diff --git a/Include/internal/pycore_opcode_metadata.h b/Include/internal/pycore_opcode_metadata.h
index 3a32967e721903..521f7a92cf08c4 100644
--- a/Include/internal/pycore_opcode_metadata.h
+++ b/Include/internal/pycore_opcode_metadata.h
@@ -1069,7 +1069,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[266] = {
     [BINARY_OP_INPLACE_ADD_UNICODE] = { true, INSTR_FMT_IXC0000, HAS_LOCAL_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_MULTIPLY_FLOAT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG },
     [BINARY_OP_MULTIPLY_INT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [BINARY_OP_SUBSCR_DICT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
+    [BINARY_OP_SUBSCR_DICT] = { true, INSTR_FMT_IXC0000, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_SUBSCR_GETITEM] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG },
     [BINARY_OP_SUBSCR_LIST_INT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [BINARY_OP_SUBSCR_STR_INT] = { true, INSTR_FMT_IXC0000, HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
@@ -1120,7 +1120,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[266] = {
     [COMPARE_OP_INT] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
     [COMPARE_OP_STR] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_EXIT_FLAG },
     [CONTAINS_OP] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [CONTAINS_OP_DICT] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
+    [CONTAINS_OP_DICT] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [CONTAINS_OP_SET] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [CONVERT_VALUE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [COPY] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_PURE_FLAG },
@@ -1265,7 +1265,7 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[266] = {
     [STORE_NAME] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [STORE_SLICE] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [STORE_SUBSCR] = { true, INSTR_FMT_IXC, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [STORE_SUBSCR_DICT] = { true, INSTR_FMT_IXC, HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
+    [STORE_SUBSCR_DICT] = { true, INSTR_FMT_IXC, HAS_EXIT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [STORE_SUBSCR_LIST_INT] = { true, INSTR_FMT_IXC, HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [SWAP] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_PURE_FLAG },
     [TO_BOOL] = { true, INSTR_FMT_IXC00, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
@@ -1280,9 +1280,9 @@ const struct opcode_metadata _PyOpcode_opcode_metadata[266] = {
     [UNARY_NOT] = { true, INSTR_FMT_IX, HAS_PURE_FLAG },
     [UNPACK_EX] = { true, INSTR_FMT_IB, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [UNPACK_SEQUENCE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
-    [UNPACK_SEQUENCE_LIST] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG },
-    [UNPACK_SEQUENCE_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG },
-    [UNPACK_SEQUENCE_TWO_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG },
+    [UNPACK_SEQUENCE_LIST] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
+    [UNPACK_SEQUENCE_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG },
+    [UNPACK_SEQUENCE_TWO_TUPLE] = { true, INSTR_FMT_IBC, HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_EXIT_FLAG | HAS_ESCAPES_FLAG },
     [WITH_EXCEPT_START] = { true, INSTR_FMT_IX, HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
     [YIELD_VALUE] = { true, INSTR_FMT_IB, HAS_ARG_FLAG },
     [JUMP] = { true, -1, HAS_ARG_FLAG | HAS_JUMP_FLAG | HAS_EVAL_BREAK_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG },
@@ -1316,11 +1316,11 @@ _PyOpcode_macro_expansion[256] = {
     [BINARY_OP_INPLACE_ADD_UNICODE] = { .nuops = 3, .uops = { { _GUARD_TOS_UNICODE, OPARG_SIMPLE, 0 }, { _GUARD_NOS_UNICODE, OPARG_SIMPLE, 0 }, { _BINARY_OP_INPLACE_ADD_UNICODE, OPARG_SIMPLE, 5 } } },
     [BINARY_OP_MULTIPLY_FLOAT] = { .nuops = 3, .uops = { { _GUARD_TOS_FLOAT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_FLOAT, OPARG_SIMPLE, 0 }, { _BINARY_OP_MULTIPLY_FLOAT, OPARG_SIMPLE, 5 } } },
     [BINARY_OP_MULTIPLY_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_INT, OPARG_SIMPLE, 0 }, { _BINARY_OP_MULTIPLY_INT, OPARG_SIMPLE, 5 } } },
-    [BINARY_OP_SUBSCR_DICT] = { .nuops = 1, .uops = { { _BINARY_OP_SUBSCR_DICT, OPARG_SIMPLE, 5 } } },
+    [BINARY_OP_SUBSCR_DICT] = { .nuops = 2, .uops = { { _GUARD_NOS_DICT, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBSCR_DICT, OPARG_SIMPLE, 5 } } },
     [BINARY_OP_SUBSCR_GETITEM] = { .nuops = 4, .uops = { { _CHECK_PEP_523, OPARG_SIMPLE, 5 }, { _BINARY_OP_SUBSCR_CHECK_FUNC, OPARG_SIMPLE, 5 }, { _BINARY_OP_SUBSCR_INIT_CALL, OPARG_SIMPLE, 5 }, { _PUSH_FRAME, OPARG_SIMPLE, 5 } } },
-    [BINARY_OP_SUBSCR_LIST_INT] = { .nuops = 2, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBSCR_LIST_INT, OPARG_SIMPLE, 5 } } },
+    [BINARY_OP_SUBSCR_LIST_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_LIST, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBSCR_LIST_INT, OPARG_SIMPLE, 5 } } },
     [BINARY_OP_SUBSCR_STR_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_UNICODE, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBSCR_STR_INT, OPARG_SIMPLE, 5 } } },
-    [BINARY_OP_SUBSCR_TUPLE_INT] = { .nuops = 2, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBSCR_TUPLE_INT, OPARG_SIMPLE, 5 } } },
+    [BINARY_OP_SUBSCR_TUPLE_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_TUPLE, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBSCR_TUPLE_INT, OPARG_SIMPLE, 5 } } },
     [BINARY_OP_SUBTRACT_FLOAT] = { .nuops = 3, .uops = { { _GUARD_TOS_FLOAT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_FLOAT, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBTRACT_FLOAT, OPARG_SIMPLE, 5 } } },
     [BINARY_OP_SUBTRACT_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_INT, OPARG_SIMPLE, 0 }, { _BINARY_OP_SUBTRACT_INT, OPARG_SIMPLE, 5 } } },
     [BINARY_SLICE] = { .nuops = 1, .uops = { { _BINARY_SLICE, OPARG_SIMPLE, 0 } } },
@@ -1362,8 +1362,8 @@ _PyOpcode_macro_expansion[256] = {
     [COMPARE_OP_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_INT, OPARG_SIMPLE, 0 }, { _COMPARE_OP_INT, OPARG_SIMPLE, 1 } } },
     [COMPARE_OP_STR] = { .nuops = 3, .uops = { { _GUARD_TOS_UNICODE, OPARG_SIMPLE, 0 }, { _GUARD_NOS_UNICODE, OPARG_SIMPLE, 0 }, { _COMPARE_OP_STR, OPARG_SIMPLE, 1 } } },
     [CONTAINS_OP] = { .nuops = 1, .uops = { { _CONTAINS_OP, OPARG_SIMPLE, 0 } } },
-    [CONTAINS_OP_DICT] = { .nuops = 1, .uops = { { _CONTAINS_OP_DICT, OPARG_SIMPLE, 1 } } },
-    [CONTAINS_OP_SET] = { .nuops = 1, .uops = { { _CONTAINS_OP_SET, OPARG_SIMPLE, 1 } } },
+    [CONTAINS_OP_DICT] = { .nuops = 2, .uops = { { _GUARD_TOS_DICT, OPARG_SIMPLE, 0 }, { _CONTAINS_OP_DICT, OPARG_SIMPLE, 1 } } },
+    [CONTAINS_OP_SET] = { .nuops = 2, .uops = { { _GUARD_TOS_ANY_SET, OPARG_SIMPLE, 0 }, { _CONTAINS_OP_SET, OPARG_SIMPLE, 1 } } },
     [CONVERT_VALUE] = { .nuops = 1, .uops = { { _CONVERT_VALUE, OPARG_SIMPLE, 0 } } },
     [COPY] = { .nuops = 1, .uops = { { _COPY, OPARG_SIMPLE, 0 } } },
     [COPY_FREE_VARS] = { .nuops = 1, .uops = { { _COPY_FREE_VARS, OPARG_SIMPLE, 0 } } },
@@ -1468,14 +1468,14 @@ _PyOpcode_macro_expansion[256] = {
     [STORE_NAME] = { .nuops = 1, .uops = { { _STORE_NAME, OPARG_SIMPLE, 0 } } },
     [STORE_SLICE] = { .nuops = 1, .uops = { { _STORE_SLICE, OPARG_SIMPLE, 0 } } },
     [STORE_SUBSCR] = { .nuops = 1, .uops = { { _STORE_SUBSCR, OPARG_SIMPLE, 0 } } },
-    [STORE_SUBSCR_DICT] = { .nuops = 1, .uops = { { _STORE_SUBSCR_DICT, OPARG_SIMPLE, 1 } } },
-    [STORE_SUBSCR_LIST_INT] = { .nuops = 2, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _STORE_SUBSCR_LIST_INT, OPARG_SIMPLE, 1 } } },
+    [STORE_SUBSCR_DICT] = { .nuops = 2, .uops = { { _GUARD_NOS_DICT, OPARG_SIMPLE, 0 }, { _STORE_SUBSCR_DICT, OPARG_SIMPLE, 1 } } },
+    [STORE_SUBSCR_LIST_INT] = { .nuops = 3, .uops = { { _GUARD_TOS_INT, OPARG_SIMPLE, 0 }, { _GUARD_NOS_LIST, OPARG_SIMPLE, 0 }, { _STORE_SUBSCR_LIST_INT, OPARG_SIMPLE, 1 } } },
     [SWAP] = { .nuops = 1, .uops = { { _SWAP, OPARG_SIMPLE, 0 } } },
     [TO_BOOL] = { .nuops = 1, .uops = { { _TO_BOOL, OPARG_SIMPLE, 2 } } },
     [TO_BOOL_ALWAYS_TRUE] = { .nuops = 2, .uops = { { _GUARD_TYPE_VERSION, 2, 1 }, { _REPLACE_WITH_TRUE, OPARG_SIMPLE, 3 } } },
     [TO_BOOL_BOOL] = { .nuops = 1, .uops = { { _TO_BOOL_BOOL, OPARG_SIMPLE, 3 } } },
     [TO_BOOL_INT] = { .nuops = 1, .uops = { { _TO_BOOL_INT, OPARG_SIMPLE, 3 } } },
-    [TO_BOOL_LIST] = { .nuops = 1, .uops = { { _TO_BOOL_LIST, OPARG_SIMPLE, 3 } } },
+    [TO_BOOL_LIST] = { .nuops = 2, .uops = { { _GUARD_TOS_LIST, OPARG_SIMPLE, 0 }, { _TO_BOOL_LIST, OPARG_SIMPLE, 3 } } },
     [TO_BOOL_NONE] = { .nuops = 1, .uops = { { _TO_BOOL_NONE, OPARG_SIMPLE, 3 } } },
     [TO_BOOL_STR] = { .nuops = 2, .uops = { { _GUARD_TOS_UNICODE, OPARG_SIMPLE, 0 }, { _TO_BOOL_STR, OPARG_SIMPLE, 3 } } },
     [UNARY_INVERT] = { .nuops = 1, .uops = { { _UNARY_INVERT, OPARG_SIMPLE, 0 } } },
@@ -1483,9 +1483,9 @@ _PyOpcode_macro_expansion[256] = {
     [UNARY_NOT] = { .nuops = 1, .uops = { { _UNARY_NOT, OPARG_SIMPLE, 0 } } },
     [UNPACK_EX] = { .nuops = 1, .uops = { { _UNPACK_EX, OPARG_SIMPLE, 0 } } },
     [UNPACK_SEQUENCE] = { .nuops = 1, .uops = { { _UNPACK_SEQUENCE, OPARG_SIMPLE, 0 } } },
-    [UNPACK_SEQUENCE_LIST] = { .nuops = 1, .uops = { { _UNPACK_SEQUENCE_LIST, OPARG_SIMPLE, 1 } } },
-    [UNPACK_SEQUENCE_TUPLE] = { .nuops = 1, .uops = { { _UNPACK_SEQUENCE_TUPLE, OPARG_SIMPLE, 1 } } },
-    [UNPACK_SEQUENCE_TWO_TUPLE] = { .nuops = 1, .uops = { { _UNPACK_SEQUENCE_TWO_TUPLE, OPARG_SIMPLE, 1 } } },
+    [UNPACK_SEQUENCE_LIST] = { .nuops = 2, .uops = { { _GUARD_TOS_LIST, OPARG_SIMPLE, 0 }, { _UNPACK_SEQUENCE_LIST, OPARG_SIMPLE, 1 } } },
+    [UNPACK_SEQUENCE_TUPLE] = { .nuops = 2, .uops = { { _GUARD_TOS_TUPLE, OPARG_SIMPLE, 0 }, { _UNPACK_SEQUENCE_TUPLE, OPARG_SIMPLE, 1 } } },
+    [UNPACK_SEQUENCE_TWO_TUPLE] = { .nuops = 2, .uops = { { _GUARD_TOS_TUPLE, OPARG_SIMPLE, 0 }, { _UNPACK_SEQUENCE_TWO_TUPLE, OPARG_SIMPLE, 1 } } },
     [WITH_EXCEPT_START] = { .nuops = 1, .uops = { { _WITH_EXCEPT_START, OPARG_SIMPLE, 0 } } },
     [YIELD_VALUE] = { .nuops = 1, .uops = { { _YIELD_VALUE, OPARG_SIMPLE, 0 } } },
 };
diff --git a/Include/internal/pycore_uop_ids.h b/Include/internal/pycore_uop_ids.h
index 2b79fffc14bc33..e9a536919da598 100644
--- a/Include/internal/pycore_uop_ids.h
+++ b/Include/internal/pycore_uop_ids.h
@@ -20,130 +20,137 @@ extern "C" {
 #define _BINARY_OP_MULTIPLY_FLOAT 308
 #define _BINARY_OP_MULTIPLY_INT 309
 #define _BINARY_OP_SUBSCR_CHECK_FUNC 310
-#define _BINARY_OP_SUBSCR_DICT BINARY_OP_SUBSCR_DICT
-#define _BINARY_OP_SUBSCR_INIT_CALL 311
-#define _BINARY_OP_SUBSCR_LIST_INT 312
-#define _BINARY_OP_SUBSCR_STR_INT 313
-#define _BINARY_OP_SUBSCR_TUPLE_INT 314
-#define _BINARY_OP_SUBTRACT_FLOAT 315
-#define _BINARY_OP_SUBTRACT_INT 316
-#define _BINARY_SLICE 317
+#define _BINARY_OP_SUBSCR_DICT 311
+#define _BINARY_OP_SUBSCR_INIT_CALL 312
+#define _BINARY_OP_SUBSCR_LIST_INT 313
+#define _BINARY_OP_SUBSCR_STR_INT 314
+#define _BINARY_OP_SUBSCR_TUPLE_INT 315
+#define _BINARY_OP_SUBTRACT_FLOAT 316
+#define _BINARY_OP_SUBTRACT_INT 317
+#define _BINARY_SLICE 318
 #define _BUILD_LIST BUILD_LIST
 #define _BUILD_MAP BUILD_MAP
 #define _BUILD_SET BUILD_SET
 #define _BUILD_SLICE BUILD_SLICE
 #define _BUILD_STRING BUILD_STRING
 #define _BUILD_TUPLE BUILD_TUPLE
-#define _CALL_BUILTIN_CLASS 318
-#define _CALL_BUILTIN_FAST 319
-#define _CALL_BUILTIN_FAST_WITH_KEYWORDS 320
-#define _CALL_BUILTIN_O 321
+#define _CALL_BUILTIN_CLASS 319
+#define _CALL_BUILTIN_FAST 320
+#define _CALL_BUILTIN_FAST_WITH_KEYWORDS 321
+#define _CALL_BUILTIN_O 322
 #define _CALL_INTRINSIC_1 CALL_INTRINSIC_1
 #define _CALL_INTRINSIC_2 CALL_INTRINSIC_2
 #define _CALL_ISINSTANCE CALL_ISINSTANCE
-#define _CALL_KW_NON_PY 322
+#define _CALL_KW_NON_PY 323
 #define _CALL_LEN CALL_LEN
 #define _CALL_LIST_APPEND CALL_LIST_APPEND
-#define _CALL_METHOD_DESCRIPTOR_FAST 323
-#define _CALL_METHOD_DESCRIPTOR_FAST_WITH_KEYWORDS 324
-#define _CALL_METHOD_DESCRIPTOR_NOARGS 325
-#define _CALL_METHOD_DESCRIPTOR_O 326
-#define _CALL_NON_PY_GENERAL 327
-#define _CALL_STR_1 328
-#define _CALL_TUPLE_1 329
+#define _CALL_METHOD_DESCRIPTOR_FAST 324
+#define _CALL_METHOD_DESCRIPTOR_FAST_WITH_KEYWORDS 325
+#define _CALL_METHOD_DESCRIPTOR_NOARGS 326
+#define _CALL_METHOD_DESCRIPTOR_O 327
+#define _CALL_NON_PY_GENERAL 328
+#define _CALL_STR_1 329
+#define _CALL_TUPLE_1 330
 #define _CALL_TYPE_1 CALL_TYPE_1
-#define _CHECK_AND_ALLOCATE_OBJECT 330
-#define _CHECK_ATTR_CLASS 331
-#define _CHECK_ATTR_METHOD_LAZY_DICT 332
-#define _CHECK_CALL_BOUND_METHOD_EXACT_ARGS 333
+#define _CHECK_AND_ALLOCATE_OBJECT 331
+#define _CHECK_ATTR_CLASS 332
+#define _CHECK_ATTR_METHOD_LAZY_DICT 333
+#define _CHECK_CALL_BOUND_METHOD_EXACT_ARGS 334
 #define _CHECK_EG_MATCH CHECK_EG_MATCH
 #define _CHECK_EXC_MATCH CHECK_EXC_MATCH
-#define _CHECK_FUNCTION 334
-#define _CHECK_FUNCTION_EXACT_ARGS 335
-#define _CHECK_FUNCTION_VERSION 336
-#define _CHECK_FUNCTION_VERSION_INLINE 337
-#define _CHECK_FUNCTION_VERSION_KW 338
-#define _CHECK_IS_NOT_PY_CALLABLE 339
-#define _CHECK_IS_NOT_PY_CALLABLE_KW 340
-#define _CHECK_MANAGED_OBJECT_HAS_VALUES 341
-#define _CHECK_METHOD_VERSION 342
-#define _CHECK_METHOD_VERSION_KW 343
-#define _CHECK_PEP_523 344
-#define _CHECK_PERIODIC 345
-#define _CHECK_PERIODIC_IF_NOT_YIELD_FROM 346
-#define _CHECK_STACK_SPACE 347
-#define _CHECK_STACK_SPACE_OPERAND 348
-#define _CHECK_VALIDITY 349
-#define _COMPARE_OP 350
-#define _COMPARE_OP_FLOAT 351
-#define _COMPARE_OP_INT 352
-#define _COMPARE_OP_STR 353
-#define _CONTAINS_OP 354
-#define _CONTAINS_OP_DICT CONTAINS_OP_DICT
-#define _CONTAINS_OP_SET CONTAINS_OP_SET
+#define _CHECK_FUNCTION 335
+#define _CHECK_FUNCTION_EXACT_ARGS 336
+#define _CHECK_FUNCTION_VERSION 337
+#define _CHECK_FUNCTION_VERSION_INLINE 338
+#define _CHECK_FUNCTION_VERSION_KW 339
+#define _CHECK_IS_NOT_PY_CALLABLE 340
+#define _CHECK_IS_NOT_PY_CALLABLE_KW 341
+#define _CHECK_MANAGED_OBJECT_HAS_VALUES 342
+#define _CHECK_METHOD_VERSION 343
+#define _CHECK_METHOD_VERSION_KW 344
+#define _CHECK_PEP_523 345
+#define _CHECK_PERIODIC 346
+#define _CHECK_PERIODIC_IF_NOT_YIELD_FROM 347
+#define _CHECK_STACK_SPACE 348
+#define _CHECK_STACK_SPACE_OPERAND 349
+#define _CHECK_VALIDITY 350
+#define _COMPARE_OP 351
+#define _COMPARE_OP_FLOAT 352
+#define _COMPARE_OP_INT 353
+#define _COMPARE_OP_STR 354
+#define _CONTAINS_OP 355
+#define _CONTAINS_OP_DICT 356
+#define _CONTAINS_OP_SET 357
 #define _CONVERT_VALUE CONVERT_VALUE
 #define _COPY COPY
 #define _COPY_FREE_VARS COPY_FREE_VARS
-#define _CREATE_INIT_FRAME 355
+#define _CREATE_INIT_FRAME 358
 #define _DELETE_ATTR DELETE_ATTR
 #define _DELETE_DEREF DELETE_DEREF
 #define _DELETE_FAST DELETE_FAST
 #define _DELETE_GLOBAL DELETE_GLOBAL
 #define _DELETE_NAME DELETE_NAME
 #define _DELETE_SUBSCR DELETE_SUBSCR
-#define _DEOPT 356
+#define _DEOPT 359
 #define _DICT_MERGE DICT_MERGE
 #define _DICT_UPDATE DICT_UPDATE
-#define _DO_CALL 357
-#define _DO_CALL_FUNCTION_EX 358
-#define _DO_CALL_KW 359
+#define _DO_CALL 360
+#define _DO_CALL_FUNCTION_EX 361
+#define _DO_CALL_KW 362
 #define _END_FOR END_FOR
 #define _END_SEND END_SEND
-#define _ERROR_POP_N 360
+#define _ERROR_POP_N 363
 #define _EXIT_INIT_CHECK EXIT_INIT_CHECK
-#define _EXPAND_METHOD 361
-#define _EXPAND_METHOD_KW 362
-#define _FATAL_ERROR 363
+#define _EXPAND_METHOD 364
+#define _EXPAND_METHOD_KW 365
+#define _FATAL_ERROR 366
 #define _FORMAT_SIMPLE FORMAT_SIMPLE
 #define _FORMAT_WITH_SPEC FORMAT_WITH_SPEC
-#define _FOR_ITER 364
-#define _FOR_ITER_GEN_FRAME 365
-#define _FOR_ITER_TIER_TWO 366
+#define _FOR_ITER 367
+#define _FOR_ITER_GEN_FRAME 368
+#define _FOR_ITER_TIER_TWO 369
 #define _GET_AITER GET_AITER
 #define _GET_ANEXT GET_ANEXT
 #define _GET_AWAITABLE GET_AWAITABLE
 #define _GET_ITER GET_ITER
 #define _GET_LEN GET_LEN
 #define _GET_YIELD_FROM_ITER GET_YIELD_FROM_ITER
-#define _GUARD_BINARY_OP_EXTEND 367
-#define _GUARD_DORV_NO_DICT 368
-#define _GUARD_DORV_VALUES_INST_ATTR_FROM_DICT 369
-#define _GUARD_GLOBALS_VERSION 370
-#define _GUARD_IS_FALSE_POP 371
-#define _GUARD_IS_NONE_POP 372
-#define _GUARD_IS_NOT_NONE_POP 373
-#define _GUARD_IS_TRUE_POP 374
-#define _GUARD_KEYS_VERSION 375
-#define _GUARD_NOS_FLOAT 376
-#define _GUARD_NOS_INT 377
-#define _GUARD_NOS_UNICODE 378
-#define _GUARD_NOT_EXHAUSTED_LIST 379
-#define _GUARD_NOT_EXHAUSTED_RANGE 380
-#define _GUARD_NOT_EXHAUSTED_TUPLE 381
-#define _GUARD_TOS_FLOAT 382
-#define _GUARD_TOS_INT 383
-#define _GUARD_TOS_UNICODE 384
-#define _GUARD_TYPE_VERSION 385
-#define _GUARD_TYPE_VERSION_AND_LOCK 386
+#define _GUARD_BINARY_OP_EXTEND 370
+#define _GUARD_DORV_NO_DICT 371
+#define _GUARD_DORV_VALUES_INST_ATTR_FROM_DICT 372
+#define _GUARD_GLOBALS_VERSION 373
+#define _GUARD_IS_FALSE_POP 374
+#define _GUARD_IS_NONE_POP 375
+#define _GUARD_IS_NOT_NONE_POP 376
+#define _GUARD_IS_TRUE_POP 377
+#define _GUARD_KEYS_VERSION 378
+#define _GUARD_NOS_DICT 379
+#define _GUARD_NOS_FLOAT 380
+#define _GUARD_NOS_INT 381
+#define _GUARD_NOS_LIST 382
+#define _GUARD_NOS_TUPLE 383
+#define _GUARD_NOS_UNICODE 384
+#define _GUARD_NOT_EXHAUSTED_LIST 385
+#define _GUARD_NOT_EXHAUSTED_RANGE 386
+#define _GUARD_NOT_EXHAUSTED_TUPLE 387
+#define _GUARD_TOS_ANY_SET 388
+#define _GUARD_TOS_DICT 389
+#define _GUARD_TOS_FLOAT 390
+#define _GUARD_TOS_INT 391
+#define _GUARD_TOS_LIST 392
+#define _GUARD_TOS_TUPLE 393
+#define _GUARD_TOS_UNICODE 394
+#define _GUARD_TYPE_VERSION 395
+#define _GUARD_TYPE_VERSION_AND_LOCK 396
 #define _IMPORT_FROM IMPORT_FROM
 #define _IMPORT_NAME IMPORT_NAME
-#define _INIT_CALL_BOUND_METHOD_EXACT_ARGS 387
-#define _INIT_CALL_PY_EXACT_ARGS 388
-#define _INIT_CALL_PY_EXACT_ARGS_0 389
-#define _INIT_CALL_PY_EXACT_ARGS_1 390
-#define _INIT_CALL_PY_EXACT_ARGS_2 391
-#define _INIT_CALL_PY_EXACT_ARGS_3 392
-#define _INIT_CALL_PY_EXACT_ARGS_4 393
+#define _INIT_CALL_BOUND_METHOD_EXACT_ARGS 397
+#define _INIT_CALL_PY_EXACT_ARGS 398
+#define _INIT_CALL_PY_EXACT_ARGS_0 399
+#define _INIT_CALL_PY_EXACT_ARGS_1 400
+#define _INIT_CALL_PY_EXACT_ARGS_2 401
+#define _INIT_CALL_PY_EXACT_ARGS_3 402
+#define _INIT_CALL_PY_EXACT_ARGS_4 403
 #define _INSTRUMENTED_FOR_ITER INSTRUMENTED_FOR_ITER
 #define _INSTRUMENTED_INSTRUCTION INSTRUMENTED_INSTRUCTION
 #define _INSTRUMENTED_JUMP_FORWARD INSTRUMENTED_JUMP_FORWARD
@@ -153,163 +160,163 @@ extern "C" {
 #define _INSTRUMENTED_POP_JUMP_IF_NONE INSTRUMENTED_POP_JUMP_IF_NONE
 #define _INSTRUMENTED_POP_JUMP_IF_NOT_NONE INSTRUMENTED_POP_JUMP_IF_NOT_NONE
 #define _INSTRUMENTED_POP_JUMP_IF_TRUE INSTRUMENTED_POP_JUMP_IF_TRUE
-#define _IS_NONE 394
+#define _IS_NONE 404
 #define _IS_OP IS_OP
-#define _ITER_CHECK_LIST 395
-#define _ITER_CHECK_RANGE 396
-#define _ITER_CHECK_TUPLE 397
-#define _ITER_JUMP_LIST 398
-#define _ITER_JUMP_RANGE 399
-#define _ITER_JUMP_TUPLE 400
-#define _ITER_NEXT_LIST 401
-#define _ITER_NEXT_LIST_TIER_TWO 402
-#define _ITER_NEXT_RANGE 403
-#define _ITER_NEXT_TUPLE 404
-#define _JUMP_TO_TOP 405
+#define _ITER_CHECK_LIST 405
+#define _ITER_CHECK_RANGE 406
+#define _ITER_CHECK_TUPLE 407
+#define _ITER_JUMP_LIST 408
+#define _ITER_JUMP_RANGE 409
+#define _ITER_JUMP_TUPLE 410
+#define _ITER_NEXT_LIST 411
+#define _ITER_NEXT_LIST_TIER_TWO 412
+#define _ITER_NEXT_RANGE 413
+#define _ITER_NEXT_TUPLE 414
+#define _JUMP_TO_TOP 415
 #define _LIST_APPEND LIST_APPEND
 #define _LIST_EXTEND LIST_EXTEND
-#define _LOAD_ATTR 406
-#define _LOAD_ATTR_CLASS 407
+#define _LOAD_ATTR 416
+#define _LOAD_ATTR_CLASS 417
 #define _LOAD_ATTR_GETATTRIBUTE_OVERRIDDEN LOAD_ATTR_GETATTRIBUTE_OVERRIDDEN
-#define _LOAD_ATTR_INSTANCE_VALUE 408
-#define _LOAD_ATTR_METHOD_LAZY_DICT 409
-#define _LOAD_ATTR_METHOD_NO_DICT 410
-#define _LOAD_ATTR_METHOD_WITH_VALUES 411
-#define _LOAD_ATTR_MODULE 412
-#define _LOAD_ATTR_NONDESCRIPTOR_NO_DICT 413
-#define _LOAD_ATTR_NONDESCRIPTOR_WITH_VALUES 414
-#define _LOAD_ATTR_PROPERTY_FRAME 415
-#define _LOAD_ATTR_SLOT 416
-#define _LOAD_ATTR_WITH_HINT 417
+#define _LOAD_ATTR_INSTANCE_VALUE 418
+#define _LOAD_ATTR_METHOD_LAZY_DICT 419
+#define _LOAD_ATTR_METHOD_NO_DICT 420
+#define _LOAD_ATTR_METHOD_WITH_VALUES 421
+#define _LOAD_ATTR_MODULE 422
+#define _LOAD_ATTR_NONDESCRIPTOR_NO_DICT 423
+#define _LOAD_ATTR_NONDESCRIPTOR_WITH_VALUES 424
+#define _LOAD_ATTR_PROPERTY_FRAME 425
+#define _LOAD_ATTR_SLOT 426
+#define _LOAD_ATTR_WITH_HINT 427
 #define _LOAD_BUILD_CLASS LOAD_BUILD_CLASS
-#define _LOAD_BYTECODE 418
+#define _LOAD_BYTECODE 428
 #define _LOAD_COMMON_CONSTANT LOAD_COMMON_CONSTANT
 #define _LOAD_CONST LOAD_CONST
 #define _LOAD_CONST_IMMORTAL LOAD_CONST_IMMORTAL
-#define _LOAD_CONST_INLINE 419
-#define _LOAD_CONST_INLINE_BORROW 420
+#define _LOAD_CONST_INLINE 429
+#define _LOAD_CONST_INLINE_BORROW 430
 #define _LOAD_CONST_MORTAL LOAD_CONST_MORTAL
 #define _LOAD_DEREF LOAD_DEREF
-#define _LOAD_FAST 421
-#define _LOAD_FAST_0 422
-#define _LOAD_FAST_1 423
-#define _LOAD_FAST_2 424
-#define _LOAD_FAST_3 425
-#define _LOAD_FAST_4 426
-#define _LOAD_FAST_5 427
-#define _LOAD_FAST_6 428
-#define _LOAD_FAST_7 429
+#define _LOAD_FAST 431
+#define _LOAD_FAST_0 432
+#define _LOAD_FAST_1 433
+#define _LOAD_FAST_2 434
+#define _LOAD_FAST_3 435
+#define _LOAD_FAST_4 436
+#define _LOAD_FAST_5 437
+#define _LOAD_FAST_6 438
+#define _LOAD_FAST_7 439
 #define _LOAD_FAST_AND_CLEAR LOAD_FAST_AND_CLEAR
-#define _LOAD_FAST_BORROW 430
-#define _LOAD_FAST_BORROW_0 431
-#define _LOAD_FAST_BORROW_1 432
-#define _LOAD_FAST_BORROW_2 433
-#define _LOAD_FAST_BORROW_3 434
-#define _LOAD_FAST_BORROW_4 435
-#define _LOAD_FAST_BORROW_5 436
-#define _LOAD_FAST_BORROW_6 437
-#define _LOAD_FAST_BORROW_7 438
+#define _LOAD_FAST_BORROW 440
+#define _LOAD_FAST_BORROW_0 441
+#define _LOAD_FAST_BORROW_1 442
+#define _LOAD_FAST_BORROW_2 443
+#define _LOAD_FAST_BORROW_3 444
+#define _LOAD_FAST_BORROW_4 445
+#define _LOAD_FAST_BORROW_5 446
+#define _LOAD_FAST_BORROW_6 447
+#define _LOAD_FAST_BORROW_7 448
 #define _LOAD_FAST_BORROW_LOAD_FAST_BORROW LOAD_FAST_BORROW_LOAD_FAST_BORROW
 #define _LOAD_FAST_CHECK LOAD_FAST_CHECK
 #define _LOAD_FAST_LOAD_FAST LOAD_FAST_LOAD_FAST
 #define _LOAD_FROM_DICT_OR_DEREF LOAD_FROM_DICT_OR_DEREF
 #define _LOAD_FROM_DICT_OR_GLOBALS LOAD_FROM_DICT_OR_GLOBALS
-#define _LOAD_GLOBAL 439
-#define _LOAD_GLOBAL_BUILTINS 440
-#define _LOAD_GLOBAL_MODULE 441
+#define _LOAD_GLOBAL 449
+#define _LOAD_GLOBAL_BUILTINS 450
+#define _LOAD_GLOBAL_MODULE 451
 #define _LOAD_LOCALS LOAD_LOCALS
 #define _LOAD_NAME LOAD_NAME
-#define _LOAD_SMALL_INT 442
-#define _LOAD_SMALL_INT_0 443
-#define _LOAD_SMALL_INT_1 444
-#define _LOAD_SMALL_INT_2 445
-#define _LOAD_SMALL_INT_3 446
+#define _LOAD_SMALL_INT 452
+#define _LOAD_SMALL_INT_0 453
+#define _LOAD_SMALL_INT_1 454
+#define _LOAD_SMALL_INT_2 455
+#define _LOAD_SMALL_INT_3 456
 #define _LOAD_SPECIAL LOAD_SPECIAL
 #define _LOAD_SUPER_ATTR_ATTR LOAD_SUPER_ATTR_ATTR
 #define _LOAD_SUPER_ATTR_METHOD LOAD_SUPER_ATTR_METHOD
-#define _MAKE_CALLARGS_A_TUPLE 447
+#define _MAKE_CALLARGS_A_TUPLE 457
 #define _MAKE_CELL MAKE_CELL
 #define _MAKE_FUNCTION MAKE_FUNCTION
-#define _MAKE_WARM 448
+#define _MAKE_WARM 458
 #define _MAP_ADD MAP_ADD
 #define _MATCH_CLASS MATCH_CLASS
 #define _MATCH_KEYS MATCH_KEYS
 #define _MATCH_MAPPING MATCH_MAPPING
 #define _MATCH_SEQUENCE MATCH_SEQUENCE
-#define _MAYBE_EXPAND_METHOD 449
-#define _MAYBE_EXPAND_METHOD_KW 450
-#define _MONITOR_CALL 451
-#define _MONITOR_CALL_KW 452
-#define _MONITOR_JUMP_BACKWARD 453
-#define _MONITOR_RESUME 454
+#define _MAYBE_EXPAND_METHOD 459
+#define _MAYBE_EXPAND_METHOD_KW 460
+#define _MONITOR_CALL 461
+#define _MONITOR_CALL_KW 462
+#define _MONITOR_JUMP_BACKWARD 463
+#define _MONITOR_RESUME 464
 #define _NOP NOP
 #define _POP_EXCEPT POP_EXCEPT
-#define _POP_JUMP_IF_FALSE 455
-#define _POP_JUMP_IF_TRUE 456
+#define _POP_JUMP_IF_FALSE 465
+#define _POP_JUMP_IF_TRUE 466
 #define _POP_TOP POP_TOP
-#define _POP_TOP_LOAD_CONST_INLINE 457
-#define _POP_TOP_LOAD_CONST_INLINE_BORROW 458
-#define _POP_TWO_LOAD_CONST_INLINE_BORROW 459
+#define _POP_TOP_LOAD_CONST_INLINE 467
+#define _POP_TOP_LOAD_CONST_INLINE_BORROW 468
+#define _POP_TWO_LOAD_CONST_INLINE_BORROW 469
 #define _PUSH_EXC_INFO PUSH_EXC_INFO
-#define _PUSH_FRAME 460
+#define _PUSH_FRAME 470
 #define _PUSH_NULL PUSH_NULL
-#define _PUSH_NULL_CONDITIONAL 461
-#define _PY_FRAME_GENERAL 462
-#define _PY_FRAME_KW 463
-#define _QUICKEN_RESUME 464
-#define _REPLACE_WITH_TRUE 465
+#define _PUSH_NULL_CONDITIONAL 471
+#define _PY_FRAME_GENERAL 472
+#define _PY_FRAME_KW 473
+#define _QUICKEN_RESUME 474
+#define _REPLACE_WITH_TRUE 475
 #define _RESUME_CHECK RESUME_CHECK
 #define _RETURN_GENERATOR RETURN_GENERATOR
 #define _RETURN_VALUE RETURN_VALUE
-#define _SAVE_RETURN_OFFSET 466
-#define _SEND 467
-#define _SEND_GEN_FRAME 468
+#define _SAVE_RETURN_OFFSET 476
+#define _SEND 477
+#define _SEND_GEN_FRAME 478
 #define _SETUP_ANNOTATIONS SETUP_ANNOTATIONS
 #define _SET_ADD SET_ADD
 #define _SET_FUNCTION_ATTRIBUTE SET_FUNCTION_ATTRIBUTE
 #define _SET_UPDATE SET_UPDATE
-#define _START_EXECUTOR 469
-#define _STORE_ATTR 470
-#define _STORE_ATTR_INSTANCE_VALUE 471
-#define _STORE_ATTR_SLOT 472
-#define _STORE_ATTR_WITH_HINT 473
+#define _START_EXECUTOR 479
+#define _STORE_ATTR 480
+#define _STORE_ATTR_INSTANCE_VALUE 481
+#define _STORE_ATTR_SLOT 482
+#define _STORE_ATTR_WITH_HINT 483
 #define _STORE_DEREF STORE_DEREF
-#define _STORE_FAST 474
-#define _STORE_FAST_0 475
-#define _STORE_FAST_1 476
-#define _STORE_FAST_2 477
-#define _STORE_FAST_3 478
-#define _STORE_FAST_4 479
-#define _STORE_FAST_5 480
-#define _STORE_FAST_6 481
-#define _STORE_FAST_7 482
+#define _STORE_FAST 484
+#define _STORE_FAST_0 485
+#define _STORE_FAST_1 486
+#define _STORE_FAST_2 487
+#define _STORE_FAST_3 488
+#define _STORE_FAST_4 489
+#define _STORE_FAST_5 490
+#define _STORE_FAST_6 491
+#define _STORE_FAST_7 492
 #define _STORE_FAST_LOAD_FAST STORE_FAST_LOAD_FAST
 #define _STORE_FAST_STORE_FAST STORE_FAST_STORE_FAST
 #define _STORE_GLOBAL STORE_GLOBAL
 #define _STORE_NAME STORE_NAME
-#define _STORE_SLICE 483
-#define _STORE_SUBSCR 484
-#define _STORE_SUBSCR_DICT STORE_SUBSCR_DICT
-#define _STORE_SUBSCR_LIST_INT 485
+#define _STORE_SLICE 493
+#define _STORE_SUBSCR 494
+#define _STORE_SUBSCR_DICT 495
+#define _STORE_SUBSCR_LIST_INT 496
 #define _SWAP SWAP
-#define _TIER2_RESUME_CHECK 486
-#define _TO_BOOL 487
+#define _TIER2_RESUME_CHECK 497
+#define _TO_BOOL 498
 #define _TO_BOOL_BOOL TO_BOOL_BOOL
 #define _TO_BOOL_INT TO_BOOL_INT
-#define _TO_BOOL_LIST TO_BOOL_LIST
+#define _TO_BOOL_LIST 499
 #define _TO_BOOL_NONE TO_BOOL_NONE
-#define _TO_BOOL_STR 488
+#define _TO_BOOL_STR 500
 #define _UNARY_INVERT UNARY_INVERT
 #define _UNARY_NEGATIVE UNARY_NEGATIVE
 #define _UNARY_NOT UNARY_NOT
 #define _UNPACK_EX UNPACK_EX
-#define _UNPACK_SEQUENCE 489
-#define _UNPACK_SEQUENCE_LIST UNPACK_SEQUENCE_LIST
-#define _UNPACK_SEQUENCE_TUPLE UNPACK_SEQUENCE_TUPLE
-#define _UNPACK_SEQUENCE_TWO_TUPLE UNPACK_SEQUENCE_TWO_TUPLE
+#define _UNPACK_SEQUENCE 501
+#define _UNPACK_SEQUENCE_LIST 502
+#define _UNPACK_SEQUENCE_TUPLE 503
+#define _UNPACK_SEQUENCE_TWO_TUPLE 504
 #define _WITH_EXCEPT_START WITH_EXCEPT_START
 #define _YIELD_VALUE YIELD_VALUE
-#define MAX_UOP_ID 489
+#define MAX_UOP_ID 504
 
