Update tsv, md and png files

Author: actions-user

_data/WP4018-bibliography.tsv

@@ -7,3 +7,4 @@ ID	Database	Citation
 25514926	Pubmed	"PhosphoSitePlus, 2014: mutations, PTMs and recalibrations. Hornbeck PV, Zhang B, Murray B, Kornhauser JM, Latham V, Skrzypek E. Nucleic Acids Res. 2015 Jan;43(Database issue):D512-20.  <a href=""http://www.ncbi.nlm.nih.gov/pubmed/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/25514926"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
 27694978	Pubmed	"Precision medicine from the renal cancer genome. Riazalhosseini Y, Lathrop M. Nat Rev Nephrol. 2016 Nov;12(11):655–66.  <a href=""http://www.ncbi.nlm.nih.gov/pubmed/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/27694978"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
 28329682	Pubmed	"The SWI/SNF Protein PBRM1 Restrains VHL-Loss-Driven Clear Cell Renal Cell Carcinoma. Nargund AM, Pham CG, Dong Y, Wang PI, Osmangeyoglu HU, Xie Y, et al. Cell Rep. 2017 Mar 21;18(12):2893–906.  <a href=""http://www.ncbi.nlm.nih.gov/pubmed/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/28329682"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"
+40677703	Pubmed	"Advances in immunotherapy and targeted therapy for advanced clear-cell renal cell carcinoma: current strategies and future directions. Wang B, Xiang Y, Liu X, Pan X, Peng L, Ma J. Front Immunol. 2025 Jul 3;16:1582887.  <a href=""http://www.ncbi.nlm.nih.gov/pubmed/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/40677703"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"

_data/WP4018-datanodes.tsv

@@ -1,5 +1,7 @@
 Label	Type	Identifier	Comment	Ensembl	NCBI gene	HGNC	UniProt	Wikidata	ChEBI	InChI	PubChem	ChemSpider	HMDB	KEGG	LipidMaps
+PT-2385	Metabolite	chebi:233314	""												
 Glucose	Metabolite	chebi:17234	""					wikidata:Q37525	chebi:17234					kegg.compound:C00293	
+Belzutifan	Metabolite	pubchem.compound:117947097	""					wikidata:Q27456641		inchikey:LOMMPXLFBTZENJ-ZACQAIPSSA-N	pubchem.compound:117947097		hmdb:HMDB0304835		
 DEPTOR	GeneProduct	ensembl:ENSG00000155792	""	ensembl:ENSG00000155792	ncbigene:64798	hgnc.symbol:DEPTOR	uniprot:Q8TB45								
 ACACA	GeneProduct	ensembl:ENSG00000278540	""	ensembl:ENSG00000278540	ncbigene:31	hgnc.symbol:ACACA	uniprot:A0A087WWN5;uniprot:A0A087WYS8;uniprot:A0A087X0W4;uniprot:A0A087X2F8;uniprot:A0A0C4DGT1;uniprot:Q59FY4;uniprot:A0A087WYK6;uniprot:A0A087X126;uniprot:Q13085;uniprot:A0A087WVR6;uniprot:A0A024R0Y2								
 KCNJ2	GeneProduct	ensembl:ENSG00000123700	""	ensembl:ENSG00000123700	ncbigene:3759	hgnc.symbol:KCNJ2	uniprot:P63252								
@@ -9,6 +11,7 @@ ENPP3	GeneProduct	ensembl:ENSG00000154269	""	ensembl:ENSG00000154269	ncbigene:51
 HK3	GeneProduct	ensembl:ENSG00000160883	""	ensembl:ENSG00000160883	ncbigene:3101	hgnc.symbol:HK3	uniprot:H0YAG4;uniprot:H0Y9N6;uniprot:H0Y8U9;uniprot:P52790;uniprot:A0A024R7R1								
 PDGFRA	GeneProduct	ensembl:ENSG00000134853	""	ensembl:ENSG00000134853	ncbigene:5156	hgnc.symbol:PDGFRA	uniprot:D6RDX0;uniprot:D6RJH0;uniprot:D6RG11;uniprot:D6RIG5;uniprot:P16234								
 FLT1	GeneProduct	ensembl:ENSG00000102755	""	ensembl:ENSG00000102755	ncbigene:2321	hgnc.symbol:FLT1	uniprot:A0A1W2PNW4;uniprot:L7RSL3;uniprot:P17948								
+MAP2K5	GeneProduct	hgnc.symbol:MAP2K5	""	ensembl:ENSG00000137764	ncbigene:5607	hgnc.symbol:MAP2K5	uniprot:A0A087X0Z8;uniprot:A0A024R5Y2;uniprot:A0A024R5X5;uniprot:A0A087WWX7;uniprot:A6NK28;uniprot:H7BZL1;uniprot:Q13163								
 STAT3	GeneProduct	ensembl:ENSG00000168610	""	ensembl:ENSG00000168610	ncbigene:6774	hgnc.symbol:STAT3	uniprot:G8JLH9;uniprot:A0A7I2V4F6;uniprot:A0A7I2V4C8;uniprot:A0A7I2V3V0;uniprot:P40763;uniprot:A0A7I2V2T1;uniprot:A0A7I2V395;uniprot:A0A7I2V552;uniprot:A0A7I2V444;uniprot:A0A7I2V4R2;uniprot:A0A7I2YQR5;uniprot:A0A7I2V4R3;uniprot:A0A7I2YQI1;uniprot:A0A7I2YQD2;uniprot:A0A7I2V2G1;uniprot:A0A7I2V5N9								
 EGFR	GeneProduct	ensembl:ENSG00000146648	""	ensembl:ENSG00000146648	ncbigene:1956	hgnc.symbol:EGFR	uniprot:P00533;uniprot:A0A8V8TPW8;uniprot:Q504U8;uniprot:C9JYS6								
 CAMK1	GeneProduct	ensembl:ENSG00000134072	""	ensembl:ENSG00000134072	ncbigene:8536	hgnc.symbol:CAMK1	uniprot:H7C071;uniprot:F8W6S9;uniprot:B0YIY3;uniprot:Q14012;uniprot:C9JES6								

