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DELETERIOUS (*WARNING! Low confidence) #33

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wpf95 opened this issue Feb 28, 2023 · 1 comment
Open

DELETERIOUS (*WARNING! Low confidence) #33

wpf95 opened this issue Feb 28, 2023 · 1 comment

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@wpf95
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wpf95 commented Feb 28, 2023

When I use sift4g，some position(114,661/145,218) it predicted to be DELETERIOUS (*WARNING! Low confidence)，Can we consider this position as deleterious ？
image
Why have this happened？ Because SIFT4G_Create_Genomic_DB run the result？My CHECK_GENES.LOG Pos with Confident Scores are around 60% to 70%.
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i use taurine reference genome ARS_UCD1.2 and uniref 90 to creat sift4g_genomic_DB， ORG be setting as bovine its right? my vcf file used to be predicted contain taurine and indicine ，but ARS_UCD1.2 reference genome is taurine ，and ORG seeting is bovine not taurine or indicine its problem？ Do I need to consider the bias of the reference genome？
@rvaser
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rvaser commented May 12, 2023

@pauline-ng, could you please advise?

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@rvaser @wpf95