Halofantrine

Developed between the 1960s and 1970s by the Walter Reed Army Institute of Research [26], halofantrine was initially used for treatment against all forms of the Plasmodium parasite. Its use has diminished over time due to a number of undesirable side effects, such as the potential for high levels of cardiotoxicity. It is only used as a curative drug and not for prophylaxis due to the high toxicity risks and its unreliable pharmacological properties. Halofantrine is still used today, under the brand name Halfan™, but only in cases where patients are known to be free of heart disease and where the infection is due to severe and resistant forms of malaria [27].