Lumefantrine

Lumefantrine (a.k.a. benflumetol) was first synthesized in 1976 as a part of the Chinese anti-malarial research effort “Project 523” which also resulted in the discovery of artemisinin [44]. It is currently sold under the trade name Coartem®. The exact MoA of lumefantrine is unknown, however, studies suggest that it inhibits nucleic acid and protein synthesis through the inhibition of β-haematin formation by complexation with haemin [41]. Lumefantrine is currently used only in combination with artemether.