 #ifdef __cplusplus
 }
diff --git a/Include/internal/pycore_uop_metadata.h b/Include/internal/pycore_uop_metadata.h
index c089328f2e967d..8fa50ff2c291c4 100644
--- a/Include/internal/pycore_uop_metadata.h
+++ b/Include/internal/pycore_uop_metadata.h
@@ -72,7 +72,9 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_TO_BOOL] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_TO_BOOL_BOOL] = HAS_EXIT_FLAG,
     [_TO_BOOL_INT] = HAS_EXIT_FLAG | HAS_ESCAPES_FLAG,
-    [_TO_BOOL_LIST] = HAS_EXIT_FLAG,
+    [_GUARD_NOS_LIST] = HAS_EXIT_FLAG,
+    [_GUARD_TOS_LIST] = HAS_EXIT_FLAG,
+    [_TO_BOOL_LIST] = 0,
     [_TO_BOOL_NONE] = HAS_EXIT_FLAG,
     [_GUARD_NOS_UNICODE] = HAS_EXIT_FLAG,
     [_GUARD_TOS_UNICODE] = HAS_EXIT_FLAG,
@@ -97,15 +99,19 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_STORE_SLICE] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BINARY_OP_SUBSCR_LIST_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
     [_BINARY_OP_SUBSCR_STR_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
+    [_GUARD_NOS_TUPLE] = HAS_EXIT_FLAG,
+    [_GUARD_TOS_TUPLE] = HAS_EXIT_FLAG,
     [_BINARY_OP_SUBSCR_TUPLE_INT] = HAS_DEOPT_FLAG,
-    [_BINARY_OP_SUBSCR_DICT] = HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
+    [_GUARD_NOS_DICT] = HAS_EXIT_FLAG,
+    [_GUARD_TOS_DICT] = HAS_EXIT_FLAG,
+    [_BINARY_OP_SUBSCR_DICT] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_BINARY_OP_SUBSCR_CHECK_FUNC] = HAS_DEOPT_FLAG,
     [_BINARY_OP_SUBSCR_INIT_CALL] = 0,
     [_LIST_APPEND] = HAS_ARG_FLAG | HAS_ERROR_FLAG,
     [_SET_ADD] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_STORE_SUBSCR] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_STORE_SUBSCR_LIST_INT] = HAS_DEOPT_FLAG | HAS_ESCAPES_FLAG,
-    [_STORE_SUBSCR_DICT] = HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
+    [_STORE_SUBSCR_DICT] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_DELETE_SUBSCR] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_CALL_INTRINSIC_1] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_CALL_INTRINSIC_2] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
@@ -177,8 +183,9 @@ const uint16_t _PyUop_Flags[MAX_UOP_ID+1] = {
     [_COMPARE_OP_STR] = HAS_ARG_FLAG,
     [_IS_OP] = HAS_ARG_FLAG,
     [_CONTAINS_OP] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
-    [_CONTAINS_OP_SET] = HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
-    [_CONTAINS_OP_DICT] = HAS_ARG_FLAG | HAS_DEOPT_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
+    [_GUARD_TOS_ANY_SET] = HAS_DEOPT_FLAG,
+    [_CONTAINS_OP_SET] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
+    [_CONTAINS_OP_DICT] = HAS_ARG_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_CHECK_EG_MATCH] = HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
     [_CHECK_EXC_MATCH] = HAS_ERROR_FLAG | HAS_ERROR_NO_POP_FLAG | HAS_ESCAPES_FLAG,
     [_IMPORT_NAME] = HAS_ARG_FLAG | HAS_NAME_FLAG | HAS_ERROR_FLAG | HAS_ESCAPES_FLAG,
@@ -411,14 +418,21 @@ const char *const _PyOpcode_uop_name[MAX_UOP_ID+1] = {
     [_GUARD_IS_NOT_NONE_POP] = "_GUARD_IS_NOT_NONE_POP",
     [_GUARD_IS_TRUE_POP] = "_GUARD_IS_TRUE_POP",
     [_GUARD_KEYS_VERSION] = "_GUARD_KEYS_VERSION",
+    [_GUARD_NOS_DICT] = "_GUARD_NOS_DICT",
     [_GUARD_NOS_FLOAT] = "_GUARD_NOS_FLOAT",
     [_GUARD_NOS_INT] = "_GUARD_NOS_INT",
+    [_GUARD_NOS_LIST] = "_GUARD_NOS_LIST",
+    [_GUARD_NOS_TUPLE] = "_GUARD_NOS_TUPLE",
     [_GUARD_NOS_UNICODE] = "_GUARD_NOS_UNICODE",
     [_GUARD_NOT_EXHAUSTED_LIST] = "_GUARD_NOT_EXHAUSTED_LIST",
     [_GUARD_NOT_EXHAUSTED_RANGE] = "_GUARD_NOT_EXHAUSTED_RANGE",
     [_GUARD_NOT_EXHAUSTED_TUPLE] = "_GUARD_NOT_EXHAUSTED_TUPLE",
+    [_GUARD_TOS_ANY_SET] = "_GUARD_TOS_ANY_SET",
+    [_GUARD_TOS_DICT] = "_GUARD_TOS_DICT",
     [_GUARD_TOS_FLOAT] = "_GUARD_TOS_FLOAT",
     [_GUARD_TOS_INT] = "_GUARD_TOS_INT",
+    [_GUARD_TOS_LIST] = "_GUARD_TOS_LIST",
+    [_GUARD_TOS_TUPLE] = "_GUARD_TOS_TUPLE",
     [_GUARD_TOS_UNICODE] = "_GUARD_TOS_UNICODE",
     [_GUARD_TYPE_VERSION] = "_GUARD_TYPE_VERSION",
     [_GUARD_TYPE_VERSION_AND_LOCK] = "_GUARD_TYPE_VERSION_AND_LOCK",
@@ -682,6 +696,10 @@ int _PyUop_num_popped(int opcode, int oparg)
             return 0;
         case _TO_BOOL_INT:
             return 1;
+        case _GUARD_NOS_LIST:
+            return 0;
+        case _GUARD_TOS_LIST:
+            return 0;
         case _TO_BOOL_LIST:
             return 1;
         case _TO_BOOL_NONE:
@@ -732,8 +750,16 @@ int _PyUop_num_popped(int opcode, int oparg)
             return 2;
         case _BINARY_OP_SUBSCR_STR_INT:
             return 2;
+        case _GUARD_NOS_TUPLE:
+            return 0;
+        case _GUARD_TOS_TUPLE:
+            return 0;
         case _BINARY_OP_SUBSCR_TUPLE_INT:
             return 2;
+        case _GUARD_NOS_DICT:
+            return 0;
+        case _GUARD_TOS_DICT:
+            return 0;
         case _BINARY_OP_SUBSCR_DICT:
             return 2;
         case _BINARY_OP_SUBSCR_CHECK_FUNC:
@@ -892,6 +918,8 @@ int _PyUop_num_popped(int opcode, int oparg)
             return 2;
         case _CONTAINS_OP:
             return 2;
+        case _GUARD_TOS_ANY_SET:
+            return 0;
         case _CONTAINS_OP_SET:
             return 2;
         case _CONTAINS_OP_DICT:
diff --git a/Lib/test/test_capi/test_opt.py b/Lib/test/test_capi/test_opt.py
index 00aebd68f9ef43..c0e771a0d59c4f 100644
--- a/Lib/test/test_capi/test_opt.py
+++ b/Lib/test/test_capi/test_opt.py
@@ -1673,6 +1673,80 @@ def f(n):
         self.assertIn("_TO_BOOL_STR", uops)
         self.assertNotIn("_GUARD_TOS_UNICODE", uops)
 
