Author's Contributions

All authors contributed to the writing, editing and proofing of the manuscript. All authors read and approved the final manuscript.

Acknowledgements

The authors thank various contributors for provision of unpublished data: these contributions have been acknowledged in the manuscript.

Competing interests

The authors declare that they have no competing interests.

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Ethics approval and consent to participate

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Funding

The authors thank the Australian Research Council and the Medicines for Malaria Venture for funding (LP150101226).

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