Chloroquine

During the 1940s, chloroquine (CQ) was used to treat all forms of malaria with few side effects [20]. Resistance to CQ was first reported in the 1950s and over the years many strains of malaria have developed resistance. Indeed, resistant strains (K1, 7GB, W2, Dd2, etc.) of the malaria parasite are now used in potency evaluation assays as a way of showing efficacy [21]. Chloroquine is on the MLEM for the treatment of P. vivax in regions where resistance has not developed [14].