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_2025_Larsen_degron_transcriptionfactors

Scripts and output from "Comprehensive degron mapping in human transcription factors" by Fia B. Larsen, Vasileios Voutsinos, Nicolas Jonsson, Kristoffer E. Johansson, Freia D. Ethelberg, Kresten Lindorff-Larsen and Rasmus Hartmann-Petersen

Preprint

Contents

  • library: Script and input files for makeing the DNA libraries based on Lambert18
  • counts: Scripts for processing FASTQ files. Output counts and raw FASTQ files are available on ERDA
  • score: Scripts for calculating scores. FACS data files are available on ERDA
  • plots: Scripts for plotting
  • annotations: Scripts for mapping scores to the library and annotating with PAP, ADPred and structural features
  • analyses: Scripts for analyses and plotting

The main resulting data is in annotations/transfac_tiles.csv.gz and transfac_proteins.csv.gz

Sequencing counts, FASTQ files and FACS data are available on ERDA

FASTQ files are deposited at NCBI SRA under BioProject ID: PRJNA1276444

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