCAGAGGCGCTCAAGGGAATGCCAATAAGGTATCAGACAACAGCAGTGAAGAGTGAACACACAGGAAAGGAGATAGTTGACCTTATGTGCCACGCCACTTTCACCATGCGTCTCCTGTCTCCCGTGAGAGTTCCCAATTACAACATGATTATCATGGATGAAGCACATTTCACCGATCCAGCCAGCATAGCGGCCAGAGGGTACATCTCAACCCGAGTGGGTATGGGTGAAGCAGCTGCGATCTTTATGACAGCCACTCCCCCAGGATCGGTGGAGGCCTTTCCACAGAGCAATGCAGTTATCCAAGATGAGGAAAGAGACATTCCTGAGAGATCATGGAACTCAGGCTATGACTGGATCACTGATTTCCCAGGTAAAACAGTCTGGTTTGTTCCAAGCATCAAATCAGGAAATGACATTGCCAACTGTTTAAGAAAGAACGGGAAACGGGTGATCCAATTGAGCAGAAAAACCTTTGACACTGAGTACCAGAAAACAAAAAACAACGACTGGGACTATGTCGTCACAACAGACATTTCCGAAATGGGAGCAAACTTCCGGGCCGACAGGGTAATAGACCCAAGGCGGTGTCTGAAACCGGTAATACTAAAAGATGGTCCAGAGCGCGTCATTCTAGCCGGACCGATGCCAGTGACTGTGGCCAGTGCCGCCCAGAGGAGAGGAAGAATTGGAAGGAACCAAAACAAGGAAGGTGATCAGTATATTTACATGGGACAGCCTTTAAACAATGATGAGGACCACGCTCATTGGACAGAAGCAAAAATGCTCCTTGACAATATAAACACACCAGAAGGGATTATCCCAGCCCTCTTTGAGCCGGAGAGAGAAAAGAGTGCAGCAATAGACGGGGAATACAGACTGCGGGGTGAAGCAAGGAAAACGTTCGTGGAGCTCATGAGAAGAGGAGATCTACCTGTCTGGCTATCCTACAAAGTTGCCTCAGAAGGCTTCCAGTACTCCGACAGAAGGTGGTGCTTTGATGGGGAAAGGAACAACCAGGTGTTGGAGGAGAACATGGACGTGGAGATCTGGACAAAAGAAGGAGAAAGAAAGAAACTACGACCCCGCTGGTTGGATGCCAGAACATACTCTGACCCACTGGCTCTGCGCGAGTTTAAAGAGTTTGCAGCAGGAAGAAGAAGCGTCTCAGGTGACCTAATATTAGAAATAGGGAAACTTCCACAACATTTGACGCAAAGGGCCCAGAATGCTTTGGACAACTTGGTCATGTTGCACAATTCCGAACAAGGAGGAAAAGCCTATAGACATGCTATGGAAGAACTACCAGACACCATAGAAACGTTGATGCTCCTAGCTTTGATAGCTGTGTTGACTGGTGGAGTGACGCTGTTCTTCCTATCAGGAAGAGGTCTAGGGAAAACATCCATCGGCCTACTCTGCGTGATGGCCTCAAGCGTACTGTTATGGATGGCCAGTGTGGAGCCCCATTGGATAGCGGCCTCCATCATACTGGAGTTCTTTCTGATGGTGCTGCTTATTCCAGAGCCAGACAGACAGCGCACTCCACAGGACAACCAGCTAGCATATGTGGTGATAGGTTTGTTATTCATGATATTGACAGTGGCAGCCAATGAGATGGGATTATTGGAAACCACAAAGAAAGACCTGGGGATTGGCCATGTAGCTGCTGAAAACCACCACCATGCTACAATGCTGGACGTAGACCTACATCCAGCTTCAGCCTGGACCCTCTATGCAGTGGCCACAACAATTATCACTCCCATGATGAGACACACAATTGAAAACACAACGGCAAATATTTCCCTGACAGCTATTGCAAACCAGGCAGCTATATTGATGGGACTTGACAAGGGATGGCCAATATCGAAGATGGACATAGGAGTTCCACTTCTCGCCTTGGGGTGCTATTCCCAGGTGAACCCGCTGACGCTGACAGCGGCGGTATTGATGCTAGTGGCTCATTACGCCATAATTGGACCTGGACTGCAAGCAAAAGCTACTAGAGAAGCTCAAAAAAGGACAGCGGCCGGAATAATGAAAAATCCAACTGTCGACGGGATTGTTGCAATAGATTTGGATCCTGTGGTTTACGATGCAAAATTTGAAAAACAGCTAGGCCAAATAATGTTGTTGATACTTTGCACATCACAGATTCTCTTGATGCGGACTACATGGGCCTTGTGTGAATCCATCACACTGGCTACTGGACCTCTGACCACTCTTTGGGAGGGATCTCCAGGAAAATTCTGGAACACCACGATAGCGGTGTCCATGGCAAACATTTTCAGGGGAAGTTATCTAGCAGGAGCAGGTCTGGCCTTCTCATTAATGAAATCTCTAGGAGGAGGTAGGAGAGGCACGGGAGCCCAAGGGGAAACACTGGGAGAAAAATGGAAAAGACAGCTAAACCAACTGAGCAAGTCAGAATTCAACACTTACAAAAGGAGTGGGATTATGGAGGTGGATAGATCCGAAGCCAAAGAGGGACTGAAAAGAGGAGAAACAACCAAACATGCAGTGTCGAGAGGAACAGCCAAACTGAGGTGGTTTGTGGAGAGGAACCTTGTGAAACCAGAAGGGAAAGTCATAGACCTCGGTTGTGGAAGAGGTGGCTGGTCATATTATTGCGCTGGGCTGAAGAAAGTCACAGAAGTGAAAGGATACACAAAAGGAGGACCTGGACATGAGGAACCAATCCCAATGGCGACCTATGGATGGAACCTAGTAAAGCTACACTCCGGAAAAGATGTATTCTTTACACCACCTGAGAAATGTGACACCCTTTTGTGTGATATTGGTGAGTCCTCTCCGAACCCAACTATAGAAGAAGGAAGAACGTTACGTGTTCTAAAGATGGTGGAACCATGGCTCAGAGGAAACCAATTTTGCATAAAAATTCTAAATCCCTATATGCCGAGTGTGGTAGAAACTCTGGAGCAAATGCAAAGAAAACATGGAGGAATGCTAGTGCGAAACCCACTCTCAAGAAATTCCACCCATGAAATGTACTGGGTTTCATGTGGAACAGGAAACATTGTGTCAGCAGTAAACATGACATCTAGAATGTTGCTAAATCGATTCACAATGGCTCACAGGAAGCCAACATATGAAAGAGACGTGGACTTAGGCGCTGGAACAAGACATGTGGCAGTGGAACCAGAGGTAGCCAACCTAGATATCATTGGCCAGAGGATAGAGAATATAAAAAATGAACATAAGTCAACATGGCATTATGATGAGGACAATCCATACAAAACATGGGCCTATCATGGATCATATGAGGTCAAGCCATCAGGATCAGCCTCATCCATGGTCAATGGCGTGGTGAGATTGCTCACCAAACCATGGGATGTTATCCCCATGGTCACACAAATAGCCATGACTGACACCACACCCTTTGGACAACAGAGGGTGTTTAAAGAGAAAGTTGACACGCGCACACCAAAAGCAAAACGAGGCACAGCACAAATTATGGAGGTGACAGCCAGGTGGTTATGGGGTTTCCTTTCTAGAAACAAAAAACCCAGAATCTGCACAAGAGAGGAGTTCACAAGAAAAGTTAGGTCAAACGCAGCTATTGGAGCAGTGTTCGTTGATGAAAATCAATGGAACTCAGCAAAAGAAGCAGTGGAAGACGAACGGTTCTGGGACCTTGTGCACAGAGAGAGGGAGCTTCATAAACAGGGAAAATGTGCCACGTGTGTCTACAATATGATGGGGAAGAGAGAGAAAAAATTAGGAGAGTTCGGAAAGGCAAAAGGAAGTCGTGCAATATGGTACATGTGGTTGGGAGCACGCTTTCTAGAGTTCGAAGCCCTTGGTTTCATGAATGAAGATCACTGGTTCAGTAGAGAGAATTCACTCAGTGGAGTGGAAGGAGAAGGACTCCACAAACTTGGATACATACTCAGAGACATATCAAAGATTCCAGGGGGAAATATGTATGCAGATGACACAGCCGGATGGGACACAAGAATAACAGAGGATGATCTTCAGAATGAGGCTAAAATCACTGACATCATGGAGCCCGAACATGCCCTATTGGCTACGTCAATCTTTAAGCTGACCTACCAAAATAAGGTGGTAAGGGTGCAGAGACCAGCAAAAAATGGAACCGTGATGGATGTTATATCCAGACGTGACCAGAGAGGAAGTGGACAGGTCGGAACTTATGGCTTAAACACTTTCACCAACATGGAGGCCCAACTAATAAGACAAATGGAGTCTGAGGGAATCTTTTTACCCAGCGAATTGGAAACCCCAAATCTAGCCGAAAGAGTTCTCGACTGGTTGGAAAAACATGGCGTCGAAAGGCTGAAAAGAATGGCAATCAGCGGAGATGACTGTGTGGTGAAACCAATTGATGACAGGTTCGCAACAGCCTTAACAGCTTTGAATGACATGGGAAAAGTAAGAAAAGACATACCGCAATGGGAACCTTCAAAAGGATGGAATGATTGGCAACAAGTGCCTTTCTGTTCACACCATTTCCACCAGCTGATTATGAAGGATGGGAGGGAGATAGTGGTGCCATGCCGCAACCAAGATGAACTTGTGGGTAGGGCCAGAGTATCACAAGGCGCCGGATGGAGCCTGAGAGAAACTGCATGCCTAGGCAAGTCATATGCACAAATGTGGCAGCTGATGTACTTCCACAGGAGAGACCTGAGACTAGCGGCTAATGCTATCTGTTCAGCCGTTCCAGTTGATTGGGTCCCAACCAGCCGCACCACCTGGTCGATCCATGCCCATCACCAATGGATGACAACAGAAGACATGTTATCAGTGTGGAATAGGGTTTGGATAGAGGAAAACCCATGGATGGAGGATAAAACTCATGTATCCAGTTGGGAAGATGTTCCATACTTAGGAAAAAGGGAAGATCAGTGGTGTGGATCCCTGATAGGCTTAACAGCAAGGGCCACCTGGGCCACTAACATACAAGTGGCCATAAACCAAGTGAGAAGGCTCATTGGGAATGAGAATTATCTAGATTACATGACATCAATGAAGAGATTCAAGAATGAGAGTGATCCCGAAGGGGCACTCTGGTAAGTCAACACATTCACAAAATAAAGGAAAATAAAAAATCAAACAAGGCAAGAAGTCAGGCCGGATTAAGCCATAGTACGGTAAGAGCTATGCTGCCTGTGAGCCCCGTCCAAGGACGTAAAATGAAGTCAGGCCGAAAGCCACGGTTTGAGCAAACCGTGCTGCCTGTGGCTCCATCGTGGGGATGTAAAAACCCGGGAGGCTGCAACCCATGGAAGCTGTACGCATGGGGTAGCAGACTAGTGGTTAGAGGAGACCCCTCCCAAGACACAACGCAGCAGCGGGGCCCAACACCAGGGGAAGCTGTACCCTGGTGGTAAGGACTAGAGGTTAGAGGAGACCCCCCGCACAACAATAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCTACAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLAYVVIGLLFMILTVAA", "C": "MNNQRKKTGRPSFNMLKRARNRVSTVSQLAKRFSKGLLSGQGPMKLVMAFIAFLRFLAIPPTAGILARWGSFKKNGAIKVLRGFKKEISNMLNIMNRRKRSVTMLLMLLPTALA", "E": "MRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKNKPTLDIELLKTEVTNPAVLRKLCIEAKISNTTTDSRCPTQGEATLVEEQDANFVCRRTFVDRGWGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVHTGDQHQVGNETTEHGTTATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSTQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGSSIGKMFEATARGARRMAILGDTAWDFGSIGGVFTSVGKLVHQVFGTAYGVLFSGVSWTMKIGIGILLTWLGLNSRSTSLSMTCIAVGMVTLYLGVMVQA", "M": "FHLTTRGGEPHMIVSKQERGKSLLFKTSAGVNMCTLIAMDLGELCEDTMTYKCPRITEAEPDDVDCWCNATDTWVTYGTCSQTGEHRRDKRSVALAPHVGLGLETRTETWMSSEGAWKQIQKVETWALRHPGFTVIALFLAHAIGTSITQKGIIFILLMLVTPSMA", "NS1": "DSGCVINWKGRELKCGSGIFVTNEVHTWTEQYKFQADSPKRLSAAIGKAWEEGVCGIRSATRLENIMWKQISNELNHILLENDMKFTVVVGDVSGILAQGKKMIRPQPMEHKYSWKSWGKAKIIGADVQNTTFIIDGPNTPECPDDQRAWNIWEVEDYGFGIFTTNIWLKLRDSYTQVCDHRLMSAAIKDSKAVHADMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGMEIRPVKEKEENLVKSMVSA", "NS2A": "GSGEVDSFSLGLLCISIMIEEVMRSRWSRKMLMTGTLAVFLLLIMGQLTWNDLIRLCIMVGANASDRMGMGTTYLALMATFKMRPMFAVGLLFRRLTSREVLLLTIGLSLVASVELPNSLEELGDGLAMGIMMLKLLTDFQSHQLWATLLSLTFIKTTFSLHYAWKTMAMVLSIVSLFPLCLSTTSQKTTWLPVLLGSLGCKPLTMFLITENKIWGRK", "NS2B": "SWPLNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPMSIPATLFVWYFWQKKKQR", "NS3": "SGVLWDTPSPPEVERAVLDDGIYRILQRGLLGRSQVGVGVFQEGVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRFQGSWNTGEEVQVIAVEPGKNPKNVQTAPGTFKTPEGEVGAIALDFKPGTSGSPIVNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPEIEDEVFRKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEERDIPERSWNSGYDWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVIQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNQNKEGDQYIYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLRGEARKTFVELMRRGDLPVWLSYKVASEGFQYSDRRWCFDGERNNQVLEENMDVEIWTKEGERKKLRPRWLDARTYSDPLALREFKEFAAGRR", "NS4A": "SVSGDLILEIGKLPQHLTQRAQNALDNLVMLHNSEQGGKAYRHAMEELPDTIETLMLLALIAVLTGGVTLFFLSGRGLGKTSIGLLCVMASSVLLWMASVEPHWIAASIILEFFLMVLLIPEPDRQR", "NS4B": "NEMGLLETTKKDLGIGHVAAENHHHATMLDVDLHPASAWTLYAVATTIITPMMRHTIENTTANISLTAIANQAAILMGLDKGWPISKMDIGVPLLALGCYSQVNPLTLTAAVLMLVAHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIVAIDLDPVVYDAKFEKQLGQIMLLILCTSQILLMRTTWALCESITLATGPLTTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFSLMKSLGGGRR", "NS5": "GTGAQGETLGEKWKRQLNQLSKSEFNTYKRSGIMEVDRSEAKEGLKRGETTKHAVSRGTAKLRWFVERNLVKPEGKVIDLGCGRGGWSYYCAGLKKVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGKDVFFTPPEKCDTLLCDIGESSPNPTIEEGRTLRVLKMVEPWLRGNQFCIKILNPYMPSVVETLEQMQRKHGGMLVRNPLSRNSTHEMYWVSCGTGNIVSAVNMTSRMLLNRFTMAHRKPTYERDVDLGAGTRHVAVEPEVANLDIIGQRIENIKNEHKSTWHYDEDNPYKTWAYHGSYEVKPSGSASSMVNGVVRLLTKPWDVIPMVTQIAMTDTTPFGQQRVFKEKVDTRTPKAKRGTAQIMEVTARWLWGFLSRNKKPRICTREEFTRKVRSNAAIGAVFVDENQWNSAKEAVEDERFWDLVHRERELHKQGKCATCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFMNEDHWFSRENSLSGVEGEGLHKLGYILRDISKIPGGNMYADDTAGWDTRITEDDLQNEAKITDIMEPEHALLATSIFKLTYQNKVVRVQRPAKNGTVMDVISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMESEGIFLPSELETPNLAERVLDWLEKHGVERLKRMAISGDDCVVKPIDDRFATALTALNDMGKVRKDIPQWEPSKGWNDWQQVPFCSHHFHQLIMKDGREIVVPCRNQDELVGRARVSQGAGWSLRETACLGKSYAQMWQLMYFHRRDLRLAANAICSAVPVDWVPTSRTTWSIHAHHQWMTTEDMLSVWNRVWIEENPWMEDKTHVSSWEDVPYLGKREDQWCGSLIGLTARATWATNIQVAINQVRRLIGNENYLDYMTSMKRFKNESDPEGALW", "pr": 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"serotype_genbank": {"value": "denv1"}, "clade_membership": {"value": "DENV1/I"}, "genotype_nextclade": {"value": "DENV1/I", "confidence": {"DENV1/I": 0.9999999964205386}, "entropy": 7.737121567235205e-08}}, "branch_attrs": {"mutations": {"nuc": ["G6109A"]}}, "children": [{"name": "DENV1_RUN_S17b57_2022", "node_attrs": {"div": 737, "genbank_accession": {"value": "OR235504"}, "author": {"author": "Frumence,E.,Traversier,N.,Jaffar Bandjee,M.-C.", "value": "Frumence,E.,Traversier,N.,Jaffar Bandjee,M.-C."}, "country": {"value": "France", "confidence": {"France": 1.0}, "entropy": -1.000088900581841e-12}, "region": {"value": "Europe", "confidence": {"Europe": 1.0}, "entropy": -1.000088900581841e-12}, "serotype_genbank": {"value": "denv1"}, "clade_membership": {"value": "DENV1/I"}, "genotype_nextclade": {"value": "DENV1/I", "confidence": {"DENV1/I": 1.0}, "entropy": -1.000088900581841e-12}}, "branch_attrs": {"mutations": {"nuc": ["G3484A", "A4825G", "C6652T", "C7540T"]}}}, {"name": "DENV1_RUN_S17b62_2022", "node_attrs": {"div": 735, "genbank_accession": {"value": "OR235500"}, "author": {"author": "Frumence,E.,Traversier,N.,Jaffar Bandjee,M.-C.", "value": "Frumence,E.,Traversier,N.,Jaffar Bandjee,M.-C."}, "country": {"value": "France", "confidence": {"France": 1.0}, "entropy": -1.000088900581841e-12}, "region": {"value": "Europe", "confidence": {"Europe": 1.0}, "entropy": -1.000088900581841e-12}, "serotype_genbank": {"value": "denv1"}, "clade_membership": {"value": "DENV1/I"}, "genotype_nextclade": {"value": "DENV1/I", "confidence": {"DENV1/I": 1.0}, "entropy": -1.000088900581841e-12}}, "branch_attrs": {"mutations": {"nuc": ["G2999A", "G5278A"], "NS1": ["V194I"]}, "labels": {"aa": "NS1: V194I"}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}, "root_sequence": {"nuc": "AGTTGTTAGTCTACGTGGACCGACAAGAACAGTTTCGAATCGGAAGCTTGCTTAACGTAGTTCTAACAGTTTTTTATTAGAGAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGTCGACCGTCTTTCAATATGCTGAAACGCGCGAGAAACCGCGTGTCAACTGTTTCACAGTTGGCGAAGAGATTCTCAAAAGGATTGCTCTCAGGCCAAGGACCCATGAAATTGGTGATGGCTTTCATAGCATTCCTAAGATTTCTAGCCATACCCCCAACAGCAGGAATTTTGGCTAGATGGGGCTCATTCAAGAAGAATGGAGCGATTAAAGTGTTACGGGGTTTCAAGAAAGAAATCTCAAACATGTTGAACATAATGAACAGGAGGAAAAGATCCGTGACCATGCTCCTTATGCTGCTGCCCACAGCCCTGGCGTTCCATCTGACCACACGAGGGGGAGAGCCGCACATGATAGTTAGCAAGCAGGAAAGAGGAAAGTCACTTTTGTTTAAGACCTCTGCAGGTGTCAACATGTGCACCCTTATTGCGATGGATTTGGGAGAGTTATGTGAGGACACAATGACCTACAAATGCCCCCGGATCACTGAGGCGGAACCAGATGACGTTGACTGTTGGTGCAATGCCACGGACACATGGGTGACCTATGGAACGTGTTCTCAAACTGGCGAACACCGACGAGACAAACGTTCCGTCGCACTGGCCCCACACGTGGGGCTTGGTCTAGAAACAAGAACCGAAACGTGGATGTCCTCTGAAGGCGCTTGGAAACAAATACAAAAAGTGGAGACTTGGGCTCTGAGACACCCAGGATTCACGGTGATAGCCCTTTTTCTAGCACATGCCATAGGAACATCCATCACCCAGAAAGGGATTATTTTCATTTTGCTGATGCTGGTAACACCATCCATGGCCATGCGATGCGTGGGAATAGGCAACAGAGACTTCGTGGAAGGACTGTCAGGAGCAACGTGGGTGGATGTGGTACTGGAGCATGGAAGTTGCGTCACCACCATGGCAAAAAATAAACCAACATTGGACATTGAACTCTTGAAGACGGAGGTCACAAACCCTGCCGTCCTGCGCAAACTGTGCATTGAAGCTAAAATATCAAACACCACCACCGATTCAAGATGTCCAACACAAGGAGAAGCCACACTGGTGGAAGAACAAGACGCGAACTTTGTGTGTCGACGAACGTTCGTGGACAGAGGCTGGGGCAATGGCTGTGGGCTATTCGGAAAAGGTAGCCTAATAACGTGTGCTAAGTTCAAGTGTGTGACAAAACTAGAAGGAAAGATAGTTCAATATGAAAACTTAAAATATTCAGTGATAGTCACCGTCCACACTGGAGACCAGCACCAGGTGGGAAATGAGACCACAGAACATGGAACAACTGCAACCATAACACCTCAAGCTCCTACGTCGGAAATACAGCTGACCGACTACGGAGCCCTTACATTGGATTGCTCACCTAGAACAGGGCTAGACTTTAATGAGATGGTGTTGTTGACAATGAAAGAAAAATCATGGCTTGTCCACAAACAATGGTTTCTAGACTTACCACTGCCTTGGACCTCGGGGGCTTCAACATCCCAAGAGACTTGGAACAGACAAGATTTGCTGGTCACATTTAAGACAGCTCATGCAAAGAAGCAGGAAGTAGTCGTACTAGGATCACAAGAAGGAGCAATGCACACTGCGTTGACTGGAGCGACAGAAATCCAAACGTCAGGAACGACAACAATTTTTGCAGGACACCTGAAATGCAGACTAAAAATGGACAAACTGACTTTAAAAGGGATGTCATATGTGATGTGCACAGGCTCATTCAAGTTAGAGAAAGAAGTGGCTGAGACCCAGCATGGAACTGTTCTAGTGCAGGTTAAATACGAAGGAACAGATGCACCATGCAAGATCCCCTTTTCGACCCAAGATGAGAAAGGAGTAACCCAGAATGGGAGATTGATAACAGCCAACCCCATAGTCACTGACAAAGAAAAACCAGTCAACATTGAGGCAGAACCACCTTTTGGTGAGAGCTACATCGTGGTAGGAGCAGGTGAAAAAGCTTTGAAACTAAGCTGGTTCAAGAAAGGAAGCAGCATAGGGAAAATGTTTGAAGCAACTGCCCGAGGAGCACGAAGGATGGCCATCCTGGGAGACACCGCATGGGACTTCGGTTCTATAGGAGGAGTGTTCACGTCTGTGGGAAAACTGGTACACCAGGTTTTTGGAACTGCATATGGAGTTTTGTTCAGCGGTGTTTCTTGGACCATGAAAATAGGAATAGGGATTCTGCTGACATGGCTAGGATTAAATTCAAGGAGCACGTCCCTTTCGATGACGTGCATTGCAGTTGGCATGGTCACACTGTACCTAGGAGTCATGGTTCAGGCGGACTCGGGATGTGTAATCAACTGGAAAGGCAGAGAACTCAAATGTGGAAGTGGCATTTTTGTCACTAATGAAGTTCACACTTGGACAGAGCAATACAAATTCCAGGCTGACTCCCCAAAGAGACTATCAGCAGCCATTGGGAAGGCATGGGAGGAGGGTGTGTGTGGAATTCGATCAGCCACTCGTCTCGAGAACATCATGTGGAAGCAAATATCAAATGAATTGAACCACATCCTACTTGAAAATGACATGAAATTCACAGTGGTCGTAGGAGATGTTAGTGGAATCTTGGCCCAAGGAAAAAAAATGATTAGGCCACAACCCATGGAACACAAATACTCGTGGAAAAGCTGGGGAAAAGCCAAAATCATAGGAGCAGATGTACAGAACACCACCTTCATCATCGACGGCCCAAACACCCCAGAATGCCCTGATGACCAAAGAGCATGGAACATTTGGGAAGTTGAGGACTATGGATTTGGAATTTTCACGACAAACATATGGTTGAAATTGCGTGACTCCTACACCCAAGTGTGTGACCACCGGCTAATGTCAGCTGCCATCAAGGACAGCAAGGCAGTCCATGCTGACATGGGGTACTGGATAGAAAGTGAAAAGAACGAGACCTGGAAGCTGGCGAGAGCCTCCTTCATAGAAGTTAAGACATGCATCTGGCCAAAATCCCACACTCTATGGAGCAATGGAGTTCTGGAAAGTGAAATGATAATCCCAAAGATATATGGAGGACCAATATCTCAGCACAACTACAGACCAGGATATTTCACACAAACAGCAGGGCCGTGGCACCTAGGCAAGTTGGAACTAGATTTTGATTTGTGTGAAGGTACCACAGTTGTTGTGGATGAACATTGTGGAAATCGAGGACCATCTCTTAGAACCACAACAGTCACAGGAAAGATAATCCATGAATGGTGCTGCAGATCTTGTACGCTACCCCCCTTACGTTTCAAAGGAGAAGACGGGTGTTGGTACGGCATGGAAATCAGACCAGTCAAGGAGAAGGAAGAGAACCTAGTCAAGTCAATGGTCTCTGCAGGGTCAGGAGAAGTGGACAGCTTTTCACTAGGACTGCTATGCATATCAATAATGATTGAAGAGGTGATGAGATCCAGATGGAGTAGAAAAATGCTGATGACTGGAACACTGGCTGTGTTCCTCCTTCTTATAATGGGACAATTGACATGGAATGATCTGATCAGGTTATGCATCATGGTTGGAGCCAATGCTTCAGACAGGATGGGGATGGGAACAACGTACCTAGCTTTGATGGCCACTTTCAAAATGAGACCAATGTTCGCTGTCGGGCTATTATTTCGCAGACTAACATCTAGAGAAGTTCTTCTTCTTACAATTGGATTGAGCCTGGTGGCATCCGTGGAGCTACCAAATTCCTTAGAGGAGCTGGGGGATGGACTTGCAATGGGCATCATGATGTTAAAATTACTGACTGATTTTCAGTCACACCAGCTATGGGCTACCTTGCTGTCCTTGACATTTATCAAAACAACTTTTTCATTGCACTATGCATGGAAGACAATGGCTATGGTACTGTCAATTGTATCTCTCTTCCCTTTATGCCTGTCCACGACCTCTCAAAAAACAACATGGCTTCCGGTGCTGTTGGGATCTCTTGGATGCAAACCACTAACCATGTTTCTTATAACAGAAAACAAAATCTGGGGAAGGAAAAGTTGGCCCCTCAATGAAGGAATTATGGCTGTTGGAATAGTTAGCATTCTACTAAGTTCACTCCTCAAAAATGATGTGCCGCTAGCCGGCCCACTAATAGCTGGAGGCATGCTAATAGCATGTTATGTCATATCCGGAAGCTCAGCCGATTTATCACTGGAGAAAGCGGCTGAGGTCTCCTGGGAAGAAGAAGCAGAACACTCTGGTGCCTCACACAACATACTAGTGGAGGTCCAAGATGATGGAACCATGAAGATAAAAGATGAAGAGAGAGATGACACACTCACCATTCTCCTTAAAGCAACTCTGCTGGCAGTCTCAGGGGTGTACCCAATGTCAATACCAGCGACCCTTTTTGTGTGGTATTTTTGGCAGAAAAAGAAACAGAGATCAGGAGTGCTATGGGACACACCCAGCCCTCCAGAAGTGGAAAGAGCAGTTCTTGATGATGGTATCTATAGAATTTTGCAAAGAGGACTGTTGGGCAGGTCCCAAGTAGGAGTAGGAGTTTTCCAAGAAGGCGTGTTCCACACAATGTGGCACGTCACCAGGGGAGCTGTCCTCATGTATCAAGGGAAGAGGCTGGAACCAAGCTGGGCCAGTGTCAAAAAAGACTTGATCTCATATGGAGGAGGTTGGAGGTTTCAAGGATCCTGGAACACGGGAGAAGAAGTGCAGGTGATTGCTGTTGAACCGGGAAAAAACCCCAAAAATGTACAGACAGCGCCGGGCACCTTCAAGACCCCTGAAGGCGAAGTTGGAGCCATAGCCCTAGATTTTAAACCCGGCACATCTGGATCTCCCATCGTGAACAGAGAGGGAAAAATAGTAGGTCTTTATGGAAATGGAGTGGTGACAACAAGTGGAACCTACGTCAGTGCCATAGCTCAAGCTAAAGCATCACAAGAAGGGCCTCTACCAGAGATTGAGGACGAGGTGTTTAGGAAAAGAAACTTAACAATAATGGACCTACATCCAGGATCGGGAAAAACAAGAAGATATCTTCCAGCCATAGTCCGTGAGGCCATAAAAAGGAAGCTGCGCACGCTAATCTTGGCTCCCACAAGAGTTGTCGCTTCTGAAATGGCAGAGGCGCTCAAGGGAATGCCAATAAGGTATCAGACAACAGCAGTGAAGAGTGAACACACAGGAAAGGAGATAGTTGACCTTATGTGCCACGCCACTTTCACCATGCGTCTCCTGTCTCCCGTGAGAGTTCCCAATTACAACATGATTATCATGGATGAAGCACATTTCACCGATCCAGCCAGCATAGCGGCCAGAGGGTACATCTCAACCCGAGTGGGTATGGGTGAAGCAGCTGCGATCTTTATGACAGCCACTCCCCCAGGATCGGTGGAGGCCTTTCCACAGAGCAATGCAGTTATCCAAGATGAGGAAAGAGACATTCCTGAGAGATCATGGAACTCAGGCTATGACTGGATCACTGATTTCCCAGGTAAAACAGTCTGGTTTGTTCCAAGCATCAAATCAGGAAATGACATTGCCAACTGTTTAAGAAAGAACGGGAAACGGGTGATCCAATTGAGCAGAAAAACCTTTGACACTGAGTACCAGAAAACAAAAAACAACGACTGGGACTATGTCGTCACAACAGACATTTCCGAAATGGGAGCAAACTTCCGGGCCGACAGGGTAATAGACCCAAGGCGGTGTCTGAAACCGGTAATACTAAAAGATGGTCCAGAGCGCGTCATTCTAGCCGGACCGATGCCAGTGACTGTGGCCAGTGCCGCCCAGAGGAGAGGAAGAATTGGAAGGAACCAAAACAAGGAAGGTGATCAGTATATTTACATGGGACAGCCTTTAAACAATGATGAGGACCACGCTCATTGGACAGAAGCAAAAATGCTCCTTGACAATATAAACACACCAGAAGGGATTATCCCAGCCCTCTTTGAGCCGGAGAGAGAAAAGAGTGCAGCAATAGACGGGGAATACAGACTGCGGGGTGAAGCAAGGAAAACGTTCGTGGAGCTCATGAGAAGAGGAGATCTACCTGTCTGGCTATCCTACAAAGTTGCCTCAGAAGGCTTCCAGTACTCCGACAGAAGGTGGTGCTTTGATGGGGAAAGGAACAACCAGGTGTTGGAGGAGAACATGGACGTGGAGATCTGGACAAAAGAAGGAGAAAGAAAGAAACTACGACCCCGCTGGTTGGATGCCAGAACATACTCTGACCCACTGGCTCTGCGCGAGTTTAAAGAGTTTGCAGCAGGAAGAAGAAGCGTCTCAGGTGACCTAATATTAGAAATAGGGAAACTTCCACAACATTTGACGCAAAGGGCCCAGAATGCTTTGGACAACTTGGTCATGTTGCACAATTCCGAACAAGGAGGAAAAGCCTATAGACATGCTATGGAAGAACTACCAGACACCATAGAAACGTTGATGCTCCTAGCTTTGATAGCTGTGTTGACTGGTGGAGTGACGCTGTTCTTCCTATCAGGAAGAGGTCTAGGGAAAACATCCATCGGCCTACTCTGCGTGATGGCCTCAAGCGTACTGTTATGGATGGCCAGTGTGGAGCCCCATTGGATAGCGGCCTCCATCATACTGGAGTTCTTTCTGATGGTGCTGCTTATTCCAGAGCCAGACAGACAGCGCACTCCACAGGACAACCAGCTAGCATATGTGGTGATAGGTTTGTTATTCATGATATTGACAGTGGCAGCCAATGAGATGGGATTATTGGAAACCACAAAGAAAGACCTGGGGATTGGCCATGTAGCTGCTGAAAACCACCACCATGCTACAATGCTGGACGTAGACCTACATCCAGCTTCAGCCTGGACCCTCTATGCAGTGGCCACAACAATTATCACTCCCATGATGAGACACACAATTGAAAACACAACGGCAAATATTTCCCTGACAGCTATTGCAAACCAGGCAGCTATATTGATGGGACTTGACAAGGGATGGCCAATATCGAAGATGGACATAGGAGTTCCACTTCTCGCCTTGGGGTGCTATTCCCAGGTGAACCCGCTGACGCTGACAGCGGCGGTATTGATGCTAGTGGCTCATTACGCCATAATTGGACCTGGACTGCAAGCAAAAGCTACTAGAGAAGCTCAAAAAAGGACAGCGGCCGGAATAATGAAAAATCCAACTGTCGACGGGATTGTTGCAATAGATTTGGATCCTGTGGTTTACGATGCAAAATTTGAAAAACAGCTAGGCCAAATAATGTTGTTGATACTTTGCACATCACAGATTCTCTTGATGCGGACTACATGGGCCTTGTGTGAATCCATCACACTGGCTACTGGACCTCTGACCACTCTTTGGGAGGGATCTCCAGGAAAATTCTGGAACACCACGATAGCGGTGTCCATGGCAAACATTTTCAGGGGAAGTTATCTAGCAGGAGCAGGTCTGGCCTTCTCATTAATGAAATCTCTAGGAGGAGGTAGGAGAGGCACGGGAGCCCAAGGGGAAACACTGGGAGAAAAATGGAAAAGACAGCTAAACCAACTGAGCAAGTCAGAATTCAACACTTACAAAAGGAGTGGGATTATGGAGGTGGATAGATCCGAAGCCAAAGAGGGACTGAAAAGAGGAGAAACAACCAAACATGCAGTGTCGAGAGGAACAGCCAAACTGAGGTGGTTTGTGGAGAGGAACCTTGTGAAACCAGAAGGGAAAGTCATAGACCTCGGTTGTGGAAGAGGTGGCTGGTCATATTATTGCGCTGGGCTGAAGAAAGTCACAGAAGTGAAAGGATACACAAAAGGAGGACCTGGACATGAGGAACCAATCCCAATGGCGACCTATGGATGGAACCTAGTAAAGCTACACTCCGGAAAAGATGTATTCTTTACACCACCTGAGAAATGTGACACCCTTTTGTGTGATATTGGTGAGTCCTCTCCGAACCCAACTATAGAAGAAGGAAGAACGTTACGTGTTCTAAAGATGGTGGAACCATGGCTCAGAGGAAACCAATTTTGCATAAAAATTCTAAATCCCTATATGCCGAGTGTGGTAGAAACTCTGGAGCAAATGCAAAGAAAACATGGAGGAATGCTAGTGCGAAACCCACTCTCAAGAAATTCCACCCATGAAATGTACTGGGTTTCATGTGGAACAGGAAACATTGTGTCAGCAGTAAACATGACATCTAGAATGTTGCTAAATCGATTCACAATGGCTCACAGGAAGCCAACATATGAAAGAGACGTGGACTTAGGCGCTGGAACAAGACATGTGGCAGTGGAACCAGAGGTAGCCAACCTAGATATCATTGGCCAGAGGATAGAGAATATAAAAAATGAACATAAGTCAACATGGCATTATGATGAGGACAATCCATACAAAACATGGGCCTATCATGGATCATATGAGGTCAAGCCATCAGGATCAGCCTCATCCATGGTCAATGGCGTGGTGAGATTGCTCACCAAACCATGGGATGTTATCCCCATGGTCACACAAATAGCCATGACTGACACCACACCCTTTGGACAACAGAGGGTGTTTAAAGAGAAAGTTGACACGCGCACACCAAAAGCAAAACGAGGCACAGCACAAATTATGGAGGTGACAGCCAGGTGGTTATGGGGTTTCCTTTCTAGAAACAAAAAACCCAGAATCTGCACAAGAGAGGAGTTCACAAGAAAAGTTAGGTCAAACGCAGCTATTGGAGCAGTGTTCGTTGATGAAAATCAATGGAACTCAGCAAAAGAAGCAGTGGAAGACGAACGGTTCTGGGACCTTGTGCACAGAGAGAGGGAGCTTCATAAACAGGGAAAATGTGCCACGTGTGTCTACAATATGATGGGGAAGAGAGAGAAAAAATTAGGAGAGTTCGGAAAGGCAAAAGGAAGTCGTGCAATATGGTACATGTGGTTGGGAGCACGCTTTCTAGAGTTCGAAGCCCTTGGTTTCATGAATGAAGATCACTGGTTCAGTAGAGAGAATTCACTCAGTGGAGTGGAAGGAGAAGGACTCCACAAACTTGGATACATACTCAGAGACATATCAAAGATTCCAGGGGGAAATATGTATGCAGATGACACAGCCGGATGGGACACAAGAATAACAGAGGATGATCTTCAGAATGAGGCTAAAATCACTGACATCATGGAGCCCGAACATGCCCTATTGGCTACGTCAATCTTTAAGCTGACCTACCAAAATAAGGTGGTAAGGGTGCAGAGACCAGCAAAAAATGGAACCGTGATGGATGTTATATCCAGACGTGACCAGAGAGGAAGTGGACAGGTCGGAACTTATGGCTTAAACACTTTCACCAACATGGAGGCCCAACTAATAAGACAAATGGAGTCTGAGGGAATCTTTTTACCCAGCGAATTGGAAACCCCAAATCTAGCCGAAAGAGTTCTCGACTGGTTGGAAAAACATGGCGTCGAAAGGCTGAAAAGAATGGCAATCAGCGGAGATGACTGTGTGGTGAAACCAATTGATGACAGGTTCGCAACAGCCTTAACAGCTTTGAATGACATGGGAAAAGTAAGAAAAGACATACCGCAATGGGAACCTTCAAAAGGATGGAATGATTGGCAACAAGTGCCTTTCTGTTCACACCATTTCCACCAGCTGATTATGAAGGATGGGAGGGAGATAGTGGTGCCATGCCGCAACCAAGATGAACTTGTGGGTAGGGCCAGAGTATCACAAGGCGCCGGATGGAGCCTGAGAGAAACTGCATGCCTAGGCAAGTCATATGCACAAATGTGGCAGCTGATGTACTTCCACAGGAGAGACCTGAGACTAGCGGCTAATGCTATCTGTTCAGCCGTTCCAGTTGATTGGGTCCCAACCAGCCGCACCACCTGGTCGATCCATGCCCATCACCAATGGATGACAACAGAAGACATGTTATCAGTGTGGAATAGGGTTTGGATAGAGGAAAACCCATGGATGGAGGATAAAACTCATGTATCCAGTTGGGAAGATGTTCCATACTTAGGAAAAAGGGAAGATCAGTGGTGTGGATCCCTGATAGGCTTAACAGCAAGGGCCACCTGGGCCACTAACATACAAGTGGCCATAAACCAAGTGAGAAGGCTCATTGGGAATGAGAATTATCTAGATTACATGACATCAATGAAGAGATTCAAGAATGAGAGTGATCCCGAAGGGGCACTCTGGTAAGTCAACACATTCACAAAATAAAGGAAAATAAAAAATCAAACAAGGCAAGAAGTCAGGCCGGATTAAGCCATAGTACGGTAAGAGCTATGCTGCCTGTGAGCCCCGTCCAAGGACGTAAAATGAAGTCAGGCCGAAAGCCACGGTTTGAGCAAACCGTGCTGCCTGTGGCTCCATCGTGGGGATGTAAAAACCCGGGAGGCTGCAACCCATGGAAGCTGTACGCATGGGGTAGCAGACTAGTGGTTAGAGGAGACCCCTCCCAAGACACAACGCAGCAGCGGGGCCCAACACCAGGGGAAGCTGTACCCTGGTGGTAAGGACTAGAGGTTAGAGGAGACCCCCCGCACAACAATAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCTACAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLAYVVIGLLFMILTVAA", "C": "MNNQRKKTGRPSFNMLKRARNRVSTVSQLAKRFSKGLLSGQGPMKLVMAFIAFLRFLAIPPTAGILARWGSFKKNGAIKVLRGFKKEISNMLNIMNRRKRSVTMLLMLLPTALA", "E": "MRCVGIGNRDFVEGLSGATWVDVVLEHGSCVTTMAKNKPTLDIELLKTEVTNPAVLRKLCIEAKISNTTTDSRCPTQGEATLVEEQDANFVCRRTFVDRGWGNGCGLFGKGSLITCAKFKCVTKLEGKIVQYENLKYSVIVTVHTGDQHQVGNETTEHGTTATITPQAPTSEIQLTDYGALTLDCSPRTGLDFNEMVLLTMKEKSWLVHKQWFLDLPLPWTSGASTSQETWNRQDLLVTFKTAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGTTTIFAGHLKCRLKMDKLTLKGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSTQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKGSSIGKMFEATARGARRMAILGDTAWDFGSIGGVFTSVGKLVHQVFGTAYGVLFSGVSWTMKIGIGILLTWLGLNSRSTSLSMTCIAVGMVTLYLGVMVQA", "M": "FHLTTRGGEPHMIVSKQERGKSLLFKTSAGVNMCTLIAMDLGELCEDTMTYKCPRITEAEPDDVDCWCNATDTWVTYGTCSQTGEHRRDKRSVALAPHVGLGLETRTETWMSSEGAWKQIQKVETWALRHPGFTVIALFLAHAIGTSITQKGIIFILLMLVTPSMA", "NS1": "DSGCVINWKGRELKCGSGIFVTNEVHTWTEQYKFQADSPKRLSAAIGKAWEEGVCGIRSATRLENIMWKQISNELNHILLENDMKFTVVVGDVSGILAQGKKMIRPQPMEHKYSWKSWGKAKIIGADVQNTTFIIDGPNTPECPDDQRAWNIWEVEDYGFGIFTTNIWLKLRDSYTQVCDHRLMSAAIKDSKAVHADMGYWIESEKNETWKLARASFIEVKTCIWPKSHTLWSNGVLESEMIIPKIYGGPISQHNYRPGYFTQTAGPWHLGKLELDFDLCEGTTVVVDEHCGNRGPSLRTTTVTGKIIHEWCCRSCTLPPLRFKGEDGCWYGMEIRPVKEKEENLVKSMVSA", "NS2A": "GSGEVDSFSLGLLCISIMIEEVMRSRWSRKMLMTGTLAVFLLLIMGQLTWNDLIRLCIMVGANASDRMGMGTTYLALMATFKMRPMFAVGLLFRRLTSREVLLLTIGLSLVASVELPNSLEELGDGLAMGIMMLKLLTDFQSHQLWATLLSLTFIKTTFSLHYAWKTMAMVLSIVSLFPLCLSTTSQKTTWLPVLLGSLGCKPLTMFLITENKIWGRK", "NS2B": "SWPLNEGIMAVGIVSILLSSLLKNDVPLAGPLIAGGMLIACYVISGSSADLSLEKAAEVSWEEEAEHSGASHNILVEVQDDGTMKIKDEERDDTLTILLKATLLAVSGVYPMSIPATLFVWYFWQKKKQR", "NS3": "SGVLWDTPSPPEVERAVLDDGIYRILQRGLLGRSQVGVGVFQEGVFHTMWHVTRGAVLMYQGKRLEPSWASVKKDLISYGGGWRFQGSWNTGEEVQVIAVEPGKNPKNVQTAPGTFKTPEGEVGAIALDFKPGTSGSPIVNREGKIVGLYGNGVVTTSGTYVSAIAQAKASQEGPLPEIEDEVFRKRNLTIMDLHPGSGKTRRYLPAIVREAIKRKLRTLILAPTRVVASEMAEALKGMPIRYQTTAVKSEHTGKEIVDLMCHATFTMRLLSPVRVPNYNMIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGSVEAFPQSNAVIQDEERDIPERSWNSGYDWITDFPGKTVWFVPSIKSGNDIANCLRKNGKRVIQLSRKTFDTEYQKTKNNDWDYVVTTDISEMGANFRADRVIDPRRCLKPVILKDGPERVILAGPMPVTVASAAQRRGRIGRNQNKEGDQYIYMGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLRGEARKTFVELMRRGDLPVWLSYKVASEGFQYSDRRWCFDGERNNQVLEENMDVEIWTKEGERKKLRPRWLDARTYSDPLALREFKEFAAGRR", "NS4A": "SVSGDLILEIGKLPQHLTQRAQNALDNLVMLHNSEQGGKAYRHAMEELPDTIETLMLLALIAVLTGGVTLFFLSGRGLGKTSIGLLCVMASSVLLWMASVEPHWIAASIILEFFLMVLLIPEPDRQR", "NS4B": "NEMGLLETTKKDLGIGHVAAENHHHATMLDVDLHPASAWTLYAVATTIITPMMRHTIENTTANISLTAIANQAAILMGLDKGWPISKMDIGVPLLALGCYSQVNPLTLTAAVLMLVAHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIVAIDLDPVVYDAKFEKQLGQIMLLILCTSQILLMRTTWALCESITLATGPLTTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFSLMKSLGGGRR", "NS5": 