11
22This is swMutSel, a program to estimate fitnesses of amino acids in protein-
3- coding genes using the evolution model of Halpern and Bruno (1998) and Tamuri et
4- al. (2012, 2014). The program takes as input an alignment of protein-coding
5- gene sequences and a phylogeny (tree) of the sequences, and outputs the
6- fitnesses of each amino acid at each location in the protein-coding gene.
3+ coding genes using the codon substitution model of Halpern and Bruno (1998),
4+ Tamuri et al. (2012, 2014), and Tamuri and dos Reis (2022). The program takes as
5+ input an alignment of protein-coding gene sequences and a phylogeny (tree) of
6+ the sequences, and outputs the fitnesses of each amino acid at each location in
7+ the protein-coding gene.
78
89
910SYNOPSIS
@@ -178,6 +179,9 @@ USAGE
178179
179180 java -jar swmutsel.jar @test_CHKPNT_9.txt -n test_restart
180181
182+ To use the new persistent positive selection model (Tamuri and dos Reis,
183+ 2022), use the -fds flag.
184+
181185CITATION
182186
183187 Halpern AL and Bruno WJ. (1998) Evolutionary distances for protein-coding
@@ -192,4 +196,6 @@ CITATION
192196 for estimating the distribution of selection coefficients from
193197 phylogenetic data. Genetics, 197: 257-271.
194198
195-
199+ Tamuri AU and dos Reis M. (2022) A mutation-selection model of protein
200+ evolution under persistent positive selection. Molecular Biology and
201+ Evolution, 39: msab309.
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