+    def test_remove_guard_for_known_type_dict(self):
+        def f(n):
+            x = 0
+            for _ in range(n):
+                d = {}
+                d["Spam"] = 1  # Guarded...
+                x += d["Spam"]  # ...unguarded!
+            return x
+
+        res, ex = self._run_with_optimizer(f, TIER2_THRESHOLD)
+        self.assertEqual(res, TIER2_THRESHOLD)
+        self.assertIsNotNone(ex)
+        uops = get_opnames(ex)
+        self.assertEqual(uops.count("_GUARD_NOS_DICT"), 1)
+        self.assertEqual(uops.count("_STORE_SUBSCR_DICT"), 1)
+        self.assertEqual(uops.count("_BINARY_OP_SUBSCR_DICT"), 1)
+
+    def test_remove_guard_for_known_type_list(self):
+        def f(n):
+            x = 0
+            for _ in range(n):
+                l = [0]
+                l[0] = 1  # Guarded...
+                [a] = l  # ...unguarded!
+                b = l[0]  # ...unguarded!
+                if l:  # ...unguarded!
+                    x += a + b
+            return x
+
+        res, ex = self._run_with_optimizer(f, TIER2_THRESHOLD)
+        self.assertEqual(res, 2 * TIER2_THRESHOLD)
+        self.assertIsNotNone(ex)
+        uops = get_opnames(ex)
+        self.assertEqual(uops.count("_GUARD_NOS_LIST"), 1)
+        self.assertEqual(uops.count("_STORE_SUBSCR_LIST_INT"), 1)
+        self.assertEqual(uops.count("_GUARD_TOS_LIST"), 0)
+        self.assertEqual(uops.count("_UNPACK_SEQUENCE_LIST"), 1)
+        self.assertEqual(uops.count("_BINARY_OP_SUBSCR_LIST_INT"), 1)
+        self.assertEqual(uops.count("_TO_BOOL_LIST"), 1)
+
+    def test_remove_guard_for_known_type_set(self):
+        def f(n):
+            x = 0
+            for _ in range(n):
+                x += "Spam" in {"Spam"}  # Unguarded!
+            return x
+
+        res, ex = self._run_with_optimizer(f, TIER2_THRESHOLD)
+        self.assertEqual(res, TIER2_THRESHOLD)
+        self.assertIsNotNone(ex)
+        uops = get_opnames(ex)
+        self.assertNotIn("_GUARD_TOS_ANY_SET", uops)
+        self.assertIn("_CONTAINS_OP_SET", uops)
+
+    def test_remove_guard_for_known_type_tuple(self):
+        def f(n):
+            x = 0
+            for _ in range(n):
+                t = (1, 2, (3, (4,)))
+                t_0, t_1, (t_2_0, t_2_1) = t  # Unguarded!
+                t_2_1_0 = t_2_1[0]  # Unguarded!
+                x += t_0 + t_1 + t_2_0 + t_2_1_0
+            return x
+
+        res, ex = self._run_with_optimizer(f, TIER2_THRESHOLD)
+        self.assertEqual(res, 10 * TIER2_THRESHOLD)
+        self.assertIsNotNone(ex)
+        uops = get_opnames(ex)
+        self.assertNotIn("_GUARD_TOS_TUPLE", uops)
+        self.assertIn("_UNPACK_SEQUENCE_TUPLE", uops)
+        self.assertIn("_UNPACK_SEQUENCE_TWO_TUPLE", uops)
+        self.assertNotIn("_GUARD_NOS_TUPLE", uops)
+        self.assertIn("_BINARY_OP_SUBSCR_TUPLE_INT", uops)
+
     def test_binary_subcsr_str_int_narrows_to_str(self):
         def testfunc(n):
             x = []
diff --git a/Misc/NEWS.d/next/Core_and_Builtins/2025-04-08-09-20-18.gh-issue-131798.Xp1mvN.rst b/Misc/NEWS.d/next/Core_and_Builtins/2025-04-08-09-20-18.gh-issue-131798.Xp1mvN.rst
new file mode 100644
index 00000000000000..91b7a6619721cd
--- /dev/null
+++ b/Misc/NEWS.d/next/Core_and_Builtins/2025-04-08-09-20-18.gh-issue-131798.Xp1mvN.rst
@@ -0,0 +1,2 @@
+Allow the JIT compiler to remove some type checks for operations on lists,
+tuples, dictionaries, and sets.
diff --git a/Python/bytecodes.c b/Python/bytecodes.c
index 53da324ee5ab89..e9dced654d1492 100644
--- a/Python/bytecodes.c
+++ b/Python/bytecodes.c
@@ -508,9 +508,21 @@ dummy_func(
             }
         }
 
