This study explores the intricate crosstalk between hormones and their receptors (HRs) across human tissues and organs. By curating hormone-HR pairing information and hormone secretion sources through literature and database searches, we constructed tissue/organ-hormone-HR networks using GTEx RNA-seq data.
- Gender-Specific Networks: Separate networks for male and female tissues reveal notable differences in reproductive-related organs and their HRs.
- Hormone Types and Origins:
- Peptide hormones dominate most tissues/organs.
- Amino acid-derived hormones are primarily secreted by the adrenal gland and brain.
- Lipid-derived hormones are mostly produced by the liver, adrenal gland, and reproductive organs.
- Regulation Patterns:
- The brain is the central regulator, influencing most tissues/organs, followed by endocrine glands and digestive organs.
- Membrane HRs are the predominant interaction targets for most hormones.
These insights provide a foundation for understanding hormone-mediated inter-organ communications and their gender-specific nuances.
Project Website: Human Organ Hormonal Communications (HOHC)
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