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"AGTTGTTAGTCTACGTGGACCGACAAAGACAGATTCTTTGAGGGAGCTAAGCTCAACGTAGTTCTAACAGTTTTTTGATTAGAGAGCAGATCTCTGATGAATAACCAACGGAAAAAGGCGAGAAATACGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTGTCGACTGTACAACAGCTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGACGAGGACCATTAAAACTGTTCATGGCCCTGGTGGCGTTCCTTCGTTTCCTAACAATCCCACCAACAGCAGGGATACTGAAAAGATGGGGAACAATCAAAAAATCAAAGGCTATCAATGTCCTGAGAGGGTTCAGGAAAGAGATTGGAAGGATGCTGAACATCTTGAACAGGAGACGCAGAACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTCCATTTGACCACACGCAACGGAGAACCACACATGATTGTCAGTAGACAAGAGAAAGGGAAAAGCCTTCTGTTTAAAACAGAGGATGGTATGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAAGACACAATCACGTACAAGTGTCCTTTTCTCAGGCAGAACGAACCAGAAGACATAGATTGTTGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCACAGAAGAGAAAAAAGATCAGTGGCACTTGTTCCACACGTGGGAATGGGACTGGAGACACGAACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGGATTCTGAGACATCCAGGCTTTACCATAATGGCAGCAATCCTGGCATACACCATAGGAACGACACATTTCCAAAGAGTCCTGATTTTCATCTTACTGACAGCCGTCGCTCCTTCAATGACAATGCGCTGCATAGGAATATCAAATAGAGACTTTGTGGAAGGAGTTTCAGGAGGAAGCTGGGTTGACATAGTCTTAGAACATGGAAGCTGTGTGACGACGATGGCAAAAAACAAACCAACATTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCTGCCACTCTAAGGAAGTACTGTATAGAGGCTAAACTGACCAACACAACAACAGAATCTCGCTGCCCAACACAAGGGGAACCCAGCCTAAATGAAGAGCAGGACAAAAGGTTCGTCTGCAAACACTCCATGGTAGACAGAGGATGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATTGTGACCTGTGCTATGTTCACATGCAAAAAGAACATGGAAGGAAAAGTTGTGCAGCCAGAAAACTTGGAATACACCATTGTGATAACACCTCACTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGCAAGGAAGTCAAGATAACACCACAGAGCTCCATCACAGAAGCAGAACTGACAGGCTATGGCACTGTCACGATGGAGTGCTCTCCGAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAAATGGAAAACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTACCATGGCTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACATTGGTCACTTTCAAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATGCACACAGCACTCACAGGGGCCACAGAAATCCAGATGTCATCAGGAAACTTACTGTTCACAGGACATCTCAAGTGCAGGCTGAGAATGGACAAACTACAGCTCAAAGGGATGTCATACTCTATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATAGTCATCAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGATCCCTTTTGAGATAATGGATTTGGAAAAAAGACATGTCTTAGGTCGCCTGATCACAGTCAACCCAATTGTAACAGAAAAAGACAGCCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATAGGAGTGGAACCAGGACAATTGAAGCTCAACTGGTTTAAGAAAGGAAGTTCTATCGGCCAAATGTTTGAGACAACAATGAGAGGAGCGAAAAGAATGGCCATTTTGGGTGACACAGCCTGGGATTTTGGATCCCTGGGAGGAGTGTTCACATCTATAGGAAAGGCTCTCCACCAAGTTTTTGGAGCAATCTATGGGGCTGCCTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGAGTTATCATCACATGGATAGGAATGAATTCACGCAGCACCTCACTGTCTGTGTCACTAGTATTAGTGGGAATCGTGACACTATACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTTGTGAGCTGGAAGAACAAAGAACTGAAATGTGGCAGTGGGATTTTCGTCACAGACAACGTGCACACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCCATCCAGAAAGCTCATGAAGAGGGCATTTGTGGAATCCGCTCAGTAACAAGACTGGAGAATCTGATGTGGAAACAGATAACACCAGAATTGAATCACATTCTATCAGAAAATGAAGTAAAGCTGACCATCATGACAGGAGACATTAAAGGAATCATGCAGGCAGGAAAACGATCTCTGCGGCCCCAACCCACTGAGCTGAGGTATTCATGGAAAACATGGGGCAAAGCGAAAATGCTCTCCACAGAGCTCCATAATCAGACCTTTCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAACACAAACAGAGCTTGGAATTCACTGGAAGTTGAGGACTATGGCTTTGGAGTATTCACCACCAATATATGGCTAAAATTGAGAGAAAAGCAGGATGTATTTTGTGACTCAAAACTCATGTCAGCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCACTCAATGACACATGGAAGATAGAGAAAGCCTCTTTCATTGAAGTTAAAAGCTGCCACTGGCCAAAGTCACACACCCTCTGGAGTAATGGAGTGCTAGAAAGTGAGATGATAATTCCAAAGAATTTCGCTGGACCAGTGTCACAACACAACTACAGACCAGGCTATTACACACAAACAGCAGGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGAACTACAGTGGTGGTGACCGAGGACTGTGGAAACAGAGGACCCTCTTTAAGAACAACCACTGCCTCTGGAAAACTCATAACAGAATGGTGCTGCCGATCTTGCACATTACCACCGCTAAGATACAGAGGTGAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAGAATCTGGTCAACTCTTTGGTCACAGCCGGACATGGGCAGATTGACAACTTTTCACTAGGAATCTTGGGAATGGCATTGTTCCTGGAAGAAATGCTCAGGACCCGAGTAGGAACGAAACATGCAATACTACTAGTTGCAGTTTCTTTCGTGACATTGATCACAGGGAACATGTCCTTTAGAGACCTGGGAAGAGTGATGGTTATGGTGGGCGCTACCATGACGGATGACATAGGTATGGGCGTGACTTATCTTGCCCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTGAGAAAACTGACCTCCAAGGAATTGATGATGACCACCATAGGAATCGTTCTCCTCTCCCAGAGTAGCATACCAGAGACCATTCTTGAACTGACTGATGCGTTAGCCTTGGGCATGATGGTCCTCAAAATAGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATCTTATGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCAGTGGTGTCTGTTTCCCCACTGCTCTTAACATCCTCACAACAGAAAGCGGATTGGATACCATTAGCATTGACGATCAAAGGTCTCAATCCAACAGCCATTTTTCTAACAACCCTTTCAAGAACCAGCAAGAAAAGGAGCTGGCCTCTAAATGAGGCTATCATGGCAGTTGGGATGGTGAGCATTTTAGCCAGTTCTCTCTTAAAGAATGACATTCCCATGACAGGACCATTAGTGGCTGGAGGGCTCCTCACTGTGTGCTACGTGCTCACTGGACGATCGGCCGATTTGGAACTGGAGAGAGCCGCCGATGTCAAATGGGAAGATCAGGCAGAGATATCAGGGAGCAGTCCAATTCTGTCAATAACAATATCAGAAGATGGTAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACACTGACCATACTCATTAGAACAGGATTGCTGGTGATCTCAGGACTTTTTCCGGTATCAATACCAATCACAGCAGCAGCATGGTACCTGTGGGAAGTGAAGAAACAACGGGCTGGAGTGTTGTGGGATGTCCCTTCACCCCCACCCGTGGGAAAGGCTGAACTGGAAGATGGAGCCTACAGAATCAAGCAAAAAGGGATTCTTGGATATTCCCAGATCGGAGCCGGAGTTTACAAAGAAGGAACATTCCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAAGGGAAGAGGATTGAACCATCATGGGCGGACGTCAAGAAAGACCTAATATCATATGGAGGAGGCTGGAAGCTAGAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGAAAAAATCCAAGAGCCGTCCAAACAAAACCTGGCCTTTTCAAAACCAACACCGGAACCATAGGTGCCGTATCTCTGGACTTTTCCCCTGGAACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAAGTTGTGGGTCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATAGCCCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAGAAAAGATTGACCATCATGGACCTCCACCCAGGAGCGGGAAAGACAAAGAGATACCTCCCAGCCATAGTCAGAGAAGCCATAAAAAGAGGCTTGAGAACACTAATCCTGGCCCCCACTAGAGTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACCCCAGCCATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACCTAATGTGTCATGCCACATTTACCATGAGGCTGCTATCACCAATTAGGGTGCCAAATTACAACCTGATCATCATGGACGAAGCCCATTTCACAGACCCAGCAAGCATAGCAGCTAGAGGATACATCTCAACTCGAGTAGAGATGGGTGAAGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGACCCATTTCCTCAGAGCAATGCACCAATCATGGACGAAGAAAGAGAAATTCCTGAACGTTCGTGGAATTCCGGACATGAGTGGGTCACGGATTTTAAAGGGAAGACTGTTTGGTTTGTTCCAAGCATAAAAGCCGGAAATGACATAGCAGCCTGCCTGAGAAAAAATGGAAAGAGAGTGATACAACTCAGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGACTTCGTGGTCACAACTGACATCTCGGAAATGGGTGCCAACTTCAAAGCTGAGAGGGTTATAGACCCCAGACGCTGCATGAAACCAGTTATACTGACAGATGGTGAAGAGCGGGTGATCCTGGCAGGACCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCAAAAAATGAAAATGACCAATACATATACATGGGGGAACCTCTGGAAAATGATGAAGACTGTGCACACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATTCCTAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATACCGCTTGAGAGGAGAAGCAAGGAAAACCTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGGTTGGCTTACAAAGTGGCAGCTGAAGGCATCAACTACGCAGACAGAAGGTGGTGTTTTGATGGAATCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAAGAAGGGGAAAGGAAGAAATTAAAACCCAGATGGTTGGATGCTAGGATCTATTCTGACCCACTGGCGCTAAAAGAATTCAAGGAATTTGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATGGGTAGGCTCCCAACTTTCATGACTCAGAAGGCAAGAGATGCACTGGACAACTTAGCAGTGCTGCACACGGCTGAAGCAGGTGGAAGGGCATACAATCATGCTCTCAGTGAACTGCCGGAGACCCTGGAGACATTGCTTTTGCTGACACTTTTGGCCACAGTCACGGGAGGAATCTTTCTATTCTTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACGGCCAGCATCCTCCTATGGTACGCACAAATACAGCCACATTGGATAGCAGCTTCAATAATACTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGAACACCCCAGGATAACCAATTGACCTATGTTGTCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCAAACGAGATGGGTTTCCTGGAAAAAACAAAGAAAGACCTCGGATTGGGAAGCATTGCAACCCAGCAACCCGAGAGCAACATCCTGGACATAGATCTACGTCCTGCATCAGCATGGACGCTGTATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCAGTGAATGTGTCCCTAACAGCCATTGCCAACCAAGCCACAGTGCTAATGGGTCTTGGGAAAGGATGGCCATTGTCAAAGATGGACATCGGAGTTCCCCTTCTCGCCATTGGATGCTACTCACAAGTCAACCCCATAACCCTCACAGCAGCTCTTCTTTTATTGGTAGCACATTATGCCATCATAGGACCAGGACTCCAAGCAAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGCATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATTGACCTAGATCCAATACCCTATGATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGCGTGACTCAAGTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACCCTAGCAACCGGGCCCATATCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCAATGGCTAACATTTTTAGAGGGAGTTACTTGGCCGGAGCTGGACTTCTCTTTTCCATCATGAAGAACACAACCAGCACAAGAAGAGGAACTGGCAACATAGGAGAGACGCTAGGAGAGAAATGGAAAAGCCGACTGAACGCATTGGGGAAAAGTGAATTCCAGATCTACAAGAAAAGTGGAATCCAGGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGACCATCACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTCGAAAGAAATATGGTCACACCAGAAGGGAAAGTAGTGGACCTTGGTTGTGGCAGAGGGGGCTGGTCATACTATTGTGGAGGACTAAAGAATGTAAGAGAAGTCAAAGGCCTAACAAAAGGAGGACCAGGACACGAAGAACCCATCCCCATGTCAACATATGGGTGGAATCTAGTGCGTCTTCAGAGTGGAGTTGACGTTTTCTTCACTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAGTCGTCACCAAATCCCACGGTAGAAGCAGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGCTGAACAACAACACCCAATTTTGCATAAAGGTTCTCAACCCATACATGCCCTCAGTCATAGAAAAAATGGAAGCACTACAAAGGAAATATGGAGGAGCCTTGGTGAGAAATCCACTCTCACGGAATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTGAACATGATTTCAAGGATGTTGATTAACAGATTCACAATGAGACACAAGAAAGCCACTTACGAGCCAGATGTTGACCTCGGAAGCGGAACCCGCAACATTGGAATTGAAAGTGAGACACCAAACCTAGACATAATTGGAAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGGCACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAACAGACTGGATCAGCATCATCCATGGTGAACGGAGTGGTCAGACTGCTGACAAAACCCTGGGACGTCGTTCCCATGGTGACACAGATGGCAATGACAGACACAACTCCTTTTGGACAACAGCGCGTTTTCAAAGAGAAAGTGGACACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAACTAATGAAAATCACGGCAGAGTGGCTTTGGAAAGAACTAGGAAAGAAAAAGACACCTAGGATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATATTCACTGATGAGAACAAGTGGAAGTCGGCACGTGAGGCTGTTGAAGATGGTAGGTTTTGGGAGCTGGTTGACAAGGAAAGGAATCTCCATCTTGAAGGAAAGTGTGAAACATGTGTGTACAACATGATGGGAAAAAGAGAGAAGAAACTAGGAGAGTTTGGCAAAGCAAAAGGCAGCAGAGCCATATGGTACATGTGGCTTGGAGCACGCTTCTTAGAGTTTGAAGCCCTAGGATTCTTGAATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTGGAAGGAGAAGGGCTGCACAAGCTAGGTTACATCTTAAGAGACGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCCGATGACACCGCAGGCTGGGACACAAGAATCACACTAGAGGACTTAAAAAATGAAGAAATGATAACAAACCACATGGAAGGAGAACACAAGAAACTTGCCGAGGCCATTTTCAAATTAACGTACCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGATATCATATCGAGAAGAGACCAAAGAGGTAGTGGACAAGTTGGCACCTATGGCCTCAATACTTTCACCAATATGGAAGCACAACTAATCAGGCAGATGGAGGGGGAAGGAATCTTCAAAAGCATCCAGCACTTGACAGCCACAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTGGGGCGTGAAAGGTTATCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTCTAGATGACAGGTTTGCAAGAGCTTTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAAGACATACAACAATGGGAACCCTCAAGAGGATGGAACGATTGGACACAAGTGCCCTTCTGTTCACACCATTTCCATGAGTTAATCATGAAAGATGGTCGCACACTCGTAGTTCCATGTAGAAACCAAGATGAACTGATTGGTAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTGCGGGAGACGGCCTGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTCAGGCTGGCGGCAAATGCCATTTGCTCGGCAGTCCCATCACATTGGGTTCCAACAAGCCGGACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTCTGGAACAGGGTGTGGATCCAAGAAAACCCATGGATGGAAGACAAAACTCCAGTGGAATCATGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGGCTAACAAGCAGGGCCACCTGGGCAAAGAACATCCAAACAGCAATAAATCAAGTCAGATCCCTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAAGAGGAAGAGGCAGGAGTCCTGTGGTAGAAGACAGAACTAACATGAAACAAGGCTAGAAGTCAGGTCGGATTAAGCCATAGTACGGAAAAAACTATGCTACCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGTCAGGCCATCACAAATGCCATAGCTTGAGCAAACTGTGCAGCCTGTAGCTCCACCTGAGAAGGTGTAAAAAATCCGGGAGGCCACAAACCATGGAAGCTGTACGCATGGCGTAGTGGACTAGCGGTTAGAGGAGACCCCTCCCTTACAAATCGCAGCAACAATGGGGGCCCAAGGTGAGATGAAGCTGTAGTCTCACTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAAAACAAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLTYVVIAILTVVAATMA", "C": "MNNQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIPPTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMA", "E": "MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA", "M": "FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGMNMCTLMAMDLGELCEDTITYKCPFLRQNEPEDIDCWCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETWILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSMT", "NS1": "DSGCVVSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQPTELRYSWKTWGKAKMLSTELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLKLREKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMIIPKNFAGPVSQHNYRPGYYTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTA", "NS2A": "GHGQIDNFSLGILGMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVTYLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMVLKIVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLLLTSSQQKADWIPLALTIKGLNPTAIFLTTLSRTSKKR", "NS2B": "SWPLNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR", "NS3": "AGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGLFKTNTGTIGAVSLDFSPGTSGSPIVDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRKKRLTIMDLHPGAGKTKRYLPAIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATFTMRLLSPIRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPFPQSNAPIMDEEREIPERSWNSGHEWVTDFKGKTVWFVPSIKAGNDIAACLRKNGKRVIQLSRKTFDSEYVKTRTNDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAGPMPVTHSSAAQRRGRIGRNPKNENDQYIYMGEPLENDEDCAHWKEAKMLLDNINTPEGIIPSMFEPEREKVDAIDGEYRLRGEARKTFVDLMRRGDLPVWLAYKVAAEGINYADRRWCFDGIRNNQILEENVEVEIWTKEGERKKLKPRWLDARIYSDPLALKEFKEFAAGRK", "NS4A": "SLTLNLITEMGRLPTFMTQKARDALDNLAVLHTAEAGGRAYNHALSELPETLETLLLLTLLATVTGGIFLFLMSGRGIGKMTLGMCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQR", "NS4B": "NEMGFLEKTKKDLGLGSIATQQPESNILDIDLRPASAWTLYAVATTFITPMLRHSIENSSVNVSLTAIANQATVLMGLGKGWPLSKMDIGVPLLAIGCYSQVNPITLTAALLLLVAHYAIIGPGLQAKATREAQKRAAAGIMKNPTVDGITVIDLDPIPYDPKFEKQLGQVMLLVLCVTQVLMMRTTWALCEALTLATGPISTLWEGNPGRFWNTTIAVSMANIFRGSYLAGAGLLFSIMKNTTSTRR", "NS5": "GTGNIGETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNMVTPEGKVVDLGCGRGGWSYYCGGLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVEAGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALVRNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTKKVRSNAALGAIFTDENKWKSAREAVEDGRFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMITNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGIFKSIQHLTATEEIAVQDWLARVGRERLSRMAISGDDCVVKPLDDRFARALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRTLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHASHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW", "pr": "FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGMNMCTLMAMDLGELCEDTITYKCPFLRQNEPEDIDCWCNSTSTWVTYGTCTTTGEHRREKR"}} \ No newline at end of file +{"version": "v2", "meta": {"title": "Real-time tracking of dengue virus evolution", "updated": "2024-06-10", "build_url": "https://github.com/nextstrain/dengue", "maintainers": [{"name": "the Nextstrain team", "url": "https://nextstrain.org/team"}], "display_defaults": {"map_triplicate": true, "color_by": "clade_membership"}, "genome_annotations": {"nuc": {"end": 10723, "start": 1, "strand": "+", "type": "##sequence-region pragma", "seqid": "resources/denv2/genome_annotation.gff3"}, "2K": {"end": 6825, "seqid": "resources/denv2/genome_annotation.gff3", "start": 6757, "strand": "+", "type": "gene"}, "C": {"end": 438, "seqid": "resources/denv2/genome_annotation.gff3", "start": 97, "strand": "+", "type": "gene"}, "E": {"end": 2421, "seqid": "resources/denv2/genome_annotation.gff3", "start": 937, "strand": "+", "type": "gene"}, "M": {"end": 936, "seqid": 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{"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["C55A", "A63T", "G122A", "G1278A", "T2274C", "T2685C", "T5994C", "T8451C", "C10236T", "A10587T"], "C": ["R9K"]}, "labels": {"aa": "C: R9K"}}}]}, {"name": "NODE_0002533", "node_attrs": {"div": 962, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 0.9999999876516448}, "entropy": 2.4228280119466333e-07}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 0.9999996427645026}, "entropy": 7.0803071278859794e-06}, "region": {"value": "North America", "confidence": {"North America": 0.9999922721522355}, "entropy": 0.00010615104596121185}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["A1242G", "T3042C", "A3423G"]}}, "children": [{"name": "NI/DB295/2018_2018", "node_attrs": {"div": 964, "genbank_accession": {"value": "OQ144226"}, "author": {"author": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L.", "value": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L."}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 1.0}, "entropy": -1.000088900581841e-12}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 1.0}, "entropy": -1.000088900581841e-12}, "region": {"value": "North America", "confidence": {"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["T5010C", "G9136A"], "NS5": ["G523S"]}, "labels": {"aa": "NS5: G523S"}}}, {"name": "NI/DB311/2018_2018", "node_attrs": {"div": 963, "genbank_accession": {"value": "OQ144242"}, "author": {"author": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L.", "value": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L."}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 1.0}, "entropy": -1.000088900581841e-12}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 1.0}, "entropy": -1.000088900581841e-12}, "region": {"value": "North America", "confidence": {"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["A3969G"]}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}, "root_sequence": {"nuc": "AGTTGTTAGTCTACGTGGACCGACAAAGACAGATTCTTTGAGGGAGCTAAGCTCAACGTAGTTCTAACAGTTTTTTGATTAGAGAGCAGATCTCTGATGAATAACCAACGGAAAAAGGCGAGAAATACGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTGTCGACTGTACAACAGCTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGACGAGGACCATTAAAACTGTTCATGGCCCTGGTGGCGTTCCTTCGTTTCCTAACAATCCCACCAACAGCAGGGATACTGAAAAGATGGGGAACAATCAAAAAATCAAAGGCTATCAATGTCCTGAGAGGGTTCAGGAAAGAGATTGGAAGGATGCTGAACATCTTGAACAGGAGACGCAGAACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTCCATTTGACCACACGCAACGGAGAACCACACATGATTGTCAGTAGACAAGAGAAAGGGAAAAGCCTTCTGTTTAAAACAGAGGATGGTATGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAAGACACAATCACGTACAAGTGTCCTTTTCTCAGGCAGAACGAACCAGAAGACATAGATTGTTGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCACAGAAGAGAAAAAAGATCAGTGGCACTTGTTCCACACGTGGGAATGGGACTGGAGACACGAACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGGATTCTGAGACATCCAGGCTTTACCATAATGGCAGCAATCCTGGCATACACCATAGGAACGACACATTTCCAAAGAGTCCTGATTTTCATCTTACTGACAGCCGTCGCTCCTTCAATGACAATGCGCTGCATAGGAATATCAAATAGAGACTTTGTGGAAGGAGTTTCAGGAGGAAGCTGGGTTGACATAGTCTTAGAACATGGAAGCTGTGTGACGACGATGGCAAAAAACAAACCAACATTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCTGCCACTCTAAGGAAGTACTGTATAGAGGCTAAACTGACCAACACAACAACAGAATCTCGCTGCCCAACACAAGGGGAACCCAGCCTAAATGAAGAGCAGGACAAAAGGTTCGTCTGCAAACACTCCATGGTAGACAGAGGATGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATTGTGACCTGTGCTATGTTCACATGCAAAAAGAACATGGAAGGAAAAGTTGTGCAGCCAGAAAACTTGGAATACACCATTGTGATAACACCTCACTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGCAAGGAAGTCAAGATAACACCACAGAGCTCCATCACAGAAGCAGAACTGACAGGCTATGGCACTGTCACGATGGAGTGCTCTCCGAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAAATGGAAAACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTACCATGGCTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACATTGGTCACTTTCAAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATGCACACAGCACTCACAGGGGCCACAGAAATCCAGATGTCATCAGGAAACTTACTGTTCACAGGACATCTCAAGTGCAGGCTGAGAATGGACAAACTACAGCTCAAAGGGATGTCATACTCTATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATAGTCATCAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGATCCCTTTTGAGATAATGGATTTGGAAAAAAGACATGTCTTAGGTCGCCTGATCACAGTCAACCCAATTGTAACAGAAAAAGACAGCCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATAGGAGTGGAACCAGGACAATTGAAGCTCAACTGGTTTAAGAAAGGAAGTTCTATCGGCCAAATGTTTGAGACAACAATGAGAGGAGCGAAAAGAATGGCCATTTTGGGTGACACAGCCTGGGATTTTGGATCCCTGGGAGGAGTGTTCACATCTATAGGAAAGGCTCTCCACCAAGTTTTTGGAGCAATCTATGGGGCTGCCTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGAGTTATCATCACATGGATAGGAATGAATTCACGCAGCACCTCACTGTCTGTGTCACTAGTATTAGTGGGAATCGTGACACTATACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTTGTGAGCTGGAAGAACAAAGAACTGAAATGTGGCAGTGGGATTTTCGTCACAGACAACGTGCACACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCCATCCAGAAAGCTCATGAAGAGGGCATTTGTGGAATCCGCTCAGTAACAAGACTGGAGAATCTGATGTGGAAACAGATAACACCAGAATTGAATCACATTCTATCAGAAAATGAAGTAAAGCTGACCATCATGACAGGAGACATTAAAGGAATCATGCAGGCAGGAAAACGATCTCTGCGGCCCCAACCCACTGAGCTGAGGTATTCATGGAAAACATGGGGCAAAGCGAAAATGCTCTCCACAGAGCTCCATAATCAGACCTTTCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAACACAAACAGAGCTTGGAATTCACTGGAAGTTGAGGACTATGGCTTTGGAGTATTCACCACCAATATATGGCTAAAATTGAGAGAAAAGCAGGATGTATTTTGTGACTCAAAACTCATGTCAGCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCACTCAATGACACATGGAAGATAGAGAAAGCCTCTTTCATTGAAGTTAAAAGCTGCCACTGGCCAAAGTCACACACCCTCTGGAGTAATGGAGTGCTAGAAAGTGAGATGATAATTCCAAAGAATTTCGCTGGACCAGTGTCACAACACAACTACAGACCAGGCTATTACACACAAACAGCAGGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGAACTACAGTGGTGGTGACCGAGGACTGTGGAAACAGAGGACCCTCTTTAAGAACAACCACTGCCTCTGGAAAACTCATAACAGAATGGTGCTGCCGATCTTGCACATTACCACCGCTAAGATACAGAGGTGAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAGAATCTGGTCAACTCTTTGGTCACAGCCGGACATGGGCAGATTGACAACTTTTCACTAGGAATCTTGGGAATGGCATTGTTCCTGGAAGAAATGCTCAGGACCCGAGTAGGAACGAAACATGCAATACTACTAGTTGCAGTTTCTTTCGTGACATTGATCACAGGGAACATGTCCTTTAGAGACCTGGGAAGAGTGATGGTTATGGTGGGCGCTACCATGACGGATGACATAGGTATGGGCGTGACTTATCTTGCCCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTGAGAAAACTGACCTCCAAGGAATTGATGATGACCACCATAGGAATCGTTCTCCTCTCCCAGAGTAGCATACCAGAGACCATTCTTGAACTGACTGATGCGTTAGCCTTGGGCATGATGGTCCTCAAAATAGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATCTTATGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCAGTGGTGTCTGTTTCCCCACTGCTCTTAACATCCTCACAACAGAAAGCGGATTGGATACCATTAGCATTGACGATCAAAGGTCTCAATCCAACAGCCATTTTTCTAACAACCCTTTCAAGAACCAGCAAGAAAAGGAGCTGGCCTCTAAATGAGGCTATCATGGCAGTTGGGATGGTGAGCATTTTAGCCAGTTCTCTCTTAAAGAATGACATTCCCATGACAGGACCATTAGTGGCTGGAGGGCTCCTCACTGTGTGCTACGTGCTCACTGGACGATCGGCCGATTTGGAACTGGAGAGAGCCGCCGATGTCAAATGGGAAGATCAGGCAGAGATATCAGGGAGCAGTCCAATTCTGTCAATAACAATATCAGAAGATGGTAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACACTGACCATACTCATTAGAACAGGATTGCTGGTGATCTCAGGACTTTTTCCGGTATCAATACCAATCACAGCAGCAGCATGGTACCTGTGGGAAGTGAAGAAACAACGGGCTGGAGTGTTGTGGGATGTCCCTTCACCCCCACCCGTGGGAAAGGCTGAACTGGAAGATGGAGCCTACAGAATCAAGCAAAAAGGGATTCTTGGATATTCCCAGATCGGAGCCGGAGTTTACAAAGAAGGAACATTCCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAAGGGAAGAGGATTGAACCATCATGGGCGGACGTCAAGAAAGACCTAATATCATATGGAGGAGGCTGGAAGCTAGAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGAAAAAATCCAAGAGCCGTCCAAACAAAACCTGGCCTTTTCAAAACCAACACCGGAACCATAGGTGCCGTATCTCTGGACTTTTCCCCTGGAACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAAGTTGTGGGTCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATAGCCCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAGAAAAGATTGACCATCATGGACCTCCACCCAGGAGCGGGAAAGACAAAGAGATACCTCCCAGCCATAGTCAGAGAAGCCATAAAAAGAGGCTTGAGAACACTAATCCTGGCCCCCACTAGAGTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACCCCAGCCATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACCTAATGTGTCATGCCACATTTACCATGAGGCTGCTATCACCAATTAGGGTGCCAAATTACAACCTGATCATCATGGACGAAGCCCATTTCACAGACCCAGCAAGCATAGCAGCTAGAGGATACATCTCAACTCGAGTAGAGATGGGTGAAGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGACCCATTTCCTCAGAGCAATGCACCAATCATGGACGAAGAAAGAGAAATTCCTGAACGTTCGTGGAATTCCGGACATGAGTGGGTCACGGATTTTAAAGGGAAGACTGTTTGGTTTGTTCCAAGCATAAAAGCCGGAAATGACATAGCAGCCTGCCTGAGAAAAAATGGAAAGAGAGTGATACAACTCAGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGACTTCGTGGTCACAACTGACATCTCGGAAATGGGTGCCAACTTCAAAGCTGAGAGGGTTATAGACCCCAGACGCTGCATGAAACCAGTTATACTGACAGATGGTGAAGAGCGGGTGATCCTGGCAGGACCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCAAAAAATGAAAATGACCAATACATATACATGGGGGAACCTCTGGAAAATGATGAAGACTGTGCACACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATTCCTAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATACCGCTTGAGAGGAGAAGCAAGGAAAACCTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGGTTGGCTTACAAAGTGGCAGCTGAAGGCATCAACTACGCAGACAGAAGGTGGTGTTTTGATGGAATCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAAGAAGGGGAAAGGAAGAAATTAAAACCCAGATGGTTGGATGCTAGGATCTATTCTGACCCACTGGCGCTAAAAGAATTCAAGGAATTTGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATGGGTAGGCTCCCAACTTTCATGACTCAGAAGGCAAGAGATGCACTGGACAACTTAGCAGTGCTGCACACGGCTGAAGCAGGTGGAAGGGCATACAATCATGCTCTCAGTGAACTGCCGGAGACCCTGGAGACATTGCTTTTGCTGACACTTTTGGCCACAGTCACGGGAGGAATCTTTCTATTCTTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACGGCCAGCATCCTCCTATGGTACGCACAAATACAGCCACATTGGATAGCAGCTTCAATAATACTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGAACACCCCAGGATAACCAATTGACCTATGTTGTCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCAAACGAGATGGGTTTCCTGGAAAAAACAAAGAAAGACCTCGGATTGGGAAGCATTGCAACCCAGCAACCCGAGAGCAACATCCTGGACATAGATCTACGTCCTGCATCAGCATGGACGCTGTATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCAGTGAATGTGTCCCTAACAGCCATTGCCAACCAAGCCACAGTGCTAATGGGTCTTGGGAAAGGATGGCCATTGTCAAAGATGGACATCGGAGTTCCCCTTCTCGCCATTGGATGCTACTCACAAGTCAACCCCATAACCCTCACAGCAGCTCTTCTTTTATTGGTAGCACATTATGCCATCATAGGACCAGGACTCCAAGCAAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGCATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATTGACCTAGATCCAATACCCTATGATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGCGTGACTCAAGTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACCCTAGCAACCGGGCCCATATCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCAATGGCTAACATTTTTAGAGGGAGTTACTTGGCCGGAGCTGGACTTCTCTTTTCCATCATGAAGAACACAACCAGCACAAGAAGAGGAACTGGCAACATAGGAGAGACGCTAGGAGAGAAATGGAAAAGCCGACTGAACGCATTGGGGAAAAGTGAATTCCAGATCTACAAGAAAAGTGGAATCCAGGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGACCATCACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTCGAAAGAAATATGGTCACACCAGAAGGGAAAGTAGTGGACCTTGGTTGTGGCAGAGGGGGCTGGTCATACTATTGTGGAGGACTAAAGAATGTAAGAGAAGTCAAAGGCCTAACAAAAGGAGGACCAGGACACGAAGAACCCATCCCCATGTCAACATATGGGTGGAATCTAGTGCGTCTTCAGAGTGGAGTTGACGTTTTCTTCACTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAGTCGTCACCAAATCCCACGGTAGAAGCAGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGCTGAACAACAACACCCAATTTTGCATAAAGGTTCTCAACCCATACATGCCCTCAGTCATAGAAAAAATGGAAGCACTACAAAGGAAATATGGAGGAGCCTTGGTGAGAAATCCACTCTCACGGAATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTGAACATGATTTCAAGGATGTTGATTAACAGATTCACAATGAGACACAAGAAAGCCACTTACGAGCCAGATGTTGACCTCGGAAGCGGAACCCGCAACATTGGAATTGAAAGTGAGACACCAAACCTAGACATAATTGGAAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGGCACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAACAGACTGGATCAGCATCATCCATGGTGAACGGAGTGGTCAGACTGCTGACAAAACCCTGGGACGTCGTTCCCATGGTGACACAGATGGCAATGACAGACACAACTCCTTTTGGACAACAGCGCGTTTTCAAAGAGAAAGTGGACACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAACTAATGAAAATCACGGCAGAGTGGCTTTGGAAAGAACTAGGAAAGAAAAAGACACCTAGGATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATATTCACTGATGAGAACAAGTGGAAGTCGGCACGTGAGGCTGTTGAAGATGGTAGGTTTTGGGAGCTGGTTGACAAGGAAAGGAATCTCCATCTTGAAGGAAAGTGTGAAACATGTGTGTACAACATGATGGGAAAAAGAGAGAAGAAACTAGGAGAGTTTGGCAAAGCAAAAGGCAGCAGAGCCATATGGTACATGTGGCTTGGAGCACGCTTCTTAGAGTTTGAAGCCCTAGGATTCTTGAATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTGGAAGGAGAAGGGCTGCACAAGCTAGGTTACATCTTAAGAGACGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCCGATGACACCGCAGGCTGGGACACAAGAATCACACTAGAGGACTTAAAAAATGAAGAAATGATAACAAACCACATGGAAGGAGAACACAAGAAACTTGCCGAGGCCATTTTCAAATTAACGTACCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGATATCATATCGAGAAGAGACCAAAGAGGTAGTGGACAAGTTGGCACCTATGGCCTCAATACTTTCACCAATATGGAAGCACAACTAATCAGGCAGATGGAGGGGGAAGGAATCTTCAAAAGCATCCAGCACTTGACAGCCACAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTGGGGCGTGAAAGGTTATCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTCTAGATGACAGGTTTGCAAGAGCTTTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAAGACATACAACAATGGGAACCCTCAAGAGGATGGAACGATTGGACACAAGTGCCCTTCTGTTCACACCATTTCCATGAGTTAATCATGAAAGATGGTCGCACACTCGTAGTTCCATGTAGAAACCAAGATGAACTGATTGGTAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTGCGGGAGACGGCCTGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTCAGGCTGGCGGCAAATGCCATTTGCTCGGCAGTCCCATCACATTGGGTTCCAACAAGCCGGACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTCTGGAACAGGGTGTGGATCCAAGAAAACCCATGGATGGAAGACAAAACTCCAGTGGAATCATGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGGCTAACAAGCAGGGCCACCTGGGCAAAGAACATCCAAACAGCAATAAATCAAGTCAGATCCCTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAAGAGGAAGAGGCAGGAGTCCTGTGGTAGAAGACAGAACTAACATGAAACAAGGCTAGAAGTCAGGTCGGATTAAGCCATAGTACGGAAAAAACTATGCTACCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGTCAGGCCATCACAAATGCCATAGCTTGAGCAAACTGTGCAGCCTGTAGCTCCACCTGAGAAGGTGTAAAAAATCCGGGAGGCCACAAACCATGGAAGCTGTACGCATGGCGTAGTGGACTAGCGGTTAGAGGAGACCCCTCCCTTACAAATCGCAGCAACAATGGGGGCCCAAGGTGAGATGAAGCTGTAGTCTCACTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAAAACAAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLTYVVIAILTVVAATMA", "C": "MNNQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIPPTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMA", "E": "MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA", "M": "FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGMNMCTLMAMDLGELCEDTITYKCPFLRQNEPEDIDCWCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETWILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSMT", "NS1": "DSGCVVSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQPTELRYSWKTWGKAKMLSTELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLKLREKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMIIPKNFAGPVSQHNYRPGYYTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTA", "NS2A": "GHGQIDNFSLGILGMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVTYLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMVLKIVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLLLTSSQQKADWIPLALTIKGLNPTAIFLTTLSRTSKKR", "NS2B": "SWPLNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR", "NS3": 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"AGTTGTTAGTCTACGTGGACCGACAAGAACAGTTTCGACTCGGAAGCTTGCTTAACGTAGTGCTGACAGTTTTTTATTAGAGAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGAAAACCGTCTATCAATATGCTGAAACGCGTGAGAAACCGTGTGTCAACTGGATCACAGTTGGCGAAGAGATTCTCAAGAGGATTGCTGAACGGCCAAGGACCAATGAAATTGGTTATGGCGTTCATAGCTTTCCTCAGATTTCTAGCCATTCCACCGACAGCAGGAGTCTTGGCTAGATGGGGTACCTTCAAGAAGTCGGGGGCTATTAAGGTCCTAAAAGGCTTCAAGAAGGAGATCTCAAACATGCTGAGCATTATCAACAAACGGAAAAAGACATCGCTCTGTCTCATGATGATGTTACCAGCAACACTTGCTTTCCACTTGACTTCACGAGATGGAGAGCCGCGCATGATTGTGGGGAAGAATGAAAGAGGAAAATCCCTACTTTTTAAGACAGCCTCTGGAATCAACATGTGCACACTCATAGCCATGGATTTGGGAGAGATGTGTGATGACACGGTCACTTACAAATGCCCCCACATTACCGAAGTGGAGCCTGAAGACATTGACTGCTGGTGCAACCTTACATCGACATGGGTGACTTATGGAACGTGCAATCAAGCTGGAGAGCATAGACGCGATAAGAGATCAGTGGCGTTAGCTCCCCATGTCGGCATGGGACTGGACACACGCACCCAAACCTGGATGTCGGCTGAAGGAGCTTGGAGACAAGTCGAGAAGGTAGAGACATGGGCCCTTAGGCACCCAGGGTTCACCATACTAGCCCTATTTCTTGCCCATTACATAGGCACTTCCTTGACCCAGAAAGTGGTTATTTTTATACTACTAATGCTGGTCACCCCATCCATGACAATGAGATGTGTGGGAGTAGGAAACAGAGATTTTGTGGAAGGCCTATCGGGAGCTACGTGGGTTGACGTGGTGCTCGAGCACGGTGGGTGTGTGACTACCATGGCTAAGAACAAGCCCACGCTGGATATAGAGCTTCAGAAGACCGAGGCCACCCAACTGGCGACCCTAAGGAAGCTATGCATTGAGGGAAAAATTACCAACATAACAACCGACTCAAGGTGTCCCACCCAAGGGGAAGCGATTTTACCTGAGGAGCAGGACCAGAACTACGTGTGTAAGCATACATACGTGGACAGAGGCTGGGGAAACGGTTGTGGTTTGTTTGGCAAGGGAAGCTTGGTGACATGCGCGAAATTTCAATGTTTAGAATCAATAGAGGGAAAAGTGGTGCAACATGAGAACCTCAAATACACCGTCATCATCACAGTGCACACAGGAGACCAACACCAGGTGGGAAATGAAACGCAGGGAGTCACGGCTGAGATAACACCCCAGGCATCAACCGCTGAAGCCATCTTACCTGAATATGGAACCCTTGGGCTAGAATGCTCACCACGGACAGGTTTGGATTTCAATGAAATGATCTTATTGACAATGAAGAACAAAGCATGGATGGTACATAGACAATGGTTCTTTGACCTACCTCTACCATGGACATCAGGAGCTACAACAGAAACACCAACCTGGAACAGGAAAGAGCTTCTTGTGACATTCAAAAACGCACATGCAAAAAAACAAGAAGTAGTTGTCCTTGGATCGCAAGAGGGAGCAATGCATACAGCACTGACAGGAGCTACAGAGATCCAAACCTCAGGAGGCACAAGCATTTTTGCGGGGCACTTAAAATGTAGACTCAAGATGGACAAATTGGAACTCAAGGGGATGAGCTATGCAATGTGCTTGAATACCTTTGTGTTGAAGAAAGAAGTCTCCGAAACGCAGCATGGGACAATACTCATTAAGGTTGAGTACAAAGGGGAAGATGCACCCTGCAAGATTCCTTTCTCCACGGAGGATGGACAAGGGAAAGCTCACAATGGCAGACTGATCACAGCCAACCCAGTGGTGACCAAGAAGGAGGAGCCTGTCAATATTGAGGCTGAACCTCCTTTTGGGGAAAGTAATATAGTAATTGGAATTGGAGACAAAGCCTTGAAAATCAACTGGTACAAGAAGGGAAGCTCGATTGGGAAGATGTTCGAGGCCACTGCCAGAGGTGCAAGGCGCATGGCCATCTTGGGAGACACAGCCTGGGACTTTGGATCAGTGGGTGGTGTTTTGAATTCATTAGGGAAAATGGTGCACCAAATATTTGGAAGTGCTTACACAGCCCTATTTAGTGGAGTCTCCTGGATAATGAAAATTGGAATAGGTGTCCTCTTAACCTGGATAGGGTTGAATTCAAAAAACACTTCTATGTCATTTTCATGCATTGCGATAGGAATCATTACACTCTATCTGGGAGCCGTGGTGCAAGCTGACATGGGGTGTGTCATAAACTGGAAAGGCAAAGAACTCAAATGTGGAAGTGGAATTTTCGTCACTAATGAGGTCCACACCTGGACAGAGCAATACAAATTTCAAGCAGACTCCCCCAAAAGACTGGCGACAGCCATTGCAGGCGCTTGGGAGAATGGAGTGTGCGGAATCAGGTCAACAACCAGAATGGAGAACCTCTTGTGGAAGCAAATAGCCAATGAACTGAACTACATATTATGGGAAAACAACATCAAATTAACGGTAGTTGTGGGCGACATAATTGGGGTCTTAGAGCAAGGGAAAAGAACACTAACACCACAACCCATGGAGCTAAAATATTCATGGAAAACATGGGGAAAGGCAAAAATAGTGACAGCTGAAACACAAAATTCCTCTTTCATAATAGATGGGCCAAACACACCGGAGTGTCCAAGTGCCTCAAGAGCATGGAATGTGTGGGAGGTGGAAGATTACGGGTTCGGAGTCTTCACAACCAACATATGGCTGAAACTCCGAGAGGTGTACACCCAACTATGTGACCATAGGCTAATGTCGGCAGCCGTCAAGGATGAGAGGGCCGTACACGCCGACATGGGCTATTGGATAGAAAGCCAAAAGAATGGAAGTTGGAAGCTAGAAAAAGCATCCCTCATAGAGGTGAAAACCTGCACATGGCCAAAATCACACACTCTTTGGAGCAATGGTGTGCTAGAGAGTGACATGATCATCCCAAAGAGTCTAGCTGGTCCTATTTCGCAACACAACCACAGGCCCGGGTACCACACCCAAACGGCAGGACCCTGGCACTTAGGAAAATTGGAGCTGGACTTCAACTATTGTGAAGGAACAACAGTTGTCATCACAGAAAACTGTGGGACAAGAGGCCCATCATTGAGAACAACAACAGTGTCAGGGAAGTTGATACACGAATGGTGTTGCCGCTCGTGCACACTTCCTCCCCTGCGATACATGGGAGAAGACGGCTGCTGGTATGGCATGGAAATTAGACCCATTAATGAGAAAGAAGAGAACATGGTAAAGTCTTTAGCCTCAGCAGGGAGTGGAAAGGTGGACAACTTCACAATGGGTGTCTTGTGTTTGGCAATCCTCTTTGAAGAGGTGATGAGAGGAAAATTTGGGAAAAAACACATGATTGCAGGGGTTCTCTTCACGTTTGTGCTCCTTCTCTCAGGGCAAATAACATGGAGAGACATGGCGCACACACTCATAATGATTGGGTCCAACGCCTCTGACAGAATGGGAATGGGCGTCACTTACCTAGCTTTAATTGCAACATTTAAAATTCAGCCATTCTTGGCTTTGGGATTCTTCCTGAGGAAACTGACATCTAGAGAAAATTTATTGTTGGGAGTTGGGTTGGCCATGGCAACAACGTTACAACTGCCAGAGGACATTGAACAAATGGCGAATGGAATTGCTTTGGGGCTCATGGCTCTTAAACTGATAACACAATTTGAAACATACCAACTATGGACGGCATTAGTCTCCCTAACGTGTTCAAATACAATTTTCACGTTGACTGTTGCCTGGAGAACAGCCACCCTGATTTTGGCCGGAATTTCGCTTTTGCCAGTGTGCCAGTCTTCGAGCATGAGGAAAACAGATTGGCTCCCAATGACTGTGGCAGCTATGGGAGTTCCACCCCTACCACTTTTTATCTTCAGTTTGAAAGATACACTCAAAAGGAGAAGCTGGCCACTGAATGAGGGGGTGATGGCTGTTGGACTTGTGAGCATTCTAGCTAGTTCTCTCCTTAGGAATGATGTGCCCATGGCTGGACCATTAGTGGCTGGGGGCTTGCTGATAGCGTGCTACGTCATAACTGGCACGTCAGCAGACCTCACTGTAGAAAAAGCAGCAGATGTAACATGGGAGGAAGAGGCTGAGCAAACAGGAGTGTCCCACAATTTAATGATCACAGTTGATGATGATGGAACAATGAGAATAAAAGATGATGAGACTGAGAACATCCTAACAGTGCTTTTAAAAACAGCATTACTAATAGTATCAGGCATCTTTCCATACTCCATACCCGCAACACTGTTGGTCTGGCATACTTGGCAAAAGCAAACCCAAAGATCCGGCGTCCTATGGGACGTACCCAGCCCCCCAGAGACACAGAAAGCAGAACTGGAAGAAGGGGTCTATAGGATCAAACAGCAAGGAATTTTTGGGAAAACCCAAGTGGGGGTTGGAGTACAGAAAGAAGGAGTTTTCCACACCATGTGGCACGTCACAAGAGGGGCAGTGTTGACACACAATGGGAAAAGACTGGAACCAAACTGGGCTAGCGTGAAAAAAGATCTGATTTCATACGGAGGAGGATGGAGATTGAGTGCACAATGGCAAAAGGGAGAGGAGGTGCAGGTTATTGCCGTAGAGCCTGGGAAGAACCCAAAGAACTTTCAAACCATGCCAGGCATTTTTCAGACAACAACAGGGGAAATAGGAGCAATTGCACTGGACTTCAAGCCTGGAACTTCAGGATCTCCCATCATAAACAGAGAGGGAAAGGTAGTGGGACTGTATGGCAATGGAGTGGTTACAAAGAATGGTGGCTATGTCAGTGGAATAGCGCAAACAAATGCAGAACCAGACGGACCGACACCAGAGTTGGAAGAAGAGATGTTCAAAAAGCGAAATCTAACCATAATGGATCTTCATCCTGGGTCAGGAAAGACGCGGAAATACCTTCCAGCTATTGTTAGAGAGGCAATCAAGAGACGCTTAAGGACTCTAATTTTGGCACCAACAAGGGTGGTTGCAGCTGAGATGGAAGAAGCATTGAAAGGGCTCCCAATAAGGTATCAAACAACTGCAACAAAATCTGAACACACAGGAAGAGAGATTGTTGATCTAATGTGCCACGCAACGTTCACAATGCGCTTGCTGTCACCAGTCAGGGTTCCAAACTACAACTTGATAATAATGGATGAGGCTCATTTCACAGACCCAGCCAGTATAGCGGCTAGAGGGTACATATCAACTCGTGTAGGAATGGGAGAGGCAGCCGCAATTTTCATGACAGCAACACCCCCTGGAACAGCTGATGCCTTTCCTCAGAGCAACGCTCCAATTCAAGATGAAGAAAGGGACATACCGGAACGCTCATGGAATTCAGGCAATGAATGGATTACCGACTTTGTTGGGAAGACGGTGTGGTTTGTCCCTAGCATCAAAGCCGGAAATGACATAGCAAACTGCTTGCGGAAAAACGGAAAAAAGGTCATTCAACTTAGTAGGAAGACTTTTGACACAGAATATCAAAAGACTAAACTGAATGATTGGGACTTTGTGGTGACAACAGACATTTCAGAAATGGGAGCCAATTTCAAAGCAGATAGAGTGATCGACCCAAGAAGATGTCTCAAGCCAGTGATTTTGACAGATGGACCCGAGCGGGTGATCCTGGCTGGACCAATGCCAGTCACCGTAGCGAGCGCTGCGCAAAGGAGAGGGAGAGTTGGCAGGAACCCACAAAAAGAAAATGACCAGTACATATTCACGGGCCAGCCTCTCAACAATGATGAAGACCATGCTCACTGGACAGAAGCAAAAATGCTGCTGGACAACATCAACACACCAGAAGGGATTATACCAGCTCTCTTTGAACCAGAAAGGGAGAAGTCAGCCGCCATAGACGGCGAATACCGCCTGAAGGGTGAGTCCAGGAAGACCTTCGTGGAACTCATGAGGAGGGGTGACCTCCCAGTTTGGCTAGCCCATAAAGTAGCATCAGAAGGGATCAAATATACAGATAGAAAATGGTGCTTTGATGGAGAACGTAATAATCAAATTTTAGAGGAGAATATGGATGTGGAAATCTGGACAAAGGAAGGAGAAAAGAAAAAATTGAGACCTAGGTGGCTTGATGCCCGCACTTATTCAGATCCCTTAGCACTCAAGGAATTCAAGGATTTTGCAGCTGGCAGAAAGTCAATCGCCCTTGATCTTGTGACAGAAATAGGAAGAGTGCCTTCACACTTAGCCCACAGAACGAGAAACGCCCTGGACAATTTGGTGATGCTGCACACGTCAGAACATGGCGGTAGGGCCTACAGGCATGCAGTGGAGGAACTACCAGAAACAATGGAAACACTCTTACTCCTGGGACTCATGATCTTGTTAACAGGTGGAGCAATGCTTTTCTTGATATCAGGTAAAGGGATTGGAAAGACTTCAATAGGACTCATTTGTGTAATTGCTTCCAGCGGCATGTTATGGATGGCTGATGTCCCACTCCAATGGATCGCGTCGGCTATAGTCCTGGAGTTTTTTATGATGGTGTTGCTCATACCAGAACCAGAAAAGCAGAGAACTCCCCAAGACAACCAACTCGCATATGTCGTGATAGGCATACTTACATTGGCTGCAATAGTAGCAGCCAATGAAATGGGACTGTTGGAAACTACAAAGAGAGATTTAGGAATGTCTAAAGAACCAGGTGTTGTTTCTCCAACCAGCTATTTGGATGTGGACTTGCACCCAGCATCAGCCTGGACATTGTACGCCGTGGCCACAACAGTAATAACACCAATGTTGAGACATACCATAGAGAATTCCACAGCAAATGTGTCCCTGGCAGCTATAGCTAACCAGGCAGTGGTCCTGATGGGTTTAGACAAAGGATGGCCGATATCGAAAATGGACTTAGGCGTACCACTACTGGCACTGGGTTGCTATTCACAAGTGAACCCACTAACTCTCACAGCGGCAGTACTTTTGCTAGTCACACATTATGCTATTATAGGTCCAGGATTGCAGGCAAAAGCCACTCGTGAAGCTCAGAAAAGGACAGCTGCTGGAATAATGAAGAATCCAACGGTGGATGGGATAATGACAATAGACCTAGATCCTGTAATATACGATTCAAAATTTGAAAAGCAACTAGGACAGGTTATGCTCCTGGTTCTGTGTGCAGTTCAACTTTTGTTAATGAGAACATCATGGGCCTTGTGTGAAGCTCTAACCCTAGCCACAGGACCAATAACAACACTCTGGGAAGGATCACCTGGGAAGTTTTGGAACACCACGATAGCTGTTTCCATGGCGAACATCTTTAGAGGGAGCTATTTAGCAGGAGCTGGGCTTGCTTTTTCTATCATGAAATCAGTTGGAACAGGAAAGAGAGGAACAGGGTCACAAGGTGAAACCTTAGGAGAAAAGTGGAAAAAGAAATTAAATCAGTTATCCCGGAAAGAGTTTGACCTTTACAAGAAATCCGGAATCACTGAAGTGGATAGAACAGAAGCCAAAGAAGGGTTGAAAAGAGGAGAAATAACACACCATGCCGTGTCCAGAGGCAGCGCAAAACTTCAATGGTTCGTGGAGAGAAACATGGTCATTCCCGAAGGAAGAGTCATAGACTTAGGCTGTGGAAGAGGAGGCTGGTCATATTACTGTGCAGGACTGAAAAAAGTTACAGAAGTGCGAGGATACACAAAAGGCGGCCCAGGACACGAAGAACCAGTACCTATGTCTACATACGGATGGAACATAGTCAAGTTAATGAGTGGAAAGGATGTGTTTTATCTTCCACCTGAAAAGTGTGATACCCTATTGTGTGACATTGGAGAATCTTCACCAAGCCCAACAGTGGAAGAAAGCAGAACCATAAGAGTCTTGAAGATGGTTGAACCATGGCTAAAAAACAACCAGTTTTGCATTAAAGTATTGAACCCTTACATGCCAACTGTGATTGAGCACCTAGAAAGACTACAAAGGAAACATGGAGGAATGCTTGTGAGAAATCCACTCTCACGAAACTCCACGCACGAAATGTACTGGATATCCAATGGTACAGGCAACATCGTCTCTTCAGTCAACATGGTATCCAGATTGCTACTGAACAGATTCACAATGACACACAGGAGACCCACCATAGAGAAAGATGTGGATTTAGGAGCAGGAACCCGACATGTCAATGCGGAACCAGAAACACCCAACATGGATGTCATTGGGGAAAGAATAAAAAGGATCAAGGAGGAGCATAGTTCAACATGGCACTATGATGATGAAAATCCTTACAAAACGTGGGCTTACCATGGATCCTATGAAGTCAAAGCCACAGGCTCAGCCTCCTCCATGATAAATGGAGTCGTGAAACTCCTCACAAAACCATGGGATGTGGTGCCCATGGTGACACAGATGGCAATGACAGATACAACCCCATTTGGCCAGCAAAGAGTTTTTAAAGAGAAAGTGGACACCAGGACACCCAGGCCCATGCCAGGAACAAGAAAGGTTATGGAGATCACAGCGGAGTGGCTTTGGAGAACCCTGGGAAGGAACAAAAGACCCAGATTATGCACAAGGGAGGAGTTCACAAAAAAGGTCAGAACCAACGCAGCTATGGGCGCCGTTTTCACAGAGGAGAACCAATGGGACAGTGCGAGAGCTGCTGTTGAGGACGAAGAATTTTGGAAACTTGTGGACAGAGAACGTGAACTCCACAAATTGGGCAAGTGTGGAAGCTGCGTTTACAACATGATGGGCAAGAGAGAGAAGAAACTTGGAGAGTTTGGCAAAGCAAAAGGCAGTAGAGCTATATGGTACATGTGGTTGGGAGCCAGGTACCTTGAGTTCGAGGCACTCGGATTCTTAAATGAAGACCACTGGTTCTCGCGTGAAAACTCTTACAGTGGAGTAGAAGGAGAAGGACTGCACAAGCTGGGATACATCTTAAGAGATATTTCCAAGATACCCGGAGGAGCTATGTATGCTGATGACACAGCTGGTTGGGACACAAGAATAACAGAAGATGACCTGCACAATGAGGAAAAAATCACACAGCAAATGGACCCTGAACACAGGCAGTTAGCGAACGCTATATTCAAGCTCACATACCAAAACAAAGTGGTCAAAGTTCAACGACCAACTCCAAAGGGCACGGTAATGGACATCATATCTAGGAAAGACCAAAGAGGCAGTGGACAGGTGGGAACTTATGGTCTGAATACATTCACCAACATGGAAGCCCAGTTAATCAGACAAATGGAAGGAGAAGGTGTGTTGTCAAAGGCAGACCTCGAGAACCCTCATCTGCTAGAGAAGAAAATTACACAATGGTTGGAAACCAAAGGAGTGGAGAGGTTAAAAAGAATGGCCATCAGCGGGGATGATTGCGTAGTGAAACCAATCGATGACAGGTTCGCCAATGCCCTGCTTGCCCTGAACGATATGGGAAAGGTTAGGAAGGACATACCTCAATGGCAGCCATCAAAGGGATGGCATGATTGGCAACAGGTCCCTTTCTGCTCCCACCACTTTCATGAATTGATCATGAAAGATGGAAGAAAGTTGGTAGTTCCCTGCAGACCCCAGGACGAACTAATAGGAAGAGCGAGAATCTCTCAAGGAGCAGGATGGAGCCTTAGAGAAACTGCATGTCTAGGGAAAGCCTACGCTCAAATGTGGACTCTCATGTATTTTCACAGAAGAGATCTTAGACTAGCATCCAACGCCATATGTTCAGCAGTACCAGTCCATTGGGTCCCCACAAGCAGAACGACATGGTCTATTCATGCTCACCATCAGTGGATGACTACAGAAGACATGCTTACTGTCTGGAACAGGGTGTGGATAGAGGACAATCCATGGATGGAAGACAAAACTCCAGTCACAACTTGGGAAGATGTTCCATATCTAGGGAAGAGAGAAGACCAATGGTGCGGATCACTCATTGGTCTCACTTCCAGAGCAACCTGGGCCCAGAACATACTCACAGCAATCCAACAGGTGAGAAGCCTTATAGGCAATGAAGAGTTTCTGGACTACATGCCTTCGATGAAGAGATTCAGGAAGGAGGAGGAGTCAGAGGGAGCCATTTGGTAAACGCAGGAAGTGAAAAAGAGGCAAACTGTCAGGCCACCTTAAGCCACAGTACGGAAGAAGCTGTGCAGCCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGAAGTCAGGCCCAAAAGCCACGGTTTGAGCAAACCGTGCTGCCTGTAGCTCCGTCGTGGGGACGTAAAGCCTGGGAGGCTGCAAACCGTGGAAGCTGTACGCACGGTGTAGCAGACTAGCGGTTAGAGGAGACCCCTCCCATGACACAACGCAGCAGCGGGGCCCGAGCACTGAGGGAAGCTGTACCTCCTTGCAAAGGACTAGAGGTTAGAGGAGACCCCCCGCAAATAAAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLAYVVIGILTLAAIVAA", "C": "MNNQRKKTGKPSINMLKRVRNRVSTGSQLAKRFSRGLLNGQGPMKLVMAFIAFLRFLAIPPTAGVLARWGTFKKSGAIKVLKGFKKEISNMLSIINKRKKTSLCLMMMLPATLA", "E": "MRCVGVGNRDFVEGLSGATWVDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLATLRKLCIEGKITNITTDSRCPTQGEAILPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTCAKFQCLESIEGKVVQHENLKYTVIITVHTGDQHQVGNETQGVTAEITPQASTAEAILPEYGTLGLECSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWTSGATTETPTWNRKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGGTSIFAGHLKCRLKMDKLELKGMSYAMCLNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDKALKINWYKKGSSIGKMFEATARGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGSAYTALFSGVSWIMKIGIGVLLTWIGLNSKNTSMSFSCIAIGIITLYLGAVVQADM", "M": "FHLTSRDGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCDDTVTYKCPHITEVEPEDIDCWCNLTSTWVTYGTCNQAGEHRRDKRSVALAPHVGMGLDTRTQTWMSAEGAWRQVEKVETWALRHPGFTILALFLAHYIGTSLTQKVVIFILLMLVTPSMT", "NS1": "DMGCVINWKGKELKCGSGIFVTNEVHTWTEQYKFQADSPKRLATAIAGAWENGVCGIRSTTRMENLLWKQIANELNYILWENNIKLTVVVGDIIGVLEQGKRTLTPQPMELKYSWKTWGKAKIVTAETQNSSFIIDGPNTPECPSASRAWNVWEVEDYGFGVFTTNIWLKLREVYTQLCDHRLMSAAVKDERAVHADMGYWIESQKNGSWKLEKASLIEVKTCTWPKSHTLWSNGVLESDMIIPKSLAGPISQHNHRPGYHTQTAGPWHLGKLELDFNYCEGTTVVITENCGTRGPSLRTTTVSGKLIHEWCCRSCTLPPLRYMGEDGCWYGMEIRPINEKEENMVKSLASA", "NS2A": "GSGKVDNFTMGVLCLAILFEEVMRGKFGKKHMIAGVLFTFVLLLSGQITWRDMAHTLIMIGSNASDRMGMGVTYLALIATFKIQPFLALGFFLRKLTSRENLLLGVGLAMATTLQLPEDIEQMANGIALGLMALKLITQFETYQLWTALVSLTCSNTIFTLTVAWRTATLILAGISLLPVCQSSSMRKTDWLPMTVAAMGVPPLPLFIFSLKDTLKRR", "NS2B": "SWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAGGLLIACYVITGTSADLTVEKAADVTWEEEAEQTGVSHNLMITVDDDGTMRIKDDETENILTVLLKTALLIVSGIFPYSIPATLLVWHTWQKQTQR", "NS3": "SGVLWDVPSPPETQKAELEEGVYRIKQQGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTHNGKRLEPNWASVKKDLISYGGGWRLSAQWQKGEEVQVIAVEPGKNPKNFQTMPGIFQTTTGEIGAIALDFKPGTSGSPIINREGKVVGLYGNGVVTKNGGYVSGIAQTNAEPDGPTPELEEEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTRVVAAEMEEALKGLPIRYQTTATKSEHTGREIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAFPQSNAPIQDEERDIPERSWNSGNEWITDFVGKTVWFVPSIKAGNDIANCLRKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDPRRCLKPVILTDGPERVILAGPMPVTVASAAQRRGRVGRNPQKENDQYIFTGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLKGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDGERNNQILEENMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRK", "NS4A": "SIALDLVTEIGRVPSHLAHRTRNALDNLVMLHTSEHGGRAYRHAVEELPETMETLLLLGLMILLTGGAMLFLISGKGIGKTSIGLICVIASSGMLWMADVPLQWIASAIVLEFFMMVLLIPEPEKQR", "NS4B": "NEMGLLETTKRDLGMSKEPGVVSPTSYLDVDLHPASAWTLYAVATTVITPMLRHTIENSTANVSLAAIANQAVVLMGLDKGWPISKMDLGVPLLALGCYSQVNPLTLTAAVLLLVTHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIMTIDLDPVIYDSKFEKQLGQVMLLVLCAVQLLLMRTSWALCEALTLATGPITTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFSIMKSVGTGKR", "NS5": "GTGSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITHHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTRHVNAEPETPNMDVIGERIKRIKEEHSSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPMPGTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNAAMGAVFTEENQWDSARAAVEDEEFWKLVDRERELHKLGKCGSCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPKGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSKADLENPHLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWTLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEDNPWMEDKTPVTTWEDVPYLGKREDQWCGSLIGLTSRATWAQNILTAIQQVRSLIGNEEFLDYMPSMKRFRKEEESEGAIW", "pr": 