_pathways/WP4018.md

@@ -1,21 +1,21 @@
 ---
 annotations:
-- id: PW:0000003
-  parent: signaling pathway
-  type: Pathway Ontology
-  value: signaling pathway
-- id: DOID:4467
-  parent: disease of cellular proliferation
-  type: Disease Ontology
-  value: clear cell renal cell carcinoma
-- id: CL:1000497
-  parent: animal cell
-  type: Cell Type Ontology
-  value: kidney cell
 - id: CL:1000838
   parent: animal cell
   type: Cell Type Ontology
   value: kidney proximal convoluted tubule epithelial cell
+- id: CL:1000497
+  parent: animal cell
+  type: Cell Type Ontology
+  value: kidney cell
+- id: DOID:4467
+  parent: disease of cellular proliferation
+  type: Disease Ontology
+  value: clear cell renal cell carcinoma
+- id: PW:0000003
+  parent: signaling pathway
+  type: Pathway Ontology
+  value: signaling pathway
 authors:
 - AlexanderPico
 - Khanspers
@@ -53,15 +53,15 @@ description: 'Inactivation of VHL due to mutation or DNA methylation is an early
   mTORC1 complex is based on [Wikipedia](https://en.wikipedia.org/wiki/Mechanistic_target_of_rapamycin#mTORC1).
   PDGFB and TGFB as targets of HIF1A based on [KEGG](http://www.genome.jp/kegg-bin/show_pathway?hsa05211).  Phosphorylation
   sites were added based on information from PhosphoSitePlus (R), www.phosphosite.org.'
-last-edited: 2025-08-30
+last-edited: 2025-12-17
 ndex: 22a3a9b0-8b69-11eb-9e72-0ac135e8bacf
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP4018
 - /instance/WP4018
-- /instance/WP4018_r140480
-revision: r140480
+- /instance/WP4018_r142204
+revision: r142204
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP4018.html
@@ -95,6 +95,7 @@ schema-jsonld:
   - ALDOC
   - BAP1
   - BHLHE41
+  - Belzutifan
   - CAMK1
   - CBP
   - CDH13
@@ -126,6 +127,7 @@ schema-jsonld:
   - LDHB
   - LDHC
   - LDHD
+  - MAP2K5
   - MDH1
   - ME1
   - MLST8
@@ -149,6 +151,7 @@ schema-jsonld:
   - PLOD2
   - PSAT1
   - PSPH
+  - PT-2385
   - PTEN
   - RAPGEF5
   - RHEB