diff --git a/src/handlers/createHandler.tsx b/src/handlers/createHandler.tsx
index 11c397479f..371d632514 100644
--- a/src/handlers/createHandler.tsx
+++ b/src/handlers/createHandler.tsx
@@ -24,6 +24,7 @@ import { ActionType } from '../ActionType';
 import { PressabilityDebugView } from './PressabilityDebugView';
 import GestureHandlerRootViewContext from '../GestureHandlerRootViewContext';
 import { ghQueueMicrotask } from '../ghQueueMicrotask';
+import { MountRegistry } from '../mountRegistry';
 
 const UIManagerAny = UIManager as any;
 
@@ -262,6 +263,8 @@ export default function createHandler<
         // eslint-disable-next-line @typescript-eslint/no-dynamic-delete
         delete handlerIDToTag[handlerID];
       }
+
+      MountRegistry.gestureHandlerWillUnmount(this);
     }
 
     private onGestureHandlerEvent = (event: GestureEvent<U>) => {
@@ -373,6 +376,10 @@ export default function createHandler<
       }
 
       scheduleFlushOperations();
+
+      ghQueueMicrotask(() => {
+        MountRegistry.gestureHandlerWillMount(this);
+      });
     };
 
     private updateGestureHandler = (
diff --git a/src/handlers/gestures/GestureDetector/attachHandlers.ts b/src/handlers/gestures/GestureDetector/attachHandlers.ts
index cd43d2a5dd..4af2b57031 100644
--- a/src/handlers/gestures/GestureDetector/attachHandlers.ts
+++ b/src/handlers/gestures/GestureDetector/attachHandlers.ts
@@ -14,6 +14,7 @@ import {
   checkGestureCallbacksForWorklets,
   ALLOWED_PROPS,
 } from './utils';
+import { MountRegistry } from '../../../mountRegistry';
 
 interface AttachHandlersConfig {
   preparedGesture: AttachedGestureState;
@@ -93,6 +94,8 @@ export function attachHandlers({
         actionType
       );
     }
+
+    MountRegistry.gestureWillMount(gesture);
   }
 
   preparedGesture.attachedGestures = gesturesToAttach;
diff --git a/src/handlers/gestures/GestureDetector/dropHandlers.ts b/src/handlers/gestures/GestureDetector/dropHandlers.ts
index 2f8510c5c2..3159d74a5f 100644
--- a/src/handlers/gestures/GestureDetector/dropHandlers.ts
+++ b/src/handlers/gestures/GestureDetector/dropHandlers.ts
@@ -2,12 +2,15 @@ import { unregisterHandler } from '../../handlersRegistry';
 import RNGestureHandlerModule from '../../../RNGestureHandlerModule';
 import { scheduleFlushOperations } from '../../utils';
 import { AttachedGestureState } from './types';
+import { MountRegistry } from '../../../mountRegistry';
 
 export function dropHandlers(preparedGesture: AttachedGestureState) {
   for (const handler of preparedGesture.attachedGestures) {
     RNGestureHandlerModule.dropGestureHandler(handler.handlerTag);
 
     unregisterHandler(handler.handlerTag, handler.config.testId);
+
+    MountRegistry.gestureWillUnmount(handler);
   }
 
   scheduleFlushOperations();
diff --git a/src/handlers/gestures/GestureDetector/index.tsx b/src/handlers/gestures/GestureDetector/index.tsx
index 222569ceb6..dac3e49495 100644
--- a/src/handlers/gestures/GestureDetector/index.tsx
+++ b/src/handlers/gestures/GestureDetector/index.tsx
@@ -23,6 +23,7 @@ import { useWebEventHandlers } from './utils';
 import { Wrap, AnimatedWrap } from './Wrap';
 import { useDetectorUpdater } from './useDetectorUpdater';
 import { useViewRefHandler } from './useViewRefHandler';
+import { useMountReactions } from './useMountReactions';
 
 function propagateDetectorConfig(
   props: GestureDetectorProps,
@@ -174,6 +175,8 @@ export const GestureDetector = (props: GestureDetectorProps) => {
     }
   }, [props]);
 
