diff --git a/appimage/AppRun b/appimage/AppRun
index d554c30..71f4006 100755
--- a/appimage/AppRun
+++ b/appimage/AppRun
@@ -6,6 +6,9 @@ export LD_LIBRARY_PATH="${APPDIR}/usr/lib:${APPDIR}/usr/conda/lib:${LD_LIBRARY_P
 # Prevent Qt to load plugins from system directories
 unset QT_PLUGIN_PATH
 
+# Prevent OpsenSSL 3.0 startup error
+export CRYPTOGRAPHY_OPENSSL_NO_LEGACY=1
+
 # Set the original working dir as the working dir.
 # Ensures relative path arguments are resolved as expected.
 cd $OWD