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Help in understanding condition_key and cell_type_key #248

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yojetsharma opened this issue Aug 30, 2024 · 0 comments
Open

Help in understanding condition_key and cell_type_key #248

yojetsharma opened this issue Aug 30, 2024 · 0 comments

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@yojetsharma
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From what I understood from the manuscript is that condition_key is something that needs to be regressed out from the analyses. But what if the query and the reference dataset are entirely different?
I have snRNA scanpy object merged from patients+healthy NSCs. So the condition_key in this case is the ‘sample’ and cell_type_key ‘leiden’. But I have a reference from Linnarsson lab (trimester human fetal scRNA seq) which has ‘CellClass’, ‘CellID’, ‘Age’ and ‘Tissue’. So, what should one give as a condition_key here?

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