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"AGTTGTTAGTCTACGTGGACCGACAAGAACAGTTTCGACTCGGAAGCTTGCTTAACGTAGTGCTGACAGTTTTTTATTAGAGAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGAAAACCGTCTATCAATATGCTGAAACGCGTGAGAAACCGTGTGTCAACTGGATCACAGTTGGCGAAGAGATTCTCAAGAGGATTGCTGAACGGCCAAGGACCAATGAAATTGGTTATGGCGTTCATAGCTTTCCTCAGATTTCTAGCCATTCCACCGACAGCAGGAGTCTTGGCTAGATGGGGTACCTTCAAGAAGTCGGGGGCTATTAAGGTCCTAAAAGGCTTCAAGAAGGAGATCTCAAACATGCTGAGCATTATCAACAAACGGAAAAAGACATCGCTCTGTCTCATGATGATGTTACCAGCAACACTTGCTTTCCACTTGACTTCACGAGATGGAGAGCCGCGCATGATTGTGGGGAAGAATGAAAGAGGAAAATCCCTACTTTTTAAGACAGCCTCTGGAATCAACATGTGCACACTCATAGCCATGGATTTGGGAGAGATGTGTGATGACACGGTCACTTACAAATGCCCCCACATTACCGAAGTGGAGCCTGAAGACATTGACTGCTGGTGCAACCTTACATCGACATGGGTGACTTATGGAACGTGCAATCAAGCTGGAGAGCATAGACGCGATAAGAGATCAGTGGCGTTAGCTCCCCATGTCGGCATGGGACTGGACACACGCACCCAAACCTGGATGTCGGCTGAAGGAGCTTGGAGACAAGTCGAGAAGGTAGAGACATGGGCCCTTAGGCACCCAGGGTTCACCATACTAGCCCTATTTCTTGCCCATTACATAGGCACTTCCTTGACCCAGAAAGTGGTTATTTTTATACTACTAATGCTGGTCACCCCATCCATGACAATGAGATGTGTGGGAGTAGGAAACAGAGATTTTGTGGAAGGCCTATCGGGAGCTACGTGGGTTGACGTGGTGCTCGAGCACGGTGGGTGTGTGACTACCATGGCTAAGAACAAGCCCACGCTGGATATAGAGCTTCAGAAGACCGAGGCCACCCAACTGGCGACCCTAAGGAAGCTATGCATTGAGGGAAAAATTACCAACATAACAACCGACTCAAGGTGTCCCACCCAAGGGGAAGCGATTTTACCTGAGGAGCAGGACCAGAACTACGTGTGTAAGCATACATACGTGGACAGAGGCTGGGGAAACGGTTGTGGTTTGTTTGGCAAGGGAAGCTTGGTGACATGCGCGAAATTTCAATGTTTAGAATCAATAGAGGGAAAAGTGGTGCAACATGAGAACCTCAAATACACCGTCATCATCACAGTGCACACAGGAGACCAACACCAGGTGGGAAATGAAACGCAGGGAGTCACGGCTGAGATAACACCCCAGGCATCAACCGCTGAAGCCATCTTACCTGAATATGGAACCCTTGGGCTAGAATGCTCACCACGGACAGGTTTGGATTTCAATGAAATGATCTTATTGACAATGAAGAACAAAGCATGGATGGTACATAGACAATGGTTCTTTGACCTACCTCTACCATGGACATCAGGAGCTACAACAGAAACACCAACCTGGAACAGGAAAGAGCTTCTTGTGACATTCAAAAACGCACATGCAAAAAAACAAGAAGTAGTTGTCCTTGGATCGCAAGAGGGAGCAATGCATACAGCACTGACAGGAGCTACAGAGATCCAAACCTCAGGAGGCACAAGCATTTTTGCGGGGCACTTAAAATGTAGACTCAAGATGGACAAATTGGAACTCAAGGGGATGAGCTATGCAATGTGCTTGAATACCTTTGTGTTGAAGAAAGAAGTCTCCGAAACGCAGCATGGGACAATACTCATTAAGGTTGAGTACAAAGGGGAAGATGCACCCTGCAAGATTCCTTTCTCCACGGAGGATGGACAAGGGAAAGCTCACAATGGCAGACTGATCACAGCCAACCCAGTGGTGACCAAGAAGGAGGAGCCTGTCAATATTGAGGCTGAACCTCCTTTTGGGGAAAGTAATATAGTAATTGGAATTGGAGACAAAGCCTTGAAAATCAACTGGTACAAGAAGGGAAGCTCGATTGGGAAGATGTTCGAGGCCACTGCCAGAGGTGCAAGGCGCATGGCCATCTTGGGAGACACAGCCTGGGACTTTGGATCAGTGGGTGGTGTTTTGAATTCATTAGGGAAAATGGTGCACCAAATATTTGGAAGTGCTTACACAGCCCTATTTAGTGGAGTCTCCTGGATAATGAAAATTGGAATAGGTGTCCTCTTAACCTGGATAGGGTTGAATTCAAAAAACACTTCTATGTCATTTTCATGCATTGCGATAGGAATCATTACACTCTATCTGGGAGCCGTGGTGCAAGCTGACATGGGGTGTGTCATAAACTGGAAAGGCAAAGAACTCAAATGTGGAAGTGGAATTTTCGTCACTAATGAGGTCCACACCTGGACAGAGCAATACAAATTTCAAGCAGACTCCCCCAAAAGACTGGCGACAGCCATTGCAGGCGCTTGGGAGAATGGAGTGTGCGGAATCAGGTCAACAACCAGAATGGAGAACCTCTTGTGGAAGCAAATAGCCAATGAACTGAACTACATATTATGGGAAAACAACATCAAATTAACGGTAGTTGTGGGCGACATAATTGGGGTCTTAGAGCAAGGGAAAAGAACACTAACACCACAACCCATGGAGCTAAAATATTCATGGAAAACATGGGGAAAGGCAAAAATAGTGACAGCTGAAACACAAAATTCCTCTTTCATAATAGATGGGCCAAACACACCGGAGTGTCCAAGTGCCTCAAGAGCATGGAATGTGTGGGAGGTGGAAGATTACGGGTTCGGAGTCTTCACAACCAACATATGGCTGAAACTCCGAGAGGTGTACACCCAACTATGTGACCATAGGCTAATGTCGGCAGCCGTCAAGGATGAGAGGGCCGTACACGCCGACATGGGCTATTGGATAGAAAGCCAAAAGAATGGAAGTTGGAAGCTAGAAAAAGCATCCCTCATAGAGGTGAAAACCTGCACATGGCCAAAATCACACACTCTTTGGAGCAATGGTGTGCTAGAGAGTGACATGATCATCCCAAAGAGTCTAGCTGGTCCTATTTCGCAACACAACCACAGGCCCGGGTACCACACCCAAACGGCAGGACCCTGGCACTTAGGAAAATTGGAGCTGGACTTCAACTATTGTGAAGGAACAACAGTTGTCATCACAGAAAACTGTGGGACAAGAGGCCCATCATTGAGAACAACAACAGTGTCAGGGAAGTTGATACACGAATGGTGTTGCCGCTCGTGCACACTTCCTCCCCTGCGATACATGGGAGAAGACGGCTGCTGGTATGGCATGGAAATTAGACCCATTAATGAGAAAGAAGAGAACATGGTAAAGTCTTTAGCCTCAGCAGGGAGTGGAAAGGTGGACAACTTCACAATGGGTGTCTTGTGTTTGGCAATCCTCTTTGAAGAGGTGATGAGAGGAAAATTTGGGAAAAAACACATGATTGCAGGGGTTCTCTTCACGTTTGTGCTCCTTCTCTCAGGGCAAATAACATGGAGAGACATGGCGCACACACTCATAATGATTGGGTCCAACGCCTCTGACAGAATGGGAATGGGCGTCACTTACCTAGCTTTAATTGCAACATTTAAAATTCAGCCATTCTTGGCTTTGGGATTCTTCCTGAGGAAACTGACATCTAGAGAAAATTTATTGTTGGGAGTTGGGTTGGCCATGGCAACAACGTTACAACTGCCAGAGGACATTGAACAAATGGCGAATGGAATTGCTTTGGGGCTCATGGCTCTTAAACTGATAACACAATTTGAAACATACCAACTATGGACGGCATTAGTCTCCCTAACGTGTTCAAATACAATTTTCACGTTGACTGTTGCCTGGAGAACAGCCACCCTGATTTTGGCCGGAATTTCGCTTTTGCCAGTGTGCCAGTCTTCGAGCATGAGGAAAACAGATTGGCTCCCAATGACTGTGGCAGCTATGGGAGTTCCACCCCTACCACTTTTTATCTTCAGTTTGAAAGATACACTCAAAAGGAGAAGCTGGCCACTGAATGAGGGGGTGATGGCTGTTGGACTTGTGAGCATTCTAGCTAGTTCTCTCCTTAGGAATGATGTGCCCATGGCTGGACCATTAGTGGCTGGGGGCTTGCTGATAGCGTGCTACGTCATAACTGGCACGTCAGCAGACCTCACTGTAGAAAAAGCAGCAGATGTAACATGGGAGGAAGAGGCTGAGCAAACAGGAGTGTCCCACAATTTAATGATCACAGTTGATGATGATGGAACAATGAGAATAAAAGATGATGAGACTGAGAACATCCTAACAGTGCTTTTAAAAACAGCATTACTAATAGTATCAGGCATCTTTCCATACTCCATACCCGCAACACTGTTGGTCTGGCATACTTGGCAAAAGCAAACCCAAAGATCCGGCGTCCTATGGGACGTACCCAGCCCCCCAGAGACACAGAAAGCAGAACTGGAAGAAGGGGTCTATAGGATCAAACAGCAAGGAATTTTTGGGAAAACCCAAGTGGGGGTTGGAGTACAGAAAGAAGGAGTTTTCCACACCATGTGGCACGTCACAAGAGGGGCAGTGTTGACACACAATGGGAAAAGACTGGAACCAAACTGGGCTAGCGTGAAAAAAGATCTGATTTCATACGGAGGAGGATGGAGATTGAGTGCACAATGGCAAAAGGGAGAGGAGGTGCAGGTTATTGCCGTAGAGCCTGGGAAGAACCCAAAGAACTTTCAAACCATGCCAGGCATTTTTCAGACAACAACAGGGGAAATAGGAGCAATTGCACTGGACTTCAAGCCTGGAACTTCAGGATCTCCCATCATAAACAGAGAGGGAAAGGTAGTGGGACTGTATGGCAATGGAGTGGTTACAAAGAATGGTGGCTATGTCAGTGGAATAGCGCAAACAAATGCAGAACCAGACGGACCGACACCAGAGTTGGAAGAAGAGATGTTCAAAAAGCGAAATCTAACCATAATGGATCTTCATCCTGGGTCAGGAAAGACGCGGAAATACCTTCCAGCTATTGTTAGAGAGGCAATCAAGAGACGCTTAAGGACTCTAATTTTGGCACCAACAAGGGTGGTTGCAGCTGAGATGGAAGAAGCATTGAAAGGGCTCCCAATAAGGTATCAAACAACTGCAACAAAATCTGAACACACAGGAAGAGAGATTGTTGATCTAATGTGCCACGCAACGTTCACAATGCGCTTGCTGTCACCAGTCAGGGTTCCAAACTACAACTTGATAATAATGGATGAGGCTCATTTCACAGACCCAGCCAGTATAGCGGCTAGAGGGTACATATCAACTCGTGTAGGAATGGGAGAGGCAGCCGCAATTTTCATGACAGCAACACCCCCTGGAACAGCTGATGCCTTTCCTCAGAGCAACGCTCCAATTCAAGATGAAGAAAGGGACATACCGGAACGCTCATGGAATTCAGGCAATGAATGGATTACCGACTTTGTTGGGAAGACGGTGTGGTTTGTCCCTAGCATCAAAGCCGGAAATGACATAGCAAACTGCTTGCGGAAAAACGGAAAAAAGGTCATTCAACTTAGTAGGAAGACTTTTGACACAGAATATCAAAAGACTAAACTGAATGATTGGGACTTTGTGGTGACAACAGACATTTCAGAAATGGGAGCCAATTTCAAAGCAGATAGAGTGATCGACCCAAGAAGATGTCTCAAGCCAGTGATTTTGACAGATGGACCCGAGCGGGTGATCCTGGCTGGACCAATGCCAGTCACCGTAGCGAGCGCTGCGCAAAGGAGAGGGAGAGTTGGCAGGAACCCACAAAAAGAAAATGACCAGTACATATTCACGGGCCAGCCTCTCAACAATGATGAAGACCATGCTCACTGGACAGAAGCAAAAATGCTGCTGGACAACATCAACACACCAGAAGGGATTATACCAGCTCTCTTTGAACCAGAAAGGGAGAAGTCAGCCGCCATAGACGGCGAATACCGCCTGAAGGGTGAGTCCAGGAAGACCTTCGTGGAACTCATGAGGAGGGGTGACCTCCCAGTTTGGCTAGCCCATAAAGTAGCATCAGAAGGGATCAAATATACAGATAGAAAATGGTGCTTTGATGGAGAACGTAATAATCAAATTTTAGAGGAGAATATGGATGTGGAAATCTGGACAAAGGAAGGAGAAAAGAAAAAATTGAGACCTAGGTGGCTTGATGCCCGCACTTATTCAGATCCCTTAGCACTCAAGGAATTCAAGGATTTTGCAGCTGGCAGAAAGTCAATCGCCCTTGATCTTGTGACAGAAATAGGAAGAGTGCCTTCACACTTAGCCCACAGAACGAGAAACGCCCTGGACAATTTGGTGATGCTGCACACGTCAGAACATGGCGGTAGGGCCTACAGGCATGCAGTGGAGGAACTACCAGAAACAATGGAAACACTCTTACTCCTGGGACTCATGATCTTGTTAACAGGTGGAGCAATGCTTTTCTTGATATCAGGTAAAGGGATTGGAAAGACTTCAATAGGACTCATTTGTGTAATTGCTTCCAGCGGCATGTTATGGATGGCTGATGTCCCACTCCAATGGATCGCGTCGGCTATAGTCCTGGAGTTTTTTATGATGGTGTTGCTCATACCAGAACCAGAAAAGCAGAGAACTCCCCAAGACAACCAACTCGCATATGTCGTGATAGGCATACTTACATTGGCTGCAATAGTAGCAGCCAATGAAATGGGACTGTTGGAAACTACAAAGAGAGATTTAGGAATGTCTAAAGAACCAGGTGTTGTTTCTCCAACCAGCTATTTGGATGTGGACTTGCACCCAGCATCAGCCTGGACATTGTACGCCGTGGCCACAACAGTAATAACACCAATGTTGAGACATACCATAGAGAATTCCACAGCAAATGTGTCCCTGGCAGCTATAGCTAACCAGGCAGTGGTCCTGATGGGTTTAGACAAAGGATGGCCGATATCGAAAATGGACTTAGGCGTACCACTACTGGCACTGGGTTGCTATTCACAAGTGAACCCACTAACTCTCACAGCGGCAGTACTTTTGCTAGTCACACATTATGCTATTATAGGTCCAGGATTGCAGGCAAAAGCCACTCGTGAAGCTCAGAAAAGGACAGCTGCTGGAATAATGAAGAATCCAACGGTGGATGGGATAATGACAATAGACCTAGATCCTGTAATATACGATTCAAAATTTGAAAAGCAACTAGGACAGGTTATGCTCCTGGTTCTGTGTGCAGTTCAACTTTTGTTAATGAGAACATCATGGGCCTTGTGTGAAGCTCTAACCCTAGCCACAGGACCAATAACAACACTCTGGGAAGGATCACCTGGGAAGTTTTGGAACACCACGATAGCTGTTTCCATGGCGAACATCTTTAGAGGGAGCTATTTAGCAGGAGCTGGGCTTGCTTTTTCTATCATGAAATCAGTTGGAACAGGAAAGAGAGGAACAGGGTCACAAGGTGAAACCTTAGGAGAAAAGTGGAAAAAGAAATTAAATCAGTTATCCCGGAAAGAGTTTGACCTTTACAAGAAATCCGGAATCACTGAAGTGGATAGAACAGAAGCCAAAGAAGGGTTGAAAAGAGGAGAAATAACACACCATGCCGTGTCCAGAGGCAGCGCAAAACTTCAATGGTTCGTGGAGAGAAACATGGTCATTCCCGAAGGAAGAGTCATAGACTTAGGCTGTGGAAGAGGAGGCTGGTCATATTACTGTGCAGGACTGAAAAAAGTTACAGAAGTGCGAGGATACACAAAAGGCGGCCCAGGACACGAAGAACCAGTACCTATGTCTACATACGGATGGAACATAGTCAAGTTAATGAGTGGAAAGGATGTGTTTTATCTTCCACCTGAAAAGTGTGATACCCTATTGTGTGACATTGGAGAATCTTCACCAAGCCCAACAGTGGAAGAAAGCAGAACCATAAGAGTCTTGAAGATGGTTGAACCATGGCTAAAAAACAACCAGTTTTGCATTAAAGTATTGAACCCTTACATGCCAACTGTGATTGAGCACCTAGAAAGACTACAAAGGAAACATGGAGGAATGCTTGTGAGAAATCCACTCTCACGAAACTCCACGCACGAAATGTACTGGATATCCAATGGTACAGGCAACATCGTCTCTTCAGTCAACATGGTATCCAGATTGCTACTGAACAGATTCACAATGACACACAGGAGACCCACCATAGAGAAAGATGTGGATTTAGGAGCAGGAACCCGACATGTCAATGCGGAACCAGAAACACCCAACATGGATGTCATTGGGGAAAGAATAAAAAGGATCAAGGAGGAGCATAGTTCAACATGGCACTATGATGATGAAAATCCTTACAAAACGTGGGCTTACCATGGATCCTATGAAGTCAAAGCCACAGGCTCAGCCTCCTCCATGATAAATGGAGTCGTGAAACTCCTCACAAAACCATGGGATGTGGTGCCCATGGTGACACAGATGGCAATGACAGATACAACCCCATTTGGCCAGCAAAGAGTTTTTAAAGAGAAAGTGGACACCAGGACACCCAGGCCCATGCCAGGAACAAGAAAGGTTATGGAGATCACAGCGGAGTGGCTTTGGAGAACCCTGGGAAGGAACAAAAGACCCAGATTATGCACAAGGGAGGAGTTCACAAAAAAGGTCAGAACCAACGCAGCTATGGGCGCCGTTTTCACAGAGGAGAACCAATGGGACAGTGCGAGAGCTGCTGTTGAGGACGAAGAATTTTGGAAACTTGTGGACAGAGAACGTGAACTCCACAAATTGGGCAAGTGTGGAAGCTGCGTTTACAACATGATGGGCAAGAGAGAGAAGAAACTTGGAGAGTTTGGCAAAGCAAAAGGCAGTAGAGCTATATGGTACATGTGGTTGGGAGCCAGGTACCTTGAGTTCGAGGCACTCGGATTCTTAAATGAAGACCACTGGTTCTCGCGTGAAAACTCTTACAGTGGAGTAGAAGGAGAAGGACTGCACAAGCTGGGATACATCTTAAGAGATATTTCCAAGATACCCGGAGGAGCTATGTATGCTGATGACACAGCTGGTTGGGACACAAGAATAACAGAAGATGACCTGCACAATGAGGAAAAAATCACACAGCAAATGGACCCTGAACACAGGCAGTTAGCGAACGCTATATTCAAGCTCACATACCAAAACAAAGTGGTCAAAGTTCAACGACCAACTCCAAAGGGCACGGTAATGGACATCATATCTAGGAAAGACCAAAGAGGCAGTGGACAGGTGGGAACTTATGGTCTGAATACATTCACCAACATGGAAGCCCAGTTAATCAGACAAATGGAAGGAGAAGGTGTGTTGTCAAAGGCAGACCTCGAGAACCCTCATCTGCTAGAGAAGAAAATTACACAATGGTTGGAAACCAAAGGAGTGGAGAGGTTAAAAAGAATGGCCATCAGCGGGGATGATTGCGTAGTGAAACCAATCGATGACAGGTTCGCCAATGCCCTGCTTGCCCTGAACGATATGGGAAAGGTTAGGAAGGACATACCTCAATGGCAGCCATCAAAGGGATGGCATGATTGGCAACAGGTCCCTTTCTGCTCCCACCACTTTCATGAATTGATCATGAAAGATGGAAGAAAGTTGGTAGTTCCCTGCAGACCCCAGGACGAACTAATAGGAAGAGCGAGAATCTCTCAAGGAGCAGGATGGAGCCTTAGAGAAACTGCATGTCTAGGGAAAGCCTACGCTCAAATGTGGACTCTCATGTATTTTCACAGAAGAGATCTTAGACTAGCATCCAACGCCATATGTTCAGCAGTACCAGTCCATTGGGTCCCCACAAGCAGAACGACATGGTCTATTCATGCTCACCATCAGTGGATGACTACAGAAGACATGCTTACTGTCTGGAACAGGGTGTGGATAGAGGACAATCCATGGATGGAAGACAAAACTCCAGTCACAACTTGGGAAGATGTTCCATATCTAGGGAAGAGAGAAGACCAATGGTGCGGATCACTCATTGGTCTCACTTCCAGAGCAACCTGGGCCCAGAACATACTCACAGCAATCCAACAGGTGAGAAGCCTTATAGGCAATGAAGAGTTTCTGGACTACATGCCTTCGATGAAGAGATTCAGGAAGGAGGAGGAGTCAGAGGGAGCCATTTGGTAAACGCAGGAAGTGAAAAAGAGGCAAACTGTCAGGCCACCTTAAGCCACAGTACGGAAGAAGCTGTGCAGCCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGAAGTCAGGCCCAAAAGCCACGGTTTGAGCAAACCGTGCTGCCTGTAGCTCCGTCGTGGGGACGTAAAGCCTGGGAGGCTGCAAACCGTGGAAGCTGTACGCACGGTGTAGCAGACTAGCGGTTAGAGGAGACCCCTCCCATGACACAACGCAGCAGCGGGGCCCGAGCACTGAGGGAAGCTGTACCTCCTTGCAAAGGACTAGAGGTTAGAGGAGACCCCCCGCAAATAAAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLAYVVIGILTLAAIVAA", "C": "MNNQRKKTGKPSINMLKRVRNRVSTGSQLAKRFSRGLLNGQGPMKLVMAFIAFLRFLAIPPTAGVLARWGTFKKSGAIKVLKGFKKEISNMLSIINKRKKTSLCLMMMLPATLA", "E": "MRCVGVGNRDFVEGLSGATWVDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLATLRKLCIEGKITNITTDSRCPTQGEAILPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTCAKFQCLESIEGKVVQHENLKYTVIITVHTGDQHQVGNETQGVTAEITPQASTAEAILPEYGTLGLECSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWTSGATTETPTWNRKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQTSGGTSIFAGHLKCRLKMDKLELKGMSYAMCLNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDKALKINWYKKGSSIGKMFEATARGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGSAYTALFSGVSWIMKIGIGVLLTWIGLNSKNTSMSFSCIAIGIITLYLGAVVQADM", "M": "FHLTSRDGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCDDTVTYKCPHITEVEPEDIDCWCNLTSTWVTYGTCNQAGEHRRDKRSVALAPHVGMGLDTRTQTWMSAEGAWRQVEKVETWALRHPGFTILALFLAHYIGTSLTQKVVIFILLMLVTPSMT", "NS1": "DMGCVINWKGKELKCGSGIFVTNEVHTWTEQYKFQADSPKRLATAIAGAWENGVCGIRSTTRMENLLWKQIANELNYILWENNIKLTVVVGDIIGVLEQGKRTLTPQPMELKYSWKTWGKAKIVTAETQNSSFIIDGPNTPECPSASRAWNVWEVEDYGFGVFTTNIWLKLREVYTQLCDHRLMSAAVKDERAVHADMGYWIESQKNGSWKLEKASLIEVKTCTWPKSHTLWSNGVLESDMIIPKSLAGPISQHNHRPGYHTQTAGPWHLGKLELDFNYCEGTTVVITENCGTRGPSLRTTTVSGKLIHEWCCRSCTLPPLRYMGEDGCWYGMEIRPINEKEENMVKSLASA", "NS2A": "GSGKVDNFTMGVLCLAILFEEVMRGKFGKKHMIAGVLFTFVLLLSGQITWRDMAHTLIMIGSNASDRMGMGVTYLALIATFKIQPFLALGFFLRKLTSRENLLLGVGLAMATTLQLPEDIEQMANGIALGLMALKLITQFETYQLWTALVSLTCSNTIFTLTVAWRTATLILAGISLLPVCQSSSMRKTDWLPMTVAAMGVPPLPLFIFSLKDTLKRR", "NS2B": "SWPLNEGVMAVGLVSILASSLLRNDVPMAGPLVAGGLLIACYVITGTSADLTVEKAADVTWEEEAEQTGVSHNLMITVDDDGTMRIKDDETENILTVLLKTALLIVSGIFPYSIPATLLVWHTWQKQTQR", "NS3": "SGVLWDVPSPPETQKAELEEGVYRIKQQGIFGKTQVGVGVQKEGVFHTMWHVTRGAVLTHNGKRLEPNWASVKKDLISYGGGWRLSAQWQKGEEVQVIAVEPGKNPKNFQTMPGIFQTTTGEIGAIALDFKPGTSGSPIINREGKVVGLYGNGVVTKNGGYVSGIAQTNAEPDGPTPELEEEMFKKRNLTIMDLHPGSGKTRKYLPAIVREAIKRRLRTLILAPTRVVAAEMEEALKGLPIRYQTTATKSEHTGREIVDLMCHATFTMRLLSPVRVPNYNLIIMDEAHFTDPASIAARGYISTRVGMGEAAAIFMTATPPGTADAFPQSNAPIQDEERDIPERSWNSGNEWITDFVGKTVWFVPSIKAGNDIANCLRKNGKKVIQLSRKTFDTEYQKTKLNDWDFVVTTDISEMGANFKADRVIDPRRCLKPVILTDGPERVILAGPMPVTVASAAQRRGRVGRNPQKENDQYIFTGQPLNNDEDHAHWTEAKMLLDNINTPEGIIPALFEPEREKSAAIDGEYRLKGESRKTFVELMRRGDLPVWLAHKVASEGIKYTDRKWCFDGERNNQILEENMDVEIWTKEGEKKKLRPRWLDARTYSDPLALKEFKDFAAGRK", "NS4A": "SIALDLVTEIGRVPSHLAHRTRNALDNLVMLHTSEHGGRAYRHAVEELPETMETLLLLGLMILLTGGAMLFLISGKGIGKTSIGLICVIASSGMLWMADVPLQWIASAIVLEFFMMVLLIPEPEKQR", "NS4B": "NEMGLLETTKRDLGMSKEPGVVSPTSYLDVDLHPASAWTLYAVATTVITPMLRHTIENSTANVSLAAIANQAVVLMGLDKGWPISKMDLGVPLLALGCYSQVNPLTLTAAVLLLVTHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGIMTIDLDPVIYDSKFEKQLGQVMLLVLCAVQLLLMRTSWALCEALTLATGPITTLWEGSPGKFWNTTIAVSMANIFRGSYLAGAGLAFSIMKSVGTGKR", "NS5": "GTGSQGETLGEKWKKKLNQLSRKEFDLYKKSGITEVDRTEAKEGLKRGEITHHAVSRGSAKLQWFVERNMVIPEGRVIDLGCGRGGWSYYCAGLKKVTEVRGYTKGGPGHEEPVPMSTYGWNIVKLMSGKDVFYLPPEKCDTLLCDIGESSPSPTVEESRTIRVLKMVEPWLKNNQFCIKVLNPYMPTVIEHLERLQRKHGGMLVRNPLSRNSTHEMYWISNGTGNIVSSVNMVSRLLLNRFTMTHRRPTIEKDVDLGAGTRHVNAEPETPNMDVIGERIKRIKEEHSSTWHYDDENPYKTWAYHGSYEVKATGSASSMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPMPGTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNAAMGAVFTEENQWDSARAAVEDEEFWKLVDRERELHKLGKCGSCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARYLEFEALGFLNEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDDLHNEEKITQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPKGTVMDIISRKDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGVLSKADLENPHLLEKKITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAGWSLRETACLGKAYAQMWTLMYFHRRDLRLASNAICSAVPVHWVPTSRTTWSIHAHHQWMTTEDMLTVWNRVWIEDNPWMEDKTPVTTWEDVPYLGKREDQWCGSLIGLTSRATWAQNILTAIQQVRSLIGNEEFLDYMPSMKRFRKEEESEGAIW", "pr": "FHLTSRDGEPRMIVGKNERGKSLLFKTASGINMCTLIAMDLGEMCDDTVTYKCPHITEVEPEDIDCWCNLTSTWVTYGTCNQAGEHRRDKR"}} \ No newline at end of file diff --git a/nextclade/datasets/denv4/tree.json b/nextclade/datasets/denv4/tree.json index a81a346d..09f8840a 100644 --- a/nextclade/datasets/denv4/tree.json +++ b/nextclade/datasets/denv4/tree.json @@ -1 +1 @@ -{"version": "v2", "meta": {"title": "Real-time tracking of dengue virus evolution", "updated": "2024-06-04", "build_url": "https://github.com/nextstrain/dengue", "maintainers": [{"name": "the Nextstrain team", "url": "https://nextstrain.org/team"}], "display_defaults": {"map_triplicate": true, "color_by": "clade_membership"}, "genome_annotations": {"nuc": {"end": 10649, "start": 1, "strand": "+", "type": "##sequence-region pragma", "seqid": "resources/denv4/genome_annotation.gff3"}, "2K": {"end": 6827, "seqid": "resources/denv4/genome_annotation.gff3", "start": 6759, "strand": "+", "type": "gene"}, "C": {"end": 440, "seqid": "resources/denv4/genome_annotation.gff3", "start": 102, "strand": "+", "type": "gene"}, "E": {"end": 2423, "seqid": "resources/denv4/genome_annotation.gff3", "start": 939, "strand": "+", "type": "gene"}, "M": {"end": 938, "seqid": "resources/denv4/genome_annotation.gff3", "start": 441, "strand": "+", "type": "gene"}, "NS1": {"end": 3479, "seqid": "resources/denv4/genome_annotation.gff3", "start": 2424, "strand": "+", "type": "gene"}, "NS2A": {"end": 4133, "seqid": "resources/denv4/genome_annotation.gff3", "start": 3480, "strand": "+", "type": "gene"}, "NS2B": {"end": 4523, "seqid": "resources/denv4/genome_annotation.gff3", "start": 4134, "strand": "+", "type": "gene"}, "NS3": {"end": 6377, "seqid": "resources/denv4/genome_annotation.gff3", "start": 4524, "strand": "+", "type": "gene"}, "NS4A": {"end": 6758, "seqid": "resources/denv4/genome_annotation.gff3", "start": 6378, "strand": "+", "type": "gene"}, "NS4B": {"end": 7562, "seqid": "resources/denv4/genome_annotation.gff3", "start": 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TGATTACGTCAGTGCCATAACGCAAGCCGAAAGAATTGGTGAGCCAGATTATGAAGTGGATGAGGACATCTTTCGAAAGAAAAGATTAACCATAATGGACTTACACCCCGGAGCTGGCAAGACAAAAAGAATTCTCCCATCAATAGTCAGAGAAGCTCTAAAAAGGAGGCTGCGAACCCTGATTTTGGCTCCCACGAGAGTGGTGGCAGCCGAGATGGAAGAGGCCCTTCGCGGACTACCAATCCGTTATCAGACCCCAGCTGTGAAATCAGAACACACAGGAAGAGAGATTGTAGACCTCATGTGTCATGCAACCTTCACAACAAGACTCTTGTCATCAACCAGAGTTCCAAATTACAACCTCATAGTAATGGATGAAGCGCATTTCACAGACCCTTCTAGTGTCGCAGCTAGAGGATACATCTCAACCAGGGTGGAAATGGGAGAGGCAGCAGCCATCTTCATGACTGCAACCCCTCCCGGAGCAACAGATCCCTTCCCCCAGAGCAACAGCCCAATAGAAGACATCGAGAGAGAAATTCCAGAAAGGTCATGGAATACAGGATTCGACTGGATAACAGACTACCAAGGGAAGACTGTGTGGTTTGTTCCCAGCATAAAAGCTGGAAATGACATTGCAAATTGCTTGAGAAAGTCGGGAAAGAAGGTGATCCAGTTGAGTAGGAAAACCTTTGACACAGAGTATCCAAAAACGAAACTCACAGACTGGGATTTTGTGGTCACCACAGACATATCTGAAATGGGGGCCAATTTTAGAGCTGGGAGAGTGATAGACCCCAGGAGATGCCTCAAGCCAGTCATCCTAACAGATGGGCCAGAGAGAGTCATTTTGGCAGGTCCCATTCCAGTGACTCCAGCAAGCGCTGCTCAGAGAAGAGGGCGAATAGGTAGAAACCCAGCACAAGAAGACGACCAGTATGTCTTCTCTGGAGACCCATTGAAAAATGATGAAGATCATGCCCACTGGACAGAAGCAAAGATGCTGCTTGACAATATCTACACCCCGGAAGGGATCATTCCAACATTGTTTGGTCCGGAAAGGGAAAAAACCCAAGCCATTGATGGAGAGTTTCGCCTCAGAGGGGAACAAAGGAAGACTTTTGTGGAATTAATGAGGAGAGGAGACCTTCCGGTGTGGCTGAGCTATAAGGTAGCTTCAGCTGGTATTTCTTACAAAGACCGGGAATGGTGCTTCACAGGGGAAAGGAATAACCAAATTTTAGAAGAAAACATGGAGGTTGAAATTTGGACTAGAGAGGGAGAAAAGAAAAAACTAAGACCAAAATGGTTAGATGCACGTGTCTATGCTGACCCCATGGCTTTGAAGGATTTCAAGGAGTTTGCTAGTGGAAGAAAGAGCATAACCCTTGACATCCTGACAGAGATTGCCAGCTTGCCAACTTACCTTTCCTCTAGGGCCAAGCTCGCCCTTGACAACATAGTCATGCTCCACACAACAGAAAGGGGAGGGAGGGCCTACCAACACGCCCTGAACGAACTCCCGGAGTCATTGGAAACACTCATGCTTGTAGCTTTATTAGGTGCTATGACAGCAGGCATCTTCCTGTTTTTTATGCAAGGAAAAGGGATAGGGAAACTGTCAATGGGTTTGATAGCTATTGCGGTAGCTAGTGGCTTACTCTGGGTAGCAGAAATTCAGCCCCAGTGGATAGCGGCCTCAATCATACTGGAGTTTTTTCTCATGGTGCTGTTGATACCAGAACCAGAAAAACAAAGGACCCCACAAGACAACCAGTTGATCTATGTCATACTGGCCATTCTCACCATTATTGGTCTCATAGCAGCCAACGAGATGGGGCTGATTGAAAAAACAAAAACGGATTTTGGGTTTTACCAGGTAAAAACAGAAACCACCATCCTCGATGTGGATTTGAGACCAGCTTCAGCATGGACGCTCTATGCAGTAGCCACCACTATTCTGACTCCCATGCTGAGACACACCATAGAAAACACATCTGCCAACCTATCTCTGGCGGCCATTGCCAATCAAGCAGCTGTCCTAATGGGGCTTGGAAAAGGATGGCCGCTCCACAGAATGGACCTTGGTGTGCCGCTGTTAGCAATGGGATGTTATTCTCAAGTGAACCCAACAACTTTGACAGCATCCTTAGTCATGCTTTTAGTCCATTATGCAATAATAGGTCCAGGATTGCAGGCAAAAGCCACAAGAGAGGCTCAGAAAAGGACAGCTGCTGGGATCATGAAGAACCCCACGGTGGATGGAATAACAGTAATAGATCTAGAACCAATATCTTATGACCCAAAGTTTGAAAAGCAATTAGGGCAGGTCATGCTACTAGTCTTGTGTGCTGGACAACTACTCTTGATGAGAACAACATGGGCTTTCTGTGAAGTCTTGACTTTGGCCACAGGACCAGTCTTAACTTTGTGGGAGGGCAACCCGGGAAGATTTTGGAACACGACTATAGCCGTATCCACTGCCAACATTTTCAGGGGAAGCTACTTGGCGGGAGCTGGACTGGCTTTCTCACTCATAAAGAATGCACAAACCCCCAGGAGGGGAACTGGGACCACAGGAGAGACACTGGGAGAGAAGTGGAAGAGACAGCTAAACTCATTAGATAGGAAGGAGTTTGAAGAGTACAAGAGAAGTGGAATACTAGAAGTGGACAGGACTGAAGCCAAGTCTGCCCTGAAAGATGGGTCTAAAATCAAGCATGCAGTGTCCAGAGGGTCCAGCAAGATCAGATGGATTGTTGAAAGAGGGATGGTAAAGCCAAAAGGGAAAGTTGTGGATCTTGGTTGCGGGAGAGGAGGATGGTCGTATTACATGGCGACACTCAAGAACGTGACTGAGGTGAAAGGGTACACGAAAGGAGGTCCAGGACATGAAGAACCGATTCCCATGGCTACCTATGGCTGGAATTTGGTCAAGCTCCATTCAGGGGTTGACGTGTTCTACAAACCCACTGAGCAAGTGGACACCCTGCTCTGTGATATTGGAGAGTCATCTTCTAATCCGACAATAGAGGAAGGAAGAACATTAAGAGTTCTGAAGATGGTGGAGCCATGGCTCTCTTCAAAACCTGAATTCTGCATCAAAGTCCTTAACCCCTACATGCCAACAGTCATAGAAGAACTGGAGAAACTGCAGAGAAAGCATGGTGGAAGTCTTATCAGATGCCCGCTATCCAGGAATTCCACTCATGAGATGTATTGGGTGTCAGGTGCGTCGGGAAACATCGTGAGCTCTGTGAACACAACATCAAAGATGCTGTTGAACAGGTTTACCACGAGGCATAGGAAACCCACCTATGAGAAGGACGTAGACCTTGGAGCAGGAACAAGAAGTGTCTCCACTGAAACAGAAAAACCAGACATGACAATCATTGGGAGAAGGCTTCAGCGATTGCAAGAAGAGCACAAAGAAACTTGGCACTATGATCAGGAAAATCCATACAGAACCTGGGCGTATCATGGAAGCTATGAAGCTCCTTCGACAGGCTCAGCATCCTCCATGGTAAACGGGGTAGTAAAACTGCTGACAAAACCTTGGGACGTGATTCCAATGGTGACCCAGTTAGCCATGACAGACACAACCCCCTTTGGGCAACAAAGAGTGTTTAAAGAGAAGGTGGACACCAGAACACCACAACCAAAACCAGGCACACGAGTGGTTATGACCACAACAGCCAATTGGCTGTGGGCCCTCCTTGGGAGGAAGAAAAATCCCAGACTGTGCACGAGGGAAGAGTTCATCTCAAAAGTTAGGTCAAACGCAGCCATAGGTGCAGTCTTTCAGGAAGAACAGGGATGGACATCAGCCAGTGAAGCTGTGAATGACAGCCGGTTTTGGGAACTGGTTGACAAAGAAAGGGCTCTGCACCAGGAAGGGAAATGTGAATCGTGTGTCTACAACATGATGGGAAAACGTGAGAAAAAACTAGGAGAGTTTGGTAGAGCCAAAGGAAGCCGAGCAATCTGGTACATGTGGCTGGGAGCGCGGTTTCTGGAATTTGAAGCCCTGGGTTTCTTAAATGAAGATCACTGGTTTGGCAGAGAAAATTCATGGAGTGGAGTGGAAGGAGAAGGTCTGCATAGATTGGGATACATCCTAGAGGACATAGACAAGAAGGATGGAGACCTGATGTATGCTGATGACACAGCAGGTTGGGACACAAGAATCACTGAAGATGACCTTCTAAATGAAGAACTGATCACGGAACAGATGGCCCCTCATCATAAGATCTTAGCCAAAGCCATTTTCAAACTAACTTATCAAAACAAAGTGGTAAAAGTCCTCAGACCCACACCGAAAGGAGCGGTGATGGACATCATATCCAGGAAAGACCAAAGAGGTAGTGGACAGGTTGGAACATATGGTTTGAACACATTCACCAACATGGAAGTACAACTCATCCGCCAAATGGAAGCTGAAGGAGTCATCACACAAGATGACATGCAGAACCCAAAAGGGCTGAAAGAAAGAGTTGAGAAATGGCTGAAAGAGTGTGGTGTCGACAGGTTGAAGAGGATGGCAATCAGTGGAGATGATTGTGTGGTGAAGCCCCTGGATGAGAGGTTCAGCACTTCCCTCCTCTTCTTGAACGACATGGGAAAGGTGAGGAAAGACATTCCGCAGTGGGAACCATCCAAGGGATGGAAAAATTGGCAAGAGGTTCCTTTTTGCTCCCACCACTTTCACAAGATCTTCATGAAGGATGGCCGCTCACTAGTTGTTCCATGTAGAAACCAGGATGAACTGATAGGGAGAGCCAGAATCTCGCAGGGGGCTGGATGGAGCTTAAAAGAAACAGCCTGTCTGGGCAAAGCTTACGCCCAGATGTGGTCGCTCATGTATTTTCACAGAAGGGACCTGCGTTTAGCCTCCATGGCCATATGCTCAGCAGTTCCAACGGAATGGTTTCCAACAAGCAGAACAACATGGTCAATCCACGCCCACCATCAGTGGATGACCACTGAAGACATGCTCAAAGTGTGGAACAGAGTGTGGATAGAAGACAACCCTAACATGACTGACAAAACTCCAGTCCATTCGTGGGAAGACATACCTTACCTAGGGAAAAGAGAGGATTTGTGGTGTGGATCCTTGATTGGACTTTCTTCCAGAGCCACCTGGGCGAAAAACATTCACACAGCCATAACCCAAGTCAGGAACCTGATCGGGAAAGAGGAGTATGTGGATTACATGCCAGTCATGAAAAGATACAGCGCTCCTTTCGAGAGTGAAGGAGTTCTGTAATTACCAACAACAAACACCAAAGCCTATTGAAGTCAGGCCACTTGTGCCACGGCTTGAGCAAACCGTGCTGCCTGTAGCTCCGCCAATAACGGGAGGCGTAAAAATTCCCAGGGAGGCCATGCGCCACGGAAGCTGTACGCGTGGCATATTGGACTAGCGGTTAGAGGAGACCCCTCCCATCACTGACAAAACGCAGCAAAAGGGGGCCCGAAGCCAGGAGGAAGCTGTACTCCTGGTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAACACAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCTGCAACATCAATCCAGGCACAGAGCGCCGCAAGATGGATTGGTGTTGTTGATCCAACAGGTTCT", "2K": "TPQDNQLIYVILAILTIIGLIAA", "C": "MNQRKKVVRPPFNMLKRERNRVSTPQGLVKRFSTGLFSGKGPLRMVLAFITFLRVLSIPPTAGILKRWGQLKKNKAIKILTGFRKEIGRMLNILNGRKRSTITLLCLIPTVMA", "E": "MRCVGVGNRDFVEGVSGGAWVDLVLEHGGCVTTMAQGKPTLDFELIKTTAKEVALLRTYCIEASISNITTATRCPTQGEPYLKEEQDQQYICRRDVVDRGWGNGCGLFGKGGVVTCAKFSCSGKITGNLVQIENLEYTVVVTVHNGDTHAVGNDTSNHGVTATITPRSPSVEVKLPDYGELTLDCEPRSGIDFNEMILMKMKKKTWLVHKQWFLDLPLPWTAGADTSEVHWNYKERMVTFKVPHAKRQDVTVLGSQEGAMHSALTGATEVDSGDGNHMFAGHLKCKVRMEKLRIKGMSYTMCSGKFSIDKEMAETQHGTTVVKVKYEGTGAPCKVPIEIRDVNKEKVVGRIISSTPFAENTNSVTNIELEPPFGDSYIVIGVGDSALTLHWFRKGSSIGKMFESTYRGAKRMAILGETAWDFGSVGGLFTSLGKAVHQVFGSVYTTMFGGVSWMVRILIGFLVLWIGTNSRNTSMAMTCIAVGGITLFLGFTVQA", "M": "FHLSTRDGEPLMIVAKHERGRPLLFKTTEGINKCTLIAMDLGEMCEDTVTYKCPLLVNTEPEDIDCWCNLTSTWVMYGTCTQSGERRREKRSVALTPHSGMGLETRAETWMSSEGAWKHAQRVESWILRNPGFALLAGFMAYMIGQTGIQRTVFFVLMMLVAPSYG", "NS1": "DMGCVVSWSGKELKCGSGIFVIDNVHTWTEQYKFQPESPARLASAILNAHKDGVCGIRSTTRLENVMWKQITNELNYVLWEGGHDLTVVAGDVKGVLTKGKRALTPPVNDLKYSWKTWGKAKIFTPEARNSTFLIDGPDTSECPNERRAWNFLEVEDYGFGMFTTNIWMKFREGSSEVCDHRLMSAAIKDQKAVHADMGYWIESSKNQTWQIEKASLIEVKTCLWPKTHTLWSNGVLESQMLIPKAYAGPFSQHNYRQGYATQTMGPWHLGKLEIDFGECPGTTVTIQEDCDHRGPSLRTTTASGKLVTQWCCRSCTMPPLRFLGEDGCWYGMEIRPLSEKEENMVKSQVSA", "NS2A": "GQGSSETFSMGLLCLTLFMEECLRRRVTRKHMILVVVTTLCAIILGGLTWMDLLRAIIMLGDTMFGRMGGQIHLAIMAVFKMSPGYVLGVFLRKLTSRETALMVIGMAMTTVFSIPHDLMEFIDGISLGLILLKMVTHFDNTQVGTLALSLTFIRSTMPLIMAWRTIMAVLFVVTLIPLCRTSCLQKQSHWVEITAIILGAQALPVYLMTLMKGASKR", "NS2B": "SWPLNEGIMAVGLVSLLGSALLKNDVPLAGPMVAGGLLLAAYVMSGSSADLSLEKAANVQWDEMADITGSSPIIEVKQDEDGSFSIRDVEETNMITLLVKLALITVSGLYPLAIPVTMTLWYMWQVKTQR", "NS3": "SGALWDVPSPATAQKATLTEGVYRIMQRGLFGKTQVGVGIHMEGVFHTMWHVTRGSVICHETGRLEPSWADVRNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLFKTLTGEIGAVTLDFKPGTSGSPIINKKGKVIGLYGNGVVTKSGDYVSAITQAERIGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALRGLPIRYQTPAVKSEHTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEAHFTDPSSVAARGYISTRVEMGEAAAIFMTATPPGATDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSGKKVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGRK", "NS4A": "SITLDILTEIASLPTYLSSRAKLALDNIVMLHTTERGGRAYQHALNELPESLETLMLVALLGAMTAGIFLFFMQGKGIGKLSMGLIAIAVASGLLWVAEIQPQWIAASIILEFFLMVLLIPEPEKQR", "NS4B": "NEMGLIEKTKTDFGFYQVKTETTILDVDLRPASAWTLYAVATTILTPMLRHTIENTSANLSLAAIANQAAVLMGLGKGWPLHRMDLGVPLLAMGCYSQVNPTTLTASLVMLLVHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGITVIDLEPISYDPKFEKQLGQVMLLVLCAGQLLLMRTTWAFCEVLTLATGPVLTLWEGNPGRFWNTTIAVSTANIFRGSYLAGAGLAFSLIKNAQTPRR", "NS5": "GTGTTGETLGEKWKRQLNSLDRKEFEEYKRSGILEVDRTEAKSALKDGSKIKHAVSRGSSKIRWIVERGMVKPKGKVVDLGCGRGGWSYYMATLKNVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGVDVFYKPTEQVDTLLCDIGESSSNPTIEEGRTLRVLKMVEPWLSSKPEFCIKVLNPYMPTVIEELEKLQRKHGGSLIRCPLSRNSTHEMYWVSGASGNIVSSVNTTSKMLLNRFTTRHRKPTYEKDVDLGAGTRSVSTETEKPDMTIIGRRLQRLQEEHKETWHYDQENPYRTWAYHGSYEAPSTGSASSMVNGVVKLLTKPWDVIPMVTQLAMTDTTPFGQQRVFKEKVDTRTPQPKPGTRVVMTTTANWLWALLGRKKNPRLCTREEFISKVRSNAAIGAVFQEEQGWTSASEAVNDSRFWELVDKERALHQEGKCESCVYNMMGKREKKLGEFGRAKGSRAIWYMWLGARFLEFEALGFLNEDHWFGRENSWSGVEGEGLHRLGYILEDIDKKDGDLMYADDTAGWDTRITEDDLLNEELITEQMAPHHKILAKAIFKLTYQNKVVKVLRPTPKGAVMDIISRKDQRGSGQVGTYGLNTFTNMEVQLIRQMEAEGVITQDDMQNPKGLKERVEKWLKECGVDRLKRMAISGDDCVVKPLDERFSTSLLFLNDMGKVRKDIPQWEPSKGWKNWQEVPFCSHHFHKIFMKDGRSLVVPCRNQDELIGRARISQGAGWSLKETACLGKAYAQMWSLMYFHRRDLRLASMAICSAVPTEWFPTSRTTWSIHAHHQWMTTEDMLKVWNRVWIEDNPNMTDKTPVHSWEDIPYLGKREDLWCGSLIGLSSRATWAKNIHTAITQVRNLIGKEEYVDYMPVMKRYSAPFESEGVL", "pr": "FHLSTRDGEPLMIVAKHERGRPLLFKTTEGINKCTLIAMDLGEMCEDTVTYKCPLLVNTEPEDIDCWCNLTSTWVMYGTCTQSGERRREKR"}} \ No newline at end of file +{"version": "v2", "meta": {"title": "Real-time tracking of dengue virus evolution", "updated": "2024-06-10", "build_url": "https://github.com/nextstrain/dengue", "maintainers": [{"name": "the Nextstrain team", "url": "https://nextstrain.org/team"}], "display_defaults": {"map_triplicate": true, "color_by": "clade_membership"}, "genome_annotations": {"nuc": {"end": 10649, "start": 1, "strand": "+", "type": "##sequence-region pragma", "seqid": "resources/denv4/genome_annotation.gff3"}, "2K": {"end": 6827, "seqid": "resources/denv4/genome_annotation.gff3", "start": 6759, "strand": "+", "type": "gene"}, "C": {"end": 440, "seqid": "resources/denv4/genome_annotation.gff3", "start": 102, "strand": "+", "type": "gene"}, "E": {"end": 2423, "seqid": "resources/denv4/genome_annotation.gff3", "start": 939, "strand": "+", "type": "gene"}, "M": {"end": 938, "seqid": 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E333K, I335E, T346S, F348Y, D349E, Y354F, S378N, K381R, L399I, T400N, R418K, G420E, I447M, P451L, A466K, Q467K, D469N, V473I, F474Y, S475M, D477E, Y499N, G510E, Q517E, F523Y, Q529A, S547A, A553E, S556K, K558T, E561R, T565D, R584K, K588R, K594R, V600T, A602S, M605L, D609E, S615A; NS4A: I6L, L7I, A11G, S12R, S18T, S19H, K22R, L23N, I28L, Q42K, S51T, L55F, V58L, G62A, A66G, F72L, Q74*, K76R, L81M, A87C, A89M, V90A, I97M, Q103H; NS4B: I6L, T11K, F13L, Y16G, Q17H, K19A, T22N, L45I, T56S, L60V, A63T, H82S, R83K, L86I, T102I, S107A, V109L, M110L, L112V, V113A, E153D, S156P, G176A, F187L, V190A, V198I, L199S, R208K, T218M, L236I, I237M, Q241G, T242S, P243A; NS5: T5I, S19P, D21G, E27I, R30K, S43E, A44G, D47R, S49E, K50T, I51T, K52H, S60A, I62L, I65F, G69N, K74E, M91C, T93G, A117S, H127Q, Y134F, K135T, T137P, Q139K, V140C, S152P, I156V, S173N, S174N, K175N, P176T, E177Q, E193K, S204I, I206V, C208N, G223N, T234M, K237R, T245M, S264N, S266A, T267I, K271T, D273N, T275D, R279K, L281I, Q282E, R283K, L284I, Q285K, E290T, E297D, R301K, P312K, S313P, K326R, L341M, Q365K, V372K, T375K, T376I, N379E, A383R, N390K, L393M, I400T, S401K, S405T, I409M, Q414T, E415D, Q417N, G418K, T420N, N427E, S429E, A440D, S449T, R467K, G499S, W504L, R514K, E520R, D523N, D528G, L529A, L548Q, L552M, E555D, A558D, D560E, I563K, K579R, L581Q, A588T, K596R, V617A, A625G, I629F, Q631P, D632K, D633E, M634F, Q635*, N636T, K638H, G639L, K641E, E642K, E645Q, K646E, K649E, E650K, C651H, D654E, E673D, S676A, S678A, L680T, F681A, K702N, N703D, E706Q, K716E, I717L, F718I, S724T, K750R, A758S, S764R, S777A, M778N, E787H, L811F, K812T, N824W, T826E, Y832*, L846Q, T869N, N873S, K877N, V881I, A886S, Y890F, S891R, A892N, P893E, L894E, S896N; pr: S4T, L11H, A15S, R21K, P22S, T28A, E29D, K33M, M44L, V49I, V57T, N58E, S83T, R86H"}}}, {"name": "NODE_0000011", "node_attrs": {"div": 1035, "region": {"value": "Asia", "confidence": {"Asia": 0.9999046896248011}, "entropy": 0.0011298739607045602}, "clade_membership": {"value": 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"AGTTGTTAGTCTGTGTGGACCGACAAGGACAGTTCCAAATCGGAAGCTTGCTTAACACAGTTCTAACAGTTTGTTTAAATAGAGAGCAGATCTCTGGAAAAATGAACCAACGAAAAAAGGTGGTTAGACCGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTATCAACCCCTCAAGGGTTGGTGAAGAGATTCTCAACCGGACTGTTTTCCGGGAAAGGACCCTTACGGATGGTGCTAGCATTCATCACGTTTTTGCGAGTCCTTTCCATCCCACCAACAGCAGGGATTCTGAAAAGATGGGGACAGTTGAAGAAAAACAAGGCCATCAAGATACTGACTGGATTCAGGAAGGAGATAGGCCGCATGCTGAACATCTTGAACGGGAGAAAGAGGTCAACAATAACATTGCTATGCTTGATTCCCACCGTAATGGCATTCCACTTGTCAACAAGAGATGGCGAACCCCTTATGATAGTAGCAAAACACGAAAGGGGGAGACCTCTCTTGTTTAAGACAACAGAAGGAATCAACAAATGCACTCTTATTGCCATGGACTTGGGTGAAATGTGTGAGGACACCGTCACGTATAAATGCCCTCTACTGGTCAACACCGAACCTGAAGACATTGATTGCTGGTGCAATCTCACGTCTACCTGGGTCATGTATGGGACATGTACCCAGAGCGGAGAACGGAGACGAGAGAAGCGCTCAGTAGCTTTAACACCACATTCAGGAATGGGATTGGAAACAAGGGCTGAGACATGGATGTCATCGGAAGGGGCTTGGAAACATGCCCAGAGAGTGGAGAGCTGGATACTCAGAAACCCAGGATTCGCGCTCTTGGCAGGATTTATGGCTTATATGATTGGGCAAACAGGAATCCAGCGAACTGTCTTCTTTGTTCTAATGATGCTGGTCGCTCCATCCTACGGAATGCGATGCGTAGGAGTGGGGAACAGAGATTTTGTGGAAGGAGTCTCAGGTGGAGCATGGGTCGATCTGGTGCTAGAACACGGAGGATGTGTCACAACCATGGCCCAGGGAAAACCAACCTTGGATTTTGAATTGATCAAGACAACAGCCAAGGAAGTGGCTCTGTTAAGAACTTATTGCATTGAAGCCTCGATATCAAACATAACCACGGCAACAAGATGTCCAACGCAAGGAGAACCTTATCTCAAAGAGGAACAAGACCAACAGTACATTTGCCGGAGAGATGTGGTAGACAGAGGGTGGGGCAATGGCTGTGGCCTGTTTGGAAAAGGAGGAGTTGTGACATGTGCAAAGTTTTCATGCTCGGGGAAGATAACAGGCAACTTGGTCCAAATTGAAAACCTTGAATACACAGTGGTTGTGACAGTCCACAATGGAGACACCCACGCAGTAGGAAATGACACATCCAACCATGGAGTGACAGCCACGATAACTCCCAGGTCACCATCGGTAGAAGTTAAATTACCGGACTATGGAGAACTAACACTCGATTGTGAACCCAGGTCCGGAATTGACTTTAATGAGATGATTCTGATGAAAATGAAAAAGAAAACGTGGCTTGTGCACAAGCAATGGTTTTTGGATCTACCTCTGCCATGGACAGCAGGAGCAGACACATCAGAAGTCCATTGGAATTATAAAGAGAGAATGGTGACATTCAAGGTTCCTCATGCCAAGAGACAGGATGTGACAGTGCTAGGATCTCAGGAAGGAGCCATGCATTCTGCCCTCACCGGAGCCACAGAAGTGGATTCCGGTGATGGAAACCACATGTTTGCAGGACATCTAAAGTGCAAAGTACGCATGGAGAAATTGAGAATCAAGGGAATGTCATACACGATGTGCTCAGGAAAGTTCTCAATTGACAAGGAGATGGCAGAAACACAGCATGGGACAACAGTGGTGAAAGTCAAGTATGAAGGTACTGGAGCTCCATGCAAAGTCCCCATAGAGATAAGAGATGTGAACAAGGAAAAAGTGGTTGGGCGCATCATTTCATCTACTCCTTTTGCTGAGAATACCAACAGTGTAACCAATATTGAATTAGAACCCCCCTTTGGGGACAGCTACATAGTGATAGGTGTTGGAGACAGTGCATTAACACTCCATTGGTTTAGGAAAGGGAGTTCCATTGGCAAGATGTTTGAGTCCACATACAGAGGTGCAAAGCGAATGGCCATTCTAGGTGAAACAGCTTGGGATTTTGGTTCTGTTGGTGGACTGTTCACATCATTGGGAAAAGCTGTGCACCAGGTTTTTGGTAGTGTCTACACAACTATGTTTGGAGGAGTCTCATGGATGGTTAGAATCCTAATTGGGTTCTTAGTGTTGTGGATCGGCACGAACTCAAGAAACACTTCAATGGCAATGACGTGCATAGCTGTTGGAGGAATCACTCTGTTTCTGGGTTTCACGGTTCAAGCAGACATGGGTTGTGTGGTGTCATGGAGTGGGAAAGAATTGAAATGTGGAAGTGGAATTTTTGTGATTGACAACGTGCACACTTGGACAGAACAGTACAAATTTCAACCAGAGTCCCCAGCGAGACTAGCGTCCGCAATATTGAATGCCCACAAAGATGGGGTCTGTGGAATTAGATCAACCACGAGGCTGGAAAATGTCATGTGGAAACAAATAACCAACGAGCTAAACTATGTTCTCTGGGAAGGAGGACATGACCTCACTGTGGTGGCCGGGGATGTGAAAGGGGTGTTGACCAAAGGCAAGAGAGCACTCACACCTCCAGTGAATGATTTGAAATATTCATGGAAGACATGGGGGAAAGCAAAAATCTTTACTCCAGAAGCAAGAAATAGCACATTCTTGATAGACGGACCAGACACCTCCGAATGCCCCAATGAACGAAGAGCATGGAACTTTCTTGAGGTAGAAGACTATGGATTTGGCATGTTCACGACCAACATATGGATGAAATTTCGAGAAGGAAGTTCAGAAGTGTGTGACCACAGGTTAATGTCAGCGGCAATCAAAGATCAGAAAGCCGTGCATGCTGACATGGGCTATTGGATAGAGAGCTCAAAAAACCAGACCTGGCAGATAGAGAAAGCATCCCTTATTGAAGTGAAAACATGTCTGTGGCCCAAGACTCACACATTGTGGAGCAATGGAGTGCTGGAAAGCCAGATGCTCATTCCAAAAGCATATGCAGGCCCCTTTTCACAGCACAATTACCGCCAGGGCTATGCCACGCAGACCATGGGCCCATGGCACTTGGGCAAATTGGAAATAGACTTTGGAGAATGCCCCGGAACAACAGTCACAATTCAGGAGGATTGTGACCACAGAGGCCCATCTTTGAGGACCACCACTGCATCTGGAAAATTGGTCACACAGTGGTGCTGCCGCTCCTGCACGATGCCTCCCTTAAGGTTTTTGGGAGAGGATGGGTGTTGGTATGGGATGGAAATTAGGCCCTTAAGTGAAAAAGAAGAGAACATGGTCAAATCACAGGTGTCGGCCGGACAGGGTTCATCAGAAACTTTTTCTATGGGGCTGTTATGTCTGACCCTGTTCATGGAAGAATGCTTGAGGAGAAGAGTCACTAGGAAACACATGATATTGGTTGTGGTGACCACCCTTTGTGCCATCATCCTAGGAGGTCTCACGTGGATGGACTTACTACGAGCCATTATCATGTTAGGGGACACCATGTTTGGTAGAATGGGAGGACAGATTCACCTAGCCATCATGGCAGTGTTCAAGATGTCACCAGGATACGTGCTGGGTGTGTTTTTAAGGAAACTCACTTCAAGAGAGACAGCACTAATGGTGATAGGAATGGCCATGACAACGGTGTTTTCAATTCCACATGACCTTATGGAATTCATTGATGGAATATCATTGGGGCTAATCTTGCTGAAAATGGTAACACATTTTGACAACACCCAAGTGGGAACTTTAGCCCTTTCCTTAACTTTCATAAGATCAACAATGCCATTGATCATGGCTTGGAGGACCATCATGGCTGTGTTGTTTGTGGTCACACTCATTCCTTTATGTAGGACAAGCTGTCTTCAAAAGCAGTCCCACTGGGTAGAAATAACAGCAATCATCTTAGGAGCCCAGGCTCTGCCAGTGTACTTAATGACTCTCATGAAAGGAGCCTCAAAAAGATCTTGGCCTCTTAACGAGGGCATAATGGCTGTGGGCTTGGTCAGTCTCTTGGGAAGCGCCCTTCTAAAGAATGATGTCCCTTTGGCTGGTCCAATGGTGGCAGGAGGTTTACTTCTGGCAGCCTACGTGATGAGTGGTAGCTCAGCAGACCTGTCACTAGAGAAGGCCGCCAATGTGCAGTGGGATGAGATGGCAGACATAACAGGCTCAAGCCCAATCATAGAAGTGAAGCAGGATGAAGATGGCTCTTTCTCCATACGGGACGTCGAGGAAACCAACATGATAACCCTTTTGGTGAAACTGGCACTGATAACTGTGTCAGGTCTCTACCCCTTGGCAATTCCAGTCACAATGACTTTATGGTACATGTGGCAAGTGAAAACACAAAGATCAGGAGCCCTGTGGGACGTTCCCTCACCCGCTACCGCTCAGAAAGCCACACTGACTGAAGGAGTGTACAGGATCATGCAAAGAGGGTTGTTTGGGAAAACTCAGGTTGGAGTAGGGATACACATGGAAGGTGTATTTCACACAATGTGGCATGTAACAAGAGGATCAGTGATCTGCCATGAGACTGGGAGATTGGAGCCATCTTGGGCTGACGTCAGGAACGACATGATATCATACGGTGGGGGATGGAGGCTCGGAGACAAATGGGACAAAGAAGAAGATGTTCAGGTCCTAGCCATAGAACCAGGAAAAAATCCGAAACATGTCCAAACGAAACCCGGCCTTTTCAAGACCCTAACTGGAGAAATTGGAGCAGTAACATTGGATTTCAAACCCGGAACATCTGGTTCTCCCATCATTAACAAGAAAGGAAAAGTTATCGGACTCTATGGAAATGGAGTAGTTACCAAATCAGGTGATTACGTCAGTGCCATAACGCAAGCCGAAAGAATTGGTGAGCCAGATTATGAAGTGGATGAGGACATCTTTCGAAAGAAAAGATTAACCATAATGGACTTACACCCCGGAGCTGGCAAGACAAAAAGAATTCTCCCATCAATAGTCAGAGAAGCTCTAAAAAGGAGGCTGCGAACCCTGATTTTGGCTCCCACGAGAGTGGTGGCAGCCGAGATGGAAGAGGCCCTTCGCGGACTACCAATCCGTTATCAGACCCCAGCTGTGAAATCAGAACACACAGGAAGAGAGATTGTAGACCTCATGTGTCATGCAACCTTCACAACAAGACTCTTGTCATCAACCAGAGTTCCAAATTACAACCTCATAGTAATGGATGAAGCGCATTTCACAGACCCTTCTAGTGTCGCAGCTAGAGGATACATCTCAACCAGGGTGGAAATGGGAGAGGCAGCAGCCATCTTCATGACTGCAACCCCTCCCGGAGCAACAGATCCCTTCCCCCAGAGCAACAGCCCAATAGAAGACATCGAGAGAGAAATTCCAGAAAGGTCATGGAATACAGGATTCGACTGGATAACAGACTACCAAGGGAAGACTGTGTGGTTTGTTCCCAGCATAAAAGCTGGAAATGACATTGCAAATTGCTTGAGAAAGTCGGGAAAGAAGGTGATCCAGTTGAGTAGGAAAACCTTTGACACAGAGTATCCAAAAACGAAACTCACAGACTGGGATTTTGTGGTCACCACAGACATATCTGAAATGGGGGCCAATTTTAGAGCTGGGAGAGTGATAGACCCCAGGAGATGCCTCAAGCCAGTCATCCTAACAGATGGGCCAGAGAGAGTCATTTTGGCAGGTCCCATTCCAGTGACTCCAGCAAGCGCTGCTCAGAGAAGAGGGCGAATAGGTAGAAACCCAGCACAAGAAGACGACCAGTATGTCTTCTCTGGAGACCCATTGAAAAATGATGAAGATCATGCCCACTGGACAGAAGCAAAGATGCTGCTTGACAATATCTACACCCCGGAAGGGATCATTCCAACATTGTTTGGTCCGGAAAGGGAAAAAACCCAAGCCATTGATGGAGAGTTTCGCCTCAGAGGGGAACAAAGGAAGACTTTTGTGGAATTAATGAGGAGAGGAGACCTTCCGGTGTGGCTGAGCTATAAGGTAGCTTCAGCTGGTATTTCTTACAAAGACCGGGAATGGTGCTTCACAGGGGAAAGGAATAACCAAATTTTAGAAGAAAACATGGAGGTTGAAATTTGGACTAGAGAGGGAGAAAAGAAAAAACTAAGACCAAAATGGTTAGATGCACGTGTCTATGCTGACCCCATGGCTTTGAAGGATTTCAAGGAGTTTGCTAGTGGAAGAAAGAGCATAACCCTTGACATCCTGACAGAGATTGCCAGCTTGCCAACTTACCTTTCCTCTAGGGCCAAGCTCGCCCTTGACAACATAGTCATGCTCCACACAACAGAAAGGGGAGGGAGGGCCTACCAACACGCCCTGAACGAACTCCCGGAGTCATTGGAAACACTCATGCTTGTAGCTTTATTAGGTGCTATGACAGCAGGCATCTTCCTGTTTTTTATGCAAGGAAAAGGGATAGGGAAACTGTCAATGGGTTTGATAGCTATTGCGGTAGCTAGTGGCTTACTCTGGGTAGCAGAAATTCAGCCCCAGTGGATAGCGGCCTCAATCATACTGGAGTTTTTTCTCATGGTGCTGTTGATACCAGAACCAGAAAAACAAAGGACCCCACAAGACAACCAGTTGATCTATGTCATACTGGCCATTCTCACCATTATTGGTCTCATAGCAGCCAACGAGATGGGGCTGATTGAAAAAACAAAAACGGATTTTGGGTTTTACCAGGTAAAAACAGAAACCACCATCCTCGATGTGGATTTGAGACCAGCTTCAGCATGGACGCTCTATGCAGTAGCCACCACTATTCTGACTCCCATGCTGAGACACACCATAGAAAACACATCTGCCAACCTATCTCTGGCGGCCATTGCCAATCAAGCAGCTGTCCTAATGGGGCTTGGAAAAGGATGGCCGCTCCACAGAATGGACCTTGGTGTGCCGCTGTTAGCAATGGGATGTTATTCTCAAGTGAACCCAACAACTTTGACAGCATCCTTAGTCATGCTTTTAGTCCATTATGCAATAATAGGTCCAGGATTGCAGGCAAAAGCCACAAGAGAGGCTCAGAAAAGGACAGCTGCTGGGATCATGAAGAACCCCACGGTGGATGGAATAACAGTAATAGATCTAGAACCAATATCTTATGACCCAAAGTTTGAAAAGCAATTAGGGCAGGTCATGCTACTAGTCTTGTGTGCTGGACAACTACTCTTGATGAGAACAACATGGGCTTTCTGTGAAGTCTTGACTTTGGCCACAGGACCAGTCTTAACTTTGTGGGAGGGCAACCCGGGAAGATTTTGGAACACGACTATAGCCGTATCCACTGCCAACATTTTCAGGGGAAGCTACTTGGCGGGAGCTGGACTGGCTTTCTCACTCATAAAGAATGCACAAACCCCCAGGAGGGGAACTGGGACCACAGGAGAGACACTGGGAGAGAAGTGGAAGAGACAGCTAAACTCATTAGATAGGAAGGAGTTTGAAGAGTACAAGAGAAGTGGAATACTAGAAGTGGACAGGACTGAAGCCAAGTCTGCCCTGAAAGATGGGTCTAAAATCAAGCATGCAGTGTCCAGAGGGTCCAGCAAGATCAGATGGATTGTTGAAAGAGGGATGGTAAAGCCAAAAGGGAAAGTTGTGGATCTTGGTTGCGGGAGAGGAGGATGGTCGTATTACATGGCGACACTCAAGAACGTGACTGAGGTGAAAGGGTACACGAAAGGAGGTCCAGGACATGAAGAACCGATTCCCATGGCTACCTATGGCTGGAATTTGGTCAAGCTCCATTCAGGGGTTGACGTGTTCTACAAACCCACTGAGCAAGTGGACACCCTGCTCTGTGATATTGGAGAGTCATCTTCTAATCCGACAATAGAGGAAGGAAGAACATTAAGAGTTCTGAAGATGGTGGAGCCATGGCTCTCTTCAAAACCTGAATTCTGCATCAAAGTCCTTAACCCCTACATGCCAACAGTCATAGAAGAACTGGAGAAACTGCAGAGAAAGCATGGTGGAAGTCTTATCAGATGCCCGCTATCCAGGAATTCCACTCATGAGATGTATTGGGTGTCAGGTGCGTCGGGAAACATCGTGAGCTCTGTGAACACAACATCAAAGATGCTGTTGAACAGGTTTACCACGAGGCATAGGAAACCCACCTATGAGAAGGACGTAGACCTTGGAGCAGGAACAAGAAGTGTCTCCACTGAAACAGAAAAACCAGACATGACAATCATTGGGAGAAGGCTTCAGCGATTGCAAGAAGAGCACAAAGAAACTTGGCACTATGATCAGGAAAATCCATACAGAACCTGGGCGTATCATGGAAGCTATGAAGCTCCTTCGACAGGCTCAGCATCCTCCATGGTAAACGGGGTAGTAAAACTGCTGACAAAACCTTGGGACGTGATTCCAATGGTGACCCAGTTAGCCATGACAGACACAACCCCCTTTGGGCAACAAAGAGTGTTTAAAGAGAAGGTGGACACCAGAACACCACAACCAAAACCAGGCACACGAGTGGTTATGACCACAACAGCCAATTGGCTGTGGGCCCTCCTTGGGAGGAAGAAAAATCCCAGACTGTGCACGAGGGAAGAGTTCATCTCAAAAGTTAGGTCAAACGCAGCCATAGGTGCAGTCTTTCAGGAAGAACAGGGATGGACATCAGCCAGTGAAGCTGTGAATGACAGCCGGTTTTGGGAACTGGTTGACAAAGAAAGGGCTCTGCACCAGGAAGGGAAATGTGAATCGTGTGTCTACAACATGATGGGAAAACGTGAGAAAAAACTAGGAGAGTTTGGTAGAGCCAAAGGAAGCCGAGCAATCTGGTACATGTGGCTGGGAGCGCGGTTTCTGGAATTTGAAGCCCTGGGTTTCTTAAATGAAGATCACTGGTTTGGCAGAGAAAATTCATGGAGTGGAGTGGAAGGAGAAGGTCTGCATAGATTGGGATACATCCTAGAGGACATAGACAAGAAGGATGGAGACCTGATGTATGCTGATGACACAGCAGGTTGGGACACAAGAATCACTGAAGATGACCTTCTAAATGAAGAACTGATCACGGAACAGATGGCCCCTCATCATAAGATCTTAGCCAAAGCCATTTTCAAACTAACTTATCAAAACAAAGTGGTAAAAGTCCTCAGACCCACACCGAAAGGAGCGGTGATGGACATCATATCCAGGAAAGACCAAAGAGGTAGTGGACAGGTTGGAACATATGGTTTGAACACATTCACCAACATGGAAGTACAACTCATCCGCCAAATGGAAGCTGAAGGAGTCATCACACAAGATGACATGCAGAACCCAAAAGGGCTGAAAGAAAGAGTTGAGAAATGGCTGAAAGAGTGTGGTGTCGACAGGTTGAAGAGGATGGCAATCAGTGGAGATGATTGTGTGGTGAAGCCCCTGGATGAGAGGTTCAGCACTTCCCTCCTCTTCTTGAACGACATGGGAAAGGTGAGGAAAGACATTCCGCAGTGGGAACCATCCAAGGGATGGAAAAATTGGCAAGAGGTTCCTTTTTGCTCCCACCACTTTCACAAGATCTTCATGAAGGATGGCCGCTCACTAGTTGTTCCATGTAGAAACCAGGATGAACTGATAGGGAGAGCCAGAATCTCGCAGGGGGCTGGATGGAGCTTAAAAGAAACAGCCTGTCTGGGCAAAGCTTACGCCCAGATGTGGTCGCTCATGTATTTTCACAGAAGGGACCTGCGTTTAGCCTCCATGGCCATATGCTCAGCAGTTCCAACGGAATGGTTTCCAACAAGCAGAACAACATGGTCAATCCACGCCCACCATCAGTGGATGACCACTGAAGACATGCTCAAAGTGTGGAACAGAGTGTGGATAGAAGACAACCCTAACATGACTGACAAAACTCCAGTCCATTCGTGGGAAGACATACCTTACCTAGGGAAAAGAGAGGATTTGTGGTGTGGATCCTTGATTGGACTTTCTTCCAGAGCCACCTGGGCGAAAAACATTCACACAGCCATAACCCAAGTCAGGAACCTGATCGGGAAAGAGGAGTATGTGGATTACATGCCAGTCATGAAAAGATACAGCGCTCCTTTCGAGAGTGAAGGAGTTCTGTAATTACCAACAACAAACACCAAAGCCTATTGAAGTCAGGCCACTTGTGCCACGGCTTGAGCAAACCGTGCTGCCTGTAGCTCCGCCAATAACGGGAGGCGTAAAAATTCCCAGGGAGGCCATGCGCCACGGAAGCTGTACGCGTGGCATATTGGACTAGCGGTTAGAGGAGACCCCTCCCATCACTGACAAAACGCAGCAAAAGGGGGCCCGAAGCCAGGAGGAAGCTGTACTCCTGGTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAACACAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCTGCAACATCAATCCAGGCACAGAGCGCCGCAAGATGGATTGGTGTTGTTGATCCAACAGGTTCT", "2K": "TPQDNQLIYVILAILTIIGLIAA", "C": "MNQRKKVVRPPFNMLKRERNRVSTPQGLVKRFSTGLFSGKGPLRMVLAFITFLRVLSIPPTAGILKRWGQLKKNKAIKILTGFRKEIGRMLNILNGRKRSTITLLCLIPTVMA", "E": "MRCVGVGNRDFVEGVSGGAWVDLVLEHGGCVTTMAQGKPTLDFELIKTTAKEVALLRTYCIEASISNITTATRCPTQGEPYLKEEQDQQYICRRDVVDRGWGNGCGLFGKGGVVTCAKFSCSGKITGNLVQIENLEYTVVVTVHNGDTHAVGNDTSNHGVTATITPRSPSVEVKLPDYGELTLDCEPRSGIDFNEMILMKMKKKTWLVHKQWFLDLPLPWTAGADTSEVHWNYKERMVTFKVPHAKRQDVTVLGSQEGAMHSALTGATEVDSGDGNHMFAGHLKCKVRMEKLRIKGMSYTMCSGKFSIDKEMAETQHGTTVVKVKYEGTGAPCKVPIEIRDVNKEKVVGRIISSTPFAENTNSVTNIELEPPFGDSYIVIGVGDSALTLHWFRKGSSIGKMFESTYRGAKRMAILGETAWDFGSVGGLFTSLGKAVHQVFGSVYTTMFGGVSWMVRILIGFLVLWIGTNSRNTSMAMTCIAVGGITLFLGFTVQA", "M": "FHLSTRDGEPLMIVAKHERGRPLLFKTTEGINKCTLIAMDLGEMCEDTVTYKCPLLVNTEPEDIDCWCNLTSTWVMYGTCTQSGERRREKRSVALTPHSGMGLETRAETWMSSEGAWKHAQRVESWILRNPGFALLAGFMAYMIGQTGIQRTVFFVLMMLVAPSYG", "NS1": "DMGCVVSWSGKELKCGSGIFVIDNVHTWTEQYKFQPESPARLASAILNAHKDGVCGIRSTTRLENVMWKQITNELNYVLWEGGHDLTVVAGDVKGVLTKGKRALTPPVNDLKYSWKTWGKAKIFTPEARNSTFLIDGPDTSECPNERRAWNFLEVEDYGFGMFTTNIWMKFREGSSEVCDHRLMSAAIKDQKAVHADMGYWIESSKNQTWQIEKASLIEVKTCLWPKTHTLWSNGVLESQMLIPKAYAGPFSQHNYRQGYATQTMGPWHLGKLEIDFGECPGTTVTIQEDCDHRGPSLRTTTASGKLVTQWCCRSCTMPPLRFLGEDGCWYGMEIRPLSEKEENMVKSQVSA", "NS2A": "GQGSSETFSMGLLCLTLFMEECLRRRVTRKHMILVVVTTLCAIILGGLTWMDLLRAIIMLGDTMFGRMGGQIHLAIMAVFKMSPGYVLGVFLRKLTSRETALMVIGMAMTTVFSIPHDLMEFIDGISLGLILLKMVTHFDNTQVGTLALSLTFIRSTMPLIMAWRTIMAVLFVVTLIPLCRTSCLQKQSHWVEITAIILGAQALPVYLMTLMKGASKR", "NS2B": "SWPLNEGIMAVGLVSLLGSALLKNDVPLAGPMVAGGLLLAAYVMSGSSADLSLEKAANVQWDEMADITGSSPIIEVKQDEDGSFSIRDVEETNMITLLVKLALITVSGLYPLAIPVTMTLWYMWQVKTQR", "NS3": "SGALWDVPSPATAQKATLTEGVYRIMQRGLFGKTQVGVGIHMEGVFHTMWHVTRGSVICHETGRLEPSWADVRNDMISYGGGWRLGDKWDKEEDVQVLAIEPGKNPKHVQTKPGLFKTLTGEIGAVTLDFKPGTSGSPIINKKGKVIGLYGNGVVTKSGDYVSAITQAERIGEPDYEVDEDIFRKKRLTIMDLHPGAGKTKRILPSIVREALKRRLRTLILAPTRVVAAEMEEALRGLPIRYQTPAVKSEHTGREIVDLMCHATFTTRLLSSTRVPNYNLIVMDEAHFTDPSSVAARGYISTRVEMGEAAAIFMTATPPGATDPFPQSNSPIEDIEREIPERSWNTGFDWITDYQGKTVWFVPSIKAGNDIANCLRKSGKKVIQLSRKTFDTEYPKTKLTDWDFVVTTDISEMGANFRAGRVIDPRRCLKPVILTDGPERVILAGPIPVTPASAAQRRGRIGRNPAQEDDQYVFSGDPLKNDEDHAHWTEAKMLLDNIYTPEGIIPTLFGPEREKTQAIDGEFRLRGEQRKTFVELMRRGDLPVWLSYKVASAGISYKDREWCFTGERNNQILEENMEVEIWTREGEKKKLRPKWLDARVYADPMALKDFKEFASGRK", "NS4A": "SITLDILTEIASLPTYLSSRAKLALDNIVMLHTTERGGRAYQHALNELPESLETLMLVALLGAMTAGIFLFFMQGKGIGKLSMGLIAIAVASGLLWVAEIQPQWIAASIILEFFLMVLLIPEPEKQR", "NS4B": "NEMGLIEKTKTDFGFYQVKTETTILDVDLRPASAWTLYAVATTILTPMLRHTIENTSANLSLAAIANQAAVLMGLGKGWPLHRMDLGVPLLAMGCYSQVNPTTLTASLVMLLVHYAIIGPGLQAKATREAQKRTAAGIMKNPTVDGITVIDLEPISYDPKFEKQLGQVMLLVLCAGQLLLMRTTWAFCEVLTLATGPVLTLWEGNPGRFWNTTIAVSTANIFRGSYLAGAGLAFSLIKNAQTPRR", "NS5": "GTGTTGETLGEKWKRQLNSLDRKEFEEYKRSGILEVDRTEAKSALKDGSKIKHAVSRGSSKIRWIVERGMVKPKGKVVDLGCGRGGWSYYMATLKNVTEVKGYTKGGPGHEEPIPMATYGWNLVKLHSGVDVFYKPTEQVDTLLCDIGESSSNPTIEEGRTLRVLKMVEPWLSSKPEFCIKVLNPYMPTVIEELEKLQRKHGGSLIRCPLSRNSTHEMYWVSGASGNIVSSVNTTSKMLLNRFTTRHRKPTYEKDVDLGAGTRSVSTETEKPDMTIIGRRLQRLQEEHKETWHYDQENPYRTWAYHGSYEAPSTGSASSMVNGVVKLLTKPWDVIPMVTQLAMTDTTPFGQQRVFKEKVDTRTPQPKPGTRVVMTTTANWLWALLGRKKNPRLCTREEFISKVRSNAAIGAVFQEEQGWTSASEAVNDSRFWELVDKERALHQEGKCESCVYNMMGKREKKLGEFGRAKGSRAIWYMWLGARFLEFEALGFLNEDHWFGRENSWSGVEGEGLHRLGYILEDIDKKDGDLMYADDTAGWDTRITEDDLLNEELITEQMAPHHKILAKAIFKLTYQNKVVKVLRPTPKGAVMDIISRKDQRGSGQVGTYGLNTFTNMEVQLIRQMEAEGVITQDDMQNPKGLKERVEKWLKECGVDRLKRMAISGDDCVVKPLDERFSTSLLFLNDMGKVRKDIPQWEPSKGWKNWQEVPFCSHHFHKIFMKDGRSLVVPCRNQDELIGRARISQGAGWSLKETACLGKAYAQMWSLMYFHRRDLRLASMAICSAVPTEWFPTSRTTWSIHAHHQWMTTEDMLKVWNRVWIEDNPNMTDKTPVHSWEDIPYLGKREDLWCGSLIGLSSRATWAKNIHTAITQVRNLIGKEEYVDYMPVMKRYSAPFESEGVL", "pr": "FHLSTRDGEPLMIVAKHERGRPLLFKTTEGINKCTLIAMDLGEMCEDTVTYKCPLLVNTEPEDIDCWCNLTSTWVMYGTCTQSGERRREKR"}} \ No newline at end of file From d3c39c7c3f77d57dfcff460292b72d1baf1c5bbd Mon Sep 17 00:00:00 2001 From: Jennifer Chang Date: Thu, 13 Jun 2024 14:09:40 -0700 Subject: [PATCH 8/8] [nextclade]: Add more outgroups to DENV2 --- nextclade/config/outgroup_denv2.fasta | 4 ++++ nextclade/datasets/denv2/tree.json | 2 +- 2 files changed, 5 insertions(+), 1 deletion(-) diff --git a/nextclade/config/outgroup_denv2.fasta b/nextclade/config/outgroup_denv2.fasta index a6b134fc..dbdc2ef5 100644 --- a/nextclade/config/outgroup_denv2.fasta +++ b/nextclade/config/outgroup_denv2.fasta @@ -1,2 +1,6 @@ +>Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv1/genome +AGTTGTTAGTCTACGTGGACCGACAAGAACAGTTTCGAATCGGAAGCTTGCTTAACGTAGTTCTAACAGTTTTTTATTAGAGAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGTCGACCGTCTTTCAATATGCTGAAACGCGCGAGAAACCGCGTGTCAACTGTTTCACAGTTGGCGAAGAGATTCTCAAAAGGATTGCTCTCAGGCCAAGGACCCATGAAATTGGTGATGGCTTTCATAGCATTCCTAAGATTTCTAGCCATACCCCCAACAGCAGGAATTTTGGCTAGATGGGGCTCATTCAAGAAGAATGGAGCGATTAAAGTGTTACGGGGTTTCAAGAAAGAAATCTCAAACATGTTGAACATAATGAACAGGAGGAAAAGATCCGTGACCATGCTCCTTATGCTGCTGCCCACAGCCCTGGCGTTCCATCTGACCACACGAGGGGGAGAGCCGCACATGATAGTTAGCAAGCAGGAAAGAGGAAAGTCACTTTTGTTTAAGACCTCTGCAGGTGTCAACATGTGCACCCTTATTGCGATGGATTTGGGAGAGTTATGTGAGGACACAATGACCTACAAATGCCCCCGGATCACTGAGGCGGAACCAGATGACGTTGACTGTTGGTGCAATGCCACGGACACATGGGTGACCTATGGAACGTGTTCTCAAACTGGCGAACACCGACGAGACAAACGTTCCGTCGCACTGGCCCCACACGTGGGGCTTGGTCTAGAAACAAGAACCGAAACGTGGATGTCCTCTGAAGGCGCTTGGAAACAAATACAAAAAGTGGAGACTTGGGCTCTGAGACACCCAGGATTCACGGTGATAGCCCTTTTTCTAGCACATGCCATAGGAACATCCATCACCCAGAAAGGGATTATTTTCATTTTGCTGATGCTGGTAACACCATCCATGGCCATGCGATGCGTGGGAATAGGCAACAGAGACTTCGTGGAAGGACTGTCAGGAGCAACGTGGGTGGATGTGGTACTGGAGCATGGAAGTTGCGTCACCACCATGGCAAAAAATAAACCAACATTGGACATTGAACTCTTGAAGACGGAGGTCACAAACCCTGCCGTCCTGCGCAAACTGTGCATTGAAGCTAAAATATCAAACACCACCACCGATTCAAGATGTCCAACACAAGGAGAAGCCACACTGGTGGAAGAACAAGACGCGAACTTTGTGTGTCGACGAACGTTCGTGGACAGAGGCTGGGGCAATGGCTGTGGGCTATTCGGAAAAGGTAGCCTAATAACGTGTGCTAAGTTCAAGTGTGTGACAAAACTAGAAGGAAAGATAGTTCAATATGAAAACTTAAAATATTCAGTGATAGTCACCGTCCACACTGGAGACCAGCACCAGGTGGGAAATGAGACCACAGAACATGGAACAACTGCAACCATAACACCTCAAGCTCCTACGTCGGAAATACAGCTGACCGACTACGGAGCCCTTACATTGGATTGCTCACCTAGAACAGGGCTAGACTTTAATGAGATGGTGTTGTTGACAATGAAAGAAAAATCATGGCTTGTCCACAAACAATGGTTTCTAGACTTACCACTGCCTTGGACCTCGGGGGCTTCAACATCCCAAGAGACTTGGAACAGACAAGATTTGCTGGTCACATTTAAGACAGCTCATGCAAAGAAGCAGGAAGTAGTCGTACTAGGATCACAAGAAGGAGCAATGCACACTGCGTTGACTGGAGCGACAGAAATCCAAACGTCAGGAACGACAACAATTTTTGCAGGACACCTGAAATGCAGACTAAAAATGGACAAACTGACTTTAAAAGGGATGTCATATGTGATGTGCACAGGCTCATTCAAGTTAGAGAAAGAAGTGGCTGAGACCCAGCATGGAACTGTTCTAGTGCAGGTTAAATACGAAGGAACAGATGCACCATGCAAGATCCCCTTTTCGACCCAAGATGAGAAAGGAGTAACCCAGAATGGGAGATTGATAACAGCCAACCCCATAGTCACTGACAAAGAAAAACCAGTCAACATTGAGGCAGAACCACCTTTTGGTGAGAGCTACATCGTGGTAGGAGCAGGTGAAAAAGCTTTGAAACTAAGCTGGTTCAAGAAAGGAAGCAGCATAGGGAAAATGTTTGAAGCAACTGCCCGAGGAGCACGAAGGATGGCCATCCTGGGAGACACCGCATGGGACTTCGGTTCTATAGGAGGAGTGTTCACGTCTGTGGGAAAACTGGTACACCAGGTTTTTGGAACTGCATATGGAGTTTTGTTCAGCGGTGTTTCTTGGACCATGAAAATAGGAATAGGGATTCTGCTGACATGGCTAGGATTAAATTCAAGGAGCACGTCCCTTTCGATGACGTGCATTGCAGTTGGCATGGTCACACTGTACCTAGGAGTCATGGTTCAGGCGGACTCGGGATGTGTAATCAACTGGAAAGGCAGAGAACTCAAATGTGGAAGTGGCATTTTTGTCACTAATGAAGTTCACACTTGGACAGAGCAATACAAATTCCAGGCTGACTCCCCAAAGAGACTATCAGCAGCCATTGGGAAGGCATGGGAGGAGGGTGTGTGTGGAATTCGATCAGCCACTCGTCTCGAGAACATCATGTGGAAGCAAATATCAAATGAATTGAACCACATCCTACTTGAAAATGACATGAAATTCACAGTGGTCGTAGGAGATGTTAGTGGAATCTTGGCCCAAGGAAAAAAAATGATTAGGCCACAACCCATGGAACACAAATACTCGTGGAAAAGCTGGGGAAAAGCCAAAATCATAGGAGCAGATGTACAGAACACCACCTTCATCATCGACGGCCCAAACACCCCAGAATGCCCTGATGACCAAAGAGCATGGAACATTTGGGAAGTTGAGGACTATGGATTTGGAATTTTCACGACAAACATATGGTTGAAATTGCGTGACTCCTACACCCAAGTGTGTGACCACCGGCTAATGTCAGCTGCCATCAAGGACAGCAAGGCAGTCCATGCTGACATGGGGTACTGGATAGAAAGTGAAAAGAACGAGACCTGGAAGCTGGCGAGAGCCTCCTTCATAGAAGTTAAGACATGCATCTGGCCAAAATCCCACACTCTATGGAGCAATGGAGTTCTGGAAAGTGAAATGATAATCCCAAAGATATATGGAGGACCAATATCTCAGCACAACTACAGACCAGGATATTTCACACAAACAGCAGGGCCGTGGCACCTAGGCAAGTTGGAACTAGATTTTGATTTGTGTGAAGGTACCACAGTTGTTGTGGATGAACATTGTGGAAATCGAGGACCATCTCTTAGAACCACAACAGTCACAGGAAAGATAATCCATGAATGGTGCTGCAGATCTTGTACGCTACCCCCCTTACGTTTCAAAGGAGAAGACGGGTGTTGGTACGGCATGGAAATCAGACCAGTCAAGGAGAAGGAAGAGAACCTAGTCAAGTCAATGGTCTCTGCAGGGTCAGGAGAAGTGGACAGCTTTTCACTAGGACTGCTATGCATATCAATAATGATTGAAGAGGTGATGAGATCCAGATGGAGTAGAAAAATGCTGATGACTGGAACACTGGCTGTGTTCCTCCTTCTTATAATGGGACAATTGACATGGAATGATCTGATCAGGTTATGCATCATGGTTGGAGCCAATGCTTCAGACAGGATGGGGATGGGAACAACGTACCTAGCTTTGATGGCCACTTTCAAAATGAGACCAATGTTCGCTGTCGGGCTATTATTTCGCAGACTAACATCTAGAGAAGTTCTTCTTCTTACAATTGGATTGAGCCTGGTGGCATCCGTGGAGCTACCAAATTCCTTAGAGGAGCTGGGGGATGGACTTGCAATGGGCATCATGATGTTAAAATTACTGACTGATTTTCAGTCACACCAGCTATGGGCTACCTTGCTGTCCTTGACATTTATCAAAACAACTTTTTCATTGCACTATGCATGGAAGACAATGGCTATGGTACTGTCAATTGTATCTCTCTTCCCTTTATGCCTGTCCACGACCTCTCAAAAAACAACATGGCTTCCGGTGCTGTTGGGATCTCTTGGATGCAAACCACTAACCATGTTTCTTATAACAGAAAACAAAATCTGGGGAAGGAAAAGTTGGCCCCTCAATGAAGGAATTATGGCTGTTGGAATAGTTAGCATTCTACTAAGTTCACTCCTCAAAAATGATGTGCCGCTAGCCGGCCCACTAATAGCTGGAGGCATGCTAATAGCATGTTATGTCATATCCGGAAGCTCAGCCGATTTATCACTGGAGAAAGCGGCTGAGGTCTCCTGGGAAGAAGAAGCAGAACACTCTGGTGCCTCACACAACATACTAGTGGAGGTCCAAGATGATGGAACCATGAAGATAAAAGATGAAGAGAGAGATGACACACTCACCATTCTCCTTAAAGCAACTCTGCTGGCAGTCTCAGGGGTGTACCCAATGTCAATACCAGCGACCCTTTTTGTGTGGTATTTTTGGCAGAAAAAGAAACAGAGATCAGGAGTGCTATGGGACACACCCAGCCCTCCAGAAGTGGAAAGAGCAGTTCTTGATGATGGTATCTATAGAATTTTGCAAAGAGGACTGTTGGGCAGGTCCCAAGTAGGAGTAGGAGTTTTCCAAGAAGGCGTGTTCCACACAATGTGGCACGTCACCAGGGGAGCTGTCCTCATGTATCAAGGGAAGAGGCTGGAACCAAGCTGGGCCAGTGTCAAAAAAGACTTGATCTCATATGGAGGAGGTTGGAGGTTTCAAGGATCCTGGAACACGGGAGAAGAAGTGCAGGTGATTGCTGTTGAACCGGGAAAAAACCCCAAAAATGTACAGACAGCGCCGGGCACCTTCAAGACCCCTGAAGGCGAAGTTGGAGCCATAGCCCTAGATTTTAAACCCGGCACATCTGGATCTCCCATCGTGAACAGAGAGGGAAAAATAGTAGGTCTTTATGGAAATGGAGTGGTGACAACAAGTGGAACCTACGTCAGTGCCATAGCTCAAGCTAAAGCATCACAAGAAGGGCCTCTACCAGAGATTGAGGACGAGGTGTTTAGGAAAAGAAACTTAACAATAATGGACCTACATCCAGGATCGGGAAAAACAAGAAGATATCTTCCAGCCATAGTCCGTGAGGCCATAAAAAGGAAGCTGCGCACGCTAATCTTGGCTCCCACAAGAGTTGTCGCTTCTGAAATGGCAGAGGCGCTCAAGGGAATGCCAATAAGGTATCAGACAACAGCAGTGAAGAGTGAACACACAGGAAAGGAGATAGTTGACCTTATGTGCCACGCCACTTTCACCATGCGTCTCCTGTCTCCCGTGAGAGTTCCCAATTACAACATGATTATCATGGATGAAGCACATTTCACCGATCCAGCCAGCATAGCGGCCAGAGGGTACATCTCAACCCGAGTGGGTATGGGTGAAGCAGCTGCGATCTTTATGACAGCCACTCCCCCAGGATCGGTGGAGGCCTTTCCACAGAGCAATGCAGTTATCCAAGATGAGGAAAGAGACATTCCTGAGAGATCATGGAACTCAGGCTATGACTGGATCACTGATTTCCCAGGTAAAACAGTCTGGTTTGTTCCAAGCATCAAATCAGGAAATGACATTGCCAACTGTTTAAGAAAGAACGGGAAACGGGTGATCCAATTGAGCAGAAAAACCTTTGACACTGAGTACCAGAAAACAAAAAACAACGACTGGGACTATGTCGTCACAACAGACATTTCCGAAATGGGAGCAAACTTCCGGGCCGACAGGGTAATAGACCCAAGGCGGTGTCTGAAACCGGTAATACTAAAAGATGGTCCAGAGCGCGTCATTCTAGCCGGACCGATGCCAGTGACTGTGGCCAGTGCCGCCCAGAGGAGAGGAAGAATTGGAAGGAACCAAAACAAGGAAGGTGATCAGTATATTTACATGGGACAGCCTTTAAACAATGATGAGGACCACGCTCATTGGACAGAAGCAAAAATGCTCCTTGACAATATAAACACACCAGAAGGGATTATCCCAGCCCTCTTTGAGCCGGAGAGAGAAAAGAGTGCAGCAATAGACGGGGAATACAGACTGCGGGGTGAAGCAAGGAAAACGTTCGTGGAGCTCATGAGAAGAGGAGATCTACCTGTCTGGCTATCCTACAAAGTTGCCTCAGAAGGCTTCCAGTACTCCGACAGAAGGTGGTGCTTTGATGGGGAAAGGAACAACCAGGTGTTGGAGGAGAACATGGACGTGGAGATCTGGACAAAAGAAGGAGAAAGAAAGAAACTACGACCCCGCTGGTTGGATGCCAGAACATACTCTGACCCACTGGCTCTGCGCGAGTTTAAAGAGTTTGCAGCAGGAAGAAGAAGCGTCTCAGGTGACCTAATATTAGAAATAGGGAAACTTCCACAACATTTGACGCAAAGGGCCCAGAATGCTTTGGACAACTTGGTCATGTTGCACAATTCCGAACAAGGAGGAAAAGCCTATAGACATGCTATGGAAGAACTACCAGACACCATAGAAACGTTGATGCTCCTAGCTTTGATAGCTGTGTTGACTGGTGGAGTGACGCTGTTCTTCCTATCAGGAAGAGGTCTAGGGAAAACATCCATCGGCCTACTCTGCGTGATGGCCTCAAGCGTACTGTTATGGATGGCCAGTGTGGAGCCCCATTGGATAGCGGCCTCCATCATACTGGAGTTCTTTCTGATGGTGCTGCTTATTCCAGAGCCAGACAGACAGCGCACTCCACAGGACAACCAGCTAGCATATGTGGTGATAGGTTTGTTATTCATGATATTGACAGTGGCAGCCAATGAGATGGGATTATTGGAAACCACAAAGAAAGACCTGGGGATTGGCCATGTAGCTGCTGAAAACCACCACCATGCTACAATGCTGGACGTAGACCTACATCCAGCTTCAGCCTGGACCCTCTATGCAGTGGCCACAACAATTATCACTCCCATGATGAGACACACAATTGAAAACACAACGGCAAATATTTCCCTGACAGCTATTGCAAACCAGGCAGCTATATTGATGGGACTTGACAAGGGATGGCCAATATCGAAGATGGACATAGGAGTTCCACTTCTCGCCTTGGGGTGCTATTCCCAGGTGAACCCGCTGACGCTGACAGCGGCGGTATTGATGCTAGTGGCTCATTACGCCATAATTGGACCTGGACTGCAAGCAAAAGCTACTAGAGAAGCTCAAAAAAGGACAGCGGCCGGAATAATGAAAAATCCAACTGTCGACGGGATTGTTGCAATAGATTTGGATCCTGTGGTTTACGATGCAAAATTTGAAAAACAGCTAGGCCAAATAATGTTGTTGATACTTTGCACATCACAGATTCTCTTGATGCGGACTACATGGGCCTTGTGTGAATCCATCACACTGGCTACTGGACCTCTGACCACTCTTTGGGAGGGATCTCCAGGAAAATTCTGGAACACCACGATAGCGGTGTCCATGGCAAACATTTTCAGGGGAAGTTATCTAGCAGGAGCAGGTCTGGCCTTCTCATTAATGAAATCTCTAGGAGGAGGTAGGAGAGGCACGGGAGCCCAAGGGGAAACACTGGGAGAAAAATGGAAAAGACAGCTAAACCAACTGAGCAAGTCAGAATTCAACACTTACAAAAGGAGTGGGATTATGGAGGTGGATAGATCCGAAGCCAAAGAGGGACTGAAAAGAGGAGAAACAACCAAACATGCAGTGTCGAGAGGAACAGCCAAACTGAGGTGGTTTGTGGAGAGGAACCTTGTGAAACCAGAAGGGAAAGTCATAGACCTCGGTTGTGGAAGAGGTGGCTGGTCATATTATTGCGCTGGGCTGAAGAAAGTCACAGAAGTGAAAGGATACACAAAAGGAGGACCTGGACATGAGGAACCAATCCCAATGGCGACCTATGGATGGAACCTAGTAAAGCTACACTCCGGAAAAGATGTATTCTTTACACCACCTGAGAAATGTGACACCCTTTTGTGTGATATTGGTGAGTCCTCTCCGAACCCAACTATAGAAGAAGGAAGAACGTTACGTGTTCTAAAGATGGTGGAACCATGGCTCAGAGGAAACCAATTTTGCATAAAAATTCTAAATCCCTATATGCCGAGTGTGGTAGAAACTCTGGAGCAAATGCAAAGAAAACATGGAGGAATGCTAGTGCGAAACCCACTCTCAAGAAATTCCACCCATGAAATGTACTGGGTTTCATGTGGAACAGGAAACATTGTGTCAGCAGTAAACATGACATCTAGAATGTTGCTAAATCGATTCACAATGGCTCACAGGAAGCCAACATATGAAAGAGACGTGGACTTAGGCGCTGGAACAAGACATGTGGCAGTGGAACCAGAGGTAGCCAACCTAGATATCATTGGCCAGAGGATAGAGAATATAAAAAATGAACATAAGTCAACATGGCATTATGATGAGGACAATCCATACAAAACATGGGCCTATCATGGATCATATGAGGTCAAGCCATCAGGATCAGCCTCATCCATGGTCAATGGCGTGGTGAGATTGCTCACCAAACCATGGGATGTTATCCCCATGGTCACACAAATAGCCATGACTGACACCACACCCTTTGGACAACAGAGGGTGTTTAAAGAGAAAGTTGACACGCGCACACCAAAAGCAAAACGAGGCACAGCACAAATTATGGAGGTGACAGCCAGGTGGTTATGGGGTTTCCTTTCTAGAAACAAAAAACCCAGAATCTGCACAAGAGAGGAGTTCACAAGAAAAGTTAGGTCAAACGCAGCTATTGGAGCAGTGTTCGTTGATGAAAATCAATGGAACTCAGCAAAAGAAGCAGTGGAAGACGAACGGTTCTGGGACCTTGTGCACAGAGAGAGGGAGCTTCATAAACAGGGAAAATGTGCCACGTGTGTCTACAATATGATGGGGAAGAGAGAGAAAAAATTAGGAGAGTTCGGAAAGGCAAAAGGAAGTCGTGCAATATGGTACATGTGGTTGGGAGCACGCTTTCTAGAGTTCGAAGCCCTTGGTTTCATGAATGAAGATCACTGGTTCAGTAGAGAGAATTCACTCAGTGGAGTGGAAGGAGAAGGACTCCACAAACTTGGATACATACTCAGAGACATATCAAAGATTCCAGGGGGAAATATGTATGCAGATGACACAGCCGGATGGGACACAAGAATAACAGAGGATGATCTTCAGAATGAGGCTAAAATCACTGACATCATGGAGCCCGAACATGCCCTATTGGCTACGTCAATCTTTAAGCTGACCTACCAAAATAAGGTGGTAAGGGTGCAGAGACCAGCAAAAAATGGAACCGTGATGGATGTTATATCCAGACGTGACCAGAGAGGAAGTGGACAGGTCGGAACTTATGGCTTAAACACTTTCACCAACATGGAGGCCCAACTAATAAGACAAATGGAGTCTGAGGGAATCTTTTTACCCAGCGAATTGGAAACCCCAAATCTAGCCGAAAGAGTTCTCGACTGGTTGGAAAAACATGGCGTCGAAAGGCTGAAAAGAATGGCAATCAGCGGAGATGACTGTGTGGTGAAACCAATTGATGACAGGTTCGCAACAGCCTTAACAGCTTTGAATGACATGGGAAAAGTAAGAAAAGACATACCGCAATGGGAACCTTCAAAAGGATGGAATGATTGGCAACAAGTGCCTTTCTGTTCACACCATTTCCACCAGCTGATTATGAAGGATGGGAGGGAGATAGTGGTGCCATGCCGCAACCAAGATGAACTTGTGGGTAGGGCCAGAGTATCACAAGGCGCCGGATGGAGCCTGAGAGAAACTGCATGCCTAGGCAAGTCATATGCACAAATGTGGCAGCTGATGTACTTCCACAGGAGAGACCTGAGACTAGCGGCTAATGCTATCTGTTCAGCCGTTCCAGTTGATTGGGTCCCAACCAGCCGCACCACCTGGTCGATCCATGCCCATCACCAATGGATGACAACAGAAGACATGTTATCAGTGTGGAATAGGGTTTGGATAGAGGAAAACCCATGGATGGAGGATAAAACTCATGTATCCAGTTGGGAAGATGTTCCATACTTAGGAAAAAGGGAAGATCAGTGGTGTGGATCCCTGATAGGCTTAACAGCAAGGGCCACCTGGGCCACTAACATACAAGTGGCCATAAACCAAGTGAGAAGGCTCATTGGGAATGAGAATTATCTAGATTACATGACATCAATGAAGAGATTCAAGAATGAGAGTGATCCCGAAGGGGCACTCTGGTAAGTCAACACATTCACAAAATAAAGGAAAATAAAAAATCAAACAAGGCAAGAAGTCAGGCCGGATTAAGCCATAGTACGGTAAGAGCTATGCTGCCTGTGAGCCCCGTCCAAGGACGTAAAATGAAGTCAGGCCGAAAGCCACGGTTTGAGCAAACCGTGCTGCCTGTGGCTCCATCGTGGGGATGTAAAAACCCGGGAGGCTGCAACCCATGGAAGCTGTACGCATGGGGTAGCAGACTAGTGGTTAGAGGAGACCCCTCCCAAGACACAACGCAGCAGCGGGGCCCAACACCAGGGGAAGCTGTACCCTGGTGGTAAGGACTAGAGGTTAGAGGAGACCCCCCGCACAACAATAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCTACAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT +>Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv3/genome +AGTTGTTAGTCTACGTGGACCGACAAGAACAGTTTCGACTCGGAAGCTTGCTTAACGTAGTGCTGACAGTTTTTTATTAGAGAGCAGATCTCTGATGAACAACCAACGGAAAAAGACGGGAAAACCGTCTATCAATATGCTGAAACGCGTGAGAAACCGTGTGTCAACTGGATCACAGTTGGCGAAGAGATTCTCAAGAGGATTGCTGAACGGCCAAGGACCAATGAAATTGGTTATGGCGTTCATAGCTTTCCTCAGATTTCTAGCCATTCCACCGACAGCAGGAGTCTTGGCTAGATGGGGTACCTTCAAGAAGTCGGGGGCTATTAAGGTCCTAAAAGGCTTCAAGAAGGAGATCTCAAACATGCTGAGCATTATCAACAAACGGAAAAAGACATCGCTCTGTCTCATGATGATGTTACCAGCAACACTTGCTTTCCACTTGACTTCACGAGATGGAGAGCCGCGCATGATTGTGGGGAAGAATGAAAGAGGAAAATCCCTACTTTTTAAGACAGCCTCTGGAATCAACATGTGCACACTCATAGCCATGGATTTGGGAGAGATGTGTGATGACACGGTCACTTACAAATGCCCCCACATTACCGAAGTGGAGCCTGAAGACATTGACTGCTGGTGCAACCTTACATCGACATGGGTGACTTATGGAACGTGCAATCAAGCTGGAGAGCATAGACGCGATAAGAGATCAGTGGCGTTAGCTCCCCATGTCGGCATGGGACTGGACACACGCACCCAAACCTGGATGTCGGCTGAAGGAGCTTGGAGACAAGTCGAGAAGGTAGAGACATGGGCCCTTAGGCACCCAGGGTTCACCATACTAGCCCTATTTCTTGCCCATTACATAGGCACTTCCTTGACCCAGAAAGTGGTTATTTTTATACTACTAATGCTGGTCACCCCATCCATGACAATGAGATGTGTGGGAGTAGGAAACAGAGATTTTGTGGAAGGCCTATCGGGAGCTACGTGGGTTGACGTGGTGCTCGAGCACGGTGGGTGTGTGACTACCATGGCTAAGAACAAGCCCACGCTGGATATAGAGCTTCAGAAGACCGAGGCCACCCAACTGGCGACCCTAAGGAAGCTATGCATTGAGGGAAAAATTACCAACATAACAACCGACTCAAGGTGTCCCACCCAAGGGGAAGCGATTTTACCTGAGGAGCAGGACCAGAACTACGTGTGTAAGCATACATACGTGGACAGAGGCTGGGGAAACGGTTGTGGTTTGTTTGGCAAGGGAAGCTTGGTGACATGCGCGAAATTTCAATGTTTAGAATCAATAGAGGGAAAAGTGGTGCAACATGAGAACCTCAAATACACCGTCATCATCACAGTGCACACAGGAGACCAACACCAGGTGGGAAATGAAACGCAGGGAGTCACGGCTGAGATAACACCCCAGGCATCAACCGCTGAAGCCATCTTACCTGAATATGGAACCCTTGGGCTAGAATGCTCACCACGGACAGGTTTGGATTTCAATGAAATGATCTTATTGACAATGAAGAACAAAGCATGGATGGTACATAGACAATGGTTCTTTGACCTACCTCTACCATGGACATCAGGAGCTACAACAGAAACACCAACCTGGAACAGGAAAGAGCTTCTTGTGACATTCAAAAACGCACATGCAAAAAAACAAGAAGTAGTTGTCCTTGGATCGCAAGAGGGAGCAATGCATACAGCACTGACAGGAGCTACAGAGATCCAAACCTCAGGAGGCACAAGCATTTTTGCGGGGCACTTAAAATGTAGACTCAAGATGGACAAATTGGAACTCAAGGGGATGAGCTATGCAATGTGCTTGAATACCTTTGTGTTGAAGAAAGAAGTCTCCGAAACGCAGCATGGGACAATACTCATTAAGGTTGAGTACAAAGGGGAAGATGCACCCTGCAAGATTCCTTTCTCCACGGAGGATGGACAAGGGAAAGCTCACAATGGCAGACTGATCACAGCCAACCCAGTGGTGACCAAGAAGGAGGAGCCTGTCAATATTGAGGCTGAACCTCCTTTTGGGGAAAGTAATATAGTAATTGGAATTGGAGACAAAGCCTTGAAAATCAACTGGTACAAGAAGGGAAGCTCGATTGGGAAGATGTTCGAGGCCACTGCCAGAGGTGCAAGGCGCATGGCCATCTTGGGAGACACAGCCTGGGACTTTGGATCAGTGGGTGGTGTTTTGAATTCATTAGGGAAAATGGTGCACCAAATATTTGGAAGTGCTTACACAGCCCTATTTAGTGGAGTCTCCTGGATAATGAAAATTGGAATAGGTGTCCTCTTAACCTGGATAGGGTTGAATTCAAAAAACACTTCTATGTCATTTTCATGCATTGCGATAGGAATCATTACACTCTATCTGGGAGCCGTGGTGCAAGCTGACATGGGGTGTGTCATAAACTGGAAAGGCAAAGAACTCAAATGTGGAAGTGGAATTTTCGTCACTAATGAGGTCCACACCTGGACAGAGCAATACAAATTTCAAGCAGACTCCCCCAAAAGACTGGCGACAGCCATTGCAGGCGCTTGGGAGAATGGAGTGTGCGGAATCAGGTCAACAACCAGAATGGAGAACCTCTTGTGGAAGCAAATAGCCAATGAACTGAACTACATATTATGGGAAAACAACATCAAATTAACGGTAGTTGTGGGCGACATAATTGGGGTCTTAGAGCAAGGGAAAAGAACACTAACACCACAACCCATGGAGCTAAAATATTCATGGAAAACATGGGGAAAGGCAAAAATAGTGACAGCTGAAACACAAAATTCCTCTTTCATAATAGATGGGCCAAACACACCGGAGTGTCCAAGTGCCTCAAGAGCATGGAATGTGTGGGAGGTGGAAGATTACGGGTTCGGAGTCTTCACAACCAACATATGGCTGAAACTCCGAGAGGTGTACACCCAACTATGTGACCATAGGCTAATGTCGGCAGCCGTCAAGGATGAGAGGGCCGTACACGCCGACATGGGCTATTGGATAGAAAGCCAAAAGAATGGAAGTTGGAAGCTAGAAAAAGCATCCCTCATAGAGGTGAAAACCTGCACATGGCCAAAATCACACACTCTTTGGAGCAATGGTGTGCTAGAGAGTGACATGATCATCCCAAAGAGTCTAGCTGGTCCTATTTCGCAACACAACCACAGGCCCGGGTACCACACCCAAACGGCAGGACCCTGGCACTTAGGAAAATTGGAGCTGGACTTCAACTATTGTGAAGGAACAACAGTTGTCATCACAGAAAACTGTGGGACAAGAGGCCCATCATTGAGAACAACAACAGTGTCAGGGAAGTTGATACACGAATGGTGTTGCCGCTCGTGCACACTTCCTCCCCTGCGATACATGGGAGAAGACGGCTGCTGGTATGGCATGGAAATTAGACCCATTAATGAGAAAGAAGAGAACATGGTAAAGTCTTTAGCCTCAGCAGGGAGTGGAAAGGTGGACAACTTCACAATGGGTGTCTTGTGTTTGGCAATCCTCTTTGAAGAGGTGATGAGAGGAAAATTTGGGAAAAAACACATGATTGCAGGGGTTCTCTTCACGTTTGTGCTCCTTCTCTCAGGGCAAATAACATGGAGAGACATGGCGCACACACTCATAATGATTGGGTCCAACGCCTCTGACAGAATGGGAATGGGCGTCACTTACCTAGCTTTAATTGCAACATTTAAAATTCAGCCATTCTTGGCTTTGGGATTCTTCCTGAGGAAACTGACATCTAGAGAAAATTTATTGTTGGGAGTTGGGTTGGCCATGGCAACAACGTTACAACTGCCAGAGGACATTGAACAAATGGCGAATGGAATTGCTTTGGGGCTCATGGCTCTTAAACTGATAACACAATTTGAAACATACCAACTATGGACGGCATTAGTCTCCCTAACGTGTTCAAATACAATTTTCACGTTGACTGTTGCCTGGAGAACAGCCACCCTGATTTTGGCCGGAATTTCGCTTTTGCCAGTGTGCCAGTCTTCGAGCATGAGGAAAACAGATTGGCTCCCAATGACTGTGGCAGCTATGGGAGTTCCACCCCTACCACTTTTTATCTTCAGTTTGAAAGATACACTCAAAAGGAGAAGCTGGCCACTGAATGAGGGGGTGATGGCTGTTGGACTTGTGAGCATTCTAGCTAGTTCTCTCCTTAGGAATGATGTGCCCATGGCTGGACCATTAGTGGCTGGGGGCTTGCTGATAGCGTGCTACGTCATAACTGGCACGTCAGCAGACCTCACTGTAGAAAAAGCAGCAGATGTAACATGGGAGGAAGAGGCTGAGCAAACAGGAGTGTCCCACAATTTAATGATCACAGTTGATGATGATGGAACAATGAGAATAAAAGATGATGAGACTGAGAACATCCTAACAGTGCTTTTAAAAACAGCATTACTAATAGTATCAGGCATCTTTCCATACTCCATACCCGCAACACTGTTGGTCTGGCATACTTGGCAAAAGCAAACCCAAAGATCCGGCGTCCTATGGGACGTACCCAGCCCCCCAGAGACACAGAAAGCAGAACTGGAAGAAGGGGTCTATAGGATCAAACAGCAAGGAATTTTTGGGAAAACCCAAGTGGGGGTTGGAGTACAGAAAGAAGGAGTTTTCCACACCATGTGGCACGTCACAAGAGGGGCAGTGTTGACACACAATGGGAAAAGACTGGAACCAAACTGGGCTAGCGTGAAAAAAGATCTGATTTCATACGGAGGAGGATGGAGATTGAGTGCACAATGGCAAAAGGGAGAGGAGGTGCAGGTTATTGCCGTAGAGCCTGGGAAGAACCCAAAGAACTTTCAAACCATGCCAGGCATTTTTCAGACAACAACAGGGGAAATAGGAGCAATTGCACTGGACTTCAAGCCTGGAACTTCAGGATCTCCCATCATAAACAGAGAGGGAAAGGTAGTGGGACTGTATGGCAATGGAGTGGTTACAAAGAATGGTGGCTATGTCAGTGGAATAGCGCAAACAAATGCAGAACCAGACGGACCGACACCAGAGTTGGAAGAAGAGATGTTCAAAAAGCGAAATCTAACCATAATGGATCTTCATCCTGGGTCAGGAAAGACGCGGAAATACCTTCCAGCTATTGTTAGAGAGGCAATCAAGAGACGCTTAAGGACTCTAATTTTGGCACCAACAAGGGTGGTTGCAGCTGAGATGGAAGAAGCATTGAAAGGGCTCCCAATAAGGTATCAAACAACTGCAACAAAATCTGAACACACAGGAAGAGAGATTGTTGATCTAATGTGCCACGCAACGTTCACAATGCGCTTGCTGTCACCAGTCAGGGTTCCAAACTACAACTTGATAATAATGGATGAGGCTCATTTCACAGACCCAGCCAGTATAGCGGCTAGAGGGTACATATCAACTCGTGTAGGAATGGGAGAGGCAGCCGCAATTTTCATGACAGCAACACCCCCTGGAACAGCTGATGCCTTTCCTCAGAGCAACGCTCCAATTCAAGATGAAGAAAGGGACATACCGGAACGCTCATGGAATTCAGGCAATGAATGGATTACCGACTTTGTTGGGAAGACGGTGTGGTTTGTCCCTAGCATCAAAGCCGGAAATGACATAGCAAACTGCTTGCGGAAAAACGGAAAAAAGGTCATTCAACTTAGTAGGAAGACTTTTGACACAGAATATCAAAAGACTAAACTGAATGATTGGGACTTTGTGGTGACAACAGACATTTCAGAAATGGGAGCCAATTTCAAAGCAGATAGAGTGATCGACCCAAGAAGATGTCTCAAGCCAGTGATTTTGACAGATGGACCCGAGCGGGTGATCCTGGCTGGACCAATGCCAGTCACCGTAGCGAGCGCTGCGCAAAGGAGAGGGAGAGTTGGCAGGAACCCACAAAAAGAAAATGACCAGTACATATTCACGGGCCAGCCTCTCAACAATGATGAAGACCATGCTCACTGGACAGAAGCAAAAATGCTGCTGGACAACATCAACACACCAGAAGGGATTATACCAGCTCTCTTTGAACCAGAAAGGGAGAAGTCAGCCGCCATAGACGGCGAATACCGCCTGAAGGGTGAGTCCAGGAAGACCTTCGTGGAACTCATGAGGAGGGGTGACCTCCCAGTTTGGCTAGCCCATAAAGTAGCATCAGAAGGGATCAAATATACAGATAGAAAATGGTGCTTTGATGGAGAACGTAATAATCAAATTTTAGAGGAGAATATGGATGTGGAAATCTGGACAAAGGAAGGAGAAAAGAAAAAATTGAGACCTAGGTGGCTTGATGCCCGCACTTATTCAGATCCCTTAGCACTCAAGGAATTCAAGGATTTTGCAGCTGGCAGAAAGTCAATCGCCCTTGATCTTGTGACAGAAATAGGAAGAGTGCCTTCACACTTAGCCCACAGAACGAGAAACGCCCTGGACAATTTGGTGATGCTGCACACGTCAGAACATGGCGGTAGGGCCTACAGGCATGCAGTGGAGGAACTACCAGAAACAATGGAAACACTCTTACTCCTGGGACTCATGATCTTGTTAACAGGTGGAGCAATGCTTTTCTTGATATCAGGTAAAGGGATTGGAAAGACTTCAATAGGACTCATTTGTGTAATTGCTTCCAGCGGCATGTTATGGATGGCTGATGTCCCACTCCAATGGATCGCGTCGGCTATAGTCCTGGAGTTTTTTATGATGGTGTTGCTCATACCAGAACCAGAAAAGCAGAGAACTCCCCAAGACAACCAACTCGCATATGTCGTGATAGGCATACTTACATTGGCTGCAATAGTAGCAGCCAATGAAATGGGACTGTTGGAAACTACAAAGAGAGATTTAGGAATGTCTAAAGAACCAGGTGTTGTTTCTCCAACCAGCTATTTGGATGTGGACTTGCACCCAGCATCAGCCTGGACATTGTACGCCGTGGCCACAACAGTAATAACACCAATGTTGAGACATACCATAGAGAATTCCACAGCAAATGTGTCCCTGGCAGCTATAGCTAACCAGGCAGTGGTCCTGATGGGTTTAGACAAAGGATGGCCGATATCGAAAATGGACTTAGGCGTACCACTACTGGCACTGGGTTGCTATTCACAAGTGAACCCACTAACTCTCACAGCGGCAGTACTTTTGCTAGTCACACATTATGCTATTATAGGTCCAGGATTGCAGGCAAAAGCCACTCGTGAAGCTCAGAAAAGGACAGCTGCTGGAATAATGAAGAATCCAACGGTGGATGGGATAATGACAATAGACCTAGATCCTGTAATATACGATTCAAAATTTGAAAAGCAACTAGGACAGGTTATGCTCCTGGTTCTGTGTGCAGTTCAACTTTTGTTAATGAGAACATCATGGGCCTTGTGTGAAGCTCTAACCCTAGCCACAGGACCAATAACAACACTCTGGGAAGGATCACCTGGGAAGTTTTGGAACACCACGATAGCTGTTTCCATGGCGAACATCTTTAGAGGGAGCTATTTAGCAGGAGCTGGGCTTGCTTTTTCTATCATGAAATCAGTTGGAACAGGAAAGAGAGGAACAGGGTCACAAGGTGAAACCTTAGGAGAAAAGTGGAAAAAGAAATTAAATCAGTTATCCCGGAAAGAGTTTGACCTTTACAAGAAATCCGGAATCACTGAAGTGGATAGAACAGAAGCCAAAGAAGGGTTGAAAAGAGGAGAAATAACACACCATGCCGTGTCCAGAGGCAGCGCAAAACTTCAATGGTTCGTGGAGAGAAACATGGTCATTCCCGAAGGAAGAGTCATAGACTTAGGCTGTGGAAGAGGAGGCTGGTCATATTACTGTGCAGGACTGAAAAAAGTTACAGAAGTGCGAGGATACACAAAAGGCGGCCCAGGACACGAAGAACCAGTACCTATGTCTACATACGGATGGAACATAGTCAAGTTAATGAGTGGAAAGGATGTGTTTTATCTTCCACCTGAAAAGTGTGATACCCTATTGTGTGACATTGGAGAATCTTCACCAAGCCCAACAGTGGAAGAAAGCAGAACCATAAGAGTCTTGAAGATGGTTGAACCATGGCTAAAAAACAACCAGTTTTGCATTAAAGTATTGAACCCTTACATGCCAACTGTGATTGAGCACCTAGAAAGACTACAAAGGAAACATGGAGGAATGCTTGTGAGAAATCCACTCTCACGAAACTCCACGCACGAAATGTACTGGATATCCAATGGTACAGGCAACATCGTCTCTTCAGTCAACATGGTATCCAGATTGCTACTGAACAGATTCACAATGACACACAGGAGACCCACCATAGAGAAAGATGTGGATTTAGGAGCAGGAACCCGACATGTCAATGCGGAACCAGAAACACCCAACATGGATGTCATTGGGGAAAGAATAAAAAGGATCAAGGAGGAGCATAGTTCAACATGGCACTATGATGATGAAAATCCTTACAAAACGTGGGCTTACCATGGATCCTATGAAGTCAAAGCCACAGGCTCAGCCTCCTCCATGATAAATGGAGTCGTGAAACTCCTCACAAAACCATGGGATGTGGTGCCCATGGTGACACAGATGGCAATGACAGATACAACCCCATTTGGCCAGCAAAGAGTTTTTAAAGAGAAAGTGGACACCAGGACACCCAGGCCCATGCCAGGAACAAGAAAGGTTATGGAGATCACAGCGGAGTGGCTTTGGAGAACCCTGGGAAGGAACAAAAGACCCAGATTATGCACAAGGGAGGAGTTCACAAAAAAGGTCAGAACCAACGCAGCTATGGGCGCCGTTTTCACAGAGGAGAACCAATGGGACAGTGCGAGAGCTGCTGTTGAGGACGAAGAATTTTGGAAACTTGTGGACAGAGAACGTGAACTCCACAAATTGGGCAAGTGTGGAAGCTGCGTTTACAACATGATGGGCAAGAGAGAGAAGAAACTTGGAGAGTTTGGCAAAGCAAAAGGCAGTAGAGCTATATGGTACATGTGGTTGGGAGCCAGGTACCTTGAGTTCGAGGCACTCGGATTCTTAAATGAAGACCACTGGTTCTCGCGTGAAAACTCTTACAGTGGAGTAGAAGGAGAAGGACTGCACAAGCTGGGATACATCTTAAGAGATATTTCCAAGATACCCGGAGGAGCTATGTATGCTGATGACACAGCTGGTTGGGACACAAGAATAACAGAAGATGACCTGCACAATGAGGAAAAAATCACACAGCAAATGGACCCTGAACACAGGCAGTTAGCGAACGCTATATTCAAGCTCACATACCAAAACAAAGTGGTCAAAGTTCAACGACCAACTCCAAAGGGCACGGTAATGGACATCATATCTAGGAAAGACCAAAGAGGCAGTGGACAGGTGGGAACTTATGGTCTGAATACATTCACCAACATGGAAGCCCAGTTAATCAGACAAATGGAAGGAGAAGGTGTGTTGTCAAAGGCAGACCTCGAGAACCCTCATCTGCTAGAGAAGAAAATTACACAATGGTTGGAAACCAAAGGAGTGGAGAGGTTAAAAAGAATGGCCATCAGCGGGGATGATTGCGTAGTGAAACCAATCGATGACAGGTTCGCCAATGCCCTGCTTGCCCTGAACGATATGGGAAAGGTTAGGAAGGACATACCTCAATGGCAGCCATCAAAGGGATGGCATGATTGGCAACAGGTCCCTTTCTGCTCCCACCACTTTCATGAATTGATCATGAAAGATGGAAGAAAGTTGGTAGTTCCCTGCAGACCCCAGGACGAACTAATAGGAAGAGCGAGAATCTCTCAAGGAGCAGGATGGAGCCTTAGAGAAACTGCATGTCTAGGGAAAGCCTACGCTCAAATGTGGACTCTCATGTATTTTCACAGAAGAGATCTTAGACTAGCATCCAACGCCATATGTTCAGCAGTACCAGTCCATTGGGTCCCCACAAGCAGAACGACATGGTCTATTCATGCTCACCATCAGTGGATGACTACAGAAGACATGCTTACTGTCTGGAACAGGGTGTGGATAGAGGACAATCCATGGATGGAAGACAAAACTCCAGTCACAACTTGGGAAGATGTTCCATATCTAGGGAAGAGAGAAGACCAATGGTGCGGATCACTCATTGGTCTCACTTCCAGAGCAACCTGGGCCCAGAACATACTCACAGCAATCCAACAGGTGAGAAGCCTTATAGGCAATGAAGAGTTTCTGGACTACATGCCTTCGATGAAGAGATTCAGGAAGGAGGAGGAGTCAGAGGGAGCCATTTGGTAAACGCAGGAAGTGAAAAAGAGGCAAACTGTCAGGCCACCTTAAGCCACAGTACGGAAGAAGCTGTGCAGCCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGAAGTCAGGCCCAAAAGCCACGGTTTGAGCAAACCGTGCTGCCTGTAGCTCCGTCGTGGGGACGTAAAGCCTGGGAGGCTGCAAACCGTGGAAGCTGTACGCACGGTGTAGCAGACTAGCGGTTAGAGGAGACCCCTCCCATGACACAACGCAGCAGCGGGGCCCGAGCACTGAGGGAAGCTGTACCTCCTTGCAAAGGACTAGAGGTTAGAGGAGACCCCCCGCAAATAAAAACAGCATATTGACGCTGGGAGAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT >Reconstructed_root_sequence_of_https_nextstrain_org_dengue/denv4/genome