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Update README with new persistent positive selection model. (#2)
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README

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This is swMutSel, a program to estimate fitnesses of amino acids in protein-
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coding genes using the evolution model of Halpern and Bruno (1998) and Tamuri et
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al. (2012, 2014). The program takes as input an alignment of protein-coding
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gene sequences and a phylogeny (tree) of the sequences, and outputs the
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fitnesses of each amino acid at each location in the protein-coding gene.
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coding genes using the codon substitution model of Halpern and Bruno (1998),
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Tamuri et al. (2012, 2014), and Tamuri and dos Reis (2022). The program takes as
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input an alignment of protein-coding gene sequences and a phylogeny (tree) of
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the sequences, and outputs the fitnesses of each amino acid at each location in
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the protein-coding gene.
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SYNOPSIS
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java -jar swmutsel.jar @test_CHKPNT_9.txt -n test_restart
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To use the new persistent positive selection model (Tamuri and dos Reis,
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2022), use the -fds flag.
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CITATION
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Halpern AL and Bruno WJ. (1998) Evolutionary distances for protein-coding
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for estimating the distribution of selection coefficients from
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phylogenetic data. Genetics, 197: 257-271.
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Tamuri AU and dos Reis M. (2022) A mutation-selection model of protein
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evolution under persistent positive selection. Molecular Biology and
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Evolution, 39: msab309.

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