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Add TARGET studies #2063

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Add TARGET studies #2063

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jamesqo
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@jamesqo jamesqo commented Sep 5, 2024

What?

Adds the following TARGET studies from GDC:

  • alal_target_gdc (TARGET-ALL-P3)
  • aml_target_gdc (TARGET-AML)
  • bll_target_gdc (TARGET-ALL-P2)
  • nbl_target_gdc (TARGET-NBL)
  • os_target_gdc (TARGET-OS)
  • wt_target_gdc (TARGET-WT)

The following TARGET projects were excluded because they lack mutation data:

  • TARGET-ALL-P1
  • TARGET-CCSK
  • TARGET-RT

Clinical mappings were provided by @sbabyanusha here: ISB-CGC Clinical Mappings

checks

For all pull requests:

  • Passes validation

For a new study (in addition to above):

  • Does study name and study ID follow our convention? e.g. Tumor_Type (Institue, Journal Year); brca_mskcc_2015
  • is study meta data complete? e.g. pmid, group of PUBLIC
  • were all samples profiled with WES/WGS? If not, is gene panel file curated?
  • are oncotree codes of all samples curated; Cancer Type and Cancer Type Detailed needs to be added in addition to Oncotree Code
  • clinical sample and patient data with meta files
  • mutations data with meta files
  • MAF is based on hg19
  • MAF with 2 isoforms: uniprot and mskcc
  • CNA data with meta files
  • CNA segment data with meta files
  • Expression data including z-scores with meta files
  • Case-lists for all profiles.
  • Manual checking (Niki or JJ): Triage or private Portal link here

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