-        inst(TO_BOOL_LIST, (unused/1, unused/2, value -- res)) {
+        op(_GUARD_NOS_LIST, (nos, unused -- nos, unused)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+            EXIT_IF(!PyList_CheckExact(o));
+        }
+
+        op(_GUARD_TOS_LIST, (tos -- tos)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            EXIT_IF(!PyList_CheckExact(o));
+        }
+
+        macro(TO_BOOL_LIST) = _GUARD_TOS_LIST + unused/1 + unused/2 + _TO_BOOL_LIST;
+
+        op(_TO_BOOL_LIST, (value -- res)) {
             PyObject *value_o = PyStackRef_AsPyObjectBorrow(value);
-            EXIT_IF(!PyList_CheckExact(value_o));
+            assert(PyList_CheckExact(value_o));
             STAT_INC(TO_BOOL, hit);
             res = PyList_GET_SIZE(value_o) ? PyStackRef_True : PyStackRef_False;
             DECREF_INPUTS();
@@ -524,8 +536,7 @@ dummy_func(
             res = PyStackRef_False;
         }
 
-        op(_GUARD_NOS_UNICODE, (nos, tos -- nos, tos)) {
-            (void)tos;
+        op(_GUARD_NOS_UNICODE, (nos, unused -- nos, unused)) {
             PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
             EXIT_IF(!PyUnicode_CheckExact(o));
         }
@@ -587,8 +598,7 @@ dummy_func(
             BINARY_OP_EXTEND,
         };
 
-        op(_GUARD_NOS_INT, (left, right -- left, right)) {
-            (void)right;
+        op(_GUARD_NOS_INT, (left, unused -- left, unused)) {
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             EXIT_IF(!PyLong_CheckExact(left_o));
         }
@@ -650,8 +660,7 @@ dummy_func(
         macro(BINARY_OP_SUBTRACT_INT) =
             _GUARD_TOS_INT + _GUARD_NOS_INT + unused/5 + _BINARY_OP_SUBTRACT_INT;
 
