Update tsv, md and png files

Author: actions-user

_data/WP3149-datanodes.tsv

@@ -27,7 +27,7 @@ PCK1	GeneProduct	ensembl:ENSBTAG00000001936	"HomologyConvert: Homo sapiens to Bo
 ACLY	GeneProduct	ensembl:ENSBTAG00000016740	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131473"	ensembl:ENSBTAG00000016740	ncbigene:511135		uniprot:A0A3Q1MQZ2;uniprot:Q32PF2;uniprot:A0A3Q1LSB6								
 CS	GeneProduct	ensembl:ENSBTAG00000004371	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000062485"	ensembl:ENSBTAG00000004371	ncbigene:280682		uniprot:Q29RK1								
 SUCLG2	GeneProduct	ensembl:ENSBTAG00000009541	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172340"	ensembl:ENSBTAG00000009541	ncbigene:537713		uniprot:Q3MHX5								
-PDHA1	GeneProduct	ensembl:ENSBTAG00000019852	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131828"	ensembl:ENSBTAG00000019852	ncbigene:407109		uniprot:A0A3Q1MI08;uniprot:A0A452DJH4								
+PDHA1	GeneProduct	ensembl:ENSBTAG00000019852	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131828"	ensembl:ENSBTAG00000019852	ncbigene:407109		uniprot:A0A3Q1MI08;uniprot:A7MB35;uniprot:A0A452DJH4								
 IDH3A	GeneProduct	ensembl:ENSBTAG00000006227	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000166411"	ensembl:ENSBTAG00000006227	ncbigene:282446		uniprot:A0A3Q1MLP3;uniprot:Q148J8								
 SDHA	GeneProduct	ensembl:ENSBTAG00000046019	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073578"	ensembl:ENSBTAG00000046019	ncbigene:281480		uniprot:A0A3Q1MCH3;uniprot:G3MY67;uniprot:G5E6M7								
 PC	GeneProduct	ensembl:ENSBTAG00000019700	"HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5091"	ensembl:ENSBTAG00000019700	ncbigene:338471		uniprot:Q29RK2;uniprot:A0A3Q1MIX4;uniprot:A0A3Q1MIC2								

_pathways/WP1356.md

@@ -18,23 +18,27 @@ citedin:
 - link: PMC3677916
   title: Liver transcriptome changes in zebrafish during acclimation to transport-associated
     stress (2013)
-description: ''
-last-edited: 2021-05-15
+communities: []
+description: Glycolysis and gluconeogenesis pathways convert metabolites in the opposite
+  direction.
+last-edited: 2025-12-04
+ndex: null
 organisms:
 - Danio rerio
 redirect_from:
 - /index.php/Pathway:WP1356
 - /instance/WP1356
-- /instance/WP1356_r116884
-revision: r116884
+- /instance/WP1356_r142118
+revision: r142118
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP1356.html
   '@type': Dataset
   creator:
     '@type': Organization
     name: WikiPathways
-  description: ''
+  description: Glycolysis and gluconeogenesis pathways convert metabolites in the
+    opposite direction.
   keywords:
   - 2-Phosphoglyceric acid
   - 3-Phosphoglyceric acid

_pathways/WP3149.md

@@ -1,9 +1,5 @@
 ---
 annotations:
-- id: PW:0001752
-  parent: disease pathway
-  type: Pathway Ontology
-  value: pyruvate decarboxylase deficiency pathway
 - id: PW:0000013
   parent: disease pathway
   type: Pathway Ontology
@@ -12,28 +8,56 @@ annotations:
   parent: classic metabolic pathway
   type: Pathway Ontology
   value: citric acid cycle pathway
+- id: PW:0001752
+  parent: disease pathway
+  type: Pathway Ontology
+  value: pyruvate decarboxylase deficiency pathway
 authors:
 - Mkutmon
 - MaintBot
 - MirellaKalafati
 - Eweitz
-description: ''
-last-edited: 2021-05-21
+- Egonw
+citedin: ''
+communities: []
+description: 'When transported into the inner mitochondrial matrix, pyruvate encounters
+  two principal metabolizing enzymes: pyruvate carboxylase, PC (a gluconeogenic enzyme)
+  and pyruvate dehydrogenase (PDH), the first enzyme of the PDH complex (PDHc). With
+  a high cell-energy charge, co-enzyme A (CoA) is highly acylated, principally as
+  acetyl-CoA, and able to obligately activate pyruvate carboxylase, directing pyruvate
+  toward gluconeogenesis. When the energy charge is low, CoA is not acylated, therefore,
+  pyruvate carboxylase is inactive, and pyruvate is preferentially metabolized via
+  the PDHc and the TCA cycle to CO2 and H2O. The acetyl-CoA produced by the PDHc enters
+  the TCA cycle and the reduced electron carriers (NADH and FADH2) that are generated
+  during the oxidative reactions can then be used to drive ATP synthesis via oxidative
+  phosphorylation.'
+last-edited: 2025-12-04
+ndex: null
 organisms:
 - Bos taurus
 redirect_from:
 - /index.php/Pathway:WP3149
 - /instance/WP3149
-- /instance/WP3149_r117622
-revision: r117622
+- /instance/WP3149_r142119
+revision: r142119
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP3149.html
   '@type': Dataset
   creator:
     '@type': Organization
     name: WikiPathways
-  description: ''
+  description: 'When transported into the inner mitochondrial matrix, pyruvate encounters
+    two principal metabolizing enzymes: pyruvate carboxylase, PC (a gluconeogenic
+    enzyme) and pyruvate dehydrogenase (PDH), the first enzyme of the PDH complex
+    (PDHc). With a high cell-energy charge, co-enzyme A (CoA) is highly acylated,
+    principally as acetyl-CoA, and able to obligately activate pyruvate carboxylase,
+    directing pyruvate toward gluconeogenesis. When the energy charge is low, CoA
+    is not acylated, therefore, pyruvate carboxylase is inactive, and pyruvate is
+    preferentially metabolized via the PDHc and the TCA cycle to CO2 and H2O. The
+    acetyl-CoA produced by the PDHc enters the TCA cycle and the reduced electron
+    carriers (NADH and FADH2) that are generated during the oxidative reactions can
+    then be used to drive ATP synthesis via oxidative phosphorylation.'
   keywords:
   - (S)-Malate
   - 2-Hydroxy-ethyl-ThPP