AGTTGTTAGTCTGTGTGGACCGACAAGGACAGTTCCAAATCGGAAGCTTGCTTAACACAGTTCTAACAGTTTGTTTAAATAGAGAGCAGATCTCTGGAAAAATGAACCAACGAAAAAAGGTGGTTAGACCGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTATCAACCCCTCAAGGGTTGGTGAAGAGATTCTCAACCGGACTGTTTTCCGGGAAAGGACCCTTACGGATGGTGCTAGCATTCATCACGTTTTTGCGAGTCCTTTCCATCCCACCAACAGCAGGGATTCTGAAAAGATGGGGACAGTTGAAGAAAAACAAGGCCATCAAGATACTGACTGGATTCAGGAAGGAGATAGGCCGCATGCTGAACATCTTGAACGGGAGAAAGAGGTCAACAATAACATTGCTATGCTTGATTCCCACCGTAATGGCATTCCACTTGTCAACAAGAGATGGCGAACCCCTTATGATAGTAGCAAAACACGAAAGGGGGAGACCTCTCTTGTTTAAGACAACAGAAGGAATCAACAAATGCACTCTTATTGCCATGGACTTGGGTGAAATGTGTGAGGACACCGTCACGTATAAATGCCCTCTACTGGTCAACACCGAACCTGAAGACATTGATTGCTGGTGCAATCTCACGTCTACCTGGGTCATGTATGGGACATGTACCCAGAGCGGAGAACGGAGACGAGAGAAGCGCTCAGTAGCTTTAACACCACATTCAGGAATGGGATTGGAAACAAGGGCTGAGACATGGATGTCATCGGAAGGGGCTTGGAAACATGCCCAGAGAGTGGAGAGCTGGATACTCAGAAACCCAGGATTCGCGCTCTTGGCAGGATTTATGGCTTATATGATTGGGCAAACAGGAATCCAGCGAACTGTCTTCTTTGTTCTAATGATGCTGGTCGCTCCATCCTACGGAATGCGATGCGTAGGAGTGGGGAACAGAGATTTTGTGGAAGGAGTCTCAGGTGGAGCATGGGTCGATCTGGTGCTAGAACACGGAGGATGTGTCACAACCATGGCCCAGGGAAAACCAACCTTGGATTTTGAATTGATCAAGACAACAGCCAAGGAAGTGGCTCTGTTAAGAACTTATTGCATTGAAGCCTCGATATCAAACATAACCACGGCAACAAGATGTCCAACGCAAGGAGAACCTTATCTCAAAGAGGAACAAGACCAACAGTACATTTGCCGGAGAGATGTGGTAGACAGAGGGTGGGGCAATGGCTGTGGCCTGTTTGGAAAAGGAGGAGTTGTGACATGTGCAAAGTTTTCATGCTCGGGGAAGATAACAGGCAACTTGGTCCAAATTGAAAACCTTGAATACACAGTGGTTGTGACAGTCCACAATGGAGACACCCACGCAGTAGGAAATGACACATCCAACCATGGAGTGACAGCCACGATAACTCCCAGGTCACCATCGGTAGAAGTTAAATTACCGGACTATGGAGAACTAACACTCGATTGTGAACCCAGGTCCGGAATTGACTTTAATGAGATGATTCTGATGAAAATGAAAAAGAAAACGTGGCTTGTGCACAAGCAATGGTTTTTGGATCTACCTCTGCCATGGACAGCAGGAGCAGACACATCAGAAGTCCATTGGAATTATAAAGAGAGAATGGTGACATTCAAGGTTCCTCATGCCAAGAGACAGGATGTGACAGTGCTAGGATCTCAGGAAGGAGCCATGCATTCTGCCCTCACCGGAGCCACAGAAGTGGATTCCGGTGATGGAAACCACATGTTTGCAGGACATCTAAAGTGCAAAGTACGCATGGAGAAATTGAGAATCAAGGGAATGTCATACACGATGTGCTCAGGAAAGTTCTCAATTGACAAGGAGATGGCAGAAACACAGCATGGGACAACAGTGGTGAAAGTCAAGTATGAAGGTACTGGAGCTCCATGCAAAGTCCCCATAGAGATAAGAGATGTGAACAAGGAAAAAGTGGTTGGGCGCATCATTTCATCTACTCCTTTTGCTGAGAATACCAACAGTGTAACCAATATTGAATTAGAACCCCCCTTTGGGGACAGCTACATAGTGATAGGTGTTGGAGACAGTGCATTAACACTCCATTGGTTTAGGAAAGGGAGTTCCATTGGCAAGATGTTTGAGTCCACATACAGAGGTGCAAAGCGAATGGCCATTCTAGGTGAAACAGCTTGGGATTTTGGTTCTGTTGGTGGACTGTTCACATCATTGGGAAAAGCTGTGCACCAGGTTTTTGGTAGTGTCTACACAACTATGTTTGGAGGAGTCTCATGGATGGTTAGAATCCTAATTGGGTTCTTAGTGTTGTGGATCGGCACGAACTCAAGAAACACTTCAATGGCAATGACGTGCATAGCTGTTGGAGGAATCACTCTGTTTCTGGGTTTCACGGTTCAAGCAGACATGGGTTGTGTGGTGTCATGGAGTGGGAAAGAATTGAAATGTGGAAGTGGAATTTTTGTGATTGACAACGTGCACACTTGGACAGAACAGTACAAATTTCAACCAGAGTCCCCAGCGAGACTAGCGTCCGCAATATTGAATGCCCACAAAGATGGGGTCTGTGGAATTAGATCAACCACGAGGCTGGAAAATGTCATGTGGAAACAAATAACCAACGAGCTAAACTATGTTCTCTGGGAAGGAGGACATGACCTCACTGTGGTGGCCGGGGATGTGAAAGGGGTGTTGACCAAAGGCAAGAGAGCACTCACACCTCCAGTGAATGATTTGAAATATTCATGGAAGACATGGGGGAAAGCAAAAATCTTTACTCCAGAAGCAAGAAATAGCACATTCTTGATAGACGGACCAGACACCTCCGAATGCCCCAATGAACGAAGAGCATGGAACTTTCTTGAGGTAGAAGACTATGGATTTGGCATGTTCACGACCAACATATGGATGAAATTTCGAGAAGGAAGTTCAGAAGTGTGTGACCACAGGTTAATGTCAGCGGCAATCAAAGATCAGAAAGCCGTGCATGCTGACATGGGCTATTGGATAGAGAGCTCAAAAAACCAGACCTGGCAGATAGAGAAAGCATCCCTTATTGAAGTGAAAACATGTCTGTGGCCCAAGACTCACACATTGTGGAGCAATGGAGTGCTGGAAAGCCAGATGCTCATTCCAAAAGCATATGCAGGCCCCTTTTCACAGCACAATTACCGCCAGGGCTATGCCACGCAGACCATGGGCCCATGGCACTTGGGCAAATTGGAAATAGACTTTGGAGAATGCCCCGGAACAACAGTCACAATTCAGGAGGATTGTGACCACAGAGGCCCATCTTTGAGGACCACCACTGCATCTGGAAAATTGGTCACACAGTGGTGCTGCCGCTCCTGCACGATGCCTCCCTTAAGGTTTTTGGGAGAGGATGGGTGTTGGTATGGGATGGAAATTAGGCCCTTAAGTGAAAAAGAAGAGAACATGGTCAAATCACAGGTGTCGGCCGGACAGGGTTCATCAGAAACTTTTTCTATGGGGCTGTTATGTCTGACCCTGTTCATGGAAGAATGCTTGAGGAGAAGAGTCACTAGGAAACACATGATATTGGTTGTGGTGACCACCCTTTGTGCCATCATCCTAGGAGGTCTCACGTGGATGGACTTACTACGAGCCATTATCATGTTAGGGGACACCATGTTTGGTAGAATGGGAGGACAGATTCACCTAGCCATCATGGCAGTGTTCAAGATGTCACCAGGATACGTGCTGGGTGTGTTTTTAAGGAAACTCACTTCAAGAGAGACAGCACTAATGGTGATAGGAATGGCCATGACAACGGTGTTTTCAATTCCACATGACCTTATGGAATTCATTGATGGAATATCATTGGGGCTAATCTTGCTGAAAATGGTAACACATTTTGACAACACCCAAGTGGGAACTTTAGCCCTTTCCTTAACTTTCATAAGATCAACAATGCCATTGATCATGGCTTGGAGGACCATCATGGCTGTGTTGTTTGTGGTCACACTCATTCCTTTATGTAGGACAAGCTGTCTTCAAAAGCAGTCCCACTGGGTAGAAATAACAGCAATCATCTTAGGAGCCCAGGCTCTGCCAGTGTACTTAATGACTCTCATGAAAGGAGCCTCAAAAAGATCTTGGCCTCTTAACGAGGGCATAATGGCTGTGGGCTTGGTCAGTCTCTTGGGAAGCGCCCTTCTAAAGAATGATGTCCCTTTGGCTGGTCCAATGGTGGCAGGAGGTTTACTTCTGGCAGCCTACGTGATGAGTGGTAGCTCAGCAGACCTGTCACTAGAGAAGGCCGCCAATGTGCAGTGGGATGAGATGGCAGACATAACAGGCTCAAGCCCAATCATAGAAGTGAAGCAGGATGAAGATGGCTCTTTCTCCATACGGGACGTCGAGGAAACCAACATGATAACCCTTTTGGTGAAACTGGCACTGATAACTGTGTCAGGTCTCTACCCCTTGGCAATTCCAGTCACAATGACTTTATGGTACATGTGGCAAGTGAAAACACAAAGATCAGGAGCCCTGTGGGACGTTCCCTCACCCGCTACCGCTCAGAAAGCCACACTGACTGAAGGAGTGTACAGGATCATGCAAAGAGGGTTGTTTGGGAAAACTCAGGTTGGAGTAGGGATACACATGGAAGGTGTATTTCACACAATGTGGCATGTAACAAGAGGATCAGTGATCTGCCATGAGACTGGGAGATTGGAGCCATCTTGGGCTGACGTCAGGAACGACATGATATCATACGGTGGGGGATGGAGGCTCGGAGACAAATGGGACAAAGAAGAAGATGTTCAGGTCCTAGCCATAGAACCAGGAAAAAATCCGAAACATGTCCAAACGAAACCCGGCCTTTTCAAGACCCTAACTGGAGAAATTGGAGCAGTAACATTGGATTTCAAACCCGGAACATCTGGTTCTCCCATCATTAACAAGAAAGGAAAAGTTATCGGACTCTATGGAAATGGAGTAGTTACCAAATCAGGTGATTACGTCAGTGCCATAACGCAAGCCGAAAGAATTGGTGAGCCAGATTATGAAGTGGATGAGGACATCTTTCGAAAGAAAAGATTAACCATAATGGACTTACACCCCGGAGCTGGCAAGACAAAAAGAATTCTCCCATCAATAGTCAGAGAAGCTCTAAAAAGGAGGCTGCGAACCCTGATTTTGGCTCCCACGAGAGTGGTGGCAGCCGAGATGGAAGAGGCCCTTCGCGGACTACCAATCCGTTATCAGACCCCAGCTGTGAAATCAGAACACACAGGAAGAGAGATTGTAGACCTCATGTGTCATGCAACCTTCACAACAAGACTCTTGTCATCAACCAGAGTTCCAAATTACAACCTCATAGTAATGGATGAAGCGCATTTCACAGACCCTTCTAGTGTCGCAGCTAGAGGATACATCTCAACCAGGGTGGAAATGGGAGAGGCAGCAGCCATCTTCATGACTGCAACCCCTCCCGGAGCAACAGATCCCTTCCCCCAGAGCAACAGCCCAATAGAAGACATCGAGAGAGAAATTCCAGAAAGGTCATGGAATACAGGATTCGACTGGATAACAGACTACCAAGGGAAGACTGTGTGGTTTGTTCCCAGCATAAAAGCTGGAAATGACATTGCAAATTGCTTGAGAAAGTCGGGAAAGAAGGTGATCCAGTTGAGTAGGAAAACCTTTGACACAGAGTATCCAAAAACGAAACTCACAGACTGGGATTTTGTGGTCACCACAGACATATCTGAAATGGGGGCCAATTTTAGAGCTGGGAGAGTGATAGACCCCAGGAGATGCCTCAAGCCAGTCATCCTAACAGATGGGCCAGAGAGAGTCATTTTGGCAGGTCCCATTCCAGTGACTCCAGCAAGCGCTGCTCAGAGAAGAGGGCGAATAGGTAGAAACCCAGCACAAGAAGACGACCAGTATGTCTTCTCTGGAGACCCATTGAAAAATGATGAAGATCATGCCCACTGGACAGAAGCAAAGATGCTGCTTGACAATATCTACACCCCGGAAGGGATCATTCCAACATTGTTTGGTCCGGAAAGGGAAAAAACCCAAGCCATTGATGGAGAGTTTCGCCTCAGAGGGGAACAAAGGAAGACTTTTGTGGAATTAATGAGGAGAGGAGACCTTCCGGTGTGGCTGAGCTATAAGGTAGCTTCAGCTGGTATTTCTTACAAAGACCGGGAATGGTGCTTCACAGGGGAAAGGAATAACCAAATTTTAGAAGAAAACATGGAGGTTGAAATTTGGACTAGAGAGGGAGAAAAGAAAAAACTAAGACCAAAATGGTTAGATGCACGTGTCTATGCTGACCCCATGGCTTTGAAGGATTTCAAGGAGTTTGCTAGTGGAAGAAAGAGCATAACCCTTGACATCCTGACAGAGATTGCCAGCTTGCCAACTTACCTTTCCTCTAGGGCCAAGCTCGCCCTTGACAACATAGTCATGCTCCACACAACAGAAAGGGGAGGGAGGGCCTACCAACACGCCCTGAACGAACTCCCGGAGTCATTGGAAACACTCATGCTTGTAGCTTTATTAGGTGCTATGACAGCAGGCATCTTCCTGTTTTTTATGCAAGGAAAAGGGATAGGGAAACTGTCAATGGGTTTGATAGCTATTGCGGTAGCTAGTGGCTTACTCTGGGTAGCAGAAATTCAGCCCCAGTGGATAGCGGCCTCAATCATACTGGAGTTTTTTCTCATGGTGCTGTTGATACCAGAACCAGAAAAACAAAGGACCCCACAAGACAACCAGTTGATCTATGTCATACTGGCCATTCTCACCATTATTGGTCTCATAGCAGCCAACGAGATGGGGCTGATTGAAAAAACAAAAACGGATTTTGGGTTTTACCAGGTAAAAACAGAAACCACCATCCTCGATGTGGATTTGAGACCAGCTTCAGCATGGACGCTCTATGCAGTAGCCACCACTATTCTGACTCCCATGCTGAGACACACCATAGAAAACACATCTGCCAACCTATCTCTGGCGGCCATTGCCAATCAAGCAGCTGTCCTAATGGGGCTTGGAAAAGGATGGCCGCTCCACAGAATGGACCTTGGTGTGCCGCTGTTAGCAATGGGATGTTATTCTCAAGTGAACCCAACAACTTTGACAGCATCCTTAGTCATGCTTTTAGTCCATTATGCAATAATAGGTCCAGGATTGCAGGCAAAAGCCACAAGAGAGGCTCAGAAAAGGACAGCTGCTGGGATCATGAAGAACCCCACGGTGGATGGAATAACAGTAATAGATCTAGAACCAATATCTTATGACCCAAAGTTTGAAAAGCAATTAGGGCAGGTCATGCTACTAGTCTTGTGTGCTGGACAACTACTCTTGATGAGAACAACATGGGCTTTCTGTGAAGTCTTGACTTTGGCCACAGGACCAGTCTTAACTTTGTGGGAGGGCAACCCGGGAAGATTTTGGAACACGACTATAGCCGTATCCACTGCCAACATTTTCAGGGGAAGCTACTTGGCGGGAGCTGGACTGGCTTTCTCACTCATAAAGAATGCACAAACCCCCAGGAGGGGAACTGGGACCACAGGAGAGACACTGGGAGAGAAGTGGAAGAGACAGCTAAACTCATTAGATAGGAAGGAGTTTGAAGAGTACAAGAGAAGTGGAATACTAGAAGTGGACAGGACTGAAGCCAAGTCTGCCCTGAAAGATGGGTCTAAAATCAAGCATGCAGTGTCCAGAGGGTCCAGCAAGATCAGATGGATTGTTGAAAGAGGGATGGTAAAGCCAAAAGGGAAAGTTGTGGATCTTGGTTGCGGGAGAGGAGGATGGTCGTATTACATGGCGACACTCAAGAACGTGACTGAGGTGAAAGGGTACACGAAAGGAGGTCCAGGACATGAAGAACCGATTCCCATGGCTACCTATGGCTGGAATTTGGTCAAGCTCCATTCAGGGGTTGACGTGTTCTACAAACCCACTGAGCAAGTGGACACCCTGCTCTGTGATATTGGAGAGTCATCTTCTAATCCGACAATAGAGGAAGGAAGAACATTAAGAGTTCTGAAGATGGTGGAGCCATGGCTCTCTTCAAAACCTGAATTCTGCATCAAAGTCCTTAACCCCTACATGCCAACAGTCATAGAAGAACTGGAGAAACTGCAGAGAAAGCATGGTGGAAGTCTTATCAGATGCCCGCTATCCAGGAATTCCACTCATGAGATGTATTGGGTGTCAGGTGCGTCGGGAAACATCGTGAGCTCTGTGAACACAACATCAAAGATGCTGTTGAACAGGTTTACCACGAGGCATAGGAAACCCACCTATGAGAAGGACGTAGACCTTGGAGCAGGAACAAGAAGTGTCTCCACTGAAACAGAAAAACCAGACATGACAATCATTGGGAGAAGGCTTCAGCGATTGCAAGAAGAGCACAAAGAAACTTGGCACTATGATCAGGAAAATCCATACAGAACCTGGGCGTATCATGGAAGCTATGAAGCTCCTTCGACAGGCTCAGCATCCTCCATGGTAAACGGGGTAGTAAAACTGCTGACAAAACCTTGGGACGTGATTCCAATGGTGACCCAGTTAGCCATGACAGACACAACCCCCTTTGGGCAACAAAGAGTGTTTAAAGAGAAGGTGGACACCAGAACACCACAACCAAAACCAGGCACACGAGTGGTTATGACCACAACAGCCAATTGGCTGTGGGCCCTCCTTGGGAGGAAGAAAAATCCCAGACTGTGCACGAGGGAAGAGTTCATCTCAAAAGTTAGGTCAAACGCAGCCATAGGTGCAGTCTTTCAGGAAGAACAGGGATGGACATCAGCCAGTGAAGCTGTGAATGACAGCCGGTTTTGGGAACTGGTTGACAAAGAAAGGGCTCTGCACCAGGAAGGGAAATGTGAATCGTGTGTCTACAACATGATGGGAAAACGTGAGAAAAAACTAGGAGAGTTTGGTAGAGCCAAAGGAAGCCGAGCAATCTGGTACATGTGGCTGGGAGCGCGGTTTCTGGAATTTGAAGCCCTGGGTTTCTTAAATGAAGATCACTGGTTTGGCAGAGAAAATTCATGGAGTGGAGTGGAAGGAGAAGGTCTGCATAGATTGGGATACATCCTAGAGGACATAGACAAGAAGGATGGAGACCTGATGTATGCTGATGACACAGCAGGTTGGGACACAAGAATCACTGAAGATGACCTTCTAAATGAAGAACTGATCACGGAACAGATGGCCCCTCATCATAAGATCTTAGCCAAAGCCATTTTCAAACTAACTTATCAAAACAAAGTGGTAAAAGTCCTCAGACCCACACCGAAAGGAGCGGTGATGGACATCATATCCAGGAAAGACCAAAGAGGTAGTGGACAGGTTGGAACATATGGTTTGAACACATTCACCAACATGGAAGTACAACTCATCCGCCAAATGGAAGCTGAAGGAGTCATCACACAAGATGACATGCAGAACCCAAAAGGGCTGAAAGAAAGAGTTGAGAAATGGCTGAAAGAGTGTGGTGTCGACAGGTTGAAGAGGATGGCAATCAGTGGAGATGATTGTGTGGTGAAGCCCCTGGATGAGAGGTTCAGCACTTCCCTCCTCTTCTTGAACGACATGGGAAAGGTGAGGAAAGACATTCCGCAGTGGGAACCATCCAAGGGATGGAAAAATTGGCAAGAGGTTCCTTTTTGCTCCCACCACTTTCACAAGATCTTCATGAAGGATGGCCGCTCACTAGTTGTTCCATGTAGAAACCAGGATGAACTGATAGGGAGAGCCAGAATCTCGCAGGGGGCTGGATGGAGCTTAAAAGAAACAGCCTGTCTGGGCAAAGCTTACGCCCAGATGTGGTCGCTCATGTATTTTCACAGAAGGGACCTGCGTTTAGCCTCCATGGCCATATGCTCAGCAGTTCCAACGGAATGGTTTCCAACAAGCAGAACAACATGGTCAATCCACGCCCACCATCAGTGGATGACCACTGAAGACATGCTCAAAGTGTGGAACAGAGTGTGGATAGAAGACAACCCTAACATGACTGACAAAACTCCAGTCCATTCGTGGGAAGACATACCTTACCTAGGGAAAAGAGAGGATTTGTGGTGTGGATCCTTGATTGGACTTTCTTCCAGAGCCACCTGGGCGAAAAACATTCACACAGCCATAACCCAAGTCAGGAACCTGATCGGGAAAGAGGAGTATGTGGATTACATGCCAGTCATGAAAAGATACAGCGCTCCTTTCGAGAGTGAAGGAGTTCTGTAATTACCAACAACAAACACCAAAGCCTATTGAAGTCAGGCCACTTGTGCCACGGCTTGAGCAAACCGTGCTGCCTGTAGCTCCGCCAATAACGGGAGGCGTAAAAATTCCCAGGGAGGCCATGCGCCACGGAAGCTGTACGCGTGGCATATTGGACTAGCGGTTAGAGGAGACCCCTCCCATCACTGACAAAACGCAGCAAAAGGGGGCCCGAAGCCAGGAGGAAGCTGTACTCCTGGTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAACACAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCTGCAACATCAATCCAGGCACAGAGCGCCGCAAGATGGATTGGTGTTGTTGATCCAACAGGTTCT diff --git a/nextclade/datasets/denv2/tree.json b/nextclade/datasets/denv2/tree.json index 9be2f173..861e9cd4 100644 --- a/nextclade/datasets/denv2/tree.json +++ b/nextclade/datasets/denv2/tree.json @@ -1 +1 @@ -{"version": "v2", "meta": {"title": "Real-time tracking of dengue virus evolution", "updated": "2024-06-10", "build_url": "https://github.com/nextstrain/dengue", "maintainers": [{"name": "the Nextstrain team", "url": "https://nextstrain.org/team"}], "display_defaults": {"map_triplicate": true, "color_by": "clade_membership"}, "genome_annotations": {"nuc": {"end": 10723, "start": 1, "strand": "+", "type": "##sequence-region pragma", "seqid": "resources/denv2/genome_annotation.gff3"}, "2K": {"end": 6825, "seqid": "resources/denv2/genome_annotation.gff3", "start": 6757, "strand": "+", "type": "gene"}, "C": {"end": 438, "seqid": "resources/denv2/genome_annotation.gff3", "start": 97, "strand": "+", "type": "gene"}, "E": {"end": 2421, "seqid": "resources/denv2/genome_annotation.gff3", "start": 937, "strand": "+", "type": "gene"}, "M": {"end": 936, "seqid": "resources/denv2/genome_annotation.gff3", "start": 439, "strand": "+", "type": "gene"}, "NS1": {"end": 3477, "seqid": "resources/denv2/genome_annotation.gff3", "start": 2422, "strand": "+", "type": "gene"}, "NS2A": {"end": 4131, "seqid": "resources/denv2/genome_annotation.gff3", "start": 3478, "strand": "+", "type": "gene"}, "NS2B": {"end": 4521, "seqid": "resources/denv2/genome_annotation.gff3", "start": 4132, "strand": "+", "type": "gene"}, "NS3": {"end": 6375, "seqid": "resources/denv2/genome_annotation.gff3", "start": 4522, "strand": "+", "type": "gene"}, "NS4A": {"end": 6756, "seqid": "resources/denv2/genome_annotation.gff3", "start": 6376, "strand": "+", "type": "gene"}, "NS4B": {"end": 7569, "seqid": "resources/denv2/genome_annotation.gff3", "start": 6826, "strand": "+", "type": "gene"}, "NS5": {"end": 10269, "seqid": "resources/denv2/genome_annotation.gff3", "start": 7570, "strand": "+", "type": "gene"}, "pr": {"end": 711, "seqid": "resources/denv2/genome_annotation.gff3", "start": 439, "strand": "+", "type": "gene"}}, "colorings": [{"key": "gt", "title": "Genotype", "type": "categorical"}, {"key": "country", "title": "Country", "type": "categorical", "scale": [["Saudi Arabia", "#5E1D9D"], ["Pakistan", "#4B25B0"], ["Maldives", "#4929B5"], ["India", "#472EB9"], ["Sri Lanka", "#4432BD"], ["Nepal", "#4236C1"], ["Bangladesh", "#403BC5"], ["Myanmar", "#4040C6"], ["Thailand", "#3F45C8"], ["Malaysia", "#3F4BCA"], ["Laos", "#3F50CC"], ["Singapore", "#3F56CE"], ["China", "#3E5BD0"], ["Cambodia", "#3F60D0"], ["Vietnam", "#4065CF"], ["Indonesia", "#416ACF"], ["Brunei", "#426FCE"], ["Taiwan", "#4274CE"], ["Philippines", "#4379CD"], ["South Korea", "#4681C9"], ["French Polynesia", "#4989C4"], ["Palau", "#4B8DC2"], ["Australia", "#4C91BF"], ["Papua New Guinea", "#4E95BD"], ["Fiji", "#56A0AE"], ["Senegal", "#59A3AA"], ["Mauritania", "#5DA8A3"], ["C\u00f4te d'Ivoire", "#60AA9F"], ["Burkina Faso", "#65AD96"], ["Ghana", "#68AF92"], ["Benin", "#6EB38A"], ["Niger", "#74B582"], ["Cameroon", "#7EB976"], ["Angola", "#81BA72"], ["Democratic Republic of the Congo", "#85BA6F"], ["Egypt", "#89BB6B"], ["Mozambique", "#90BC65"], ["Tanzania", "#94BD62"], ["Kenya", "#98BD5E"], ["Djibouti", "#9FBE59"], ["Somalia", "#A3BE57"], ["Seychelles", "#A7BE54"], ["Spain", "#B2BD4D"], ["France", "#BABC4A"], ["Paraguay", "#CBB742"], ["Brazil", "#D1B440"], ["Peru", "#D3B23F"], ["Ecuador", "#D6B03E"], ["Colombia", "#D9AE3E"], ["Suriname", "#DCAC3D"], ["Guyana", "#DDA83C"], ["Venezuela", "#DFA53B"], ["Panama", "#E39A39"], ["Costa Rica", "#E59738"], ["Nicaragua", "#E68E36"], ["Honduras", "#E67431"], ["Guatemala", "#E4682F"], ["Guadeloupe", "#E3622D"], ["Belize", "#E25B2C"], ["Saint Kitts and Nevis", "#E1552B"], ["Jamaica", "#E04E2A"], ["Dominican Republic", "#E04828"], ["Haiti", "#DF4227"], ["Mexico", "#DE3B26"], ["Cuba", "#DD3525"], ["USA", "#DB2823"]]}, {"key": "region", "title": "Region", "type": "categorical", "scale": [["Asia", "#447CCD"], ["Oceania", "#5EA9A1"], ["Africa", "#8ABB6A"], ["Europe", "#BEBB48"], ["South America", "#E29E39"], ["North America", "#E2562B"]]}, {"key": "genotype_nextclade", "title": "Dengue Genotype (Nextclade)", "type": "categorical", "scale": [["DENV2/AA", "#447CCD"], ["DENV2/AI", "#5EA9A1"], ["DENV2/AII", "#8ABB6A"], ["DENV2/AM", "#BEBB48"], ["DENV2/C", "#E29E39"], ["DENV2/S", "#E2562B"]]}, {"key": "serotype_genbank", "title": "Serotype (Genbank metadata)", "type": "categorical", "scale": [["denv2", "#4C90C0"]]}, {"key": "clade_membership", "title": "Dengue Genotype (Nextstrain)", "type": "categorical"}], "filters": ["country", "region", "author"], "geo_resolutions": [{"key": "country", "demes": {"Pakistan": {"latitude": 30.0, "longitude": 70.0}, "Haiti": {"latitude": 19.1399952, "longitude": -72.3570971}, "Guadeloupe": {"latitude": 16.265, "longitude": -61.551}, "Paraguay": {"latitude": -23.33333, "longitude": -58.0}, "Tonga": {"latitude": -19.9160818, "longitude": -175.2026423}, "Guatemala": {"latitude": 15.6356088, "longitude": -89.8988086}, "Papua New Guinea": {"latitude": -6.0, "longitude": 147.0}, "Indonesia": {"latitude": -5.0, "longitude": 120.0}, "Costa Rica": {"latitude": 10.0, "longitude": -84.0}, "Laos": {"latitude": 20.0171109, "longitude": 103.378253}, "Samoa": {"latitude": -13.598724, "longitude": -172.454467}, "Peru": {"latitude": -10.0, "longitude": -75.25}, "Senegal": {"latitude": 14.5, "longitude": -14.25}, "Nepal": {"latitude": 28.0, "longitude": 84.0}, "Sri Lanka": {"latitude": 7.75, "longitude": 80.75}, "South Korea": {"latitude": 35.3985008, "longitude": 127.937111}, "Australia": {"latitude": -24.7761085, "longitude": 134.755}, "Panama": {"latitude": 8.3096067, "longitude": -81.3066245}, "Cuba": {"latitude": 22.0, "longitude": -79.5}, "Cambodia": {"latitude": 13.0, "longitude": 105.0}, "Jamaica": {"latitude": 18.16667, "longitude": -77.25}, "Somalia": 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{"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["C55A", "A63T", "G122A", "G1278A", "T2274C", "T2685C", "T5994C", "T8451C", "C10236T", "A10587T"], "C": ["R9K"]}, "labels": {"aa": "C: R9K"}}}]}, {"name": "NODE_0002533", "node_attrs": {"div": 962, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 0.9999999876516448}, "entropy": 2.4228280119466333e-07}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 0.9999996427645026}, "entropy": 7.0803071278859794e-06}, "region": {"value": "North America", "confidence": {"North America": 0.9999922721522355}, "entropy": 0.00010615104596121185}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["A1242G", "T3042C", "A3423G"]}}, "children": [{"name": "NI/DB295/2018_2018", "node_attrs": {"div": 964, "genbank_accession": {"value": "OQ144226"}, "author": {"author": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L.", "value": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L."}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 1.0}, "entropy": -1.000088900581841e-12}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 1.0}, "entropy": -1.000088900581841e-12}, "region": {"value": "North America", "confidence": {"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["T5010C", "G9136A"], "NS5": ["G523S"]}, "labels": {"aa": "NS5: G523S"}}}, {"name": "NI/DB311/2018_2018", "node_attrs": {"div": 963, "genbank_accession": {"value": "OQ144242"}, "author": {"author": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L.", "value": "Santiago,G.A.,Gonzalez-Morales,G.,Flores,B.,Charriez,K.N.,Reller,M.,Matute,A.,Reyes,Y.,Centeno-Cuadra,E.,Bucardo,F.,Munoz-Jordan,J.L."}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 1.0}, "entropy": -1.000088900581841e-12}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 1.0}, "entropy": -1.000088900581841e-12}, "region": {"value": "North America", "confidence": {"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}}, "branch_attrs": {"mutations": {"nuc": ["A3969G"]}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}, "root_sequence": {"nuc": "AGTTGTTAGTCTACGTGGACCGACAAAGACAGATTCTTTGAGGGAGCTAAGCTCAACGTAGTTCTAACAGTTTTTTGATTAGAGAGCAGATCTCTGATGAATAACCAACGGAAAAAGGCGAGAAATACGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTGTCGACTGTACAACAGCTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGACGAGGACCATTAAAACTGTTCATGGCCCTGGTGGCGTTCCTTCGTTTCCTAACAATCCCACCAACAGCAGGGATACTGAAAAGATGGGGAACAATCAAAAAATCAAAGGCTATCAATGTCCTGAGAGGGTTCAGGAAAGAGATTGGAAGGATGCTGAACATCTTGAACAGGAGACGCAGAACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTCCATTTGACCACACGCAACGGAGAACCACACATGATTGTCAGTAGACAAGAGAAAGGGAAAAGCCTTCTGTTTAAAACAGAGGATGGTATGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAAGACACAATCACGTACAAGTGTCCTTTTCTCAGGCAGAACGAACCAGAAGACATAGATTGTTGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCACAGAAGAGAAAAAAGATCAGTGGCACTTGTTCCACACGTGGGAATGGGACTGGAGACACGAACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGGATTCTGAGACATCCAGGCTTTACCATAATGGCAGCAATCCTGGCATACACCATAGGAACGACACATTTCCAAAGAGTCCTGATTTTCATCTTACTGACAGCCGTCGCTCCTTCAATGACAATGCGCTGCATAGGAATATCAAATAGAGACTTTGTGGAAGGAGTTTCAGGAGGAAGCTGGGTTGACATAGTCTTAGAACATGGAAGCTGTGTGACGACGATGGCAAAAAACAAACCAACATTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCTGCCACTCTAAGGAAGTACTGTATAGAGGCTAAACTGACCAACACAACAACAGAATCTCGCTGCCCAACACAAGGGGAACCCAGCCTAAATGAAGAGCAGGACAAAAGGTTCGTCTGCAAACACTCCATGGTAGACAGAGGATGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATTGTGACCTGTGCTATGTTCACATGCAAAAAGAACATGGAAGGAAAAGTTGTGCAGCCAGAAAACTTGGAATACACCATTGTGATAACACCTCACTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGCAAGGAAGTCAAGATAACACCACAGAGCTCCATCACAGAAGCAGAACTGACAGGCTATGGCACTGTCACGATGGAGTGCTCTCCGAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAAATGGAAAACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTACCATGGCTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACATTGGTCACTTTCAAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATGCACACAGCACTCACAGGGGCCACAGAAATCCAGATGTCATCAGGAAACTTACTGTTCACAGGACATCTCAAGTGCAGGCTGAGAATGGACAAACTACAGCTCAAAGGGATGTCATACTCTATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATAGTCATCAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGATCCCTTTTGAGATAATGGATTTGGAAAAAAGACATGTCTTAGGTCGCCTGATCACAGTCAACCCAATTGTAACAGAAAAAGACAGCCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATAGGAGTGGAACCAGGACAATTGAAGCTCAACTGGTTTAAGAAAGGAAGTTCTATCGGCCAAATGTTTGAGACAACAATGAGAGGAGCGAAAAGAATGGCCATTTTGGGTGACACAGCCTGGGATTTTGGATCCCTGGGAGGAGTGTTCACATCTATAGGAAAGGCTCTCCACCAAGTTTTTGGAGCAATCTATGGGGCTGCCTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGAGTTATCATCACATGGATAGGAATGAATTCACGCAGCACCTCACTGTCTGTGTCACTAGTATTAGTGGGAATCGTGACACTATACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTTGTGAGCTGGAAGAACAAAGAACTGAAATGTGGCAGTGGGATTTTCGTCACAGACAACGTGCACACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCCATCCAGAAAGCTCATGAAGAGGGCATTTGTGGAATCCGCTCAGTAACAAGACTGGAGAATCTGATGTGGAAACAGATAACACCAGAATTGAATCACATTCTATCAGAAAATGAAGTAAAGCTGACCATCATGACAGGAGACATTAAAGGAATCATGCAGGCAGGAAAACGATCTCTGCGGCCCCAACCCACTGAGCTGAGGTATTCATGGAAAACATGGGGCAAAGCGAAAATGCTCTCCACAGAGCTCCATAATCAGACCTTTCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAACACAAACAGAGCTTGGAATTCACTGGAAGTTGAGGACTATGGCTTTGGAGTATTCACCACCAATATATGGCTAAAATTGAGAGAAAAGCAGGATGTATTTTGTGACTCAAAACTCATGTCAGCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCACTCAATGACACATGGAAGATAGAGAAAGCCTCTTTCATTGAAGTTAAAAGCTGCCACTGGCCAAAGTCACACACCCTCTGGAGTAATGGAGTGCTAGAAAGTGAGATGATAATTCCAAAGAATTTCGCTGGACCAGTGTCACAACACAACTACAGACCAGGCTATTACACACAAACAGCAGGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGAACTACAGTGGTGGTGACCGAGGACTGTGGAAACAGAGGACCCTCTTTAAGAACAACCACTGCCTCTGGAAAACTCATAACAGAATGGTGCTGCCGATCTTGCACATTACCACCGCTAAGATACAGAGGTGAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAGAATCTGGTCAACTCTTTGGTCACAGCCGGACATGGGCAGATTGACAACTTTTCACTAGGAATCTTGGGAATGGCATTGTTCCTGGAAGAAATGCTCAGGACCCGAGTAGGAACGAAACATGCAATACTACTAGTTGCAGTTTCTTTCGTGACATTGATCACAGGGAACATGTCCTTTAGAGACCTGGGAAGAGTGATGGTTATGGTGGGCGCTACCATGACGGATGACATAGGTATGGGCGTGACTTATCTTGCCCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTGAGAAAACTGACCTCCAAGGAATTGATGATGACCACCATAGGAATCGTTCTCCTCTCCCAGAGTAGCATACCAGAGACCATTCTTGAACTGACTGATGCGTTAGCCTTGGGCATGATGGTCCTCAAAATAGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATCTTATGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCAGTGGTGTCTGTTTCCCCACTGCTCTTAACATCCTCACAACAGAAAGCGGATTGGATACCATTAGCATTGACGATCAAAGGTCTCAATCCAACAGCCATTTTTCTAACAACCCTTTCAAGAACCAGCAAGAAAAGGAGCTGGCCTCTAAATGAGGCTATCATGGCAGTTGGGATGGTGAGCATTTTAGCCAGTTCTCTCTTAAAGAATGACATTCCCATGACAGGACCATTAGTGGCTGGAGGGCTCCTCACTGTGTGCTACGTGCTCACTGGACGATCGGCCGATTTGGAACTGGAGAGAGCCGCCGATGTCAAATGGGAAGATCAGGCAGAGATATCAGGGAGCAGTCCAATTCTGTCAATAACAATATCAGAAGATGGTAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACACTGACCATACTCATTAGAACAGGATTGCTGGTGATCTCAGGACTTTTTCCGGTATCAATACCAATCACAGCAGCAGCATGGTACCTGTGGGAAGTGAAGAAACAACGGGCTGGAGTGTTGTGGGATGTCCCTTCACCCCCACCCGTGGGAAAGGCTGAACTGGAAGATGGAGCCTACAGAATCAAGCAAAAAGGGATTCTTGGATATTCCCAGATCGGAGCCGGAGTTTACAAAGAAGGAACATTCCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAAGGGAAGAGGATTGAACCATCATGGGCGGACGTCAAGAAAGACCTAATATCATATGGAGGAGGCTGGAAGCTAGAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGAAAAAATCCAAGAGCCGTCCAAACAAAACCTGGCCTTTTCAAAACCAACACCGGAACCATAGGTGCCGTATCTCTGGACTTTTCCCCTGGAACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAAGTTGTGGGTCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATAGCCCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAGAAAAGATTGACCATCATGGACCTCCACCCAGGAGCGGGAAAGACAAAGAGATACCTCCCAGCCATAGTCAGAGAAGCCATAAAAAGAGGCTTGAGAACACTAATCCTGGCCCCCACTAGAGTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACCCCAGCCATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACCTAATGTGTCATGCCACATTTACCATGAGGCTGCTATCACCAATTAGGGTGCCAAATTACAACCTGATCATCATGGACGAAGCCCATTTCACAGACCCAGCAAGCATAGCAGCTAGAGGATACATCTCAACTCGAGTAGAGATGGGTGAAGