Important

Due to technical issues, this repository will not be maintained temporarily. Active maintenance and development have moved to zhuchcn/package-moPepGen. For issues or support, please open an issue in that repository.

Multi-Omics Peptide Generator

moPepGen (multi-omics peptide generator) uses data from one or more omics experiments and calls variant peptides as custom databases for proteogenomic library search.

moPepGen takes genomic and transcriptomic variants such as single nucleotide variants (SNPs or SNVs), small insertions/deletions (indels), gene fusion, alternative splicing, RNA circularization and RNA editing events, and generates noncanonical peptides affected by the variants.

Installation

Install from PyPI

pip install mopepgen

Install directly from GitHub

pip install git+ssh://[email protected]/uclahs-cds/package-moPepGen.git

Documentation

See here

Citation

1. Zhu, C., Liu, L.Y., Ha, A. et al. Identification of non-canonical peptides with moPepGen. Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02701-0