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Fix typos in pre-processing vignette #143

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16 changes: 8 additions & 8 deletions vignettes/articles/pre-processing.Rmd
Original file line number Diff line number Diff line change
Expand Up @@ -52,7 +52,7 @@ recommended prior to executing an analysis on SomaScan data, along with
## Filtering Features

The goal of this pre-processing step is to remove features (SeqIds) typically
not useful for analalysis from a SomaScan dataset, while also retaining
not useful for analysis from a SomaScan dataset, while also retaining
*relevant* features that will enable broad discovery during downstream analysis.

The filtering logic typically used for protein features (i.e. SOMAmer
Expand Down Expand Up @@ -532,8 +532,8 @@ assessment and further evaluation.
While centering and scaling standardizes the RFU distributions across all
SeqIds for multivariate analysis, it is important to understand that this does
*not* enable meaningful comparison of expression values between different
SeqIds. Take, for instance, hypothetical SeqId A with a z-socre of 2 and
hypothetical SeqId B with a z-socre of -1. One cannot infer that the protein
SeqIds. Take, for instance, hypothetical SeqId A with a z-score of 2 and
hypothetical SeqId B with a z-score of -1. One cannot infer that the protein
target of SeqId A was present at a higher concentration than the target of
SeqId B in the original sample prep. All comparisons should be made between
sample groups *within* a given SeqId. The RFU value, as well as log10 RFU and
Expand All @@ -550,11 +550,11 @@ factors intrinsic to the SOMAmer Reagent within the SomaScan assay.
The `preProcessAdat()` function is available to perform the steps
outlined in this vignette. By default, it will filter features and
samples using the standard QC and normalization acceptance criteria
described earlier, and drop sample-level RFU outliers. It also has option to
perform log-10 and center & scale transformations to the untransformed RFU
values. If data QC plots by endpoints or clinical variables are desired,
the names of the variables should be explicitly passed to the `data.qc`
argument. Please see the `preProcessAdat()` function documentation for
described earlier, but _will not_ drop sample-level RFU outliers. It also has
the option to perform log-10 and center & scale transformations to the
untransformed RFU values. If data QC plots by endpoints or clinical variables
are desired,the names of the variables should be explicitly passed to the
`data.qc` argument. Please see the `preProcessAdat()` function documentation for
more details.

```{r recreate-vignette-data}
Expand Down