+  useMountReactions(updateAttachedGestures, preparedGesture);
+
   if (shouldUseReanimated) {
     return (
       <AnimatedWrap
diff --git a/src/handlers/gestures/GestureDetector/useMountReactions.ts b/src/handlers/gestures/GestureDetector/useMountReactions.ts
new file mode 100644
index 0000000000..61190d29a9
--- /dev/null
+++ b/src/handlers/gestures/GestureDetector/useMountReactions.ts
@@ -0,0 +1,51 @@
+import { transformIntoHandlerTags } from '../../utils';
+import { MountRegistry } from '../../../mountRegistry';
+import { AttachedGestureState } from './types';
+import { useEffect } from 'react';
+import { GestureRef } from '../gesture';
+
+function shouldUpdateDetector(
+  relation: GestureRef[] | undefined,
+  gesture: { handlerTag: number }
+) {
+  if (relation === undefined) {
+    return false;
+  }
+
+  for (const tag of transformIntoHandlerTags(relation)) {
+    if (tag === gesture.handlerTag) {
+      return true;
+    }
+  }
+
+  return false;
+}
+
+export function useMountReactions(
+  updateDetector: () => void,
+  state: AttachedGestureState
+) {
+  useEffect(() => {
+    return MountRegistry.addMountListener((gesture) => {
+      // At this point the ref in the gesture config should be updated, so we can check if one of the gestures
+      // set in a relation with the gesture got mounted. If so, we need to update the detector to propagate
+      // the changes to the native side.
+      for (const attachedGesture of state.attachedGestures) {
+        const blocksHandlers = attachedGesture.config.blocksHandlers;
+        const requireToFail = attachedGesture.config.requireToFail;
+        const simultaneousWith = attachedGesture.config.simultaneousWith;
+
+        if (
+          shouldUpdateDetector(blocksHandlers, gesture) ||
+          shouldUpdateDetector(requireToFail, gesture) ||
+          shouldUpdateDetector(simultaneousWith, gesture)
+        ) {
+          updateDetector();
+
+          // We can safely return here, if any other gestures should be updated, they will be by the above call
+          return;
+        }
+      }
+    });
+  }, [updateDetector, state]);
+}
diff --git a/src/handlers/utils.ts b/src/handlers/utils.ts
index 13fdc488ab..02e200dedd 100644
--- a/src/handlers/utils.ts
+++ b/src/handlers/utils.ts
@@ -36,7 +36,8 @@ export function filterConfig(
   }
   return filteredConfig;
 }
-function transformIntoHandlerTags(handlerIDs: any) {
+
+export function transformIntoHandlerTags(handlerIDs: any) {
   handlerIDs = toArray(handlerIDs);
 
   if (Platform.OS === 'web') {
diff --git a/src/mountRegistry.ts b/src/mountRegistry.ts
new file mode 100644
index 0000000000..e61ba9dd07
--- /dev/null
+++ b/src/mountRegistry.ts
@@ -0,0 +1,51 @@
+import { GestureType } from './handlers/gestures/gesture';
+
+interface ReactComponentWithHandlerTag extends React.Component {
+  handlerTag: number;
+}
+
+export type GestureMountListener = (
+  gesture: GestureType | ReactComponentWithHandlerTag
+) => void;
+
+// eslint-disable-next-line @typescript-eslint/no-extraneous-class
+export class MountRegistry {
+  private static mountListeners = new Set<GestureMountListener>();
+  private static unmountListeners = new Set<GestureMountListener>();
+
+  static addMountListener(listener: GestureMountListener): () => void {
+    this.mountListeners.add(listener);
+
+    return () => {
+      this.mountListeners.delete(listener);
+    };
+  }
+
+  static addUnmountListener(listener: GestureMountListener): () => void {
+    this.unmountListeners.add(listener);
+
+    return () => {
+      this.unmountListeners.delete(listener);
+    };
+  }
+
+  static gestureHandlerWillMount(handler: React.Component) {
+    this.mountListeners.forEach((listener) =>
+      listener(handler as ReactComponentWithHandlerTag)
+    );
+  }
+
+  static gestureHandlerWillUnmount(handler: React.Component) {
+    this.unmountListeners.forEach((listener) =>
+      listener(handler as ReactComponentWithHandlerTag)
+    );
+  }
+
+  static gestureWillMount(gesture: GestureType) {
+    this.mountListeners.forEach((listener) => listener(gesture));
+  }
+
+  static gestureWillUnmount(gesture: GestureType) {
+    this.unmountListeners.forEach((listener) => listener(gesture));
+  }
+}