-        op(_GUARD_NOS_FLOAT, (left, right -- left, right)) {
-            (void)right;
+        op(_GUARD_NOS_FLOAT, (left, unused -- left, unused)) {
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             EXIT_IF(!PyFloat_CheckExact(left_o));
         }
@@ -862,14 +871,14 @@ dummy_func(
         macro(STORE_SLICE) = _SPECIALIZE_STORE_SLICE + _STORE_SLICE;
 
         macro(BINARY_OP_SUBSCR_LIST_INT) =
-            _GUARD_TOS_INT + unused/5 + _BINARY_OP_SUBSCR_LIST_INT;
+            _GUARD_TOS_INT + _GUARD_NOS_LIST + unused/5 + _BINARY_OP_SUBSCR_LIST_INT;
 
         op(_BINARY_OP_SUBSCR_LIST_INT, (list_st, sub_st -- res)) {
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *list = PyStackRef_AsPyObjectBorrow(list_st);
 
             assert(PyLong_CheckExact(sub));
-            DEOPT_IF(!PyList_CheckExact(list));
+            assert(PyList_CheckExact(list));
 
             // Deopt unless 0 <= sub < PyList_Size(list)
             DEOPT_IF(!_PyLong_IsNonNegativeCompact((PyLongObject *)sub));
@@ -913,15 +922,25 @@ dummy_func(
             res = PyStackRef_FromPyObjectImmortal(res_o);
         }
 
+        op(_GUARD_NOS_TUPLE, (nos, unused -- nos, unused)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+            EXIT_IF(!PyTuple_CheckExact(o));
+        }
+
+        op(_GUARD_TOS_TUPLE, (tos -- tos)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            EXIT_IF(!PyTuple_CheckExact(o));
+        }
+
         macro(BINARY_OP_SUBSCR_TUPLE_INT) =
-            _GUARD_TOS_INT + unused/5 + _BINARY_OP_SUBSCR_TUPLE_INT;
+            _GUARD_TOS_INT + _GUARD_NOS_TUPLE + unused/5 + _BINARY_OP_SUBSCR_TUPLE_INT;
 
         op(_BINARY_OP_SUBSCR_TUPLE_INT, (tuple_st, sub_st -- res)) {
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *tuple = PyStackRef_AsPyObjectBorrow(tuple_st);
 
             assert(PyLong_CheckExact(sub));
-            DEOPT_IF(!PyTuple_CheckExact(tuple));
+            assert(PyTuple_CheckExact(tuple));
 
             // Deopt unless 0 <= sub < PyTuple_Size(list)
             DEOPT_IF(!_PyLong_IsNonNegativeCompact((PyLongObject *)sub));
@@ -935,11 +954,24 @@ dummy_func(
             DECREF_INPUTS();
         }
 
-        inst(BINARY_OP_SUBSCR_DICT, (unused/5, dict_st, sub_st -- res)) {
+        op(_GUARD_NOS_DICT, (nos, unused -- nos, unused)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+            EXIT_IF(!PyDict_CheckExact(o));
+        }
+
+        op(_GUARD_TOS_DICT, (tos -- tos)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            EXIT_IF(!PyDict_CheckExact(o));
+        }
+
+        macro(BINARY_OP_SUBSCR_DICT) =
+            _GUARD_NOS_DICT + unused/5 + _BINARY_OP_SUBSCR_DICT;
+
+        op(_BINARY_OP_SUBSCR_DICT, (dict_st, sub_st -- res)) {
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
 
-            DEOPT_IF(!PyDict_CheckExact(dict));
+            assert(PyDict_CheckExact(dict));
             STAT_INC(BINARY_OP, hit);
             PyObject *res_o;
             int rc = PyDict_GetItemRef(dict, sub, &res_o);
@@ -1021,14 +1053,14 @@ dummy_func(
         macro(STORE_SUBSCR) = _SPECIALIZE_STORE_SUBSCR + _STORE_SUBSCR;
 
         macro(STORE_SUBSCR_LIST_INT) =
-            _GUARD_TOS_INT + unused/1 + _STORE_SUBSCR_LIST_INT;
+            _GUARD_TOS_INT + _GUARD_NOS_LIST + unused/1 + _STORE_SUBSCR_LIST_INT;
 
         op(_STORE_SUBSCR_LIST_INT, (value, list_st, sub_st -- )) {
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *list = PyStackRef_AsPyObjectBorrow(list_st);
 
             assert(PyLong_CheckExact(sub));
-            DEOPT_IF(!PyList_CheckExact(list));
+            assert(PyList_CheckExact(list));
 
             // Ensure nonnegative, zero-or-one-digit ints.
             DEOPT_IF(!_PyLong_IsNonNegativeCompact((PyLongObject *)sub));
@@ -1052,10 +1084,13 @@ dummy_func(
             Py_DECREF(old_value);
         }
 
-        inst(STORE_SUBSCR_DICT, (unused/1, value, dict_st, sub -- )) {
+        macro(STORE_SUBSCR_DICT) =
+            _GUARD_NOS_DICT + unused/1 + _STORE_SUBSCR_DICT;
+
+        op(_STORE_SUBSCR_DICT, (value, dict_st, sub -- )) {
             PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
 
-            DEOPT_IF(!PyDict_CheckExact(dict));
+            assert(PyDict_CheckExact(dict));
             STAT_INC(STORE_SUBSCR, hit);
             int err = _PyDict_SetItem_Take2((PyDictObject *)dict,
                                             PyStackRef_AsPyObjectSteal(sub),
@@ -1502,10 +1537,13 @@ dummy_func(
 
         macro(UNPACK_SEQUENCE) = _SPECIALIZE_UNPACK_SEQUENCE + _UNPACK_SEQUENCE;
 
-        inst(UNPACK_SEQUENCE_TWO_TUPLE, (unused/1, seq -- val1, val0)) {
+        macro(UNPACK_SEQUENCE_TWO_TUPLE) =
+            _GUARD_TOS_TUPLE + unused/1 + _UNPACK_SEQUENCE_TWO_TUPLE;
+
+        op(_UNPACK_SEQUENCE_TWO_TUPLE, (seq -- val1, val0)) {
             assert(oparg == 2);
             PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            DEOPT_IF(!PyTuple_CheckExact(seq_o));
+            assert(PyTuple_CheckExact(seq_o));
             DEOPT_IF(PyTuple_GET_SIZE(seq_o) != 2);
             STAT_INC(UNPACK_SEQUENCE, hit);
             val0 = PyStackRef_FromPyObjectNew(PyTuple_GET_ITEM(seq_o, 0));
@@ -1513,9 +1551,12 @@ dummy_func(
             PyStackRef_CLOSE(seq);
         }
 
-        inst(UNPACK_SEQUENCE_TUPLE, (unused/1, seq -- values[oparg])) {
+        macro(UNPACK_SEQUENCE_TUPLE) =
+            _GUARD_TOS_TUPLE + unused/1 + _UNPACK_SEQUENCE_TUPLE;
+
+        op(_UNPACK_SEQUENCE_TUPLE, (seq -- values[oparg])) {
             PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            DEOPT_IF(!PyTuple_CheckExact(seq_o));
+            assert(PyTuple_CheckExact(seq_o));
             DEOPT_IF(PyTuple_GET_SIZE(seq_o) != oparg);
             STAT_INC(UNPACK_SEQUENCE, hit);
             PyObject **items = _PyTuple_ITEMS(seq_o);
@@ -1525,9 +1566,12 @@ dummy_func(
             DECREF_INPUTS();
         }
 
-        inst(UNPACK_SEQUENCE_LIST, (unused/1, seq -- values[oparg])) {
+        macro(UNPACK_SEQUENCE_LIST) =
+            _GUARD_TOS_LIST + unused/1 + _UNPACK_SEQUENCE_LIST;
+
+        op(_UNPACK_SEQUENCE_LIST, (seq -- values[oparg])) {
             PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            DEOPT_IF(!PyList_CheckExact(seq_o));
+            assert(PyList_CheckExact(seq_o));
             DEOPT_IF(!LOCK_OBJECT(seq_o));
             if (PyList_GET_SIZE(seq_o) != oparg) {
                 UNLOCK_OBJECT(seq_o);
@@ -2686,11 +2730,18 @@ dummy_func(
 
         macro(CONTAINS_OP) = _SPECIALIZE_CONTAINS_OP + _CONTAINS_OP;
 
-        inst(CONTAINS_OP_SET, (unused/1, left, right -- b)) {
+        op(_GUARD_TOS_ANY_SET, (tos -- tos)) {
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            DEOPT_IF(!PyAnySet_CheckExact(o));
+        }
+
+        macro(CONTAINS_OP_SET) = _GUARD_TOS_ANY_SET + unused/1 + _CONTAINS_OP_SET;
+
+        op(_CONTAINS_OP_SET, (left, right -- b)) {
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
 
-            DEOPT_IF(!(PySet_CheckExact(right_o) || PyFrozenSet_CheckExact(right_o)));
+            assert(PyAnySet_CheckExact(right_o));
             STAT_INC(CONTAINS_OP, hit);
             // Note: both set and frozenset use the same seq_contains method!
             int res = _PySet_Contains((PySetObject *)right_o, left_o);
@@ -2699,11 +2750,13 @@ dummy_func(
             b = (res ^ oparg) ? PyStackRef_True : PyStackRef_False;
         }
 
-        inst(CONTAINS_OP_DICT, (unused/1, left, right -- b)) {
+        macro(CONTAINS_OP_DICT) = _GUARD_TOS_DICT + unused/1 + _CONTAINS_OP_DICT;
+
+        op(_CONTAINS_OP_DICT, (left, right -- b)) {
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
 
-            DEOPT_IF(!PyDict_CheckExact(right_o));
+            assert(PyDict_CheckExact(right_o));
             STAT_INC(CONTAINS_OP, hit);
             int res = PyDict_Contains(right_o, left_o);
             DECREF_INPUTS();
diff --git a/Python/executor_cases.c.h b/Python/executor_cases.c.h
index 3457ff0d6a1c06..938a80fe665c0b 100644
--- a/Python/executor_cases.c.h
+++ b/Python/executor_cases.c.h
@@ -719,15 +719,34 @@
             break;
         }
 
+        case _GUARD_NOS_LIST: {
+            _PyStackRef nos;
+            nos = stack_pointer[-2];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+            if (!PyList_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
+        case _GUARD_TOS_LIST: {
+            _PyStackRef tos;
+            tos = stack_pointer[-1];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            if (!PyList_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
         case _TO_BOOL_LIST: {
             _PyStackRef value;
             _PyStackRef res;
             value = stack_pointer[-1];
             PyObject *value_o = PyStackRef_AsPyObjectBorrow(value);
-            if (!PyList_CheckExact(value_o)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyList_CheckExact(value_o));
             STAT_INC(TO_BOOL, hit);
             res = PyList_GET_SIZE(value_o) ? PyStackRef_True : PyStackRef_False;
             _PyFrame_SetStackPointer(frame, stack_pointer);
@@ -754,11 +773,8 @@
         }
 
         case _GUARD_NOS_UNICODE: {
-            _PyStackRef tos;
             _PyStackRef nos;
-            tos = stack_pointer[-1];
             nos = stack_pointer[-2];
-            (void)tos;
             PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
             if (!PyUnicode_CheckExact(o)) {
                 UOP_STAT_INC(uopcode, miss);
@@ -841,11 +857,8 @@
         }
 
         case _GUARD_NOS_INT: {
-            _PyStackRef right;
             _PyStackRef left;
-            right = stack_pointer[-1];
             left = stack_pointer[-2];
-            (void)right;
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             if (!PyLong_CheckExact(left_o)) {
                 UOP_STAT_INC(uopcode, miss);
@@ -950,11 +963,8 @@
         }
 
         case _GUARD_NOS_FLOAT: {
-            _PyStackRef right;
             _PyStackRef left;
-            right = stack_pointer[-1];
             left = stack_pointer[-2];
-            (void)right;
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             if (!PyFloat_CheckExact(left_o)) {
                 UOP_STAT_INC(uopcode, miss);
@@ -1273,10 +1283,7 @@
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *list = PyStackRef_AsPyObjectBorrow(list_st);
             assert(PyLong_CheckExact(sub));
-            if (!PyList_CheckExact(list)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyList_CheckExact(list));
             if (!_PyLong_IsNonNegativeCompact((PyLongObject *)sub)) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
@@ -1357,6 +1364,28 @@
             break;
         }
 
+        case _GUARD_NOS_TUPLE: {
+            _PyStackRef nos;
+            nos = stack_pointer[-2];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+            if (!PyTuple_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
+        case _GUARD_TOS_TUPLE: {
+            _PyStackRef tos;
+            tos = stack_pointer[-1];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            if (!PyTuple_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
         case _BINARY_OP_SUBSCR_TUPLE_INT: {
             _PyStackRef sub_st;
             _PyStackRef tuple_st;
@@ -1366,10 +1395,7 @@
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *tuple = PyStackRef_AsPyObjectBorrow(tuple_st);
             assert(PyLong_CheckExact(sub));
-            if (!PyTuple_CheckExact(tuple)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyTuple_CheckExact(tuple));
             if (!_PyLong_IsNonNegativeCompact((PyLongObject *)sub)) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
@@ -1395,6 +1421,28 @@
             break;
         }
 
