🧬 Gene2Trials Navigator

Gene2Trials Navigator is a Streamlit web app that allows users to explore gene-related biomedical knowledge.
Given a gene symbol (e.g., TP53, BRCA1), the app fetches mutations, diseases, drugs, and clinical trials from public biomedical APIs and provides AI-powered summaries.

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🚀 Features

• 🔍 Gene Mutations: Extract mutations, CADD scores, and clinical significance using MyVariant.info / ClinVar.
• 🧪 Associated Diseases: Discover diseases linked to mutations.
• 💊 Drug Information: Retrieve drug candidates via ChEMBL.
• 📊 Clinical Trials: Get live data from ClinicalTrials.gov.
• 📝 AI Summarization: Summarize PubMed abstracts with Hugging Face Transformers.
• ✅ Clickable Links: Direct links to variants, drugs, and trial pages.

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🛠️ Tech Stack

• Languages: Python
• Frameworks: Streamlit
• APIs:
  • MyVariant.info
  • ChEMBL
  • ClinicalTrials.gov
  • PubMed / Entrez
• AI Models: HuggingFace Transformers
• Deployment: Hugging Face Spaces / GitHub

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streamlit run app.py

📝 Usage Enter a gene symbol (e.g., TP53). Navigate tabs: 🦠 Mutations 🧬 Diseases 💊 Drugs 📋 Clinical Trials 📝 Summaries Click on IDs to open external references.

📂 Project Structure gene2trials-navigator/ │── app.py # Main Streamlit app │── utils/ │ ├── mutations.py # MyVariant/ClinVar fetch │ ├── diseases.py # Disease associations │ ├── drugs.py # ChEMBL fetch │ ├── trials.py # ClinicalTrials.gov fetch │ └── summaries.py # PubMed summarization │── requirements.txt │── README.md 🤝 Contributing

PRs are welcome! If you find a bug, please open an issue. https://huggingface.co/spaces/bano1/gene2trials-navigator

📦 Installation

git clone https://github.com/Bano733-code/gene2trials-navigator.git
cd gene2trials-navigator
pip install -r requirements.txt```