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGACCCATTTCCTCAGAGCAATGCACCAATCATGGACGAAGAAAGAGAAATTCCTGAACGTTCGTGGAATTCCGGACATGAGTGGGTCACGGATTTTAAAGGGAAGACTGTTTGGTTTGTTCCAAGCATAAAAGCCGGAAATGACATAGCAGCCTGCCTGAGAAAAAATGGAAAGAGAGTGATACAACTCAGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGACTTCGTGGTCACAACTGACATCTCGGAAATGGGTGCCAACTTCAAAGCTGAGAGGGTTATAGACCCCAGACGCTGCATGAAACCAGTTATACTGACAGATGGTGAAGAGCGGGTGATCCTGGCAGGACCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCAAAAAATGAAAATGACCAATACATATACATGGGGGAACCTCTGGAAAATGATGAAGACTGTGCACACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATTCCTAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATACCGCTTGAGAGGAGAAGCAAGGAAAACCTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGGTTGGCTTACAAAGTGGCAGCTGAAGGCATCAACTACGCAGACAGAAGGTGGTGTTTTGATGGAATCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAAGAAGGGGAAAGGAAGAAATTAAAACCCAGATGGTTGGATGCTAGGATCTATTCTGACCCACTGGCGCTAAAAGAATTCAAGGAATTTGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATGGGTAGGCTCCCAACTTTCATGACTCAGAAGGCAAGAGATGCACTGGACAACTTAGCAGTGCTGCACACGGCTGAAGCAGGTGGAAGGGCATACAATCATGCTCTCAGTGAACTGCCGGAGACCCTGGAGACATTGCTTTTGCTGACACTTTTGGCCACAGTCACGGGAGGAATCTTTCTATTCTTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACGGCCAGCATCCTCCTATGGTACGCACAAATACAGCCACATTGGATAGCAGCTTCAATAATACTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGAACACCCCAGGATAACCAATTGACCTATGTTGTCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCAAACGAGATGGGTTTCCTGGAAAAAACAAAGAAAGACCTCGGATTGGGAAGCATTGCAACCCAGCAACCCGAGAGCAACATCCTGGACATAGATCTACGTCCTGCATCAGCATGGACGCTGTATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCAGTGAATGTGTCCCTAACAGCCATTGCCAACCAAGCCACAGTGCTAATGGGTCTTGGGAAAGGATGGCCATTGTCAAAGATGGACATCGGAGTTCCCCTTCTCGCCATTGGATGCTACTCACAAGTCAACCCCATAACCCTCACAGCAGCTCTTCTTTTATTGGTAGCACATTATGCCATCATAGGACCAGGACTCCAAGCAAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGCATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATTGACCTAGATCCAATACCCTATGATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGCGTGACTCAAGTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACCCTAGCAACCGGGCCCATATCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCAATGGCTAACATTTTTAGAGGGAGTTACTTGGCCGGAGCTGGACTTCTCTTTTCCATCATGAAGAACACAACCAGCACAAGAAGAGGAACTGGCAACATAGGAGAGACGCTAGGAGAGAAATGGAAAAGCCGACTGAACGCATTGGGGAAAAGTGAATTCCAGATCTACAAGAAAAGTGGAATCCAGGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGACCATCACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTCGAAAGAAATATGGTCACACCAGAAGGGAAAGTAGTGGACCTTGGTTGTGGCAGAGGGGGCTGGTCATACTATTGTGGAGGACTAAAGAATGTAAGAGAAGTCAAAGGCCTAACAAAAGGAGGACCAGGACACGAAGAACCCATCCCCATGTCAACATATGGGTGGAATCTAGTGCGTCTTCAGAGTGGAGTTGACGTTTTCTTCACTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAGTCGTCACCAAATCCCACGGTAGAAGCAGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGCTGAACAACAACACCCAATTTTGCATAAAGGTTCTCAACCCATACATGCCCTCAGTCATAGAAAAAATGGAAGCACTACAAAGGAAATATGGAGGAGCCTTGGTGAGAAATCCACTCTCACGGAATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTGAACATGATTTCAAGGATGTTGATTAACAGATTCACAATGAGACACAAGAAAGCCACTTACGAGCCAGATGTTGACCTCGGAAGCGGAACCCGCAACATTGGAATTGAAAGTGAGACACCAAACCTAGACATAATTGGAAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGGCACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAACAGACTGGATCAGCATCATCCATGGTGAACGGAGTGGTCAGACTGCTGACAAAACCCTGGGACGTCGTTCCCATGGTGACACAGATGGCAATGACAGACACAACTCCTTTTGGACAACAGCGCGTTTTCAAAGAGAAAGTGGACACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAACTAATGAAAATCACGGCAGAGTGGCTTTGGAAAGAACTAGGAAAGAAAAAGACACCTAGGATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATATTCACTGATGAGAACAAGTGGAAGTCGGCACGTGAGGCTGTTGAAGATGGTAGGTTTTGGGAGCTGGTTGACAAGGAAAGGAATCTCCATCTTGAAGGAAAGTGTGAAACATGTGTGTACAACATGATGGGAAAAAGAGAGAAGAAACTAGGAGAGTTTGGCAAAGCAAAAGGCAGCAGAGCCATATGGTACATGTGGCTTGGAGCACGCTTCTTAGAGTTTGAAGCCCTAGGATTCTTGAATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTGGAAGGAGAAGGGCTGCACAAGCTAGGTTACATCTTAAGAGACGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCCGATGACACCGCAGGCTGGGACACAAGAATCACACTAGAGGACTTAAAAAATGAAGAAATGATAACAAACCACATGGAAGGAGAACACAAGAAACTTGCCGAGGCCATTTTCAAATTAACGTACCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGATATCATATCGAGAAGAGACCAAAGAGGTAGTGGACAAGTTGGCACCTATGGCCTCAATACTTTCACCAATATGGAAGCACAACTAATCAGGCAGATGGAGGGGGAAGGAATCTTCAAAAGCATCCAGCACTTGACAGCCACAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTGGGGCGTGAAAGGTTATCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTCTAGATGACAGGTTTGCAAGAGCTTTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAAGACATACAACAATGGGAACCCTCAAGAGGATGGAACGATTGGACACAAGTGCCCTTCTGTTCACACCATTTCCATGAGTTAATCATGAAAGATGGTCGCACACTCGTAGTTCCATGTAGAAACCAAGATGAACTGATTGGTAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTGCGGGAGACGGCCTGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTCAGGCTGGCGGCAAATGCCATTTGCTCGGCAGTCCCATCACATTGGGTTCCAACAAGCCGGACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTCTGGAACAGGGTGTGGATCCAAGAAAACCCATGGATGGAAGACAAAACTCCAGTGGAATCATGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGGCTAACAAGCAGGGCCACCTGGGCAAAGAACATCCAAACAGCAATAAATCAAGTCAGATCCCTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAAGAGGAAGAGGCAGGAGTCCTGTGGTAGAAGACAGAACTAACATGAAACAAGGCTAGAAGTCAGGTCGGATTAAGCCATAGTACGGAAAAAACTATGCTACCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGTCAGGCCATCACAAATGCCATAGCTTGAGCAAACTGTGCAGCCTGTAGCTCCACCTGAGAAGGTGTAAAAAATCCGGGAGGCCACAAACCATGGAAGCTGTACGCATGGCGTAGTGGACTAGCGGTTAGAGGAGACCCCTCCCTTACAAATCGCAGCAACAATGGGGGCCCAAGGTGAGATGAAGCTGTAGTCTCACTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAAAACAAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLTYVVIAILTVVAATMA", "C": "MNNQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIPPTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMA", "E": "MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA", "M": "FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGMNMCTLMAMDLGELCEDTITYKCPFLRQNEPEDIDCWCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETWILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSMT", "NS1": "DSGCVVSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQPTELRYSWKTWGKAKMLSTELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLKLREKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMIIPKNFAGPVSQHNYRPGYYTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTA", "NS2A": "GHGQIDNFSLGILGMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVTYLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMVLKIVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLLLTSSQQKADWIPLALTIKGLNPTAIFLTTLSRTSKKR", "NS2B": "SWPLNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR", "NS3": 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"entropy": 0.00012557246865136786}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 0.9999996132752933}, "entropy": 7.623316396258994e-06}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 0.9999999806739951}, "entropy": 3.6875209704240787e-07}}, "branch_attrs": {"mutations": {"nuc": ["G7770A"]}}, "children": [{"name": "LLE1878", "node_attrs": {"div": 972, "genbank_accession": {"value": "OQ782218"}, "author": {"author": "Thongrsipong,P.,Edgerton,S.V.,Bos,S.,Saborio,S.,Kuan,G.,Balmaseda,A.,Harris,E.,Bennett,S.N.,Thongsripong,P.", "value": "Thongrsipong,P.,Edgerton,S.V.,Bos,S.,Saborio,S.,Kuan,G.,Balmaseda,A.,Harris,E.,Bennett,S.N.,Thongsripong,P."}, "region": {"value": "North America", "confidence": {"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 1.0}, "entropy": -1.000088900581841e-12}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 1.0}, "entropy": -1.000088900581841e-12}}, "branch_attrs": {"mutations": {}}}, {"name": "LLE1877", "node_attrs": {"div": 972, "genbank_accession": {"value": "OQ782219"}, "author": {"author": "Thongrsipong,P.,Edgerton,S.V.,Bos,S.,Saborio,S.,Kuan,G.,Balmaseda,A.,Harris,E.,Bennett,S.N.,Thongsripong,P.", "value": "Thongrsipong,P.,Edgerton,S.V.,Bos,S.,Saborio,S.,Kuan,G.,Balmaseda,A.,Harris,E.,Bennett,S.N.,Thongsripong,P."}, "region": {"value": "North America", "confidence": {"North America": 1.0}, "entropy": -1.000088900581841e-12}, "clade_membership": {"value": "DENV2/AA"}, "serotype_genbank": {"value": "denv2"}, "country": {"value": "Nicaragua", "confidence": {"Nicaragua": 1.0}, "entropy": -1.000088900581841e-12}, "genotype_nextclade": {"value": "DENV2/AA", "confidence": {"DENV2/AA": 1.0}, "entropy": -1.000088900581841e-12}}, "branch_attrs": {"mutations": {}}}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}]}, "root_sequence": {"nuc": "AGTTGTTAGTCTACGTGGACCGACAAAGACAGATTCTTTGAGGGAGCTAAGCTCAACGTAGTTCTAACAGTTTTTTGATTAGAGAGCAGATCTCTGATGAATAACCAACGGAAAAAGGCGAGAAATACGCCTTTCAATATGCTGAAACGCGAGAGAAACCGCGTGTCGACTGTACAACAGCTGACAAAGAGATTCTCACTTGGAATGCTGCAGGGACGAGGACCATTAAAACTGTTCATGGCCCTGGTGGCGTTCCTTCGTTTCCTAACAATCCCACCAACAGCAGGGATACTGAAAAGATGGGGAACAATCAAAAAATCAAAGGCTATCAATGTCCTGAGAGGGTTCAGGAAAGAGATTGGAAGGATGCTGAACATCTTGAACAGGAGACGCAGAACTGCAGGCATGATCATCATGCTGATTCCAACAGTGATGGCGTTCCATTTGACCACACGCAACGGAGAACCACACATGATTGTCAGTAGACAAGAGAAAGGGAAAAGCCTTCTGTTTAAAACAGAGGATGGTATGAACATGTGTACCCTCATGGCCATGGACCTTGGTGAGTTGTGTGAAGACACAATCACGTACAAGTGTCCTTTTCTCAGGCAGAACGAACCAGAAGACATAGATTGTTGGTGCAACTCCACGTCCACATGGGTAACTTATGGGACATGTACCACCACAGGAGAGCACAGAAGAGAAAAAAGATCAGTGGCACTTGTTCCACACGTGGGAATGGGACTGGAGACACGAACTGAAACATGGATGTCATCAGAAGGGGCCTGGAAACATGCCCAGAGAATTGAAACTTGGATTCTGAGACATCCAGGCTTTACCATAATGGCAGCAATCCTGGCATACACCATAGGAACGACACATTTCCAAAGAGTCCTGATTTTCATCTTACTGACAGCCGTCGCTCCTTCAATGACAATGCGCTGCATAGGAATATCAAATAGAGACTTTGTGGAAGGAGTTTCAGGAGGAAGCTGGGTTGACATAGTCTTAGAACATGGAAGCTGTGTGACGACGATGGCAAAAAACAAACCAACATTGGACTTTGAACTGATAAAAACAGAAGCCAAACAACCTGCCACTCTAAGGAAGTACTGTATAGAGGCTAAACTGACCAACACAACAACAGAATCTCGCTGCCCAACACAAGGGGAACCCAGCCTAAATGAAGAGCAGGACAAAAGGTTCGTCTGCAAACACTCCATGGTAGACAGAGGATGGGGAAATGGATGTGGATTATTTGGAAAAGGAGGCATTGTGACCTGTGCTATGTTCACATGCAAAAAGAACATGGAAGGAAAAGTTGTGCAGCCAGAAAACTTGGAATACACCATTGTGATAACACCTCACTCAGGGGAAGAACATGCAGTCGGAAATGACACAGGAAAACATGGCAAGGAAGTCAAGATAACACCACAGAGCTCCATCACAGAAGCAGAACTGACAGGCTATGGCACTGTCACGATGGAGTGCTCTCCGAGAACGGGCCTCGACTTCAATGAGATGGTGTTGCTGCAAATGGAAAACAAAGCTTGGCTGGTGCACAGACAATGGTTCCTAGACCTACCGTTACCATGGCTGCCCGGAGCAGACACACAAGGATCAAATTGGATACAGAAAGAGACATTGGTCACTTTCAAAAATCCCCATGCGAAAAAACAGGATGTTGTTGTCTTAGGATCCCAAGAGGGGGCCATGCACACAGCACTCACAGGGGCCACAGAAATCCAGATGTCATCAGGAAACTTACTGTTCACAGGACATCTCAAGTGCAGGCTGAGAATGGACAAACTACAGCTCAAAGGGATGTCATACTCTATGTGCACAGGAAAGTTTAAAGTTGTGAAGGAAATAGCAGAAACACAACATGGAACAATAGTCATCAGAGTACAATATGAAGGAGACGGCTCTCCATGCAAGATCCCTTTTGAGATAATGGATTTGGAAAAAAGACATGTCTTAGGTCGCCTGATCACAGTCAACCCAATTGTAACAGAAAAAGACAGCCCAGTCAACATAGAAGCAGAACCTCCATTCGGAGACAGCTACATCATCATAGGAGTGGAACCAGGACAATTGAAGCTCAACTGGTTTAAGAAAGGAAGTTCTATCGGCCAAATGTTTGAGACAACAATGAGAGGAGCGAAAAGAATGGCCATTTTGGGTGACACAGCCTGGGATTTTGGATCCCTGGGAGGAGTGTTCACATCTATAGGAAAGGCTCTCCACCAAGTTTTTGGAGCAATCTATGGGGCTGCCTTCAGTGGGGTCTCATGGACTATGAAGATCCTCATAGGAGTTATCATCACATGGATAGGAATGAATTCACGCAGCACCTCACTGTCTGTGTCACTAGTATTAGTGGGAATCGTGACACTATACTTGGGAGTTATGGTGCAGGCCGATAGTGGTTGCGTTGTGAGCTGGAAGAACAAAGAACTGAAATGTGGCAGTGGGATTTTCGTCACAGACAACGTGCACACATGGACAGAACAATACAAGTTCCAACCAGAATCCCCTTCAAAACTGGCTTCAGCCATCCAGAAAGCTCATGAAGAGGGCATTTGTGGAATCCGCTCAGTAACAAGACTGGAGAATCTGATGTGGAAACAGATAACACCAGAATTGAATCACATTCTATCAGAAAATGAAGTAAAGCTGACCATCATGACAGGAGACATTAAAGGAATCATGCAGGCAGGAAAACGATCTCTGCGGCCCCAACCCACTGAGCTGAGGTATTCATGGAAAACATGGGGCAAAGCGAAAATGCTCTCCACAGAGCTCCATAATCAGACCTTTCTCATTGATGGTCCCGAAACAGCAGAATGCCCCAACACAAACAGAGCTTGGAATTCACTGGAAGTTGAGGACTATGGCTTTGGAGTATTCACCACCAATATATGGCTAAAATTGAGAGAAAAGCAGGATGTATTTTGTGACTCAAAACTCATGTCAGCGGCCATAAAGGACAACAGAGCCGTCCATGCTGATATGGGTTATTGGATAGAAAGCGCACTCAATGACACATGGAAGATAGAGAAAGCCTCTTTCATTGAAGTTAAAAGCTGCCACTGGCCAAAGTCACACACCCTCTGGAGTAATGGAGTGCTAGAAAGTGAGATGATAATTCCAAAGAATTTCGCTGGACCAGTGTCACAACACAACTACAGACCAGGCTATTACACACAAACAGCAGGACCTTGGCATCTAGGCAAGCTTGAGATGGACTTTGATTTCTGCGAAGGAACTACAGTGGTGGTGACCGAGGACTGTGGAAACAGAGGACCCTCTTTAAGAACAACCACTGCCTCTGGAAAACTCATAACAGAATGGTGCTGCCGATCTTGCACATTACCACCGCTAAGATACAGAGGTGAGGATGGATGCTGGTACGGGATGGAAATCAGACCATTGAAAGAGAAAGAAGAGAATCTGGTCAACTCTTTGGTCACAGCCGGACATGGGCAGATTGACAACTTTTCACTAGGAATCTTGGGAATGGCATTGTTCCTGGAAGAAATGCTCAGGACCCGAGTAGGAACGAAACATGCAATACTACTAGTTGCAGTTTCTTTCGTGACATTGATCACAGGGAACATGTCCTTTAGAGACCTGGGAAGAGTGATGGTTATGGTGGGCGCTACCATGACGGATGACATAGGTATGGGCGTGACTTATCTTGCCCTACTAGCAGCTTTCAAAGTCAGACCAACCTTTGCAGCTGGACTGCTCTTGAGAAAACTGACCTCCAAGGAATTGATGATGACCACCATAGGAATCGTTCTCCTCTCCCAGAGTAGCATACCAGAGACCATTCTTGAACTGACTGATGCGTTAGCCTTGGGCATGATGGTCCTCAAAATAGTGAGAAACATGGAAAAATATCAGCTGGCAGTGACCATCATGGCTATCTTATGCGTCCCAAATGCTGTGATATTACAGAACGCATGGAAAGTGAGTTGCACAATATTGGCAGTGGTGTCTGTTTCCCCACTGCTCTTAACATCCTCACAACAGAAAGCGGATTGGATACCATTAGCATTGACGATCAAAGGTCTCAATCCAACAGCCATTTTTCTAACAACCCTTTCAAGAACCAGCAAGAAAAGGAGCTGGCCTCTAAATGAGGCTATCATGGCAGTTGGGATGGTGAGCATTTTAGCCAGTTCTCTCTTAAAGAATGACATTCCCATGACAGGACCATTAGTGGCTGGAGGGCTCCTCACTGTGTGCTACGTGCTCACTGGACGATCGGCCGATTTGGAACTGGAGAGAGCCGCCGATGTCAAATGGGAAGATCAGGCAGAGATATCAGGGAGCAGTCCAATTCTGTCAATAACAATATCAGAAGATGGTAGCATGTCAATAAAGAATGAAGAGGAAGAGCAAACACTGACCATACTCATTAGAACAGGATTGCTGGTGATCTCAGGACTTTTTCCGGTATCAATACCAATCACAGCAGCAGCATGGTACCTGTGGGAAGTGAAGAAACAACGGGCTGGAGTGTTGTGGGATGTCCCTTCACCCCCACCCGTGGGAAAGGCTGAACTGGAAGATGGAGCCTACAGAATCAAGCAAAAAGGGATTCTTGGATATTCCCAGATCGGAGCCGGAGTTTACAAAGAAGGAACATTCCACACAATGTGGCACGTCACACGTGGCGCTGTCCTAATGCATAAAGGGAAGAGGATTGAACCATCATGGGCGGACGTCAAGAAAGACCTAATATCATATGGAGGAGGCTGGAAGCTAGAAGGAGAATGGAAAGAAGGAGAAGAAGTCCAGGTCTTGGCATTGGAGCCTGGAAAAAATCCAAGAGCCGTCCAAACAAAACCTGGCCTTTTCAAAACCAACACCGGAACCATAGGTGCCGTATCTCTGGACTTTTCCCCTGGAACGTCAGGATCTCCAATCGTCGACAAAAAAGGAAAAGTTGTGGGTCTCTATGGCAATGGTGTCGTTACAAGGAGTGGAGCATATGTGAGTGCCATAGCCCAGACTGAAAAAAGCATTGAAGACAATCCAGAGATTGAAGATGACATCTTTCGAAAGAAAAGATTGACCATCATGGACCTCCACCCAGGAGCGGGAAAGACAAAGAGATACCTCCCAGCCATAGTCAGAGAAGCCATAAAAAGAGGCTTGAGAACACTAATCCTGGCCCCCACTAGAGTCGTGGCAGCTGAAATGGAGGAAGCCCTTAGAGGACTTCCAATAAGATACCAAACCCCAGCCATCAGGGCTGAGCACACCGGGCGGGAGATTGTGGACCTAATGTGTCATGCCACATTTACCATGAGGCTGCTATCACCAATTAGGGTGCCAAATTACAACCTGATCATCATGGACGAAGCCCATTTCACAGACCCAGCAAGCATAGCAGCTAGAGGATACATCTCAACTCGAGTAGAGATGGGTGAAGCAGCTGGAATTTTTATGACAGCCACTCCTCCGGGTAGCAGAGACCCATTTCCTCAGAGCAATGCACCAATCATGGACGAAGAAAGAGAAATTCCTGAACGTTCGTGGAATTCCGGACATGAGTGGGTCACGGATTTTAAAGGGAAGACTGTTTGGTTTGTTCCAAGCATAAAAGCCGGAAATGACATAGCAGCCTGCCTGAGAAAAAATGGAAAGAGAGTGATACAACTCAGTAGGAAGACCTTTGATTCTGAATATGTCAAGACTAGAACCAATGACTGGGACTTCGTGGTCACAACTGACATCTCGGAAATGGGTGCCAACTTCAAAGCTGAGAGGGTTATAGACCCCAGACGCTGCATGAAACCAGTTATACTGACAGATGGTGAAGAGCGGGTGATCCTGGCAGGACCCATGCCAGTGACCCACTCTAGTGCAGCACAAAGAAGAGGGAGAATAGGAAGGAATCCAAAAAATGAAAATGACCAATACATATACATGGGGGAACCTCTGGAAAATGATGAAGACTGTGCACACTGGAAGGAAGCTAAGATGCTCCTAGATAACATCAACACACCTGAAGGAATCATTCCTAGCATGTTCGAGCCAGAGCGTGAAAAGGTGGATGCCATTGACGGTGAATACCGCTTGAGAGGAGAAGCAAGGAAAACCTTTGTGGACCTAATGAGAAGAGGAGACCTACCAGTCTGGTTGGCTTACAAAGTGGCAGCTGAAGGCATCAACTACGCAGACAGAAGGTGGTGTTTTGATGGAATCAGAAACAATCAAATCTTGGAAGAAAATGTGGAAGTGGAAATCTGGACAAAAGAAGGGGAAAGGAAGAAATTAAAACCCAGATGGTTGGATGCTAGGATCTATTCTGACCCACTGGCGCTAAAAGAATTCAAGGAATTTGCAGCCGGAAGAAAGTCCCTAACCCTGAACCTAATCACAGAGATGGGTAGGCTCCCAACTTTCATGACTCAGAAGGCAAGAGATGCACTGGACAACTTAGCAGTGCTGCACACGGCTGAAGCAGGTGGAAGGGCATACAATCATGCTCTCAGTGAACTGCCGGAGACCCTGGAGACATTGCTTTTGCTGACACTTTTGGCCACAGTCACGGGAGGAATCTTTCTATTCTTGATGAGCGGAAGGGGTATAGGGAAGATGACCCTGGGAATGTGCTGCATAATCACGGCCAGCATCCTCCTATGGTACGCACAAATACAGCCACATTGGATAGCAGCTTCAATAATACTGGAGTTCTTTCTCATAGTCTTGCTCATTCCAGAACCAGAAAAGCAGAGAACACCCCAGGATAACCAATTGACCTATGTTGTCATAGCCATCCTCACAGTGGTGGCCGCAACCATGGCAAACGAGATGGGTTTCCTGGAAAAAACAAAGAAAGACCTCGGATTGGGAAGCATTGCAACCCAGCAACCCGAGAGCAACATCCTGGACATAGATCTACGTCCTGCATCAGCATGGACGCTGTATGCCGTGGCCACAACATTTATCACACCAATGTTGAGACATAGCATTGAAAATTCCTCAGTGAATGTGTCCCTAACAGCCATTGCCAACCAAGCCACAGTGCTAATGGGTCTTGGGAAAGGATGGCCATTGTCAAAGATGGACATCGGAGTTCCCCTTCTCGCCATTGGATGCTACTCACAAGTCAACCCCATAACCCTCACAGCAGCTCTTCTTTTATTGGTAGCACATTATGCCATCATAGGACCAGGACTCCAAGCAAAAGCAACCAGAGAAGCTCAGAAAAGAGCAGCAGCGGGCATCATGAAAAACCCAACTGTGGATGGAATAACAGTGATTGACCTAGATCCAATACCCTATGATCCAAAGTTTGAAAAGCAGTTGGGACAAGTAATGCTCCTAGTCCTCTGCGTGACTCAAGTGCTGATGATGAGGACTACGTGGGCTTTGTGTGAAGCCTTAACCCTAGCAACCGGGCCCATATCCACATTGTGGGAAGGAAATCCAGGGAGATTCTGGAACACAACCATTGCAGTGTCAATGGCTAACATTTTTAGAGGGAGTTACTTGGCCGGAGCTGGACTTCTCTTTTCCATCATGAAGAACACAACCAGCACAAGAAGAGGAACTGGCAACATAGGAGAGACGCTAGGAGAGAAATGGAAAAGCCGACTGAACGCATTGGGGAAAAGTGAATTCCAGATCTACAAGAAAAGTGGAATCCAGGAAGTGGACAGAACCTTAGCAAAAGAAGGCATTAAAAGAGGAGAAACGGACCATCACGCTGTGTCGCGAGGCTCAGCAAAACTGAGATGGTTCGTCGAAAGAAATATGGTCACACCAGAAGGGAAAGTAGTGGACCTTGGTTGTGGCAGAGGGGGCTGGTCATACTATTGTGGAGGACTAAAGAATGTAAGAGAAGTCAAAGGCCTAACAAAAGGAGGACCAGGACACGAAGAACCCATCCCCATGTCAACATATGGGTGGAATCTAGTGCGTCTTCAGAGTGGAGTTGACGTTTTCTTCACTCCACCAGAGAAGTGTGACACATTGTTGTGTGACATAGGGGAGTCGTCACCAAATCCCACGGTAGAAGCAGGACGAACACTCAGAGTCCTTAACCTAGTGGAAAATTGGCTGAACAACAACACCCAATTTTGCATAAAGGTTCTCAACCCATACATGCCCTCAGTCATAGAAAAAATGGAAGCACTACAAAGGAAATATGGAGGAGCCTTGGTGAGAAATCCACTCTCACGGAATTCCACACATGAGATGTACTGGGTGTCCAATGCTTCCGGGAACATAGTGTCATCAGTGAACATGATTTCAAGGATGTTGATTAACAGATTCACAATGAGACACAAGAAAGCCACTTACGAGCCAGATGTTGACCTCGGAAGCGGAACCCGCAACATTGGAATTGAAAGTGAGACACCAAACCTAGACATAATTGGAAAAAGAATAGAAAAAATAAAACAAGAGCATGAAACGTCATGGCACTATGACCAAGACCACCCATACAAAACATGGGCTTACCATGGCAGCTATGAAACAAAACAGACTGGATCAGCATCATCCATGGTGAACGGAGTGGTCAGACTGCTGACAAAACCCTGGGACGTCGTTCCCATGGTGACACAGATGGCAATGACAGACACAACTCCTTTTGGACAACAGCGCGTTTTCAAAGAGAAAGTGGACACGAGAACCCAAGAACCAAAAGAAGGCACAAAAAAACTAATGAAAATCACGGCAGAGTGGCTTTGGAAAGAACTAGGAAAGAAAAAGACACCTAGGATGTGCACCAGAGAAGAATTCACAAAAAAGGTGAGAAGCAATGCAGCCTTGGGGGCCATATTCACTGATGAGAACAAGTGGAAGTCGGCACGTGAGGCTGTTGAAGATGGTAGGTTTTGGGAGCTGGTTGACAAGGAAAGGAATCTCCATCTTGAAGGAAAGTGTGAAACATGTGTGTACAACATGATGGGAAAAAGAGAGAAGAAACTAGGAGAGTTTGGCAAAGCAAAAGGCAGCAGAGCCATATGGTACATGTGGCTTGGAGCACGCTTCTTAGAGTTTGAAGCCCTAGGATTCTTGAATGAAGACCATTGGTTCTCCAGAGAGAACTCCCTGAGTGGAGTGGAAGGAGAAGGGCTGCACAAGCTAGGTTACATCTTAAGAGACGTGAGCAAGAAAGAAGGAGGAGCAATGTATGCCGATGACACCGCAGGCTGGGACACAAGAATCACACTAGAGGACTTAAAAAATGAAGAAATGATAACAAACCACATGGAAGGAGAACACAAGAAACTTGCCGAGGCCATTTTCAAATTAACGTACCAAAACAAGGTGGTGCGTGTGCAAAGACCAACACCAAGAGGCACAGTAATGGATATCATATCGAGAAGAGACCAAAGAGGTAGTGGACAAGTTGGCACCTATGGCCTCAATACTTTCACCAATATGGAAGCACAACTAATCAGGCAGATGGAGGGGGAAGGAATCTTCAAAAGCATCCAGCACTTGACAGCCACAGAAGAAATCGCTGTGCAAGATTGGCTAGCAAGAGTGGGGCGTGAAAGGTTATCAAGAATGGCCATCAGTGGAGATGATTGTGTTGTGAAACCTCTAGATGACAGGTTTGCAAGAGCTTTAACAGCTCTAAATGACATGGGAAAGGTTAGGAAAGACATACAACAATGGGAACCCTCAAGAGGATGGAACGATTGGACACAAGTGCCCTTCTGTTCACACCATTTCCATGAGTTAATCATGAAAGATGGTCGCACACTCGTAGTTCCATGTAGAAACCAAGATGAACTGATTGGTAGAGCCCGAATTTCCCAGGGAGCTGGGTGGTCTTTGCGGGAGACGGCCTGTTTGGGGAAGTCTTACGCCCAAATGTGGAGCTTGATGTACTTCCACAGACGTGATCTCAGGCTGGCGGCAAATGCCATTTGCTCGGCAGTCCCATCACATTGGGTTCCAACAAGCCGGACAACCTGGTCCATACACGCCAGCCATGAATGGATGACGACGGAAGACATGTTGACAGTCTGGAACAGGGTGTGGATCCAAGAAAACCCATGGATGGAAGACAAAACTCCAGTGGAATCATGGGAGGAAATCCCATACCTGGGAAAAAGAGAAGACCAATGGTGCGGCTCACTGATTGGGCTAACAAGCAGGGCCACCTGGGCAAAGAACATCCAAACAGCAATAAATCAAGTCAGATCCCTCATTGGCAATGAGGAATACACAGATTACATGCCATCCATGAAAAGATTCAGAAGAGAAGAGGAAGAGGCAGGAGTCCTGTGGTAGAAGACAGAACTAACATGAAACAAGGCTAGAAGTCAGGTCGGATTAAGCCATAGTACGGAAAAAACTATGCTACCTGTGAGCCCCGTCCAAGGACGTTAAAAGAAGTCAGGCCATCACAAATGCCATAGCTTGAGCAAACTGTGCAGCCTGTAGCTCCACCTGAGAAGGTGTAAAAAATCCGGGAGGCCACAAACCATGGAAGCTGTACGCATGGCGTAGTGGACTAGCGGTTAGAGGAGACCCCTCCCTTACAAATCGCAGCAACAATGGGGGCCCAAGGTGAGATGAAGCTGTAGTCTCACTGGAAGGACTAGAGGTTAGAGGAGACCCCCCCAAAACAAAAAACAGCATATTGACGCTGGGAAAGACCAGAGATCCTGCTGTCTCCTCAGCATCATTCCAGGCACAGAACGCCAGAAAATGGAATGGTGCTGTTGAATCAACAGGTTCT", "2K": "TPQDNQLTYVVIAILTVVAATMA", "C": "MNNQRKKARNTPFNMLKRERNRVSTVQQLTKRFSLGMLQGRGPLKLFMALVAFLRFLTIPPTAGILKRWGTIKKSKAINVLRGFRKEIGRMLNILNRRRRTAGMIIMLIPTVMA", "E": "MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCKKNMEGKVVQPENLEYTIVITPHSGEEHAVGNDTGKHGKEVKITPQSSITEAELTGYGTVTMECSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSNWIQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMRGAKRMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA", "M": "FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGMNMCTLMAMDLGELCEDTITYKCPFLRQNEPEDIDCWCNSTSTWVTYGTCTTTGEHRREKRSVALVPHVGMGLETRTETWMSSEGAWKHAQRIETWILRHPGFTIMAAILAYTIGTTHFQRVLIFILLTAVAPSMT", "NS1": "DSGCVVSWKNKELKCGSGIFVTDNVHTWTEQYKFQPESPSKLASAIQKAHEEGICGIRSVTRLENLMWKQITPELNHILSENEVKLTIMTGDIKGIMQAGKRSLRPQPTELRYSWKTWGKAKMLSTELHNQTFLIDGPETAECPNTNRAWNSLEVEDYGFGVFTTNIWLKLREKQDVFCDSKLMSAAIKDNRAVHADMGYWIESALNDTWKIEKASFIEVKSCHWPKSHTLWSNGVLESEMIIPKNFAGPVSQHNYRPGYYTQTAGPWHLGKLEMDFDFCEGTTVVVTEDCGNRGPSLRTTTASGKLITEWCCRSCTLPPLRYRGEDGCWYGMEIRPLKEKEENLVNSLVTA", "NS2A": "GHGQIDNFSLGILGMALFLEEMLRTRVGTKHAILLVAVSFVTLITGNMSFRDLGRVMVMVGATMTDDIGMGVTYLALLAAFKVRPTFAAGLLLRKLTSKELMMTTIGIVLLSQSSIPETILELTDALALGMMVLKIVRNMEKYQLAVTIMAILCVPNAVILQNAWKVSCTILAVVSVSPLLLTSSQQKADWIPLALTIKGLNPTAIFLTTLSRTSKKR", "NS2B": "SWPLNEAIMAVGMVSILASSLLKNDIPMTGPLVAGGLLTVCYVLTGRSADLELERAADVKWEDQAEISGSSPILSITISEDGSMSIKNEEEEQTLTILIRTGLLVISGLFPVSIPITAAAWYLWEVKKQR", "NS3": "AGVLWDVPSPPPVGKAELEDGAYRIKQKGILGYSQIGAGVYKEGTFHTMWHVTRGAVLMHKGKRIEPSWADVKKDLISYGGGWKLEGEWKEGEEVQVLALEPGKNPRAVQTKPGLFKTNTGTIGAVSLDFSPGTSGSPIVDKKGKVVGLYGNGVVTRSGAYVSAIAQTEKSIEDNPEIEDDIFRKKRLTIMDLHPGAGKTKRYLPAIVREAIKRGLRTLILAPTRVVAAEMEEALRGLPIRYQTPAIRAEHTGREIVDLMCHATFTMRLLSPIRVPNYNLIIMDEAHFTDPASIAARGYISTRVEMGEAAGIFMTATPPGSRDPFPQSNAPIMDEEREIPERSWNSGHEWVTDFKGKTVWFVPSIKAGNDIAACLRKNGKRVIQLSRKTFDSEYVKTRTNDWDFVVTTDISEMGANFKAERVIDPRRCMKPVILTDGEERVILAGPMPVTHSSAAQRRGRIGRNPKNENDQYIYMGEPLENDEDCAHWKEAKMLLDNINTPEGIIPSMFEPEREKVDAIDGEYRLRGEARKTFVDLMRRGDLPVWLAYKVAAEGINYADRRWCFDGIRNNQILEENVEVEIWTKEGERKKLKPRWLDARIYSDPLALKEFKEFAAGRK", "NS4A": "SLTLNLITEMGRLPTFMTQKARDALDNLAVLHTAEAGGRAYNHALSELPETLETLLLLTLLATVTGGIFLFLMSGRGIGKMTLGMCCIITASILLWYAQIQPHWIAASIILEFFLIVLLIPEPEKQR", "NS4B": "NEMGFLEKTKKDLGLGSIATQQPESNILDIDLRPASAWTLYAVATTFITPMLRHSIENSSVNVSLTAIANQATVLMGLGKGWPLSKMDIGVPLLAIGCYSQVNPITLTAALLLLVAHYAIIGPGLQAKATREAQKRAAAGIMKNPTVDGITVIDLDPIPYDPKFEKQLGQVMLLVLCVTQVLMMRTTWALCEALTLATGPISTLWEGNPGRFWNTTIAVSMANIFRGSYLAGAGLLFSIMKNTTSTRR", "NS5": "GTGNIGETLGEKWKSRLNALGKSEFQIYKKSGIQEVDRTLAKEGIKRGETDHHAVSRGSAKLRWFVERNMVTPEGKVVDLGCGRGGWSYYCGGLKNVREVKGLTKGGPGHEEPIPMSTYGWNLVRLQSGVDVFFTPPEKCDTLLCDIGESSPNPTVEAGRTLRVLNLVENWLNNNTQFCIKVLNPYMPSVIEKMEALQRKYGGALVRNPLSRNSTHEMYWVSNASGNIVSSVNMISRMLINRFTMRHKKATYEPDVDLGSGTRNIGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTKKVRSNAALGAIFTDENKWKSAREAVEDGRFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMITNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVGTYGLNTFTNMEAQLIRQMEGEGIFKSIQHLTATEEIAVQDWLARVGRERLSRMAISGDDCVVKPLDDRFARALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRTLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHASHEWMTTEDMLTVWNRVWIQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW", "pr": "FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGMNMCTLMAMDLGELCEDTITYKCPFLRQNEPEDIDCWCNSTSTWVTYGTCTTTGEHRREKR"}} \ No newline at end of file