+        case _GUARD_NOS_DICT: {
+            _PyStackRef nos;
+            nos = stack_pointer[-2];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+            if (!PyDict_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
+        case _GUARD_TOS_DICT: {
+            _PyStackRef tos;
+            tos = stack_pointer[-1];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            if (!PyDict_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
         case _BINARY_OP_SUBSCR_DICT: {
             _PyStackRef sub_st;
             _PyStackRef dict_st;
@@ -1403,10 +1451,7 @@
             dict_st = stack_pointer[-2];
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
-            if (!PyDict_CheckExact(dict)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyDict_CheckExact(dict));
             STAT_INC(BINARY_OP, hit);
             PyObject *res_o;
             _PyFrame_SetStackPointer(frame, stack_pointer);
@@ -1570,10 +1615,7 @@
             PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
             PyObject *list = PyStackRef_AsPyObjectBorrow(list_st);
             assert(PyLong_CheckExact(sub));
-            if (!PyList_CheckExact(list)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyList_CheckExact(list));
             if (!_PyLong_IsNonNegativeCompact((PyLongObject *)sub)) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
@@ -1614,10 +1656,7 @@
             dict_st = stack_pointer[-2];
             value = stack_pointer[-3];
             PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
-            if (!PyDict_CheckExact(dict)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyDict_CheckExact(dict));
             STAT_INC(STORE_SUBSCR, hit);
             _PyFrame_SetStackPointer(frame, stack_pointer);
             int err = _PyDict_SetItem_Take2((PyDictObject *)dict,
@@ -2049,10 +2088,7 @@
             seq = stack_pointer[-1];
             assert(oparg == 2);
             PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            if (!PyTuple_CheckExact(seq_o)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyTuple_CheckExact(seq_o));
             if (PyTuple_GET_SIZE(seq_o) != 2) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
@@ -2077,10 +2113,7 @@
             seq = stack_pointer[-1];
             values = &stack_pointer[-1];
             PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            if (!PyTuple_CheckExact(seq_o)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyTuple_CheckExact(seq_o));
             if (PyTuple_GET_SIZE(seq_o) != oparg) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
@@ -2105,10 +2138,7 @@
             seq = stack_pointer[-1];
             values = &stack_pointer[-1];
             PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            if (!PyList_CheckExact(seq_o)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyList_CheckExact(seq_o));
             if (!LOCK_OBJECT(seq_o)) {
                 UOP_STAT_INC(uopcode, miss);
                 JUMP_TO_JUMP_TARGET();
@@ -3682,6 +3712,17 @@
             break;
         }
 
