Abbreviations

ACT: artemisinin-based combination therapy

CG: cycloguanil

CL_int: intrinsic clearance

CQ: chloroquine

DDU: Drug Discovery Unit

EC₅₀ : half maximal effective concentration

ED₉₀ : 90% effective dose

GSK: GlaxoSmithKline

hERG: human ether-à-go-go-related gene

HLM: human liver microsome

IC₅₀: half maximal inhibitory concentration

i.p.: intraperitoneally

IVIEWGA: in vitro evolution and whole-genome analysis

IVIVC: in vitro-in vivo correlation

MLEM: Model List of Essential Medicines

MLM: mouse liver microsome

MMV: Medicines for Malaria Venture

MoA: mode/mechanism of action

mRNA: messenger ribonucleic acid

MTX: methotrexate

OSM: Open Source Malaria

P.: Plasmodium

p.o.: (per os) orally

Pb: Plasmodium berghei

Pc: Plasmodium cynomolgi

Pf: Plasmodium falciparum

Pf ATP4: Plasmodium falciparum ATPase transporter

Pf CARL: Plasmodium falciparum cyclic amine resistance locus

Pf CPSF3: Plasmodium falciparum cleavage and polyadenylation specificity factor

Pf DHFR: Plasmodium falciparum dihydrofolate reductase

Pf DHODH: Plasmodium falciparum dihydroorotate dehydrogenase

Pf eEF2: Plasmodium falciparum translational elongation factor 2

Pf PI3K: Plasmodium falciparum phosphatidylinositol-3-kinase

Pf PI4K: Plasmodium falciparum phosphatidylinositol-4-OH kinase

Py : Plasmodium yoelli

PYR: pyrimethamine

q.d.: (quaque die) one a day

RCQ(s): reversed chloroquine(s)

SAR: structure-activity relationship

SCID: severe combined immunodeficiency

STPHI: Swiss Tropical and Public Health Institute

TAP: triaminopyrimidine

TQ: tafenoquine

tRNA: transfer ribonucleic acid

WHO: World Health Organization