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_data/WP108-bibliography.tsv

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ID Database Citation
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22440326 Pubmed "Understanding selenoprotein function and regulation through the use of rodent models. Kasaikina MV, Hatfield DL, Gladyshev VN. Biochim Biophys Acta. 2012 Sep;1823(9):1633–42. <a href=""http://www.ncbi.nlm.nih.gov/pubmed/22440326"" target=""_blank"" class=""external"" rel=""nofollow"">PubMed</a> <a href=""https://europepmc.org/abstract/MED/22440326"" target=""_blank"" class=""external"" rel=""nofollow"">Europe PMC</a> <a href=""https://scholia.toolforge.org/pubmed/22440326"" target=""_blank"" class=""external"" rel=""nofollow"">Scholia</a>"

_data/WP108-datanodes.tsv

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SelI GeneProduct ncbigene:28042 "" ensembl:ENSMUSG00000075703 ncbigene:28042 uniprot:D6RE20;uniprot:Q8CET7;uniprot:Q80TA1
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SEPP1 GeneProduct ncbigene:20363 "" ensembl:ENSMUSG00000064373 ncbigene:20363 uniprot:P70274;uniprot:E0CX80;uniprot:E0CZ76;uniprot:E0CY03
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Sep15 GeneProduct ncbigene:9403 ""
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DIO2 GeneProduct ncbigene:13371 "" ensembl:ENSMUSG00000007682 ncbigene:13371 uniprot:Q9Z1Y9
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DIO2 GeneProduct ncbigene:13371 "" ensembl:ENSMUSG00000007682 ncbigene:13371 uniprot:A0A8Z1S5Q0
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SelH GeneProduct ncbigene:72657 "" ensembl:ENSMUSG00000076437 ncbigene:72657 uniprot:Q3UQA7;uniprot:A0A087WPM0;uniprot:A0A087WNU1
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Sars GeneProduct ncbigene:20226 "" ensembl:ENSMUSG00000068739 ncbigene:20226 uniprot:P26638;uniprot:Q8C483;uniprot:A2AFS1;uniprot:A2AFS0
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TXNRD1 GeneProduct ncbigene:50493 "" ensembl:ENSMUSG00000020250 ncbigene:50493 uniprot:Q9JMH6;uniprot:A0A1W2P6U1
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Sp1 GeneProduct ncbigene:20683 "" ensembl:ENSMUSG00000001280 ncbigene:20683 uniprot:O89090;uniprot:G3X8Q0;uniprot:E9Q2V3;uniprot:E9Q0S7;uniprot:E9Q113
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Sp1 GeneProduct ncbigene:20683 "" ensembl:ENSMUSG00000001280 ncbigene:20683 uniprot:O89090;uniprot:G3X8Q0;uniprot:A0A979HLR9;uniprot:E9Q2V3;uniprot:E9Q0S7;uniprot:E9Q113
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Sla GeneProduct ncbigene:211006 "" ensembl:ENSMUSG00000029173 ncbigene:211006 uniprot:D6RGM2;uniprot:F6ZFG8;uniprot:F6YLP3;uniprot:Q6P6M7
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Sephs1 GeneProduct ncbigene:109079 "" ensembl:ENSMUSG00000026662 ncbigene:109079 uniprot:Q8BH69
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Crem GeneProduct ncbigene:12916 "" ensembl:ENSMUSG00000063889 ncbigene:12916 uniprot:D3Z011;uniprot:F6QKL8;uniprot:F6QWT6;uniprot:D3Z773;uniprot:D6RFR5;uniprot:D3Z0R0;uniprot:F6Q346;uniprot:D3Z6A5;uniprot:A0A0R4J1S0;uniprot:F6U9F5;uniprot:F6VJ22;uniprot:D3Z7P7;uniprot:D3YXV5;uniprot:D3YVP3;uniprot:Q9CQ87;uniprot:F6W4F5;uniprot:F6XRJ7;uniprot:P27699;uniprot:A0A0R4J1V7;uniprot:D3Z0B6;uniprot:Q3TTH6;uniprot:D3Z7M6;uniprot:D3Z4K8;uniprot:E9PV35;uniprot:E9PWV9;uniprot:F6RB97;uniprot:D6RG82;uniprot:D3Z2U7;uniprot:D3Z326