+        case _GUARD_TOS_ANY_SET: {
+            _PyStackRef tos;
+            tos = stack_pointer[-1];
+            PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+            if (!PyAnySet_CheckExact(o)) {
+                UOP_STAT_INC(uopcode, miss);
+                JUMP_TO_JUMP_TARGET();
+            }
+            break;
+        }
+
         case _CONTAINS_OP_SET: {
             _PyStackRef right;
             _PyStackRef left;
@@ -3691,10 +3732,7 @@
             left = stack_pointer[-2];
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
-            if (!(PySet_CheckExact(right_o) || PyFrozenSet_CheckExact(right_o))) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyAnySet_CheckExact(right_o));
             STAT_INC(CONTAINS_OP, hit);
             _PyFrame_SetStackPointer(frame, stack_pointer);
             int res = _PySet_Contains((PySetObject *)right_o, left_o);
@@ -3728,10 +3766,7 @@
             left = stack_pointer[-2];
             PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
             PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
-            if (!PyDict_CheckExact(right_o)) {
-                UOP_STAT_INC(uopcode, miss);
-                JUMP_TO_JUMP_TARGET();
-            }
+            assert(PyDict_CheckExact(right_o));
             STAT_INC(CONTAINS_OP, hit);
             _PyFrame_SetStackPointer(frame, stack_pointer);
             int res = PyDict_Contains(right_o, left_o);
diff --git a/Python/generated_cases.c.h b/Python/generated_cases.c.h
index fb4ab92c635d9e..97bffce8d82767 100644
--- a/Python/generated_cases.c.h
+++ b/Python/generated_cases.c.h
@@ -108,9 +108,7 @@
             }
             // _GUARD_NOS_FLOAT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyFloat_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -121,6 +119,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_ADD_FLOAT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 assert(PyFloat_CheckExact(left_o));
@@ -167,9 +166,7 @@
             }
             // _GUARD_NOS_INT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyLong_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -180,6 +177,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_ADD_INT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 assert(PyLong_CheckExact(left_o));
@@ -214,7 +212,6 @@
             static_assert(INLINE_CACHE_ENTRIES_BINARY_OP == 5, "incorrect cache size");
             _PyStackRef value;
             _PyStackRef nos;
-            _PyStackRef tos;
             _PyStackRef left;
             _PyStackRef right;
             _PyStackRef res;
@@ -230,9 +227,7 @@
             }
             // _GUARD_NOS_UNICODE
             {
-                tos = value;
                 nos = stack_pointer[-2];
-                (void)tos;
                 PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
                 if (!PyUnicode_CheckExact(o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -243,7 +238,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_ADD_UNICODE
             {
-                right = tos;
+                right = value;
                 left = nos;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
@@ -341,7 +336,6 @@
             static_assert(INLINE_CACHE_ENTRIES_BINARY_OP == 5, "incorrect cache size");
             _PyStackRef value;
             _PyStackRef nos;
-            _PyStackRef tos;
             _PyStackRef left;
             _PyStackRef right;
             // _GUARD_TOS_UNICODE
@@ -356,9 +350,7 @@
             }
             // _GUARD_NOS_UNICODE
             {
-                tos = value;
                 nos = stack_pointer[-2];
-                (void)tos;
                 PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
                 if (!PyUnicode_CheckExact(o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -369,7 +361,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_INPLACE_ADD_UNICODE
             {
-                right = tos;
+                right = value;
                 left = nos;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 assert(PyUnicode_CheckExact(left_o));
@@ -441,9 +433,7 @@
             }
             // _GUARD_NOS_FLOAT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyFloat_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -454,6 +444,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_MULTIPLY_FLOAT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 assert(PyFloat_CheckExact(left_o));
@@ -500,9 +491,7 @@
             }
             // _GUARD_NOS_INT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyLong_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -513,6 +502,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_MULTIPLY_INT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 assert(PyLong_CheckExact(left_o));
@@ -545,45 +535,55 @@
             next_instr += 6;
             INSTRUCTION_STATS(BINARY_OP_SUBSCR_DICT);
             static_assert(INLINE_CACHE_ENTRIES_BINARY_OP == 5, "incorrect cache size");
+            _PyStackRef nos;
             _PyStackRef dict_st;
             _PyStackRef sub_st;
             _PyStackRef res;
-            /* Skip 5 cache entries */
-            sub_st = stack_pointer[-1];
-            dict_st = stack_pointer[-2];
-            PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
-            PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
-            if (!PyDict_CheckExact(dict)) {
-                UPDATE_MISS_STATS(BINARY_OP);
-                assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
-                JUMP_TO_PREDICTED(BINARY_OP);
+            // _GUARD_NOS_DICT
+            {
+                nos = stack_pointer[-2];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+                if (!PyDict_CheckExact(o)) {
+                    UPDATE_MISS_STATS(BINARY_OP);
+                    assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
+                    JUMP_TO_PREDICTED(BINARY_OP);
+                }
             }
-            STAT_INC(BINARY_OP, hit);
-            PyObject *res_o;
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            int rc = PyDict_GetItemRef(dict, sub, &res_o);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
-            if (rc == 0) {
+            /* Skip 5 cache entries */
+            // _BINARY_OP_SUBSCR_DICT
+            {
+                sub_st = stack_pointer[-1];
+                dict_st = nos;
+                PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
+                PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
+                assert(PyDict_CheckExact(dict));
+                STAT_INC(BINARY_OP, hit);
+                PyObject *res_o;
                 _PyFrame_SetStackPointer(frame, stack_pointer);
-                _PyErr_SetKeyError(sub);
+                int rc = PyDict_GetItemRef(dict, sub, &res_o);
                 stack_pointer = _PyFrame_GetStackPointer(frame);
+                if (rc == 0) {
+                    _PyFrame_SetStackPointer(frame, stack_pointer);
+                    _PyErr_SetKeyError(sub);
+                    stack_pointer = _PyFrame_GetStackPointer(frame);
+                }
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                _PyStackRef tmp = sub_st;
+                sub_st = PyStackRef_NULL;
+                stack_pointer[-1] = sub_st;
+                PyStackRef_CLOSE(tmp);
+                tmp = dict_st;
+                dict_st = PyStackRef_NULL;
+                stack_pointer[-2] = dict_st;
+                PyStackRef_CLOSE(tmp);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+                stack_pointer += -2;
+                assert(WITHIN_STACK_BOUNDS());
+                if (rc <= 0) {
+                    JUMP_TO_LABEL(error);
+                }
+                res = PyStackRef_FromPyObjectSteal(res_o);
             }
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            _PyStackRef tmp = sub_st;
-            sub_st = PyStackRef_NULL;
-            stack_pointer[-1] = sub_st;
-            PyStackRef_CLOSE(tmp);
-            tmp = dict_st;
-            dict_st = PyStackRef_NULL;
-            stack_pointer[-2] = dict_st;
-            PyStackRef_CLOSE(tmp);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
-            stack_pointer += -2;
-            assert(WITHIN_STACK_BOUNDS());
-            if (rc <= 0) {
-                JUMP_TO_LABEL(error);
-            }
-            res = PyStackRef_FromPyObjectSteal(res_o);
             stack_pointer[0] = res;
             stack_pointer += 1;
             assert(WITHIN_STACK_BOUNDS());
@@ -685,6 +685,7 @@
             INSTRUCTION_STATS(BINARY_OP_SUBSCR_LIST_INT);
             static_assert(INLINE_CACHE_ENTRIES_BINARY_OP == 5, "incorrect cache size");
             _PyStackRef value;
+            _PyStackRef nos;
             _PyStackRef list_st;
             _PyStackRef sub_st;
             _PyStackRef res;
@@ -698,19 +699,25 @@
                     JUMP_TO_PREDICTED(BINARY_OP);
                 }
             }
+            // _GUARD_NOS_LIST
+            {
+                nos = stack_pointer[-2];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+                if (!PyList_CheckExact(o)) {
+                    UPDATE_MISS_STATS(BINARY_OP);
+                    assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
+                    JUMP_TO_PREDICTED(BINARY_OP);
+                }
+            }
             /* Skip 5 cache entries */
             // _BINARY_OP_SUBSCR_LIST_INT
             {
                 sub_st = value;
-                list_st = stack_pointer[-2];
+                list_st = nos;
                 PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
                 PyObject *list = PyStackRef_AsPyObjectBorrow(list_st);
                 assert(PyLong_CheckExact(sub));
-                if (!PyList_CheckExact(list)) {
-                    UPDATE_MISS_STATS(BINARY_OP);
-                    assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
-                    JUMP_TO_PREDICTED(BINARY_OP);
-                }
+                assert(PyList_CheckExact(list));
                 if (!_PyLong_IsNonNegativeCompact((PyLongObject *)sub)) {
                     UPDATE_MISS_STATS(BINARY_OP);
                     assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
@@ -769,7 +776,6 @@
             static_assert(INLINE_CACHE_ENTRIES_BINARY_OP == 5, "incorrect cache size");
             _PyStackRef value;
             _PyStackRef nos;
-            _PyStackRef tos;
             _PyStackRef str_st;
             _PyStackRef sub_st;
             _PyStackRef res;
@@ -785,9 +791,7 @@
             }
             // _GUARD_NOS_UNICODE
             {
-                tos = value;
                 nos = stack_pointer[-2];
-                (void)tos;
                 PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
                 if (!PyUnicode_CheckExact(o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -798,7 +802,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_SUBSCR_STR_INT
             {
-                sub_st = tos;
+                sub_st = value;
                 str_st = nos;
                 PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
                 PyObject *str = PyStackRef_AsPyObjectBorrow(str_st);
@@ -849,6 +853,7 @@
             INSTRUCTION_STATS(BINARY_OP_SUBSCR_TUPLE_INT);
             static_assert(INLINE_CACHE_ENTRIES_BINARY_OP == 5, "incorrect cache size");
             _PyStackRef value;
+            _PyStackRef nos;
             _PyStackRef tuple_st;
             _PyStackRef sub_st;
             _PyStackRef res;
@@ -862,19 +867,25 @@
                     JUMP_TO_PREDICTED(BINARY_OP);
                 }
             }
+            // _GUARD_NOS_TUPLE
+            {
+                nos = stack_pointer[-2];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+                if (!PyTuple_CheckExact(o)) {
+                    UPDATE_MISS_STATS(BINARY_OP);
+                    assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
+                    JUMP_TO_PREDICTED(BINARY_OP);
+                }
+            }
             /* Skip 5 cache entries */
             // _BINARY_OP_SUBSCR_TUPLE_INT
             {
                 sub_st = value;
-                tuple_st = stack_pointer[-2];
+                tuple_st = nos;
                 PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
                 PyObject *tuple = PyStackRef_AsPyObjectBorrow(tuple_st);
                 assert(PyLong_CheckExact(sub));
-                if (!PyTuple_CheckExact(tuple)) {
-                    UPDATE_MISS_STATS(BINARY_OP);
-                    assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
-                    JUMP_TO_PREDICTED(BINARY_OP);
-                }
+                assert(PyTuple_CheckExact(tuple));
                 if (!_PyLong_IsNonNegativeCompact((PyLongObject *)sub)) {
                     UPDATE_MISS_STATS(BINARY_OP);
                     assert(_PyOpcode_Deopt[opcode] == (BINARY_OP));
@@ -930,9 +941,7 @@
             }
             // _GUARD_NOS_FLOAT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyFloat_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -943,6 +952,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_SUBTRACT_FLOAT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 assert(PyFloat_CheckExact(left_o));
@@ -989,9 +999,7 @@
             }
             // _GUARD_NOS_INT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyLong_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(BINARY_OP);
@@ -1002,6 +1010,7 @@
             /* Skip 5 cache entries */
             // _BINARY_OP_SUBTRACT_INT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 assert(PyLong_CheckExact(left_o));
@@ -4546,9 +4555,7 @@
             }
             // _GUARD_NOS_FLOAT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyFloat_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(COMPARE_OP);
@@ -4559,6 +4566,7 @@
             /* Skip 1 cache entry */
             // _COMPARE_OP_FLOAT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 STAT_INC(COMPARE_OP, hit);
@@ -4602,9 +4610,7 @@
             }
             // _GUARD_NOS_INT
             {
-                right = value;
                 left = stack_pointer[-2];
-                (void)right;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 if (!PyLong_CheckExact(left_o)) {
                     UPDATE_MISS_STATS(COMPARE_OP);
@@ -4615,6 +4621,7 @@
             /* Skip 1 cache entry */
             // _COMPARE_OP_INT
             {
+                right = value;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
                 if (!_PyLong_IsCompact((PyLongObject *)left_o)) {
@@ -4656,7 +4663,6 @@
             static_assert(INLINE_CACHE_ENTRIES_COMPARE_OP == 1, "incorrect cache size");
             _PyStackRef value;
             _PyStackRef nos;
-            _PyStackRef tos;
             _PyStackRef left;
             _PyStackRef right;
             _PyStackRef res;
@@ -4672,9 +4678,7 @@
             }
             // _GUARD_NOS_UNICODE
             {
-                tos = value;
                 nos = stack_pointer[-2];
-                (void)tos;
                 PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
                 if (!PyUnicode_CheckExact(o)) {
                     UPDATE_MISS_STATS(COMPARE_OP);
@@ -4685,7 +4689,7 @@
             /* Skip 1 cache entry */
             // _COMPARE_OP_STR
             {
-                right = tos;
+                right = value;
                 left = nos;
                 PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
                 PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
@@ -4776,37 +4780,47 @@
             next_instr += 2;
             INSTRUCTION_STATS(CONTAINS_OP_DICT);
             static_assert(INLINE_CACHE_ENTRIES_CONTAINS_OP == 1, "incorrect cache size");
+            _PyStackRef tos;
             _PyStackRef left;
             _PyStackRef right;
             _PyStackRef b;
-            /* Skip 1 cache entry */
-            right = stack_pointer[-1];
-            left = stack_pointer[-2];
-            PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
-            PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
-            if (!PyDict_CheckExact(right_o)) {
-                UPDATE_MISS_STATS(CONTAINS_OP);
-                assert(_PyOpcode_Deopt[opcode] == (CONTAINS_OP));
-                JUMP_TO_PREDICTED(CONTAINS_OP);
+            // _GUARD_TOS_DICT
+            {
+                tos = stack_pointer[-1];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+                if (!PyDict_CheckExact(o)) {
+                    UPDATE_MISS_STATS(CONTAINS_OP);
+                    assert(_PyOpcode_Deopt[opcode] == (CONTAINS_OP));
+                    JUMP_TO_PREDICTED(CONTAINS_OP);
+                }
             }
-            STAT_INC(CONTAINS_OP, hit);
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            int res = PyDict_Contains(right_o, left_o);
-            _PyStackRef tmp = right;
-            right = PyStackRef_NULL;
-            stack_pointer[-1] = right;
-            PyStackRef_CLOSE(tmp);
-            tmp = left;
-            left = PyStackRef_NULL;
-            stack_pointer[-2] = left;
-            PyStackRef_CLOSE(tmp);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
-            stack_pointer += -2;
-            assert(WITHIN_STACK_BOUNDS());
-            if (res < 0) {
-                JUMP_TO_LABEL(error);
+            /* Skip 1 cache entry */
+            // _CONTAINS_OP_DICT
+            {
+                right = tos;
+                left = stack_pointer[-2];
+                PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
+                PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
+                assert(PyDict_CheckExact(right_o));
+                STAT_INC(CONTAINS_OP, hit);
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                int res = PyDict_Contains(right_o, left_o);
+                _PyStackRef tmp = right;
+                right = PyStackRef_NULL;
+                stack_pointer[-1] = right;
+                PyStackRef_CLOSE(tmp);
+                tmp = left;
+                left = PyStackRef_NULL;
+                stack_pointer[-2] = left;
+                PyStackRef_CLOSE(tmp);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+                stack_pointer += -2;
+                assert(WITHIN_STACK_BOUNDS());
+                if (res < 0) {
+                    JUMP_TO_LABEL(error);
+                }
+                b = (res ^ oparg) ? PyStackRef_True : PyStackRef_False;
             }
-            b = (res ^ oparg) ? PyStackRef_True : PyStackRef_False;
             stack_pointer[0] = b;
             stack_pointer += 1;
             assert(WITHIN_STACK_BOUNDS());
@@ -4824,37 +4838,47 @@
             next_instr += 2;
             INSTRUCTION_STATS(CONTAINS_OP_SET);
             static_assert(INLINE_CACHE_ENTRIES_CONTAINS_OP == 1, "incorrect cache size");
+            _PyStackRef tos;
             _PyStackRef left;
             _PyStackRef right;
             _PyStackRef b;
-            /* Skip 1 cache entry */
-            right = stack_pointer[-1];
-            left = stack_pointer[-2];
-            PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
-            PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
-            if (!(PySet_CheckExact(right_o) || PyFrozenSet_CheckExact(right_o))) {
-                UPDATE_MISS_STATS(CONTAINS_OP);
-                assert(_PyOpcode_Deopt[opcode] == (CONTAINS_OP));
-                JUMP_TO_PREDICTED(CONTAINS_OP);
+            // _GUARD_TOS_ANY_SET
+            {
+                tos = stack_pointer[-1];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+                if (!PyAnySet_CheckExact(o)) {
+                    UPDATE_MISS_STATS(CONTAINS_OP);
+                    assert(_PyOpcode_Deopt[opcode] == (CONTAINS_OP));
+                    JUMP_TO_PREDICTED(CONTAINS_OP);
+                }
             }
-            STAT_INC(CONTAINS_OP, hit);
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            int res = _PySet_Contains((PySetObject *)right_o, left_o);
-            _PyStackRef tmp = right;
-            right = PyStackRef_NULL;
-            stack_pointer[-1] = right;
-            PyStackRef_CLOSE(tmp);
-            tmp = left;
-            left = PyStackRef_NULL;
-            stack_pointer[-2] = left;
-            PyStackRef_CLOSE(tmp);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
-            stack_pointer += -2;
-            assert(WITHIN_STACK_BOUNDS());
-            if (res < 0) {
-                JUMP_TO_LABEL(error);
+            /* Skip 1 cache entry */
+            // _CONTAINS_OP_SET
+            {
+                right = tos;
+                left = stack_pointer[-2];
+                PyObject *left_o = PyStackRef_AsPyObjectBorrow(left);
+                PyObject *right_o = PyStackRef_AsPyObjectBorrow(right);
+                assert(PyAnySet_CheckExact(right_o));
+                STAT_INC(CONTAINS_OP, hit);
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                int res = _PySet_Contains((PySetObject *)right_o, left_o);
+                _PyStackRef tmp = right;
+                right = PyStackRef_NULL;
+                stack_pointer[-1] = right;
+                PyStackRef_CLOSE(tmp);
+                tmp = left;
+                left = PyStackRef_NULL;
+                stack_pointer[-2] = left;
+                PyStackRef_CLOSE(tmp);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+                stack_pointer += -2;
+                assert(WITHIN_STACK_BOUNDS());
+                if (res < 0) {
+                    JUMP_TO_LABEL(error);
+                }
+                b = (res ^ oparg) ? PyStackRef_True : PyStackRef_False;
             }
-            b = (res ^ oparg) ? PyStackRef_True : PyStackRef_False;
             stack_pointer[0] = b;
             stack_pointer += 1;
             assert(WITHIN_STACK_BOUNDS());
@@ -11205,32 +11229,42 @@
             next_instr += 2;
             INSTRUCTION_STATS(STORE_SUBSCR_DICT);
             static_assert(INLINE_CACHE_ENTRIES_STORE_SUBSCR == 1, "incorrect cache size");
+            _PyStackRef nos;
             _PyStackRef value;
             _PyStackRef dict_st;
             _PyStackRef sub;
-            /* Skip 1 cache entry */
-            sub = stack_pointer[-1];
-            dict_st = stack_pointer[-2];
-            value = stack_pointer[-3];
-            PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
-            if (!PyDict_CheckExact(dict)) {
-                UPDATE_MISS_STATS(STORE_SUBSCR);
-                assert(_PyOpcode_Deopt[opcode] == (STORE_SUBSCR));
-                JUMP_TO_PREDICTED(STORE_SUBSCR);
+            // _GUARD_NOS_DICT
+            {
+                nos = stack_pointer[-2];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+                if (!PyDict_CheckExact(o)) {
+                    UPDATE_MISS_STATS(STORE_SUBSCR);
+                    assert(_PyOpcode_Deopt[opcode] == (STORE_SUBSCR));
+                    JUMP_TO_PREDICTED(STORE_SUBSCR);
+                }
             }
-            STAT_INC(STORE_SUBSCR, hit);
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            int err = _PyDict_SetItem_Take2((PyDictObject *)dict,
-                PyStackRef_AsPyObjectSteal(sub),
-                PyStackRef_AsPyObjectSteal(value));
-            stack_pointer = _PyFrame_GetStackPointer(frame);
-            stack_pointer += -3;
-            assert(WITHIN_STACK_BOUNDS());
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            PyStackRef_CLOSE(dict_st);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
-            if (err) {
-                JUMP_TO_LABEL(error);
+            /* Skip 1 cache entry */
+            // _STORE_SUBSCR_DICT
+            {
+                sub = stack_pointer[-1];
+                dict_st = nos;
+                value = stack_pointer[-3];
+                PyObject *dict = PyStackRef_AsPyObjectBorrow(dict_st);
+                assert(PyDict_CheckExact(dict));
+                STAT_INC(STORE_SUBSCR, hit);
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                int err = _PyDict_SetItem_Take2((PyDictObject *)dict,
+                    PyStackRef_AsPyObjectSteal(sub),
+                    PyStackRef_AsPyObjectSteal(value));
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+                stack_pointer += -3;
+                assert(WITHIN_STACK_BOUNDS());
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                PyStackRef_CLOSE(dict_st);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+                if (err) {
+                    JUMP_TO_LABEL(error);
+                }
             }
             DISPATCH();
         }
@@ -11247,6 +11281,7 @@
             INSTRUCTION_STATS(STORE_SUBSCR_LIST_INT);
             static_assert(INLINE_CACHE_ENTRIES_STORE_SUBSCR == 1, "incorrect cache size");
             _PyStackRef value;
+            _PyStackRef nos;
             _PyStackRef list_st;
             _PyStackRef sub_st;
             // _GUARD_TOS_INT
@@ -11259,20 +11294,26 @@
                     JUMP_TO_PREDICTED(STORE_SUBSCR);
                 }
             }
+            // _GUARD_NOS_LIST
+            {
+                nos = stack_pointer[-2];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(nos);
+                if (!PyList_CheckExact(o)) {
+                    UPDATE_MISS_STATS(STORE_SUBSCR);
+                    assert(_PyOpcode_Deopt[opcode] == (STORE_SUBSCR));
+                    JUMP_TO_PREDICTED(STORE_SUBSCR);
+                }
+            }
             /* Skip 1 cache entry */
             // _STORE_SUBSCR_LIST_INT
             {
                 sub_st = value;
-                list_st = stack_pointer[-2];
+                list_st = nos;
                 value = stack_pointer[-3];
                 PyObject *sub = PyStackRef_AsPyObjectBorrow(sub_st);
                 PyObject *list = PyStackRef_AsPyObjectBorrow(list_st);
                 assert(PyLong_CheckExact(sub));
-                if (!PyList_CheckExact(list)) {
-                    UPDATE_MISS_STATS(STORE_SUBSCR);
-                    assert(_PyOpcode_Deopt[opcode] == (STORE_SUBSCR));
-                    JUMP_TO_PREDICTED(STORE_SUBSCR);
-                }
+                assert(PyList_CheckExact(list));
                 if (!_PyLong_IsNonNegativeCompact((PyLongObject *)sub)) {
                     UPDATE_MISS_STATS(STORE_SUBSCR);
                     assert(_PyOpcode_Deopt[opcode] == (STORE_SUBSCR));
@@ -11498,25 +11539,35 @@
             next_instr += 4;
             INSTRUCTION_STATS(TO_BOOL_LIST);
             static_assert(INLINE_CACHE_ENTRIES_TO_BOOL == 3, "incorrect cache size");
+            _PyStackRef tos;
             _PyStackRef value;
             _PyStackRef res;
+            // _GUARD_TOS_LIST
+            {
+                tos = stack_pointer[-1];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+                if (!PyList_CheckExact(o)) {
+                    UPDATE_MISS_STATS(TO_BOOL);
+                    assert(_PyOpcode_Deopt[opcode] == (TO_BOOL));
+                    JUMP_TO_PREDICTED(TO_BOOL);
+                }
+            }
             /* Skip 1 cache entry */
             /* Skip 2 cache entries */
-            value = stack_pointer[-1];
-            PyObject *value_o = PyStackRef_AsPyObjectBorrow(value);
-            if (!PyList_CheckExact(value_o)) {
-                UPDATE_MISS_STATS(TO_BOOL);
-                assert(_PyOpcode_Deopt[opcode] == (TO_BOOL));
-                JUMP_TO_PREDICTED(TO_BOOL);
+            // _TO_BOOL_LIST
+            {
+                value = tos;
+                PyObject *value_o = PyStackRef_AsPyObjectBorrow(value);
+                assert(PyList_CheckExact(value_o));
+                STAT_INC(TO_BOOL, hit);
+                res = PyList_GET_SIZE(value_o) ? PyStackRef_True : PyStackRef_False;
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                _PyStackRef tmp = value;
+                value = res;
+                stack_pointer[-1] = value;
+                PyStackRef_CLOSE(tmp);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
             }
-            STAT_INC(TO_BOOL, hit);
-            res = PyList_GET_SIZE(value_o) ? PyStackRef_True : PyStackRef_False;
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            _PyStackRef tmp = value;
-            value = res;
-            stack_pointer[-1] = value;
-            PyStackRef_CLOSE(tmp);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
             DISPATCH();
         }
 
