iPSC-Derived Mesenchymal and Epithelial Cells in IBD and their Response to Different Treatments

Fig1.

Fig1a. Experiment Design

Fig1b. PCA for the epithelial group

Before batch correction

After batch correction

Fig1c. PCA for the mesenchymal group

Before batch correction

After batch correction

Fig2. Global Treatment response

Fig2a. Global Treatment response for TGFb

Scatter polts

by signed_-logP

labeled with common up- and down-regulated genes

labeled with up- and down-regulated genes only in meschymal

labeled with up- and down-regulated genes only in epithelial

Fig2b. Global Treatment response for TNFa

Scatter polts

by signed_-logP

labeled with up- and down-regulated common genes

labeled with up- and down-regulated genes only in meschymal

labeled with up- and down-regulated genes only in epithelial

Fig3. WGCNA

Fig3a. all modules top 20 genes in the mesenchymal group

module_black

module_blue

module_green

module_grey

module_pink

module_red

Fig3b. all modules top 20 genes in the epithelial group

module_black

module_blue

module_pink

module_red

module_turquoise

module_yellow

Fig4. NF vs F

Fig4a. mes_CC_WGCNA_MRMR_Pairwise_top100_umap

WGCNA

MRMR

Pairwise comparison

Fig4b. mes_TG_WGCNA_MRMR_Pairwise_top100_umap

WGCNA

MRMR

Pairwise comparison

Fig4c. mes_TN_WGCNA_MRMR_Pairwise_top100_umap

WGCNA

MRMR

Pairwise comparison

Fig4d. epi_CC_WGCNA_MRMR_Pairwise_top100_umap

WGCNA

MRMR

Pairwise comparison

Fig4e. epi_TG_WGCNA_MRMR_Pairwise_top100_umap

WGCNA

MRMR

Pairwise comparison

Fig4f. epi_TN_WGCNA_MRMR_Pairwise_top100_umap

WGCNA

MRMR

Pairwise comparison

Fig5. Patient-Specfic responses

mes_CC

epi_CC

mes_TG

epi_TG

mes_TN

epi_TN

mes_TT

epi_TT

Fig6. Ligand-Receptors interactions

CC