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Quinine
Swapnil Jha edited this page Oct 4, 2020
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First isolated from the bark of the cinchona tree in 1820, quinine has been used as one of the most effective treatments for malaria to date [12]. Resistance was first reported in the 1980s [13] and as of 2006, quinine is no longer used as a front-line treatment for malaria but is still on the WHO’s Model List of Essential Medicines (MLEM) [14] for the treatment of severe malaria in cases where artemisinins are not available.
Keywords: Malaria, Plasmodium, Mechanism of action, Drug discovery, Drug development
Original online version of this article (DOI: 10.1186/s12936-019-2724-z).