diff --git a/src/js/models/panel_model.js b/src/js/models/panel_model.js
index 75c3b92f3..847a29cf0 100644
--- a/src/js/models/panel_model.js
+++ b/src/js/models/panel_model.js
@@ -457,7 +457,7 @@
         // labels_map is {labelKey: {size:s, text:t, position:p, color:c}} or {labelKey: false} to delete
         // where labelKey specifies the label to edit. "l.text + '_' + l.size + '_' + l.color + '_' + l.position"
         edit_labels: function(labels_map) {
-            
+
             var oldLabs = this.get('labels');
             // Need to clone the list of labels...
             var labs = [],
@@ -483,7 +483,7 @@
             // Extract all the keys (even duplicates)
             var keys = labs.map(lbl => this.get_label_key(lbl));
 
-            // get all unique labels based on filtering keys 
+            // get all unique labels based on filtering keys
             //(i.e removing duplicate keys based on the index of the first occurrence of the value)
             var filtered_lbls = labs.filter((lbl, index) => index == keys.indexOf(this.get_label_key(lbl)));
 
@@ -515,12 +515,19 @@
             this.save('channels', chs);
         },
 
-        toggle_channel: function(cIndex, active ) {
-
+        toggle_channel: function(cIndex, active) {
             if (typeof active == "undefined") {
                 active = !this.get('channels')[cIndex].active;
             }
-            this.save_channel(cIndex, 'active', active);
+
+            if (this.get("hilo_enabled") && active) {
+                let newChs = this.get('channels').map(function(channel, idx) {
+                    return {'active': idx == cIndex};
+                });
+                this.save_channels(newChs);
+            } else {
+                this.save_channel(cIndex, 'active', active);
+            }
         },
 
         save_channel_window: function(cIndex, new_w) {
diff --git a/src/js/views/channel_slider_view.js b/src/js/views/channel_slider_view.js
index 057ba8c48..0d2c36685 100644
--- a/src/js/views/channel_slider_view.js
+++ b/src/js/views/channel_slider_view.js
@@ -281,8 +281,16 @@ var ChannelSliderView = Backbone.View.extend({
                         return channel.color;
                     })
                 });
+                let foundActive = false;
                 let newChs = m.get('channels').map(function(channel, idx) {
-                    return {'color': 'hilo.lut'};
+                    // Switch LUT to HiLo for all channels
+                    // Keep only the first active channel active
+                    let new_state = {
+                        'color': 'hilo.lut',
+                        'active': (!foundActive && channel.active)
+                    }
+                    foundActive = (foundActive || channel.active);
+                    return new_state;
                 });
                 m.save_channels(newChs);
             } else if (!checkboxState && m.get("hilo_enabled")){