_pathways/WP108.md

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- link: PMC3885437
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title: A provisional gene regulatory atlas for mouse heart development (2014)
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communities: []
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description: ''
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last-edited: 2024-08-02
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description: Pathway describing the selenium metabolism and the related selenoproteins.
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last-edited: 2025-12-13
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ndex: null
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organisms:
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- Mus musculus
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redirect_from:
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- /index.php/Pathway:WP108
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- /instance/WP108
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- /instance/WP108_r135035
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revision: r135035
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- /instance/WP108_r142196
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revision: r142196
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP108.html
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'@type': Dataset
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creator:
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'@type': Organization
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name: WikiPathways
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description: ''
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description: Pathway describing the selenium metabolism and the related selenoproteins.
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keywords:
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- Crem
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- Cystathionine g-lyase

_pathways/WP5604.md

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---
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annotations:
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- id: CL:0000115
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- id: CL:0000233
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parent: native cell
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type: Cell Type Ontology
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value: endothelial cell
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value: platelet
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- id: CL:0000232
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parent: animal cell
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type: Cell Type Ontology
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value: erythrocyte
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- id: DOID:0081445
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type: Disease Ontology
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- id: DOID:10923
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parent: genetic disease
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type: Disease Ontology
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value: sickle cell anemia
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- id: CL:0000775
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parent: animal cell
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type: Cell Type Ontology
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value: neutrophil
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- id: CL:0000233
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- id: DOID:10923
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parent: genetic disease
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type: Disease Ontology
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value: sickle cell anemia
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- id: DOID:0081445
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type: Disease Ontology
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- id: CL:0000115
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parent: native cell
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type: Cell Type Ontology
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value: platelet
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value: endothelial cell
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authors:
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- Eweitz
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- Ash iyer
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- Egonw
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- Khanspers
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citedin: ''
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communities: []
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description: This pathway shows the molecular pathophysiology of sickle cell disease. (A)
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cells, leading to IL-1β release. Sterile inflammation then reinforces vaso-occlusion
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through a positive feedback loop that increases neutrophil, platelet, and endothelial
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adhesiveness. Inspired by figure 1 in [Sundd 2018](https://pmc.ncbi.nlm.nih.gov/articles/PMC7053558/#S2).
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last-edited: 2025-11-17
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last-edited: 2025-12-13
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ndex: null
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organisms:
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- Homo sapiens
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redirect_from:
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- /index.php/Pathway:WP5604
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- /instance/WP5604
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- /instance/WP5604_r141502
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revision: r141502
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- /instance/WP5604_r142198
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revision: r142198
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP5604.html

_pathways/WP5609.md

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---
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annotations:
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- id: PW:0000025
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parent: classic metabolic pathway
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type: Pathway Ontology
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value: glycolysis/gluconeogenesis pathway
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- id: PW:0000641
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parent: regulatory pathway
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type: Pathway Ontology
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value: gluconeogenesis pathway
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- id: PW:0000026
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- id: PW:0000640
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parent: classic metabolic pathway
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type: Pathway Ontology
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value: citric acid cycle pathway
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value: glycolysis pathway
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- id: PW:0000025
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parent: classic metabolic pathway
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type: Pathway Ontology
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value: glycolysis/gluconeogenesis pathway
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- id: PW:0000262
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parent: classic metabolic pathway
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type: Pathway Ontology
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parent: disease pathway
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type: Pathway Ontology
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value: melanoma pathway
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- id: PW:0000640
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- id: PW:0000026
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parent: classic metabolic pathway
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type: Pathway Ontology
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value: glycolysis pathway
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value: citric acid cycle pathway
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authors:
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- Khanspers
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citedin: ''
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communities: []
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description: draft
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last-edited: 2025-12-12
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last-edited: 2025-12-13
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ndex: null
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organisms:
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- Homo sapiens
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redirect_from:
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- /index.php/Pathway:WP5609
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- /instance/WP5609
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- /instance/WP5609_r142194
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- /instance/WP5609_r142197
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revision: r142197
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schema-jsonld:
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- '@context': https://schema.org/
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'@id': https://wikipathways.github.io/pathways/WP5609.html

assets/img/WP108/WP108-thumb.png

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assets/img/WP5609/WP5609-thumb.png

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