@@ -11760,41 +11811,51 @@
             next_instr += 2;
             INSTRUCTION_STATS(UNPACK_SEQUENCE_LIST);
             static_assert(INLINE_CACHE_ENTRIES_UNPACK_SEQUENCE == 1, "incorrect cache size");
+            _PyStackRef tos;
             _PyStackRef seq;
             _PyStackRef *values;
-            /* Skip 1 cache entry */
-            seq = stack_pointer[-1];
-            values = &stack_pointer[-1];
-            PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            if (!PyList_CheckExact(seq_o)) {
-                UPDATE_MISS_STATS(UNPACK_SEQUENCE);
-                assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
-                JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
-            }
-            if (!LOCK_OBJECT(seq_o)) {
-                UPDATE_MISS_STATS(UNPACK_SEQUENCE);
-                assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
-                JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
-            }
-            if (PyList_GET_SIZE(seq_o) != oparg) {
-                UNLOCK_OBJECT(seq_o);
-                if (true) {
+            // _GUARD_TOS_LIST
+            {
+                tos = stack_pointer[-1];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+                if (!PyList_CheckExact(o)) {
                     UPDATE_MISS_STATS(UNPACK_SEQUENCE);
                     assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
                     JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
                 }
             }
-            STAT_INC(UNPACK_SEQUENCE, hit);
-            PyObject **items = _PyList_ITEMS(seq_o);
-            for (int i = oparg; --i >= 0; ) {
-                *values++ = PyStackRef_FromPyObjectNew(items[i]);
+            /* Skip 1 cache entry */
+            // _UNPACK_SEQUENCE_LIST
+            {
+                seq = tos;
+                values = &stack_pointer[-1];
+                PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
+                assert(PyList_CheckExact(seq_o));
+                if (!LOCK_OBJECT(seq_o)) {
+                    UPDATE_MISS_STATS(UNPACK_SEQUENCE);
+                    assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
+                    JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+                }
+                if (PyList_GET_SIZE(seq_o) != oparg) {
+                    UNLOCK_OBJECT(seq_o);
+                    if (true) {
+                        UPDATE_MISS_STATS(UNPACK_SEQUENCE);
+                        assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
+                        JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+                    }
+                }
+                STAT_INC(UNPACK_SEQUENCE, hit);
+                PyObject **items = _PyList_ITEMS(seq_o);
+                for (int i = oparg; --i >= 0; ) {
+                    *values++ = PyStackRef_FromPyObjectNew(items[i]);
+                }
+                UNLOCK_OBJECT(seq_o);
+                stack_pointer += -1 + oparg;
+                assert(WITHIN_STACK_BOUNDS());
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                PyStackRef_CLOSE(seq);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
             }
-            UNLOCK_OBJECT(seq_o);
-            stack_pointer += -1 + oparg;
-            assert(WITHIN_STACK_BOUNDS());
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            PyStackRef_CLOSE(seq);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
             DISPATCH();
         }
 
@@ -11809,32 +11870,42 @@
             next_instr += 2;
             INSTRUCTION_STATS(UNPACK_SEQUENCE_TUPLE);
             static_assert(INLINE_CACHE_ENTRIES_UNPACK_SEQUENCE == 1, "incorrect cache size");
+            _PyStackRef tos;
             _PyStackRef seq;
             _PyStackRef *values;
-            /* Skip 1 cache entry */
-            seq = stack_pointer[-1];
-            values = &stack_pointer[-1];
-            PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            if (!PyTuple_CheckExact(seq_o)) {
-                UPDATE_MISS_STATS(UNPACK_SEQUENCE);
-                assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
-                JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
-            }
-            if (PyTuple_GET_SIZE(seq_o) != oparg) {
-                UPDATE_MISS_STATS(UNPACK_SEQUENCE);
-                assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
-                JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+            // _GUARD_TOS_TUPLE
+            {
+                tos = stack_pointer[-1];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+                if (!PyTuple_CheckExact(o)) {
+                    UPDATE_MISS_STATS(UNPACK_SEQUENCE);
+                    assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
+                    JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+                }
             }
-            STAT_INC(UNPACK_SEQUENCE, hit);
-            PyObject **items = _PyTuple_ITEMS(seq_o);
-            for (int i = oparg; --i >= 0; ) {
-                *values++ = PyStackRef_FromPyObjectNew(items[i]);
+            /* Skip 1 cache entry */
+            // _UNPACK_SEQUENCE_TUPLE
+            {
+                seq = tos;
+                values = &stack_pointer[-1];
+                PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
+                assert(PyTuple_CheckExact(seq_o));
+                if (PyTuple_GET_SIZE(seq_o) != oparg) {
+                    UPDATE_MISS_STATS(UNPACK_SEQUENCE);
+                    assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
+                    JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+                }
+                STAT_INC(UNPACK_SEQUENCE, hit);
+                PyObject **items = _PyTuple_ITEMS(seq_o);
+                for (int i = oparg; --i >= 0; ) {
+                    *values++ = PyStackRef_FromPyObjectNew(items[i]);
+                }
+                stack_pointer += -1 + oparg;
+                assert(WITHIN_STACK_BOUNDS());
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                PyStackRef_CLOSE(seq);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
             }
-            stack_pointer += -1 + oparg;
-            assert(WITHIN_STACK_BOUNDS());
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            PyStackRef_CLOSE(seq);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
             DISPATCH();
         }
 
@@ -11849,33 +11920,43 @@
             next_instr += 2;
             INSTRUCTION_STATS(UNPACK_SEQUENCE_TWO_TUPLE);
             static_assert(INLINE_CACHE_ENTRIES_UNPACK_SEQUENCE == 1, "incorrect cache size");
+            _PyStackRef tos;
             _PyStackRef seq;
             _PyStackRef val1;
             _PyStackRef val0;
+            // _GUARD_TOS_TUPLE
+            {
+                tos = stack_pointer[-1];
+                PyObject *o = PyStackRef_AsPyObjectBorrow(tos);
+                if (!PyTuple_CheckExact(o)) {
+                    UPDATE_MISS_STATS(UNPACK_SEQUENCE);
+                    assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
+                    JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+                }
+            }
             /* Skip 1 cache entry */
-            seq = stack_pointer[-1];
-            assert(oparg == 2);
-            PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
-            if (!PyTuple_CheckExact(seq_o)) {
-                UPDATE_MISS_STATS(UNPACK_SEQUENCE);
-                assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
-                JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
-            }
-            if (PyTuple_GET_SIZE(seq_o) != 2) {
-                UPDATE_MISS_STATS(UNPACK_SEQUENCE);
-                assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
-                JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
-            }
-            STAT_INC(UNPACK_SEQUENCE, hit);
-            val0 = PyStackRef_FromPyObjectNew(PyTuple_GET_ITEM(seq_o, 0));
-            val1 = PyStackRef_FromPyObjectNew(PyTuple_GET_ITEM(seq_o, 1));
-            stack_pointer[-1] = val1;
-            stack_pointer[0] = val0;
-            stack_pointer += 1;
-            assert(WITHIN_STACK_BOUNDS());
-            _PyFrame_SetStackPointer(frame, stack_pointer);
-            PyStackRef_CLOSE(seq);
-            stack_pointer = _PyFrame_GetStackPointer(frame);
+            // _UNPACK_SEQUENCE_TWO_TUPLE
+            {
+                seq = tos;
+                assert(oparg == 2);
+                PyObject *seq_o = PyStackRef_AsPyObjectBorrow(seq);
+                assert(PyTuple_CheckExact(seq_o));
+                if (PyTuple_GET_SIZE(seq_o) != 2) {
+                    UPDATE_MISS_STATS(UNPACK_SEQUENCE);
+                    assert(_PyOpcode_Deopt[opcode] == (UNPACK_SEQUENCE));
+                    JUMP_TO_PREDICTED(UNPACK_SEQUENCE);
+                }
+                STAT_INC(UNPACK_SEQUENCE, hit);
+                val0 = PyStackRef_FromPyObjectNew(PyTuple_GET_ITEM(seq_o, 0));
+                val1 = PyStackRef_FromPyObjectNew(PyTuple_GET_ITEM(seq_o, 1));
+                stack_pointer[-1] = val1;
+                stack_pointer[0] = val0;
+                stack_pointer += 1;
+                assert(WITHIN_STACK_BOUNDS());
+                _PyFrame_SetStackPointer(frame, stack_pointer);
+                PyStackRef_CLOSE(seq);
+                stack_pointer = _PyFrame_GetStackPointer(frame);
+            }
             DISPATCH();
         }
 
diff --git a/Python/optimizer_bytecodes.c b/Python/optimizer_bytecodes.c
index 0f7e183608e3e9..8e1eacfec83e95 100644
--- a/Python/optimizer_bytecodes.c
+++ b/Python/optimizer_bytecodes.c
@@ -396,7 +396,6 @@ dummy_func(void) {
     op(_TO_BOOL_LIST, (value -- res)) {
         int already_bool = optimize_to_bool(this_instr, ctx, value, &res);
         if (!already_bool) {
-            sym_set_type(value, &PyList_Type);
             res = sym_new_type(ctx, &PyBool_Type);
         }
     }
@@ -927,7 +926,57 @@ dummy_func(void) {
 
     op(_UNPACK_SEQUENCE_TUPLE, (seq -- values[oparg])) {
         for (int i = 0; i < oparg; i++) {
-            values[i] = sym_tuple_getitem(ctx, seq, i);
+            values[i] = sym_tuple_getitem(ctx, seq, oparg - i - 1);
+        }
+    }
+
+    op(_GUARD_TOS_LIST, (tos -- tos)) {
+        if (sym_matches_type(tos, &PyList_Type)) {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
+        }
+        sym_set_type(tos, &PyList_Type);
+    }
+
+    op(_GUARD_NOS_LIST, (nos, unused -- nos, unused)) {
+        if (sym_matches_type(nos, &PyList_Type)) {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
+        }
+        sym_set_type(nos, &PyList_Type);
+    }
+
+    op(_GUARD_TOS_TUPLE, (tos -- tos)) {
+        if (sym_matches_type(tos, &PyTuple_Type)) {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
+        }
+        sym_set_type(tos, &PyTuple_Type);
+    }
+
+    op(_GUARD_NOS_TUPLE, (nos, unused -- nos, unused)) {
+        if (sym_matches_type(nos, &PyTuple_Type)) {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
+        }
+        sym_set_type(nos, &PyTuple_Type);
+    }
+
+    op(_GUARD_TOS_DICT, (tos -- tos)) {
+        if (sym_matches_type(tos, &PyDict_Type)) {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
+        }
+        sym_set_type(tos, &PyDict_Type);
+    }
+
+    op(_GUARD_NOS_DICT, (nos, unused -- nos, unused)) {
+        if (sym_matches_type(nos, &PyDict_Type)) {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
+        }
+        sym_set_type(nos, &PyDict_Type);
+    }
+
+    op(_GUARD_TOS_ANY_SET, (tos -- tos)) {
+        if (sym_matches_type(tos, &PySet_Type) ||
+            sym_matches_type(tos, &PyFrozenSet_Type))
+        {
+            REPLACE_OP(this_instr, _NOP, 0, 0);
         }
     }
 
diff --git a/Python/optimizer_cases.c.h b/Python/optimizer_cases.c.h
index 0df52e654432b6..0c617137a8893d 100644
--- a/Python/optimizer_cases.c.h
+++ b/Python/optimizer_cases.c.h
@@ -195,13 +195,32 @@
             break;
         }
 
+        case _GUARD_NOS_LIST: {
+            JitOptSymbol *nos;
+            nos = stack_pointer[-2];
+            if (sym_matches_type(nos, &PyList_Type)) {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            sym_set_type(nos, &PyList_Type);
+            break;
+        }
+
+        case _GUARD_TOS_LIST: {
+            JitOptSymbol *tos;
+            tos = stack_pointer[-1];
+            if (sym_matches_type(tos, &PyList_Type)) {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            sym_set_type(tos, &PyList_Type);
+            break;
+        }
+
         case _TO_BOOL_LIST: {
             JitOptSymbol *value;
             JitOptSymbol *res;
             value = stack_pointer[-1];
             int already_bool = optimize_to_bool(this_instr, ctx, value, &res);
             if (!already_bool) {
-                sym_set_type(value, &PyList_Type);
                 res = sym_new_type(ctx, &PyBool_Type);
             }
             stack_pointer[-1] = res;
@@ -576,6 +595,26 @@
             break;
         }
 
+        case _GUARD_NOS_TUPLE: {
+            JitOptSymbol *nos;
+            nos = stack_pointer[-2];
+            if (sym_matches_type(nos, &PyTuple_Type)) {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            sym_set_type(nos, &PyTuple_Type);
+            break;
+        }
+
+        case _GUARD_TOS_TUPLE: {
+            JitOptSymbol *tos;
+            tos = stack_pointer[-1];
+            if (sym_matches_type(tos, &PyTuple_Type)) {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            sym_set_type(tos, &PyTuple_Type);
+            break;
+        }
+
         case _BINARY_OP_SUBSCR_TUPLE_INT: {
             JitOptSymbol *res;
             res = sym_new_not_null(ctx);
@@ -585,6 +624,26 @@
             break;
         }
 
+        case _GUARD_NOS_DICT: {
+            JitOptSymbol *nos;
+            nos = stack_pointer[-2];
+            if (sym_matches_type(nos, &PyDict_Type)) {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            sym_set_type(nos, &PyDict_Type);
+            break;
+        }
+
+        case _GUARD_TOS_DICT: {
+            JitOptSymbol *tos;
+            tos = stack_pointer[-1];
+            if (sym_matches_type(tos, &PyDict_Type)) {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            sym_set_type(tos, &PyDict_Type);
+            break;
+        }
+
         case _BINARY_OP_SUBSCR_DICT: {
             JitOptSymbol *res;
             res = sym_new_not_null(ctx);
@@ -794,7 +853,7 @@
             seq = stack_pointer[-1];
             values = &stack_pointer[-1];
             for (int i = 0; i < oparg; i++) {
-                values[i] = sym_tuple_getitem(ctx, seq, i);
+                values[i] = sym_tuple_getitem(ctx, seq, oparg - i - 1);
             }
             stack_pointer += -1 + oparg;
             assert(WITHIN_STACK_BOUNDS());
@@ -1282,6 +1341,17 @@
             break;
         }
 
+        case _GUARD_TOS_ANY_SET: {
+            JitOptSymbol *tos;
+            tos = stack_pointer[-1];
+            if (sym_matches_type(tos, &PySet_Type) ||
+                sym_matches_type(tos, &PyFrozenSet_Type))
+            {
+                REPLACE_OP(this_instr, _NOP, 0, 0);
+            }
+            break;
+        }
+
         case _CONTAINS_OP_SET: {
             JitOptSymbol *res;
             res = sym_new_type(ctx, &PyBool_Type);