Mepacrine

Mepacrine (a.k.a quinacrine) was predominantly used throughout the Second World War as a prophylactic, sold under the trade name Atabrine [15]. This compound is a derivative of methylene blue, another anti-malarial that was discovered in 1891 and found to be an effective treatment for malaria [16, 17]. Its use has declined over the years but methylene blue and its derivatives are, however, the subject of increasing current interest [18] and it is currently in clinical trials as a combination with primaquine (vide infra). Mepacrine itself is no longer used today due to the high chance of undesirable side effects such as toxic psychosis [19].