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Copy pathRMD_shal.channel.nml
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RMD_shal.channel.nml
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<neuroml xmlns="http://www.neuroml.org/schema/neuroml2" xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.neuroml.org/schema/neuroml2 https://raw.github.com/NeuroML/NeuroML2/development/Schemas/NeuroML2/NeuroML_v2.3.1.xsd" id="RMD_shal">
<notes>An ion channel from cell RMD from Nicoletti et al. 2019</notes>
<ionChannelHH id="RMD_shal" species="k" conductance="10pS">
<notes>RMD_shal channel from Nicoletti et al. 2019</notes>
<gate id="m" instances="3" type="gateHHtauInf">
<timeCourse type="shal_m_tau"/>
<steadyState type="shal_m_inf"/>
</gate>
<gate id="h" instances="1" type="gateFractional">
<subGate id="hf" fractionalConductance="0.7">
<steadyState type="shal_h_hf_inf"/>
<timeCourse type="shal_h_hf_tau"/>
</subGate>
<subGate id="hs" fractionalConductance="0.3">
<steadyState type="shal_h_hs_inf"/>
<timeCourse type="shal_h_hs_tau"/>
</subGate>
</gate>
</ionChannelHH>
<ComponentType name="shal_m_inf" extends="baseVoltageDepVariable">
<Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
<Constant name="shalsfhit" dimension="none" value="18.0"/>
<Constant name="vashal" dimension="none" value="11.2"/>
<Constant name="kashal" dimension="none" value="14.1"/>
<Dynamics>
<DerivedVariable name="V" dimension="none" value="(v) / VOLT_SCALE"/>
<DerivedVariable name="x" dimension="none" exposure="x" value="1/(exp((-V - shalsfhit + vashal)/kashal) + 1)"/>
</Dynamics>
</ComponentType>
<ComponentType name="shal_m_tau" extends="baseVoltageDepTime">
<Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
<Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
<Constant name="ptmshal1" dimension="none" value="13.8"/>
<Constant name="ptmshal2" dimension="none" value="-17.5165"/>
<Constant name="ptmshal3" dimension="none" value="12.9213"/>
<Constant name="ptmshal4" dimension="none" value="-3.7082"/>
<Constant name="ptmshal5" dimension="none" value="6.4876"/>
<Constant name="ptmshal6" dimension="none" value="1.8849"/>
<Constant name="cashal" dimension="none" value="0.1"/>
<Dynamics>
<DerivedVariable name="V" dimension="none" value="(v) / VOLT_SCALE"/>
<DerivedVariable name="t" dimension="time" exposure="t" value="(cashal*(ptmshal1/(exp((-V + ptmshal2)/ptmshal3) + exp((V - ptmshal4)/ptmshal5)) + ptmshal6))* TIME_SCALE"/>
</Dynamics>
</ComponentType>
<ComponentType name="shal_h_hf_inf" extends="baseVoltageDepVariable">
<Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
<Constant name="shalsfhit" dimension="none" value="18.0"/>
<Constant name="kishal" dimension="none" value="8.3"/>
<Constant name="vishal" dimension="none" value="-33.1"/>
<Dynamics>
<DerivedVariable name="V" dimension="none" value="(v) / VOLT_SCALE"/>
<DerivedVariable name="x" dimension="none" exposure="x" value="1/(exp((V + shalsfhit - vishal)/kishal) + 1)"/>
</Dynamics>
</ComponentType>
<ComponentType name="shal_h_hf_tau" extends="baseVoltageDepTime">
<Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
<Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
<Constant name="pthfshal1" dimension="none" value="539.1584"/>
<Constant name="pthfshal2" dimension="none" value="-28.199"/>
<Constant name="pthfshal3" dimension="none" value="4.9199"/>
<Constant name="pthfshal4" dimension="none" value="27.2811"/>
<Constant name="cshal" dimension="none" value="0.1"/>
<Dynamics>
<DerivedVariable name="V" dimension="none" value="(v) / VOLT_SCALE"/>
<DerivedVariable name="t" dimension="time" exposure="t" value="(cshal*(pthfshal1/(exp((V - pthfshal2)/pthfshal3) + 1) + pthfshal4))* TIME_SCALE"/>
</Dynamics>
</ComponentType>
<ComponentType name="shal_h_hs_inf" extends="baseVoltageDepVariable">
<Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
<Constant name="shalsfhit" dimension="none" value="18.0"/>
<Constant name="kishal" dimension="none" value="8.3"/>
<Constant name="vishal" dimension="none" value="-33.1"/>
<Dynamics>
<DerivedVariable name="V" dimension="none" value="(v) / VOLT_SCALE"/>
<DerivedVariable name="x" dimension="none" exposure="x" value="1/(exp((V + shalsfhit - vishal)/kishal) + 1)"/>
</Dynamics>
</ComponentType>
<ComponentType name="shal_h_hs_tau" extends="baseVoltageDepTime">
<Constant name="VOLT_SCALE" dimension="voltage" value="1 mV"/>
<Constant name="TIME_SCALE" dimension="time" value="1 ms"/>
<Constant name="pthsshal1" dimension="none" value="8422.0"/>
<Constant name="pthsshal2" dimension="none" value="-37.7391"/>
<Constant name="pthsshal3" dimension="none" value="6.3785"/>
<Constant name="pthsshal4" dimension="none" value="118.8983"/>
<Constant name="cshal" dimension="none" value="0.1"/>
<Dynamics>
<DerivedVariable name="V" dimension="none" value="(v) / VOLT_SCALE"/>
<DerivedVariable name="t" dimension="time" exposure="t" value="(cshal*(pthsshal1/(exp((V - pthsshal2)/pthsshal3) + 1) + pthsshal4))* TIME_SCALE"/>
</Dynamics>
</ComponentType>
</neuroml>